{"id":"https://openalex.org/W2166840790","doi":"https://doi.org/10.1007/bf03206563","title":"Mechanisms of neural cell death: Implications for development of neuroprotective treatment strategies","display_name":"Mechanisms of neural cell death: Implications for development of neuroprotective treatment strategies","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2166840790","doi":"https://doi.org/10.1007/bf03206563","mag":"2166840790","pmid":"https://pubmed.ncbi.nlm.nih.gov/15717003","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/534908"},"language":"en","primary_location":{"id":"doi:10.1007/bf03206563","doi":"https://doi.org/10.1007/bf03206563","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf03206563","pdf_url":null,"source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1602/neurorx.1.1.5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103360587","display_name":"Alexander G. Yakovlev","orcid":"https://orcid.org/0009-0002-2773-2052","observed_orcids":["https://orcid.org/0009-0002-2773-2052"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander G. Yakovlev","raw_affiliation_strings":["Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Room EP-12, 20057, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Room EP-12, 20057, Washington, DC","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011395603","display_name":"Alan I. Faden","orcid":"https://orcid.org/0000-0003-0128-2348","observed_orcids":["https://orcid.org/0000-0003-0128-2348"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan I. Faden","raw_affiliation_strings":["Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Room EP-12, 20057, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Room EP-12, 20057, Washington, DC","institution_ids":["https://openalex.org/I2799903593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011395603"],"corresponding_institution_ids":["https://openalex.org/I2799903593"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":3.2222,"has_fulltext":true,"cited_by_count":160,"citation_normalized_percentile":{"value":0.9343599,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"1","issue":"1","first_page":"5","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.9490000009536743},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9200000166893005},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/caspase-independent-apoptosis","display_name":"caspase-independent apoptosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/caspase-dependent-apoptosis","display_name":"caspase-dependent apoptosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.9419999718666077},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.652999997138977},{"id":"https://openalex.org/keywords/cell-death-pathways","display_name":"cell death pathways","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.9044828414916992},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8901005983352661},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6896778345108032},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.6148098707199097},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5816106200218201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5661776065826416},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.5589715242385864},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5459576845169067},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5372493267059326},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5160526633262634},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5125720500946045},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.46453505754470825},{"id":"https://openalex.org/C2992459734","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neural cell","level":3,"score":0.43269839882850647},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1303619146347046},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08377397060394287},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/bf03206563","doi":"https://doi.org/10.1007/bf03206563","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf03206563","pdf_url":null,"source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},{"id":"doi:10.1602/neurorx.1.1.5","doi":"https://doi.org/10.1602/neurorx.1.1.5","is_oa":true,"landing_page_url":"https://doi.org/10.1602/neurorx.1.1.5","pdf_url":"https://link.springer.com/content/pdf/10.1602/neurorx.1.1.5.pdf","source":{"id":"https://openalex.org/S4210170130","display_name":"NeuroRx","issn_l":"1545-5343","issn":["1545-5343","1545-5351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroRX","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:534908","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/534908","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroRx","raw_type":"Text"},{"id":"pmid:15717003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15717003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1602/neurorx.1.1.5","doi":"https://doi.org/10.1602/neurorx.1.1.5","is_oa":true,"landing_page_url":"https://doi.org/10.1602/neurorx.1.1.5","pdf_url":"https://link.springer.com/content/pdf/10.1602/neurorx.1.1.5.pdf","source":{"id":"https://openalex.org/S4210170130","display_name":"NeuroRx","issn_l":"1545-5343","issn":["1545-5343","1545-5351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroRX","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3438909367","display_name":"REGULATION OF CASPASE 3 GENE EXPRESSION IN NEURONAL CELL","funder_award_id":"R01NS038941","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3677652942","display_name":"MULTIPONTENTIAL DRUG TREATMENT STRATEGIES IN NEUROTRAMA","funder_award_id":"R01NS041119","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5253387754","display_name":"Apoptosis Induced by Traumatic Brain Injury","funder_award_id":"R01NS036537","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6735454813","display_name":"IDDRC at Children's Research Institute","funder_award_id":"P30HD040677","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8323229858","display_name":"GEORGETOWN INSTITUTE FOR COGNITIVE AND COMPUTATIONAL SCIENCES (GICCS)","funder_award_id":"DAMD179929007","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2166840790.pdf","grobid_xml":"https://content.openalex.org/works/W2166840790.grobid-xml"},"referenced_works_count":134,"referenced_works":["https://openalex.org/W91819719","https://openalex.org/W173271069","https://openalex.org/W173807663","https://openalex.org/W193161715","https://openalex.org/W390283485","https://openalex.org/W1480948328","https://openalex.org/W1519250999","https://openalex.org/W1532302462","https://openalex.org/W1584278440","https://openalex.org/W1597830591","https://openalex.org/W1601923831","https://openalex.org/W1904882776","https://openalex.org/W1942214720","https://openalex.org/W1945945498","https://openalex.org/W1966798559","https://openalex.org/W1970863115","https://openalex.org/W1971335269","https://openalex.org/W1972594822","https://openalex.org/W1972636570","https://openalex.org/W1978427824","https://openalex.org/W1978559408","https://openalex.org/W1979623498","https://openalex.org/W1979664185","https://openalex.org/W1981106016","https://openalex.org/W1985339713","https://openalex.org/W1987785848","https://openalex.org/W1987870690","https://openalex.org/W1993614010","https://openalex.org/W1997879915","https://openalex.org/W1998974178","https://openalex.org/W2000352412","https://openalex.org/W2000894919","https://openalex.org/W2002099577","https://openalex.org/W2002439304","https://openalex.org/W2002926498","https://openalex.org/W2004139620","https://openalex.org/W2010478401","https://openalex.org/W2012173926","https://openalex.org/W2012337697","https://openalex.org/W2012485229","https://openalex.org/W2012543314","https://openalex.org/W2012725823","https://openalex.org/W2012844571","https://openalex.org/W2013685285","https://openalex.org/W2024267786","https://openalex.org/W2024306318","https://openalex.org/W2024445545","https://openalex.org/W2027133795","https://openalex.org/W2029083682","https://openalex.org/W2030546970","https://openalex.org/W2032413974","https://openalex.org/W2033873142","https://openalex.org/W2034213169","https://openalex.org/W2036158708","https://openalex.org/W2039188961","https://openalex.org/W2039386747","https://openalex.org/W2041207883","https://openalex.org/W2042409437","https://openalex.org/W2042779695","https://openalex.org/W2045114648","https://openalex.org/W2045724381","https://openalex.org/W2046205790","https://openalex.org/W2049033330","https://openalex.org/W2049875635","https://openalex.org/W2052452850","https://openalex.org/W2052853635","https://openalex.org/W2054820743","https://openalex.org/W2056695281","https://openalex.org/W2057713336","https://openalex.org/W2059901120","https://openalex.org/W2060594848","https://openalex.org/W2063087507","https://openalex.org/W2067213521","https://openalex.org/W2068890239","https://openalex.org/W2071277764","https://openalex.org/W2073179464","https://openalex.org/W2073186504","https://openalex.org/W2074514843","https://openalex.org/W2079930944","https://openalex.org/W2082259697","https://openalex.org/W2082831926","https://openalex.org/W2083906562","https://openalex.org/W2087877138","https://openalex.org/W2088046563","https://openalex.org/W2089540661","https://openalex.org/W2091871031","https://openalex.org/W2092884999","https://openalex.org/W2092921862","https://openalex.org/W2093076184","https://openalex.org/W2095468287","https://openalex.org/W2095578202","https://openalex.org/W2096043228","https://openalex.org/W2097767970","https://openalex.org/W2102443458","https://openalex.org/W2102560361","https://openalex.org/W2103677278","https://openalex.org/W2105263387","https://openalex.org/W2106966818","https://openalex.org/W2107789276","https://openalex.org/W2111853402","https://openalex.org/W2112647530","https://openalex.org/W2114028050","https://openalex.org/W2114360920","https://openalex.org/W2117998622","https://openalex.org/W2119874123","https://openalex.org/W2120231451","https://openalex.org/W2121095034","https://openalex.org/W2122857482","https://openalex.org/W2124129686","https://openalex.org/W2124331303","https://openalex.org/W2126825296","https://openalex.org/W2128330442","https://openalex.org/W2135364357","https://openalex.org/W2140233572","https://openalex.org/W2140967934","https://openalex.org/W2142911279","https://openalex.org/W2149605526","https://openalex.org/W2150356795","https://openalex.org/W2151098840","https://openalex.org/W2156483686","https://openalex.org/W2157999078","https://openalex.org/W2159650080","https://openalex.org/W2163142681","https://openalex.org/W2166256921","https://openalex.org/W2167490100","https://openalex.org/W2168910137","https://openalex.org/W2188651990","https://openalex.org/W2223219944","https://openalex.org/W2324537964","https://openalex.org/W2328267773","https://openalex.org/W2407389652","https://openalex.org/W2413170079","https://openalex.org/W2764624667","https://openalex.org/W4211045864"],"related_works":["https://openalex.org/W1997265216","https://openalex.org/W1980621373","https://openalex.org/W2156945415","https://openalex.org/W2132914691","https://openalex.org/W23608664","https://openalex.org/W34345462","https://openalex.org/W2072310161","https://openalex.org/W2152139403","https://openalex.org/W2400208984","https://openalex.org/W2047093912"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
