{"id":"https://openalex.org/W2166781237","doi":"https://doi.org/10.1146/annurev.immunol.14.1.649","title":"THE NF-\u03baB AND I\u03baB PROTEINS: New Discoveries and Insights","display_name":"THE NF-\u03baB AND I\u03baB PROTEINS: New Discoveries and Insights","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W2166781237","doi":"https://doi.org/10.1146/annurev.immunol.14.1.649","mag":"2166781237","pmid":"https://pubmed.ncbi.nlm.nih.gov/8717528"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.immunol.14.1.649","doi":"https://doi.org/10.1146/annurev.immunol.14.1.649","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.immunol.14.1.649","pdf_url":null,"source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034236608","display_name":"Albert S. Baldwin","orcid":"https://orcid.org/0000-0003-1246-1333","observed_orcids":["https://orcid.org/0000-0003-1246-1333","https://orcid.org/0000-0003-1246-1346","https://orcid.org/0000-0003-1246-1347","https://orcid.org/0000-0003-1246-1348","https://orcid.org/0000-0003-1246-1349","https://orcid.org/0000-0003-1246-1350","https://orcid.org/0000-0003-1246-1357","https://orcid.org/0000-0003-1246-1359","https://orcid.org/0000-0003-1246-1360","https://orcid.org/0000-0003-1246-1361","https://orcid.org/0000-0003-1246-1362"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Albert S. Baldwin","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, and Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, and Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034236608"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"],"apc_list":null,"apc_paid":null,"fwci":12.3602,"has_fulltext":false,"cited_by_count":5950,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"649","last_page":"681"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9490000009536743},{"id":"https://openalex.org/keywords/ikappab","display_name":"I\u03baB","score":0.8999999761581421},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/transcription-factor-regulation","display_name":"transcription factor regulation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/lps-signaling","display_name":"LPS signaling","score":0.550000011920929},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/viral-gene-products","display_name":"viral gene products","score":0.7480000257492065},{"id":"https://openalex.org/keywords/uv-irradiation","display_name":"UV irradiation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7699999809265137},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.7279999852180481},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7684558629989624},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.7279884815216064},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7127344608306885},{"id":"https://openalex.org/C2779730028","wikidata":"https://www.wikidata.org/wiki/Q15325101","display_name":"I\u03baB\u03b1","level":4,"score":0.572493314743042},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5629552006721497},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5565090179443359},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.544623076915741},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.49750879406929016},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.4960246980190277},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4451505243778229},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.427762508392334},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4251430034637451},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41858386993408203},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41357290744781494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3123742938041687},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3015122413635254},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23693600296974182},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.14996594190597534},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev.immunol.14.1.649","doi":"https://doi.org/10.1146/annurev.immunol.14.1.649","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.immunol.14.1.649","pdf_url":null,"source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},{"id":"pmid:8717528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8717528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:cdr.lib.unc.edu:uuid:ac4a905e-d22c-42a3-a3fa-656535b1143a","doi":null,"is_oa":false,"landing_page_url":"https://cdr.lib.unc.edu/record/uuid:ac4a905e-d22c-42a3-a3fa-656535b1143a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6600000262260437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":191,"referenced_works":["https://openalex.org/W21746843","https://openalex.org/W37351408","https://openalex.org/W46689513","https://openalex.org/W64342747","https://openalex.org/W75708282","https://openalex.org/W78369961","https://openalex.org/W89090581","https://openalex.org/W95988660","https://openalex.org/W120387323","https://openalex.org/W128911665","https://openalex.org/W143287638","https://openalex.org/W155134865","https://openalex.org/W169397793","https://openalex.org/W200654024","https://openalex.org/W293684771","https://openalex.org/W1479762169","https://openalex.org/W1485904813","https://openalex.org/W1486001184","https://openalex.org/W1513349945","https://openalex.org/W1517251498","https://openalex.org/W1522773084","https://openalex.org/W1523451636","https://openalex.org/W1531291958","https://openalex.org/W1554605625","https://openalex.org/W1561376991","https://openalex.org/W1562045776","https://openalex.org/W1565998937","https://openalex.org/W1571432275","https://openalex.org/W1572004867","https://openalex.org/W1581994384","https://openalex.org/W1586722842","https://openalex.org/W1588777732","https://openalex.org/W1591881963","https://openalex.org/W1592606160","https://openalex.org/W1605613258","https://openalex.org/W1634459475","https://openalex.org/W1701546247","https://openalex.org/W1717444875","https://openalex.org/W1738590766","https://openalex.org/W1771892390","https://openalex.org/W1776494781","https://openalex.org/W1778867513","https://openalex.org/W1822081448","https://openalex.org/W1825703274","https://openalex.org/W1846712328","https://openalex.org/W1849404587","https://openalex.org/W1869391303","https://openalex.org/W1870752655","https://openalex.org/W1914692347","https://openalex.org/W1915074145","https://openalex.org/W1934239664","https://openalex.org/W1947336377","https://openalex.org/W1950350164","https://openalex.org/W1952068404","https://openalex.org/W1963705823","https://openalex.org/W1964562798","https://openalex.org/W1965459549","https://openalex.org/W1968019392","https://openalex.org/W1968987342","https://openalex.org/W1971755644","https://openalex.org/W1973422045","https://openalex.org/W1973562827","https://openalex.org/W1974178581","https://openalex.org/W1975077455","https://openalex.org/W1975437758","https://openalex.org/W1976989696","https://openalex.org/W1977348907","https://openalex.org/W1977662482","https://openalex.org/W1980166683","https://openalex.org/W1981741774","https://openalex.org/W1981792394","https://openalex.org/W1982062664","https://openalex.org/W1983668987","https://openalex.org/W1984380214","https://openalex.org/W1992155578","https://openalex.org/W1992889151","https://openalex.org/W1993847641","https://openalex.org/W1994835768","https://openalex.org/W1994915896","https://openalex.org/W1995184275","https://openalex.org/W1996242303","https://openalex.org/W1997124556","https://openalex.org/W1997555839","https://openalex.org/W2002674047","https://openalex.org/W2003243698","https://openalex.org/W2006014863","https://openalex.org/W2006705806","https://openalex.org/W2008608024","https://openalex.org/W2009550948","https://openalex.org/W2010237936","https://openalex.org/W2015686762","https://openalex.org/W2017467565","https://openalex.org/W2018718597","https://openalex.org/W2021656955","https://openalex.org/W2024185310","https://openalex.org/W2029673189","https://openalex.org/W2033810895","https://openalex.org/W2035280748","https://openalex.org/W2035616122","https://openalex.org/W2036500213","https://openalex.org/W2036528355","https://openalex.org/W2036770241","https://openalex.org/W2045164993","https://openalex.org/W2048963024","https://openalex.org/W2049671131","https://openalex.org/W2051237803","https://openalex.org/W2051895005","https://openalex.org/W2052463317","https://openalex.org/W2053475175","https://openalex.org/W2054487299","https://openalex.org/W2056945702","https://openalex.org/W2059570070","https://openalex.org/W2059906441","https://openalex.org/W2061727101","https://openalex.org/W2061903251","https://openalex.org/W2062800478","https://openalex.org/W2063081233","https://openalex.org/W2069032252","https://openalex.org/W2069292681","https://openalex.org/W2069355785","https://openalex.org/W2070005836","https://openalex.org/W2070853191","https://openalex.org/W2073993982","https://openalex.org/W2074011532","https://openalex.org/W2074069338","https://openalex.org/W2078707053","https://openalex.org/W2079457084","https://openalex.org/W2088094960","https://openalex.org/W2093398266","https://openalex.org/W2095019663","https://openalex.org/W2096115392","https://openalex.org/W2096589599","https://openalex.org/W2096606942","https://openalex.org/W2097513054","https://openalex.org/W2099644089","https://openalex.org/W2100250344","https://openalex.org/W2100841967","https://openalex.org/W2101441975","https://openalex.org/W2101759139","https://openalex.org/W2103079216","https://openalex.org/W2103918307","https://openalex.org/W2104007937","https://openalex.org/W2109478329","https://openalex.org/W2109486527","https://openalex.org/W2110006646","https://openalex.org/W2112135370","https://openalex.org/W2116650665","https://openalex.org/W2117495711","https://openalex.org/W2118318403","https://openalex.org/W2122515902","https://openalex.org/W2124902862","https://openalex.org/W2129358952","https://openalex.org/W2133074755","https://openalex.org/W2137924986","https://openalex.org/W2142277736","https://openalex.org/W2142541950","https://openalex.org/W2143257167","https://openalex.org/W2144047144","https://openalex.org/W2146391433","https://openalex.org/W2149902181","https://openalex.org/W2151892297","https://openalex.org/W2156255102","https://openalex.org/W2156657499","https://openalex.org/W2156797532","https://openalex.org/W2158110584","https://openalex.org/W2158708535","https://openalex.org/W2158748165","https://openalex.org/W2159168998","https://openalex.org/W2165117243","https://openalex.org/W2168889062","https://openalex.org/W2169053713","https://openalex.org/W2169150729","https://openalex.org/W2275307165","https://openalex.org/W2277011491","https://openalex.org/W2289810771","https://openalex.org/W2344003127","https://openalex.org/W2400313130","https://openalex.org/W2409650525","https://openalex.org/W2411211523","https://openalex.org/W2412463516","https://openalex.org/W2427880780","https://openalex.org/W3213553087","https://openalex.org/W4231938941","https://openalex.org/W4233281395","https://openalex.org/W4237429324","https://openalex.org/W4241294365","https://openalex.org/W4247527407","https://openalex.org/W4251045844","https://openalex.org/W4251712623","https://openalex.org/W4254644374","https://openalex.org/W4322388302"],"related_works":["https://openalex.org/W4313377149","https://openalex.org/W2091162155","https://openalex.org/W2069649695","https://openalex.org/W1988970488","https://openalex.org/W1963709111","https://openalex.org/W2070597393","https://openalex.org/W3148259388","https://openalex.org/W2349610456","https://openalex.org/W1971473840","https://openalex.org/W2466582515"],"abstract_inverted_index":{"The":[0],"transcription":[1,186],"factor":[2],"NF-kappa":[3,55,84,89,133,171,176,207,234,239,257,288],"B":[4,56,79,85,90,119,134,177,208,235,240],"has":[5,156,242],"attracted":[6],"widespread":[7],"attention":[8],"among":[9],"researchers":[10],"in":[11,34,46,167,212,220,229,238],"many":[12],"fields":[13],"based":[14],"on":[15],"the":[16,23,37,71,138,143,168,174,231,246,259,275,284],"following:":[17],"its":[18,31,40,43],"unusual":[19],"and":[20,42,124,128,146,160,184,197,269,274],"rapid":[21],"regulation,":[22],"wide":[24],"range":[25],"of":[26,39,52,73,76,96,112,132,149,170,187,222,233,249,256,267,270,279,287],"genes":[27,188],"that":[28,80,163,206],"it":[29],"controls,":[30],"central":[32],"role":[33],"immunological":[35],"processes,":[36],"complexity":[38],"subunits,":[41],"apparent":[44],"involvement":[45],"several":[47,158,213],"diseases.":[48],"A":[49],"primary":[50],"level":[51],"control":[53],"for":[54,253,264,277],"is":[57,140,209],"through":[58],"interactions":[59],"with":[60,192,198],"an":[61],"inhibitor":[62],"protein":[63],"called":[64],"I":[65,77,150,271],"kappa":[66,78,151,272],"B.":[67,152,172,289],"Recent":[68,202],"evidence":[69,205],"confirms":[70],"existence":[72],"multiple":[74],"forms":[75,266],"appear":[81],"to":[82,98,135,180,227,282],"regulate":[83],"by":[86,94,125,142,245],"distinct":[87],"mechanisms.":[88],"can":[91],"be":[92],"activated":[93],"exposure":[95],"cells":[97],"LPS":[99],"or":[100,106,110,120,194],"inflammatory":[101],"cytokines":[102],"such":[103],"as":[104],"TNF":[105],"IL-1,":[107],"viral":[108,114],"infection":[109],"expression":[111],"certain":[113],"gene":[115,223,261],"products,":[116],"UV":[117],"irradiation,":[118],"T":[121],"cell":[122,199,214],"activation,":[123,236],"other":[126],"physiological":[127],"nonphysiological":[129],"stimuli.":[130],"Activation":[131],"move":[136],"into":[137],"nucleus":[139],"controlled":[141],"targeted":[144],"phosphorylation":[145],"subsequent":[147],"degradation":[148],"Exciting":[153],"new":[154],"research":[155,241],"elaborated":[157],"important":[159],"unexpected":[161,218],"findings":[162],"explain":[164],"mechanisms":[165,232],"involved":[166,191],"activation":[169,286],"In":[173,225],"nucleus,":[175],"dimers":[178],"bind":[179],"target":[181],"DNA":[182],"elements":[183],"activate":[185],"encoding":[189],"proteins":[190],"immune":[193],"inflammation":[195],"responses":[196],"growth":[200],"control.":[201],"data":[203],"provide":[204],"constitutively":[210],"active":[211],"types,":[215],"potentially":[216],"playing":[217],"roles":[219],"regulation":[221],"expression.":[224],"addition":[226],"advances":[228],"describing":[230],"excitement":[237],"been":[243],"generated":[244],"first":[247,260],"report":[248],"a":[250],"crystal":[251],"structure":[252],"one":[254],"form":[255],"B,":[258,273],"knockout":[262],"studies":[263],"different":[265],"NF-kB":[268],"implications":[276],"therapies":[278],"diseases":[280],"thought":[281],"involve":[283],"inappropriate":[285]},"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":66},{"year":2024,"cited_by_count":68},{"year":2023,"cited_by_count":79},{"year":2022,"cited_by_count":106},{"year":2021,"cited_by_count":108},{"year":2020,"cited_by_count":119},{"year":2019,"cited_by_count":118},{"year":2018,"cited_by_count":130},{"year":2017,"cited_by_count":136},{"year":2016,"cited_by_count":135},{"year":2015,"cited_by_count":162},{"year":2014,"cited_by_count":148},{"year":2013,"cited_by_count":198},{"year":2012,"cited_by_count":191}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}