{"id":"https://openalex.org/W2166765846","doi":null,"title":"Effects of chronic ethanol consumption on benzo(a)pyrene metabolism and glutathione S-transferase activities in Syrian golden hamster cheek pouch and liver.","display_name":"Effects of chronic ethanol consumption on benzo(a)pyrene metabolism and glutathione S-transferase activities in Syrian golden hamster cheek pouch and liver.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2166765846","mag":"2166765846","pmid":"https://pubmed.ncbi.nlm.nih.gov/3940187"},"language":"en","primary_location":{"id":"pmid:3940187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3940187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022126431","display_name":"Sharon E. Murphy","orcid":"https://orcid.org/0000-0001-5391-8104","observed_orcids":["https://orcid.org/0000-0001-5391-8104"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S E Murphy","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033402104","display_name":"Stephen S. Hecht","orcid":"https://orcid.org/0000-0001-7228-1356","observed_orcids":["https://orcid.org/0000-0001-7228-1356"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S S Hecht","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":0.4493,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.63157895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"1","first_page":"141","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzo-a-pyrene-metabolism","display_name":"benzo[a]pyrene metabolism","score":0.9449999928474426},{"id":"https://openalex.org/keywords/chronic-alcohol-consumption","display_name":"chronic alcohol consumption","score":0.9240000247955322},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.8949999809265137},{"id":"https://openalex.org/keywords/9-hydroxybenzo-a-pyrene","display_name":"9-hydroxybenzo[a]pyrene","score":0.9110000133514404},{"id":"https://openalex.org/keywords/3-hydroxybenzo-a-pyrene","display_name":"3-hydroxybenzo[a]pyrene","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hepatic-glutathione","display_name":"hepatic glutathione","score":0.7580000162124634},{"id":"https://openalex.org/keywords/syrian-hamster","display_name":"golden hamster","score":0.5889999866485596},{"id":"https://openalex.org/keywords/carcinogen-metabolism","display_name":"carcinogen metabolism","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C34439696","wikidata":"https://www.wikidata.org/wiki/Q95539","display_name":"Cheek pouch","level":3,"score":0.809285044670105},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.6966415643692017},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.658882737159729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6463956832885742},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.6304716467857361},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.6187750101089478},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5030538439750671},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.4365406632423401},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4227275848388672},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4101966619491577},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4059852063655853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3823101222515106},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.3819219470024109},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36112862825393677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24246636033058167},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16572609543800354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09421882033348083},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.04687386751174927}],"mesh":[{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3940187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3940187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2166765846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3940187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1917019992","https://openalex.org/W2049965223","https://openalex.org/W2079172498","https://openalex.org/W2082837008","https://openalex.org/W2163278516"],"related_works":["https://openalex.org/W2065026754","https://openalex.org/W2022854167","https://openalex.org/W1973394800","https://openalex.org/W2121159081","https://openalex.org/W2039783655","https://openalex.org/W2192938089","https://openalex.org/W2046239665","https://openalex.org/W2034238960","https://openalex.org/W2401515904","https://openalex.org/W1972023571"],"abstract_inverted_index":{"The":[0,71,202],"metabolism":[1,72,113],"of":[2,55,73,114,129,140,150,162,199],"benzo(a)pyrene":[3],"(BaP)":[4],"by":[5,85,145,207],"hepatic":[6,60,86,163],"or":[7,39,51,143,164,176],"cheek":[8,52,126,146,165,217],"pouch":[9,53,127,147,166],"epithelium":[10,54,128,148,167],"microsomes":[11,87,123,149],"obtained":[12,47],"from":[13,29,48,88,124],"Syrian":[14],"golden":[15],"hamsters":[16,90,152,173],"which":[17,208],"had":[18],"been":[19],"consuming":[20],"an":[21],"ethanol-containing":[22],"liquid":[23],"diet":[24],"for":[25],"4":[26,196],"wk":[27,193,197],"and":[28,68,82,118,171,195],"pair-fed":[30],"controls":[31],"was":[32,43,91,120,133,179,184],"measured.":[33],"Glutathione":[34],"S-transferase":[35,160],"activity":[36,161],"with":[37,122],"1-chloro-2,4-dinitrobenzene":[38,175],"(+/-)-r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene":[40],"as":[41],"substrates":[42],"measured":[44,64,121],"in":[45,65,111,137,158,214],"cytosol":[46,168],"the":[49,56,112,125,138,215],"liver":[50],"same":[57],"animals.":[58,70,131],"Cytosolic":[59],"glutathione":[61,159,182],"levels":[62],"were":[63],"both":[66],"ethanol-consuming":[67,89,130,151,172],"control":[69,101,170],"BaP":[74,115,212],"to":[75,100,116,154],"4,5-dihydro-4,5-dihydroxybenzo(a)pyrene":[76],"(BaP-4,5-diol),":[77],"7,8-dihydro-7,8-dihydroxybenzo(a)pyrene":[78],"(BaP-7,8-diol),":[79],"9-hydroxybenzo(a)pyrene":[80],"(9-OH-BaP),":[81],"3-hydroxybenzo(a)pyrene":[83],"(3-OH-BaP)":[84],"significantly":[92,185],"reduced":[93],"(40-52%)":[94],"(P":[95,107,186],"less":[96,108,187],"than":[97,109,188],"0.05)":[98,110,189],"compared":[99,153],"microsomes.":[102],"However,":[103],"a":[104,205],"2-fold":[105],"increase":[106],"BaP-7,8-diol":[117],"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene":[119],"There":[132],"no":[134],"significant":[135],"change":[136],"production":[139],"BaP-4,5-diol,":[141],"9-OH-BaP,":[142],"3-OH-BaP":[144],"controls.":[155],"No":[156],"difference":[157],"between":[169],"towards":[174],"(+/-)-r-7,t-8-dihydroxy-t-9,10-":[177],"epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene":[178],"observed.":[180],"Hepatic":[181],"content":[183],"decreased":[190],"after":[191],"2":[192],"(23%)":[194],"(33%)":[198],"ethanol":[200,209],"consumption.":[201],"results":[203],"suggest":[204],"mechanism":[206],"might":[210],"enhance":[211],"tumorigenesis":[213],"hamster":[216],"pouch.":[218]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}