{"id":"https://openalex.org/W2166685519","doi":"https://doi.org/10.1172/jci200421767","title":"T cell\u2013mediated vascular dysfunction of human allografts results from IFN-\u03b3 dysregulation of NO synthase","display_name":"T cell\u2013mediated vascular dysfunction of human allografts results from IFN-\u03b3 dysregulation of NO synthase","publication_year":2004,"publication_date":"2004-09-15","ids":{"openalex":"https://openalex.org/W2166685519","doi":"https://doi.org/10.1172/jci200421767","mag":"2166685519","pmid":"https://pubmed.ncbi.nlm.nih.gov/15372109","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/516264"},"language":"en","primary_location":{"id":"doi:10.1172/jci200421767","doi":"https://doi.org/10.1172/jci200421767","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci200421767","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/21767/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026203926","display_name":"Kian Peng Koh","orcid":"https://orcid.org/0000-0003-2523-5175","observed_orcids":["https://orcid.org/0000-0003-2523-5175"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kian Peng Koh","raw_affiliation_strings":["Department of Pharmacology,","Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology,","institution_ids":[]},{"raw_affiliation_string":"Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004434222","display_name":"Yinong Wang","orcid":"https://orcid.org/0000-0003-0954-3493","observed_orcids":["https://orcid.org/0000-0003-0954-3493"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yinong Wang","raw_affiliation_strings":["Department of Surgery,","Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery,","institution_ids":[]},{"raw_affiliation_string":"Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028806508","display_name":"Tai Yi","orcid":"https://orcid.org/0000-0003-0464-1043","observed_orcids":["https://orcid.org/0000-0003-0464-1043"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tai Yi","raw_affiliation_strings":["Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063600668","display_name":"Stephen Lawrence Shiao","orcid":"https://orcid.org/0000-0001-7586-2885","observed_orcids":["https://orcid.org/0000-0001-7586-2885"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L. Shiao","raw_affiliation_strings":["Department of Surgery,","Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,","Section of Immunobiology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery,","institution_ids":[]},{"raw_affiliation_string":"Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Section of Immunobiology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055641686","display_name":"Marc I. Lorber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc I. Lorber","raw_affiliation_strings":["Department of Surgery,","Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery,","institution_ids":[]},{"raw_affiliation_string":"Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019471332","display_name":"William C. Sessa","orcid":"https://orcid.org/0000-0001-5759-1938","observed_orcids":["https://orcid.org/0000-0001-5759-1938"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C. Sessa","raw_affiliation_strings":["Department of Pharmacology,","Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology,","institution_ids":[]},{"raw_affiliation_string":"Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036202065","display_name":"George Tellides","orcid":"https://orcid.org/0000-0001-7042-8190","observed_orcids":["https://orcid.org/0000-0001-7042-8190"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Tellides","raw_affiliation_strings":["Department of Surgery,","Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery,","institution_ids":[]},{"raw_affiliation_string":"Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022235365","display_name":"Jordan S. Pober","orcid":"https://orcid.org/0000-0001-5990-1071","observed_orcids":["https://orcid.org/0000-0001-5990-1071"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jordan S. Pober","raw_affiliation_strings":["Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA","Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,","Section of Immunobiology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Section of Immunobiology, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022235365"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":10.0258,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.98540099,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"114","issue":"6","first_page":"846","last_page":"856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.09470000118017197,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8029999732971191},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.8080000281333923},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7239999771118164},{"id":"https://openalex.org/keywords/arteriosclerosis","display_name":"arteriosclerosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/graft-loss","display_name":"graft loss","score":0.5680000185966492},{"id":"https://openalex.org/keywords/allogeneic-t-cells","display_name":"allogeneic T cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/memory-cd4-t-cells","display_name":"memory CD4+ T cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9120000004768372},{"id":"https://openalex.org/keywords/lfa-3","display_name":"LFA-3","score":0.8059999942779541},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.5676555037498474},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5287120938301086},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.5227439403533936},{"id":"https://openalex.org/C2776393769","wikidata":"https://www.wikidata.org/wiki/Q184559","display_name":"Arteriosclerosis","level":2,"score":0.49828100204467773},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4763098955154419},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.46320903301239014},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4589342772960663},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4534575343132019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42275574803352356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3586816191673279},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3584432005882263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33293578028678894},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.30856674909591675},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.215545654296875},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.16146916151046753},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci200421767","doi":"https://doi.org/10.1172/jci200421767","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci200421767","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"doi:10.1172/jci21767","doi":"https://doi.org/10.1172/jci21767","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci21767","pdf_url":"http://www.jci.org/articles/view/21767/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:516264","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/516264","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:15372109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15372109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci21767","doi":"https://doi.org/10.1172/jci21767","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci21767","pdf_url":"http://www.jci.org/articles/view/21767/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1692468525","display_name":"Chronic DTH and IFN-gamma in Human Graft Arteriosclerosis","funder_award_id":"P01HL070295","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2166685519.pdf","grobid_xml":"https://content.openalex.org/works/W2166685519.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W282283539","https://openalex.org/W1466598573","https://openalex.org/W1523840697","https://openalex.org/W1560571961","https://openalex.org/W1569511882","https://openalex.org/W1602588097","https://openalex.org/W1791996532","https://openalex.org/W1929009802","https://openalex.org/W1972724464","https://openalex.org/W1974316554","https://openalex.org/W1981568036","https://openalex.org/W1990793066","https://openalex.org/W1999803444","https://openalex.org/W2000086866","https://openalex.org/W2014592293","https://openalex.org/W2017160514","https://openalex.org/W2022745297","https://openalex.org/W2030435101","https://openalex.org/W2039000358","https://openalex.org/W2041075406","https://openalex.org/W2044263892","https://openalex.org/W2051605684","https://openalex.org/W2051645126","https://openalex.org/W2052391094","https://openalex.org/W2052939007","https://openalex.org/W2054501376","https://openalex.org/W2057841877","https://openalex.org/W2059787313","https://openalex.org/W2066052096","https://openalex.org/W2072734854","https://openalex.org/W2074858413","https://openalex.org/W2078370178","https://openalex.org/W2080672608","https://openalex.org/W2085663049","https://openalex.org/W2099528876","https://openalex.org/W2102935782","https://openalex.org/W2107947903","https://openalex.org/W2112656429","https://openalex.org/W2116958277","https://openalex.org/W2117107523","https://openalex.org/W2118284746","https://openalex.org/W2132621489","https://openalex.org/W2134339845","https://openalex.org/W2139980064","https://openalex.org/W2144979976","https://openalex.org/W2145570729","https://openalex.org/W2155715610","https://openalex.org/W2159819332","https://openalex.org/W2172210013","https://openalex.org/W2176987607","https://openalex.org/W2212609883","https://openalex.org/W2240542889","https://openalex.org/W2284527445","https://openalex.org/W2318018840","https://openalex.org/W2335973780","https://openalex.org/W2395932275","https://openalex.org/W2415420446","https://openalex.org/W4210657423","https://openalex.org/W4213297656"],"related_works":["https://openalex.org/W2069254113","https://openalex.org/W1966252111","https://openalex.org/W1593792120","https://openalex.org/W2121519417","https://openalex.org/W1981568036","https://openalex.org/W2404627379","https://openalex.org/W2037094262","https://openalex.org/W2059787313","https://openalex.org/W2942791908","https://openalex.org/W2085663049"],"abstract_inverted_index":{"Allograft":[0],"vascular":[1,88,188],"dysfunction":[2,12,40,89,189,198],"predisposes":[3],"to":[4,20,44,57,109,135],"arteriosclerosis":[5],"and":[6,55,73,90,100,114,139,143,156,167,177],"graft":[7,116],"loss.":[8],"We":[9,179],"examined":[10],"how":[11],"develops":[13],"in":[14,18,25,92,122],"transplanted":[15,34],"human":[16],"arteries":[17,35],"response":[19],"circulating":[21],"allogeneic":[22,132],"T":[23,65,81,128,148],"cells":[24,129],"vivo":[26],"using":[27],"immunodeficient":[28],"murine":[29],"hosts.":[30],"Within":[31],"7-9":[32],"days,":[33],"developed":[36,52],"endothelial":[37],"cell":[38,149],"(EC)":[39],"but":[41],"remained":[42],"sensitive":[43],"exogenous":[45],"NO.":[46],"By":[47],"2":[48,112],"weeks,":[49],"the":[50,165],"grafts":[51],"impaired":[53],"contractility":[54],"desensitization":[56],"NO,":[58],"both":[59,87],"signs":[60],"of":[61,71,75,141,172,187,193],"VSMC":[62],"dysfunction.":[63,103],"These":[64,145],"cell-dependent":[66],"changes":[67,91],"correlated":[68],"with":[69,199],"loss":[70],"eNOS":[72,137],"expression":[74,140],"iNOS--the":[76],"latter":[77],"predominantly":[78],"within":[79],"infiltrating":[80],"cells.":[82],"Neutralizing":[83],"IFN-gamma":[84,98,176,182],"completely":[85],"prevented":[86,102],"NOS":[93,194],"expression;":[94],"neutralizing":[95],"TNF":[96],"reduced":[97,115],"production":[99,171],"partially":[101,106],"Inhibiting":[104],"iNOS":[105],"preserved":[107],"responses":[108],"NO":[110],"at":[111],"weeks":[113,121],"intimal":[117],"expansion":[118],"after":[119],"4":[120],"vivo.":[123],"In":[124],"vitro,":[125],"memory":[126],"CD4+":[127],"acted":[130],"on":[131,164],"cultured":[133],"ECs":[134,166],"reduce":[136],"activity":[138],"protein":[142],"mRNA.":[144],"effects":[146],"required":[147],"activation":[150],"by":[151,170],"class":[152],"II":[153],"MHC":[154],"antigens":[155],"costimulators":[157],"(principally":[158],"lymphocyte":[159],"function-associated":[160],"antigen-3,":[161],"or":[162],"LFA-3)":[163],"were":[168],"mediated":[169],"soluble":[173],"mediators":[174],"including":[175],"TNF.":[178],"conclude":[180],"that":[181],"is":[183],"a":[184],"central":[185],"mediator":[186],"and,":[190],"through":[191],"dysregulation":[192],"expression,":[195],"links":[196],"early":[197],"late":[200],"arteriosclerosis.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}