{"id":"https://openalex.org/W2166560360","doi":null,"title":"Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration.","display_name":"Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration.","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2166560360","mag":"2166560360","pmid":"https://pubmed.ncbi.nlm.nih.gov/20083846","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6714047"},"language":"en","primary_location":{"id":"pmid:20083846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20083846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6714047","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054533447","display_name":"Rosetta Merline","orcid":"https://orcid.org/0000-0002-0476-4695","observed_orcids":["https://orcid.org/0000-0002-0476-4695"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Merline","raw_affiliation_strings":["Pharmazentrum Frankfurt/ZAFES, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe-Universit\u00e4t Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmazentrum Frankfurt/ZAFES, Institut fur Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe-Universit\u00e4t Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009703894","display_name":"Sandra Lazaroski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Lazaroski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059864807","display_name":"Andrea B\u00e1belov\u00e1","orcid":"https://orcid.org/0000-0001-9548-6602","observed_orcids":["https://orcid.org/0000-0001-9548-6602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Babelova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007588836","display_name":"Wasiliki Tsalastra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Tsalastra-Greul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113493690","display_name":"Josef M. Pfeilschifter","orcid":"https://orcid.org/0000-0001-9315-9122","observed_orcids":["https://orcid.org/0000-0001-9315-9122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Pfeilschifter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088724322","display_name":"Klaus\u2010Dieter Schl\u00fcter","orcid":"https://orcid.org/0000-0002-6093-4919","observed_orcids":["https://orcid.org/0000-0002-6093-4919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K D Schluter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110709590","display_name":"Andreas G\u00fcnther","orcid":"https://orcid.org/0000-0002-2187-0975","observed_orcids":["https://orcid.org/0000-0002-2187-0975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Gunther","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030553564","display_name":"Renato V. Iozzo","orcid":"https://orcid.org/0000-0002-5908-5112","observed_orcids":["https://orcid.org/0000-0002-5908-5112"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R V Iozzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109948156","display_name":"R. M. Schaefer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Schaefer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002720012","display_name":"Liliana Schaefer","orcid":"https://orcid.org/0000-0002-3318-3005","observed_orcids":["https://orcid.org/0000-0002-3318-3005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Schaefer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9611,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.95483551,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"60 Suppl 4","issue":null,"first_page":"5","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decorin","display_name":"decorin","score":0.984000027179718},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/small-leucine-rich-proteoglycans","display_name":"small leucine-rich proteoglycans","score":0.8809999823570251},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.8740000128746033},{"id":"https://openalex.org/keywords/podocyte-apoptosis","display_name":"podocyte apoptosis","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tubular-epithelial-cells","display_name":"tubular epithelial cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8799999952316284},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/extracellular-matrix-accumulation","display_name":"extracellular matrix accumulation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/biglycan","display_name":"biglycan","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mononuclear-cell-infiltration","display_name":"mononuclear cell infiltration","score":0.9430000185966492},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.9169999957084656},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9229999780654907},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.9763372540473938},{"id":"https://openalex.org/C2778916964","wikidata":"https://www.wikidata.org/wiki/Q14905499","display_name":"Biglycan","level":5,"score":0.824142336845398},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.7389485836029053},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.5615552663803101},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.5593835711479187},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5536172389984131},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4621577560901642},{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.43794485926628113},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.4372095465660095},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.426339328289032},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4114556312561035},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3987441062927246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.387448787689209},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.37506115436553955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33810701966285706},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.33765342831611633},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3365671634674072},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24344423413276672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19734051823616028},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.19223526120185852},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08861887454986572},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.08757385611534119},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07543724775314331}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020556","descriptor_name":"Neutrophil Infiltration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050199","descriptor_name":"Podocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055513","descriptor_name":"Connective Tissue Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058575","descriptor_name":"Decorin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:20083846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20083846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6714047","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6714047","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Physiol Pharmacol","raw_type":"Text"},{"id":"mag:2166560360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20083846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6714047","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6714047","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Physiol Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2183386414","display_name":"The Biology of Perlecan in Cancer and Angiogenesis","funder_award_id":"R01CA047282","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G860411865","display_name":"Altered Proteoglycan Gene Expression and Cancer","funder_award_id":"R01CA039481","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1499047562","https://openalex.org/W1544527238","https://openalex.org/W1970395087","https://openalex.org/W1977389835","https://openalex.org/W1982158849","https://openalex.org/W1987383242","https://openalex.org/W1991388845","https://openalex.org/W1993507992","https://openalex.org/W1994344567","https://openalex.org/W1994496207","https://openalex.org/W1999064607","https://openalex.org/W1999265533","https://openalex.org/W1999568257","https://openalex.org/W2007378287","https://openalex.org/W2009219948","https://openalex.org/W2010571724","https://openalex.org/W2015766406","https://openalex.org/W2016005410","https://openalex.org/W2017096535","https://openalex.org/W2017120435","https://openalex.org/W2023104790","https://openalex.org/W2023713176","https://openalex.org/W2040961193","https://openalex.org/W2044614528","https://openalex.org/W2053352199","https://openalex.org/W2054796044","https://openalex.org/W2063436800","https://openalex.org/W2070013317","https://openalex.org/W2071812783","https://openalex.org/W2077684583","https://openalex.org/W2078317541","https://openalex.org/W2080505183","https://openalex.org/W2083106832","https://openalex.org/W2085574022","https://openalex.org/W2091321868","https://openalex.org/W2094375438","https://openalex.org/W2105662115","https://openalex.org/W2106704887","https://openalex.org/W2116253638","https://openalex.org/W2117326627","https://openalex.org/W2122071480","https://openalex.org/W2123080884","https://openalex.org/W2139518267","https://openalex.org/W2156854685","https://openalex.org/W2189211944","https://openalex.org/W2993228826"],"related_works":["https://openalex.org/W2023713176","https://openalex.org/W2049454415","https://openalex.org/W2189211944","https://openalex.org/W2396515341","https://openalex.org/W2008619404","https://openalex.org/W2117326627","https://openalex.org/W2635777747","https://openalex.org/W2136598700","https://openalex.org/W2119135680","https://openalex.org/W2888707342"],"abstract_inverted_index":{"Although":[0],"deficiency":[1,126],"of":[2,16,42,73,78,83,90,119,131,144,152,168,181,195],"the":[3,13,23,34,39,76,84,109,145,166,178,188,193],"small":[4],"leucine-rich":[5],"proteoglycan":[6,147],"decorin":[7,43,74,105,125,160,182,186],"aggravates":[8],"diabetic":[9,91,135,138,169,198],"nephropathy":[10],"in":[11,38,44,51,65,86,128,134],"mice,":[12],"precise":[14],"mechanisms":[15,36],"action":[17,41],"are":[18],"not":[19],"fully":[20],"understood.":[21],"In":[22,93],"present":[24],"study":[25],"we":[26],"used":[27],"decorin-deficient":[28],"mice":[29,53],"(Dcn(-/-))":[30],"to":[31,55,108,187],"further":[32],"elucidate":[33],"molecular":[35],"involved":[37],"protective":[40,163],"diabetes.":[45],"We":[46],"discovered":[47],"that":[48,103,159,174],"streptozotocin-induced":[49],"diabetes":[50],"Dcn(-/-)":[52,139],"led":[54],"increased":[56,75],"proteinuria":[57],"associated":[58],"with":[59,197],"enhanced":[60,129,150],"cyclin-dependent":[61],"kinase":[62],"inhibitor":[63],"p27Kip1":[64],"podocytes":[66],"and":[67,80,111,121,149],"tubular":[68,87],"epithelial":[69,88,100],"cells.":[70,154],"Furthermore,":[71,117],"lack":[72],"rate":[77],"apoptosis":[79],"caused":[81],"overexpression":[82,118],"IGF-IR":[85,110],"cells":[89,101],"kidneys.":[92,136],"vitro":[94],"experiments":[95],"using":[96],"human":[97],"proximal":[98],"renal":[99],"showed":[102],"recombinant":[104,185],"was":[106],"bound":[107],"protected":[112],"against":[113],"high":[114],"glucose-mediated":[115],"apoptosis.":[116],"TGFbeta1":[120],"CTGF":[122],"triggered":[123],"by":[124],"resulted":[127],"accumulation":[130],"extracellular":[132],"matrix":[133],"Notably,":[137],"kidneys":[140],"revealed":[141],"marked":[142],"upregulation":[143],"proinflammatory":[146],"biglycan":[148],"infiltration":[151],"mononuclear":[153],"Collectively,":[155],"our":[156],"results":[157],"indicate":[158],"is":[161],"a":[162],"agent":[164],"during":[165],"development":[167],"nephropathy.":[170,199],"Future":[171],"therapeutic":[172],"approaches":[173],"would":[175],"either":[176],"enhance":[177],"endogenous":[179],"production":[180],"or":[183],"deliver":[184],"diseased":[189],"kidney":[190],"might":[191],"improve":[192],"outcome":[194],"patients":[196]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":9},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
