{"id":"https://openalex.org/W2166500616","doi":"https://doi.org/10.7554/elife.07000","title":"Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish","display_name":"Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish","publication_year":2015,"publication_date":"2015-09-16","ids":{"openalex":"https://openalex.org/W2166500616","doi":"https://doi.org/10.7554/elife.07000","mag":"2166500616","pmid":"https://pubmed.ncbi.nlm.nih.gov/26374985","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4606453"},"language":"en","primary_location":{"id":"doi:10.7554/elife.07000","doi":"https://doi.org/10.7554/elife.07000","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.07000","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.07000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017547997","display_name":"Chanpreet Singh","orcid":"https://orcid.org/0000-0002-2697-3033","observed_orcids":["https://orcid.org/0000-0002-2697-3033"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chanpreet Singh","raw_affiliation_strings":["Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States","University of California, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"University of California, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021183394","display_name":"Grigorios Oikonomou","orcid":"https://orcid.org/0000-0001-6797-7375","observed_orcids":["https://orcid.org/0000-0001-6797-7375"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grigorios Oikonomou","raw_affiliation_strings":["Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States","University of California, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"University of California, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063329234","display_name":"David A. Prober","orcid":"https://orcid.org/0000-0002-7371-4675","observed_orcids":["https://orcid.org/0000-0002-7371-4675"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David A Prober","raw_affiliation_strings":["Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States","University of California, San Francisco, United States"],"raw_orcid":"https://orcid.org/0000-0002-7371-4675","affiliations":[{"raw_affiliation_string":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"University of California, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063329234"],"corresponding_institution_ids":["https://openalex.org/I122411786","https://openalex.org/I180670191"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":7.2063,"has_fulltext":false,"cited_by_count":133,"citation_normalized_percentile":{"value":0.97751219,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"4","issue":null,"first_page":"e07000","last_page":"e07000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":1.0},{"id":"https://openalex.org/keywords/orexin","display_name":"orexin","score":0.8029999732971191},{"id":"https://openalex.org/keywords/arousal","display_name":"arousal","score":0.8500000238418579},{"id":"https://openalex.org/keywords/wakefulness","display_name":"wakefulness","score":0.9430000185966492},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.8119999766349792},{"id":"https://openalex.org/keywords/dopamine-beta-hydroxylase","display_name":"dopamine beta-hydroxylase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hypocretin-neurons","display_name":"hypocretin neurons","score":0.8240000009536743},{"id":"https://openalex.org/keywords/optogenetic-stimulation","display_name":"optogenetic stimulation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/sleep-wake-regulation","display_name":"sleep-wake regulation","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.889075756072998},{"id":"https://openalex.org/C36951298","wikidata":"https://www.wikidata.org/wiki/Q379784","display_name":"Arousal","level":2,"score":0.7801118493080139},{"id":"https://openalex.org/C2779320081","wikidata":"https://www.wikidata.org/wiki/Q246710","display_name":"Wakefulness","level":3,"score":0.7090374231338501},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5589628219604492},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.5067301392555237},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.5019214153289795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4988124370574951},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.495461106300354},{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.4933406412601471},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4758698344230652},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4536932110786438},{"id":"https://openalex.org/C2779494582","wikidata":"https://www.wikidata.org/wiki/Q189561","display_name":"Narcolepsy","level":3,"score":0.4457545280456543},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4341081976890564},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41782650351524353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38484734296798706},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17612791061401367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16472023725509644},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.1268916130065918},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09347662329673767},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07314121723175049},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.0},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068797","descriptor_name":"Orexins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001143","descriptor_name":"Arousal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001342","descriptor_name":"Autonomic Nervous System Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004299","descriptor_name":"Dopamine beta-Hydroxylase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D004299","descriptor_name":"Dopamine beta-Hydroxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004299","descriptor_name":"Dopamine beta-Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.7554/elife.07000","doi":"https://doi.org/10.7554/elife.07000","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.07000","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4606453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4606453","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:26374985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26374985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:authors.library.caltech.edu:60235","doi":null,"is_oa":true,"landing_page_url":"https://authors.library.caltech.edu/60235/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:4a947489be95487185e0d41cb4527aee","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4a947489be95487185e0d41cb4527aee","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 4 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.07000","doi":"https://doi.org/10.7554/elife.07000","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.07000","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G23501068","display_name":"Hypocretin and Locus Ceruleus Interactions in Zebrafish Development and Behavior","funder_award_id":"F32NS082010","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4958081552","display_name":"Neuropeptidergic Regulation of Zebrafish Sleep","funder_award_id":"R01NS070911","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6666332951","display_name":"Genetic and neuronal regulation of sleep by adenosine in zebrafish","funder_award_id":"R01DA031367","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7092678515","display_name":"Genetic Analysis of Sleep Disorders in Zebrafish","funder_award_id":"R00NS060996","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8933614353","display_name":"Genetic Analysis of Sleep Disorders in Zebrafish","funder_award_id":"K99NS060996","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306147","display_name":"Brain and Behavior Research Foundation","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320306590","display_name":"Rita Allen Foundation","ror":"https://ror.org/0515k5w36"},{"id":"https://openalex.org/F4320313698","display_name":"Edward Mallinckrodt, Jr. Foundation","ror":"https://ror.org/035yf7a66"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1506056789","https://openalex.org/W1537021862","https://openalex.org/W1556198965","https://openalex.org/W1627229807","https://openalex.org/W1965520671","https://openalex.org/W1969665042","https://openalex.org/W1970323512","https://openalex.org/W1973327970","https://openalex.org/W1977320288","https://openalex.org/W1980043169","https://openalex.org/W1984299054","https://openalex.org/W1984917376","https://openalex.org/W1985294550","https://openalex.org/W1985471830","https://openalex.org/W1996214950","https://openalex.org/W1996424712","https://openalex.org/W1999331745","https://openalex.org/W1999919528","https://openalex.org/W2002293846","https://openalex.org/W2013130334","https://openalex.org/W2013173507","https://openalex.org/W2015747269","https://openalex.org/W2021185182","https://openalex.org/W2028121897","https://openalex.org/W2030325164","https://openalex.org/W2031462960","https://openalex.org/W2032389394","https://openalex.org/W2034726350","https://openalex.org/W2035086406","https://openalex.org/W2035761153","https://openalex.org/W2036886541","https://openalex.org/W2042388304","https://openalex.org/W2043474702","https://openalex.org/W2045003633","https://openalex.org/W2045310648","https://openalex.org/W2046584597","https://openalex.org/W2049197563","https://openalex.org/W2053188090","https://openalex.org/W2054635454","https://openalex.org/W2054684288","https://openalex.org/W2055116892","https://openalex.org/W2062408203","https://openalex.org/W2063210874","https://openalex.org/W2072154498","https://openalex.org/W2074548799","https://openalex.org/W2074791476","https://openalex.org/W2075465016","https://openalex.org/W2076495702","https://openalex.org/W2079978401","https://openalex.org/W2082692578","https://openalex.org/W2085712847","https://openalex.org/W2086200773","https://openalex.org/W2088944569","https://openalex.org/W2089678845","https://openalex.org/W2090162633","https://openalex.org/W2091239691","https://openalex.org/W2097685453","https://openalex.org/W2099540110","https://openalex.org/W2099927467","https://openalex.org/W2100743305","https://openalex.org/W2102693281","https://openalex.org/W2105728643","https://openalex.org/W2110175860","https://openalex.org/W2115861749","https://openalex.org/W2117213785","https://openalex.org/W2127183925","https://openalex.org/W2129928127","https://openalex.org/W2132358997","https://openalex.org/W2138262820","https://openalex.org/W2138595310","https://openalex.org/W2141066952","https://openalex.org/W2154534807","https://openalex.org/W2168415226","https://openalex.org/W2171332611","https://openalex.org/W2186124249","https://openalex.org/W2337178257","https://openalex.org/W6633315448"],"related_works":["https://openalex.org/W2273790468","https://openalex.org/W2588657333","https://openalex.org/W4385074357","https://openalex.org/W2045310648","https://openalex.org/W1981497895","https://openalex.org/W2032389394","https://openalex.org/W2042825259","https://openalex.org/W2560898680","https://openalex.org/W2125727006","https://openalex.org/W2608679855"],"abstract_inverted_index":{"Pharmacological":[0],"studies":[1],"in":[2,12,45,69,84,134],"mammals":[3],"suggest":[4],"that":[5,90,95,119,139],"norepinephrine":[6],"(NE)":[7],"plays":[8],"an":[9,46,67],"important":[10,122],"role":[11,17,130],"promoting":[13,135],"arousal.":[14,125],"However,":[15],"the":[16,27,100],"of":[18,30,37,102,107,113,146],"endogenous":[19,132],"NE":[20,33,43,92,120,133,140],"is":[21,121,141],"unclear,":[22],"with":[23,87],"contradicting":[24],"reports":[25],"concerning":[26],"sleep":[28],"phenotypes":[29,80],"mice":[31],"lacking":[32],"due":[34],"to":[35,57],"mutation":[36],"dopamine":[38],"\u03b2-hydroxylase":[39],"(dbh).":[40],"To":[41],"investigate":[42],"function":[44],"alternative":[47],"vertebrate":[48],"model,":[49],"we":[50,116],"generated":[51],"dbh":[52,71],"mutant":[53,72],"zebrafish.":[54],"In":[55],"contrast":[56],"mice,":[58],"these":[59],"animals":[60],"exhibit":[61],"dramatically":[62],"increased":[63],"sleep.":[64],"Surprisingly,":[65],"despite":[66],"increase":[68],"sleep,":[70],"zebrafish":[73,85],"have":[74],"a":[75,129,142],"reduced":[76],"arousal":[77,136],"threshold.":[78],"These":[79,126],"are":[81,97],"also":[82,117],"observed":[83],"treated":[86],"small":[88],"molecules":[89],"inhibit":[91],"signaling,":[93],"suggesting":[94],"they":[96],"caused":[98],"by":[99],"lack":[101],"NE.":[103],"Using":[104],"genetic":[105],"overexpression":[106],"hypocretin":[108],"(Hcrt)":[109],"and":[110,137],"optogenetic":[111],"activation":[112],"hcrt-expressing":[114],"neurons,":[115],"find":[118],"for":[123,131],"Hcrt-induced":[124],"results":[127],"establish":[128],"indicate":[138],"critical":[143],"downstream":[144],"effector":[145],"Hcrt":[147],"neurons.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
