{"id":"https://openalex.org/W2166474875","doi":"https://doi.org/10.1124/dmd.112.049312","title":"Species Differences in Biliary Clearance and Possible Relevance of Hepatic Uptake and Efflux Transporters Involvement","display_name":"Species Differences in Biliary Clearance and Possible Relevance of Hepatic Uptake and Efflux Transporters Involvement","publication_year":2012,"publication_date":"2012-11-08","ids":{"openalex":"https://openalex.org/W2166474875","doi":"https://doi.org/10.1124/dmd.112.049312","mag":"2166474875","pmid":"https://pubmed.ncbi.nlm.nih.gov/23139379"},"language":"en","primary_location":{"id":"doi:10.1124/dmd.112.049312","doi":"https://doi.org/10.1124/dmd.112.049312","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.112.049312","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111701733","display_name":"Ken Grime","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Ken Grime","raw_affiliation_strings":["Respiratory and Inflammation Drug Metabolism and Pharmacokinetics, Astra Zeneca R&D, M\u00f6lndal, Sweden. ken.grime@astrazeneca.com","Respiratory and Inflammation Drug Metabolism and Pharmacokinetics, AstraZeneca R&D, M\u00f6lndal, Sweden (K.G.), and School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire, United Kingdom (S.W.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory and Inflammation Drug Metabolism and Pharmacokinetics, Astra Zeneca R&D, M\u00f6lndal, Sweden. ken.grime@astrazeneca.com","institution_ids":["https://openalex.org/I4210143795"]},{"raw_affiliation_string":"Respiratory and Inflammation Drug Metabolism and Pharmacokinetics, AstraZeneca R&D, M\u00f6lndal, Sweden (K.G.), and School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire, United Kingdom (S.W.P.)","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037657912","display_name":"Stuart W. Paine","orcid":"https://orcid.org/0000-0001-9443-2311","observed_orcids":["https://orcid.org/0000-0001-9443-2311"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stuart W. Paine","raw_affiliation_strings":["Respiratory and Inflammation Drug Metabolism and Pharmacokinetics, AstraZeneca R&D, M\u00f6lndal, Sweden (K.G.), and School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire, United Kingdom (S.W.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory and Inflammation Drug Metabolism and Pharmacokinetics, AstraZeneca R&D, M\u00f6lndal, Sweden (K.G.), and School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire, United Kingdom (S.W.P.)","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.4726,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.82553781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"41","issue":"2","first_page":"372","last_page":"378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biliary-excretion","display_name":"biliary excretion","score":0.9570000171661377},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.7829999923706055},{"id":"https://openalex.org/keywords/human-rat-comparison","display_name":"human-rat comparison","score":0.6570000052452087},{"id":"https://openalex.org/keywords/hepatic-uptake-transporters","display_name":"hepatic uptake transporters","score":0.9419999718666077},{"id":"https://openalex.org/keywords/organic-anion-transporting-polypeptides","display_name":"organic anion transporting polypeptides","score":0.9480000138282776},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.5249999761581421},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.8669999837875366},{"id":"https://openalex.org/keywords/body-weight-normalization","display_name":"body weight normalization","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.820703387260437},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.7741342782974243},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6363001465797424},{"id":"https://openalex.org/C123584848","wikidata":"https://www.wikidata.org/wiki/Q18034026","display_name":"Organic anion transporter 1","level":4,"score":0.6126978397369385},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.561936616897583},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5361051559448242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4917607605457306},{"id":"https://openalex.org/C2776678969","wikidata":"https://www.wikidata.org/wiki/Q28209167","display_name":"Organic anion-transporting polypeptide","level":4,"score":0.48660337924957275},{"id":"https://openalex.org/C36201501","wikidata":"https://www.wikidata.org/wiki/Q17907816","display_name":"Multidrug resistance-associated protein 2","level":5,"score":0.45117583870887756},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40614667534828186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37113887071609497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22657501697540283},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.21987000107765198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21470636129379272},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000089762","descriptor_name":"Multidrug Resistance-Associated Protein 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004333","descriptor_name":"Drug Administration Routes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1124/dmd.112.049312","doi":"https://doi.org/10.1124/dmd.112.049312","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.112.049312","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},{"id":"pmid:23139379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23139379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism and disposition: the biological fate of chemicals","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.873.236","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.873.236","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dmd.aspetjournals.org/content/41/2/372.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":102,"referenced_works":["https://openalex.org/W173241825","https://openalex.org/W1463893461","https://openalex.org/W1482451012","https://openalex.org/W1520846800","https://openalex.org/W1544086131","https://openalex.org/W1573855997","https://openalex.org/W1920820875","https://openalex.org/W1941666726","https://openalex.org/W1963516478","https://openalex.org/W1964151743","https://openalex.org/W1965639567","https://openalex.org/W1971263174","https://openalex.org/W1975659153","https://openalex.org/W1977566226","https://openalex.org/W1981802141","https://openalex.org/W1984557560","https://openalex.org/W1989291589","https://openalex.org/W1989880043","https://openalex.org/W2001240294","https://openalex.org/W2006676591","https://openalex.org/W2006953842","https://openalex.org/W2011865865","https://openalex.org/W2015830110","https://openalex.org/W2020016102","https://openalex.org/W2020158842","https://openalex.org/W2026881218","https://openalex.org/W2027127607","https://openalex.org/W2028990038","https://openalex.org/W2029976619","https://openalex.org/W2032502073","https://openalex.org/W2033133387","https://openalex.org/W2035967320","https://openalex.org/W2038643214","https://openalex.org/W2039286264","https://openalex.org/W2042260301","https://openalex.org/W2045493018","https://openalex.org/W2047306923","https://openalex.org/W2047700663","https://openalex.org/W2048295825","https://openalex.org/W2053684254","https://openalex.org/W2054657245","https://openalex.org/W2064413682","https://openalex.org/W2064658424","https://openalex.org/W2065038872","https://openalex.org/W2066763741","https://openalex.org/W2066869671","https://openalex.org/W2072784247","https://openalex.org/W2073846534","https://openalex.org/W2076312333","https://openalex.org/W2076759278","https://openalex.org/W2078883566","https://openalex.org/W2080143292","https://openalex.org/W2084486155","https://openalex.org/W2092789823","https://openalex.org/W2097832070","https://openalex.org/W2099086608","https://openalex.org/W2100553745","https://openalex.org/W2100764580","https://openalex.org/W2101817712","https://openalex.org/W2102551031","https://openalex.org/W2102576653","https://openalex.org/W2102628972","https://openalex.org/W2103855721","https://openalex.org/W2104649907","https://openalex.org/W2108458189","https://openalex.org/W2113716869","https://openalex.org/W2114700593","https://openalex.org/W2115568308","https://openalex.org/W2116760577","https://openalex.org/W2117905778","https://openalex.org/W2121714881","https://openalex.org/W2132632422","https://openalex.org/W2134736428","https://openalex.org/W2136698512","https://openalex.org/W2141930972","https://openalex.org/W2146316557","https://openalex.org/W2146325518","https://openalex.org/W2147311092","https://openalex.org/W2148925220","https://openalex.org/W2150060563","https://openalex.org/W2150964648","https://openalex.org/W2155097092","https://openalex.org/W2157772258","https://openalex.org/W2160143461","https://openalex.org/W2160350843","https://openalex.org/W2161213051","https://openalex.org/W2161787769","https://openalex.org/W2161869258","https://openalex.org/W2171167058","https://openalex.org/W2213806353","https://openalex.org/W2270474355","https://openalex.org/W2324942598","https://openalex.org/W2341672273","https://openalex.org/W2386619336","https://openalex.org/W2401535043","https://openalex.org/W2412738759","https://openalex.org/W2414795090","https://openalex.org/W2414945378","https://openalex.org/W3022626893","https://openalex.org/W4290155668","https://openalex.org/W6628553593","https://openalex.org/W6682560713"],"related_works":["https://openalex.org/W7097577490","https://openalex.org/W2096823812","https://openalex.org/W2055488999","https://openalex.org/W1977837914","https://openalex.org/W1506802620","https://openalex.org/W2293693458","https://openalex.org/W2143471587","https://openalex.org/W2078075173","https://openalex.org/W2053684254","https://openalex.org/W1971263174"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
