{"id":"https://openalex.org/W2166448258","doi":null,"title":"Arterial thrombosis in the antiphospholipid syndrome","display_name":"Arterial thrombosis in the antiphospholipid syndrome","publication_year":2008,"publication_date":"2008-11-27","ids":{"openalex":"https://openalex.org/W2166448258","mag":"2166448258"},"language":"en","primary_location":{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/31270","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/31270","pdf_url":"https://dspace.library.uu.nl/handle/1874/31270","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/31270","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012431332","display_name":"Rolf T. Urbanus","orcid":"https://orcid.org/0000-0002-1601-9393","observed_orcids":["https://orcid.org/0000-0002-1601-9393"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rolf T. Urbanus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1601-9393","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012431332"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiphospholipid-syndrome","display_name":"antiphospholipid syndrome","score":0.9800000190734863},{"id":"https://openalex.org/keywords/arterial-thrombosis","display_name":"arterial thrombosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/antiphospholipid-antibodies","display_name":"antiphospholipid antibodies","score":0.9589999914169312},{"id":"https://openalex.org/keywords/lupus-anticoagulant","display_name":"lupus anticoagulant","score":0.9409999847412109},{"id":"https://openalex.org/keywords/beta2-glycoprotein-i","display_name":"beta2-glycoprotein I","score":0.9779999852180481},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":1.0},{"id":"https://openalex.org/keywords/young-women","display_name":"young women","score":0.6819999814033508},{"id":"https://openalex.org/keywords/apoer2","display_name":"ApoER2","score":0.6909999847412109},{"id":"https://openalex.org/keywords/glycoprotein-ibalpha","display_name":"GPIb\u03b1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.652999997138977},{"id":"https://openalex.org/keywords/prothrombotic-mechanisms","display_name":"prothrombotic mechanisms","score":0.753000020980835},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.49300000071525574},{"id":"https://openalex.org/keywords/oral-contraceptive-use","display_name":"oral contraceptive use","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8206396102905273},{"id":"https://openalex.org/C2776874634","wikidata":"https://www.wikidata.org/wiki/Q582207","display_name":"Antiphospholipid syndrome","level":3,"score":0.7573634386062622},{"id":"https://openalex.org/C2780022809","wikidata":"https://www.wikidata.org/wiki/Q5786759","display_name":"Lupus anticoagulant","level":3,"score":0.7440994381904602},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5478408932685852},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.543552815914154},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5390320420265198},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5258753299713135},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5150015354156494},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/31270","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/31270","pdf_url":"https://dspace.library.uu.nl/handle/1874/31270","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:dspace.library.uu.nl:1874/31270","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/31270","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/31270","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/31270","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2166448258","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/handle/1874/31270/urbanus.pdf?sequence=2","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/31270","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/31270","pdf_url":"https://dspace.library.uu.nl/handle/1874/31270","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2166448258.pdf","grobid_xml":"https://content.openalex.org/works/W2166448258.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W86943527","https://openalex.org/W1485388354","https://openalex.org/W1491481195","https://openalex.org/W1492769522","https://openalex.org/W1563492198","https://openalex.org/W1567044188","https://openalex.org/W1574269074","https://openalex.org/W1596249994","https://openalex.org/W1613089346","https://openalex.org/W1965958910","https://openalex.org/W1970954194","https://openalex.org/W1971393350","https://openalex.org/W1981224038","https://openalex.org/W1986921303","https://openalex.org/W1989161570","https://openalex.org/W1999898230","https://openalex.org/W2003024037","https://openalex.org/W2018830765","https://openalex.org/W2034249586","https://openalex.org/W2065278880","https://openalex.org/W2084897695","https://openalex.org/W2085062419","https://openalex.org/W2085728145","https://openalex.org/W2092330685","https://openalex.org/W2097802875","https://openalex.org/W2099288634","https://openalex.org/W2101831374","https://openalex.org/W2109110124","https://openalex.org/W2110832637","https://openalex.org/W2115956404","https://openalex.org/W2129233041","https://openalex.org/W2137045058","https://openalex.org/W2142649232","https://openalex.org/W2143086319","https://openalex.org/W2146226041","https://openalex.org/W2163384287","https://openalex.org/W2164922254","https://openalex.org/W2224177631","https://openalex.org/W2327141264","https://openalex.org/W2328300666","https://openalex.org/W2331901704","https://openalex.org/W2336877490","https://openalex.org/W2409741663","https://openalex.org/W2418550408","https://openalex.org/W2427508948"],"related_works":["https://openalex.org/W2048420521","https://openalex.org/W2992451759","https://openalex.org/W2101727819","https://openalex.org/W2069794594","https://openalex.org/W2057897272","https://openalex.org/W2194406839","https://openalex.org/W4242410809","https://openalex.org/W2132421890","https://openalex.org/W2048262213","https://openalex.org/W4249780551"],"abstract_inverted_index":{"The":[0,14,53,148,389],"antiphospholipid":[1,32,73,95,111,207,247,271,309,319,332,387,399,417,456,493],"syndrome":[2,15,400],"(APS)":[3],"is":[4,16,59,71,89,253],"a":[5,40,79,178,259,322,405],"non-inflammatory":[6],"autoimmune":[7],"disease":[8],"that":[9,72,327,336],"mainly":[10],"affects":[11],"young":[12,186],"women.":[13],"characterized":[17],"by":[18],"recurrent":[19],"thrombosis":[20,407,490],"or":[21,101,142,157,168,321,415,454],"pregnancy":[22],"morbidity":[23],"in":[24,65,87,104,185,194,294,308,360,379,385,393,404,423,483,491],"association":[25],"with":[26,119,132,286,318,353,444,447],"the":[27,61,66,69,76,82,94,126,162,202,216,233,243,262,279,301,329,347,369,380,386,394,398,479,484,492],"persistent":[28],"serological":[29],"presence":[30,149],"of":[31,43,47,78,84,98,123,136,150,164,201,246,250,261,303,316,325,331,346,349,351,391,397,411,413,429,450,452,481,486],"antibodies.":[33,248],"Antiphospholipid":[34,218],"antibodies":[35,74,208,219,320,418,457],"are":[36,114,220,239,377],"heterogeneous":[37],"and":[38,231,278,306,341,437,473],"recognize":[39],"wide":[41],"variety":[42],"protein":[44,55],"ligands,":[45],"all":[46],"which":[48,206,289,477],"have":[49],"phospholipid":[50],"binding":[51],"properties.":[52],"plasma":[54],"beta2-glycoprotein":[56],"I":[57],"(beta2-GPI)":[58],"considered":[60],"most":[62],"relevant":[63],"antigen":[64],"syndrome.":[67,388,494],"Although":[68,109],"consensus":[70],"increase":[75,86],"risk":[77,88,97,122,135,152,163,180],"thrombotic":[80,395],"event,":[81],"extent":[83],"this":[85],"unclear.":[90],"We":[91,298],"therefore":[92],"assessed":[93],"antibody-related":[96],"myocardial":[99,137,166,183],"infarction":[100,138,167,184],"ischemic":[102,143,169],"stroke":[103,144,170],"women":[105],"below":[106,196],"age":[107,197],"50.":[108],"several":[110],"antibody":[112,310],"subpopulations":[113],"reported":[115],"to":[116,176,222,241,275,419,458,489],"be":[117,177],"associated":[118,131],"an":[120,133,361],"increased":[121,134,140,146,161,214,228,291,424,432,438],"thrombosis,":[124],"only":[125],"lupus":[127,173],"anticoagulant":[128,174],"subpopulation":[129],"was":[130,343,401],"(5-fold":[139],"risk)":[141],"(43-fold":[145],"risk).":[147],"additional":[151],"factors":[153],"such":[154],"as":[155],"smoking":[156],"oral":[158],"contraceptive":[159],"use":[160],"both":[165,276,304,339,375],"further.":[171],"While":[172],"appeared":[175],"strong":[179],"factor":[181,435,441,471],"for":[182],"women,":[187],"we":[188],"could":[189],"not":[190],"confirm":[191],"these":[192,251],"results":[193,373],"men":[195],"70.":[198],"Our":[199],"understanding":[200],"molecular":[203],"mechanisms":[204],"through":[205,368],"exert":[209],"their":[210],"prothrombotic":[211,244],"influence":[212,232],"has":[213,269],"over":[215],"years.":[217],"known":[221],"induce":[223],"endothelial":[224],"cell":[225],"activation,":[226,476],"cause":[227],"platelet":[229,280,312,358,383],"activation":[230,359,384],"coagulation":[234],"system.":[235],"Several":[236],"cellular":[237],"receptors":[238,252,376],"postulated":[240],"mediate":[242],"effects":[245],"One":[249],"Apolipoprotein":[254],"E":[255],"receptor":[256,282,355],"2\u2019":[257],"(ApoER2\u2019),":[258],"member":[260],"low":[263],"density":[264],"lipoprotein-receptor":[265],"family.":[266],"Previous":[267],"work":[268],"shown":[270],"antibody-beta2-GPI":[272],"complexes":[273],"bind":[274],"ApoER2\u2019":[277,307,342],"adhesive":[281],"glycoprotein":[283],"Ibalpha":[284],"(gpIbalpha)":[285],"high":[287],"affinity,":[288],"mediates":[290],"thrombus":[292,425,463],"formation":[293,426,464],"in-vitro":[295,362],"flow":[296,363],"models.":[297],"further":[299,402],"investigated":[300,403],"role":[302,390],"gpIbalpha":[305,340],"induced":[311],"activation.":[313],"Upon":[314],"stimulation":[315],"platelets":[317],"recombinant":[323],"dimer":[324],"beta2GPI":[326],"mimics":[328],"function":[330],"antibodies,":[333],"intracellular":[334],"signalling":[335,367],"originated":[337],"from":[338],"observed.":[344],"Inhibition":[345],"interaction":[348],"dimers":[350,412,451],"beta2-GPI":[352,414,453],"either":[354],"completely":[356],"abrogated":[357],"model,":[364],"despite":[365],"continued":[366],"uninhibited":[370],"receptor.":[371],"These":[372],"suggest":[374],"crucial":[378],"mechanism":[381],"behind":[382],"ApoER2":[392,482],"manifestations":[396],"murine":[406],"model.":[408],"Intraperitoneal":[409],"administration":[410],"patient-derived":[416],"wild-type":[420],"mice":[421,445,460],"resulted":[422],"upon":[427],"induction":[428],"vascular":[430,433,466,469],"injury,":[431,467],"tissue":[434,440,470],"activity":[436,442,472],"monocytic":[439],"compared":[443],"injected":[446],"buffer.":[448],"Administration":[449],"purified":[455],"ApoER2-deficient":[459],"caused":[461],"normal":[462,468,474],"after":[465],"monocyte":[475],"confirms":[478],"importance":[480],"chain":[485],"events":[487],"leading":[488]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
