{"id":"https://openalex.org/W2166360844","doi":"https://doi.org/10.1109/iembs.1999.802059","title":"Differential genomic expression after in vitro mechanical injury of organotypic brain slice cultures","display_name":"Differential genomic expression after in vitro mechanical injury of organotypic brain slice cultures","publication_year":2003,"publication_date":"2003-01-20","ids":{"openalex":"https://openalex.org/W2166360844","doi":"https://doi.org/10.1109/iembs.1999.802059","mag":"2166360844"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.1999.802059","doi":"https://doi.org/10.1109/iembs.1999.802059","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.1999.802059","pdf_url":null,"source":{"id":"https://openalex.org/S4363608786","display_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","issn_l":"2375-7477","issn":["2375-7477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["doyens","jufo-1","ki-jl-1","medline","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019039663","display_name":"Barclay Morrison","orcid":"https://orcid.org/0000-0001-7676-0864","observed_orcids":["https://orcid.org/0000-0001-7676-0864"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Morrison","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010152737","display_name":"Tracy K. McIntosh","orcid":"https://orcid.org/0000-0002-8612-6725","observed_orcids":["https://orcid.org/0000-0002-8612-6725"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.K. McIntosh","raw_affiliation_strings":["Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13684211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"38","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11487","display_name":"Automotive and Human Injury Biomechanics","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":1.0},{"id":"https://openalex.org/keywords/organotypic-brain-slice-culture","display_name":"organotypic brain slice culture","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mechanical-damage","display_name":"mechanical damage","score":0.621999979019165},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8669999837875366},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.777999997138977},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/trka","display_name":"TrkA","score":0.9729999899864197},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.996999979019165},{"id":"https://openalex.org/keywords/gad65","display_name":"GAD65","score":0.9620000123977661},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.6769999861717224},{"id":"https://openalex.org/keywords/in-vitro-injury-model","display_name":"in vitro injury model","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.8628076314926147},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.6282245516777039},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6114726066589355},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5428109765052795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.535519003868103},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5341823101043701},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5018908977508545},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4678678512573242},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.467567503452301},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.42982104420661926},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.39033037424087524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28161877393722534},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2396053969860077},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15573498606681824},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.10239449143409729},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09606301784515381},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09171396493911743},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iembs.1999.802059","doi":"https://doi.org/10.1109/iembs.1999.802059","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.1999.802059","pdf_url":null,"source":{"id":"https://openalex.org/S4363608786","display_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","issn_l":"2375-7477","issn":["2375-7477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["doyens","jufo-1","ki-jl-1","medline","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1977071806","https://openalex.org/W2098107049","https://openalex.org/W2121777852","https://openalex.org/W2352727163","https://openalex.org/W2413226124","https://openalex.org/W6715719222"],"related_works":["https://openalex.org/W43125445","https://openalex.org/W2125283089","https://openalex.org/W7100752504","https://openalex.org/W1988354171","https://openalex.org/W93135132","https://openalex.org/W145131943","https://openalex.org/W2940381692","https://openalex.org/W203884557","https://openalex.org/W2008386989","https://openalex.org/W610060655"],"abstract_inverted_index":{"Traumatic":[0],"brain":[1,64,120],"injury":[2,115],"(TBI)":[3],"is":[4,16,40],"responsible":[5,30,132],"for":[6,21,31,83,133,182],"approximately":[7],"80,000":[8],"permanently":[9],"disabled":[10],"persons":[11],"per":[12],"year,":[13],"however,":[14],"there":[15],"currently":[17],"no":[18],"pharmacological":[19],"treatment":[20],"the":[22,61,84,96,145,183],"head":[23],"injured":[24],"patient.":[25],"The":[26],"primary":[27],"mechanical":[28,114],"stimulus":[29],"TBI":[32,85,105,177],"occurs":[33],"in":[34,60,76,101,134,141,173],"less":[35],"than":[36],"a":[37,110,171],"second,":[38],"but":[39],"capable":[41],"of":[42,63,70,95,104,116,147,156,187],"initiating":[43],"an":[44],"extended":[45],"cellular":[46],"and":[47,112,126,150,159,178],"molecular":[48,72],"sequelae":[49],"requiring":[50],"hours":[51],"or":[52,54,91,193],"days":[53],"years":[55],"to":[56,87,108,130],"develop":[57],"which":[58],"results":[59,165],"death":[62,175],"cells.":[65],"A":[66,99],"more":[67],"thorough":[68],"understanding":[69],"these":[71],"changes,":[73],"including":[74,185],"alterations":[75],"gene":[77],"expression,":[78],"could":[79],"suggest":[80,179],"new":[81,180],"therapies":[82,181],"patient":[86,184],"either":[88],"ameliorate":[89],"detrimental":[90],"augment":[92],"beneficial":[93],"aspects":[94],"post-traumatic":[97],"sequelae.":[98],"novel":[100],"vitro":[102,142],"model":[103],"was":[106,152,162],"developed":[107],"produce":[109],"precise":[111],"reproducible":[113],"long":[117],"term":[118],"organotypic":[119],"slice":[121],"cultures":[122],"(OBSC)":[123],"at":[124],"strains":[125],"strain":[127],"rates":[128],"thought":[129],"be":[131],"vivo":[135],"TBI.":[136],"At":[137],"24":[138],"h":[139],"after":[140,176],"stretch":[143],"injury,":[144],"expression":[146],"BDNF,":[148],"NGF,":[149],"TrkA":[151],"increased":[153],"whereas":[154],"that":[155,167],"bcl-2,":[157],"CREB,":[158],"GAD/sub":[160],"65/":[161],"decreased.":[163],"These":[164],"imply":[166],"apoptosis":[168],"may":[169],"play":[170],"role":[172],"cell":[174],"infusion":[186],"growth":[188],"factors":[189],"such":[190],"as":[191],"BDNF":[192],"NGF.":[194]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}