{"id":"https://openalex.org/W2166356293","doi":"https://doi.org/10.1136/gut.2007.135053","title":"IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn\u2019s disease","display_name":"IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn\u2019s disease","publication_year":2008,"publication_date":"2008-07-24","ids":{"openalex":"https://openalex.org/W2166356293","doi":"https://doi.org/10.1136/gut.2007.135053","mag":"2166356293","pmid":"https://pubmed.ncbi.nlm.nih.gov/18653729"},"language":"en","primary_location":{"id":"doi:10.1136/gut.2007.135053","doi":"https://doi.org/10.1136/gut.2007.135053","is_oa":false,"landing_page_url":"https://doi.org/10.1136/gut.2007.135053","pdf_url":null,"source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109323626","display_name":"Taku Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Kobayashi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan","Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Okamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Okamoto","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037730409","display_name":"Tadakazu Hisamatsu","orcid":"https://orcid.org/0000-0002-1178-3536","observed_orcids":["https://orcid.org/0000-0002-1178-3536"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Hisamatsu","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026071924","display_name":"Nobuhiko Kamada","orcid":"https://orcid.org/0000-0002-1980-4178","observed_orcids":["https://orcid.org/0000-0002-1980-4178"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Kamada","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032978590","display_name":"Hiroshi Chinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Chinen","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R Saito","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111502963","display_name":"Mina T. Kitazume","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M T Kitazume","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Nakazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Nakazawa","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019901311","display_name":"Akira Sugita","orcid":"https://orcid.org/0000-0002-5990-2629","observed_orcids":["https://orcid.org/0000-0002-5990-2629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Sugita","raw_affiliation_strings":["Department of Surgery, Yokohama City Hospital, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Yokohama City Hospital, Yokohama, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054481321","display_name":"Kazutaka Koganei","orcid":"https://orcid.org/0009-0000-0401-9524","observed_orcids":["https://orcid.org/0009-0000-0401-9524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Koganei","raw_affiliation_strings":["Department of Surgery, Yokohama City Hospital, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Yokohama City Hospital, Yokohama, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109073213","display_name":"K. Isobe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Isobe","raw_affiliation_strings":["Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026205612","display_name":"Toshifumi Hibi\u2225","orcid":"https://orcid.org/0000-0002-6256-1204","observed_orcids":["https://orcid.org/0000-0002-6256-1204"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"T Hibi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan","Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026205612"],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":null,"apc_paid":null,"fwci":39.052,"has_fulltext":false,"cited_by_count":599,"citation_normalized_percentile":{"value":0.99856938,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"57","issue":"12","first_page":"1682","last_page":"1689"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.061799999326467514,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.8230000138282776},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9430000185966492},{"id":"https://openalex.org/keywords/th1-th17-balance","display_name":"Th1/Th17 balance","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":1.0},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9520000219345093},{"id":"https://openalex.org/keywords/rorc","display_name":"RORC","score":0.9760000109672546},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mucosal-inflammation","display_name":"mucosal inflammation","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C156730664","wikidata":"https://www.wikidata.org/wiki/Q23308590","display_name":"Interleukin 23","level":4,"score":0.7580357789993286},{"id":"https://openalex.org/C74737994","wikidata":"https://www.wikidata.org/wiki/Q18031207","display_name":"RAR-related orphan receptor gamma","level":4,"score":0.7136276960372925},{"id":"https://openalex.org/C47348012","wikidata":"https://www.wikidata.org/wiki/Q99486570","display_name":"Interleukin 17","level":3,"score":0.6288544535636902},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.6217048764228821},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49506035447120667},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.4915488660335541},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.46500834822654724},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.4571229815483093},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.44907575845718384},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.367011696100235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3636786937713623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2970921993255615},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2527637481689453},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.13501441478729248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12875208258628845},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09765002131462097},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.09118926525115967},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1136/gut.2007.135053","doi":"https://doi.org/10.1136/gut.2007.135053","is_oa":false,"landing_page_url":"https://doi.org/10.1136/gut.2007.135053","pdf_url":null,"source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmid:18653729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18653729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1510193398","https://openalex.org/W1535980982","https://openalex.org/W1548931116","https://openalex.org/W1867019379","https://openalex.org/W1942668068","https://openalex.org/W1946093640","https://openalex.org/W1964300433","https://openalex.org/W1969531292","https://openalex.org/W1972926790","https://openalex.org/W1980668544","https://openalex.org/W1981714996","https://openalex.org/W1987628377","https://openalex.org/W1990701314","https://openalex.org/W1991733645","https://openalex.org/W1997638368","https://openalex.org/W2035313919","https://openalex.org/W2038131331","https://openalex.org/W2043004968","https://openalex.org/W2052049015","https://openalex.org/W2065307318","https://openalex.org/W2070715537","https://openalex.org/W2073007458","https://openalex.org/W2075345182","https://openalex.org/W2082615180","https://openalex.org/W2085587260","https://openalex.org/W2087905758","https://openalex.org/W2090901744","https://openalex.org/W2095690951","https://openalex.org/W2101180663","https://openalex.org/W2105507544","https://openalex.org/W2107235439","https://openalex.org/W2117047064","https://openalex.org/W2122939321","https://openalex.org/W2123093300","https://openalex.org/W2126874760","https://openalex.org/W2131727319","https://openalex.org/W2133657961","https://openalex.org/W2139008734","https://openalex.org/W2142017607","https://openalex.org/W2147836420","https://openalex.org/W2155013311","https://openalex.org/W2171463669","https://openalex.org/W2776663677","https://openalex.org/W4253323169","https://openalex.org/W4292198229"],"related_works":["https://openalex.org/W1969127506","https://openalex.org/W2006553963","https://openalex.org/W2357172167","https://openalex.org/W7095751984","https://openalex.org/W2073022365","https://openalex.org/W2947844770","https://openalex.org/W2090426493","https://openalex.org/W2169584514","https://openalex.org/W1994196052","https://openalex.org/W2106555006"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"novel":[2],"T":[3],"helper":[4],"(Th)":[5],"cell":[6],"lineage,":[7],"Th17,":[8],"that":[9],"exclusively":[10],"produces":[11],"the":[12,41,44,105,240],"proinflammatory":[13],"cytokine":[14],"interleukin":[15],"17":[16],"(IL17)":[17],"has":[18],"been":[19],"reported":[20],"to":[21,37,103],"play":[22,235],"important":[23,236],"roles":[24,42,237],"in":[25,47,124,138,162,167,173,179,185,192,209,226,230,238,244,254],"various":[26],"inflammatory":[27,48],"diseases.":[28,256],"IL23":[29,114,146,208,233],"is":[30],"also":[31,155],"focused":[32],"upon":[33],"for":[34],"its":[35],"potential":[36],"promote":[38],"Th17.":[39],"Here,":[40],"of":[43,109,144],"IL23/IL17":[45],"axis":[46],"bowel":[49],"diseases":[50],"such":[51,132],"as":[52,133],"ulcerative":[53],"colitis":[54],"(UC)":[55],"and":[56,90,117,128,136,188,200,228,247],"Crohn's":[57],"disease":[58],"(CD)":[59],"were":[60,65,154,190],"investigated.":[61],"METHODS:":[62],"Mucosal":[63],"samples":[64],"obtained":[66],"from":[67,197,213],"surgically":[68],"resected":[69],"specimens":[70],"(controls,":[71],"n":[72,76,80],"=":[73,77,81],"12;":[74],"UC,":[75,180],"17;":[78],"CD,":[79,248],"22).":[82],"IL17":[83,148,158,170,202,225],"production":[84,149,159,203],"by":[85,150,207],"isolated":[86,196],"peripheral":[87],"blood":[88],"(PB)":[89],"lamina":[91],"propria":[92],"(LP)":[93],"CD4(+)":[94,126,152,164,175,194,211],"cells":[95,153,165,176,195,212,251],"was":[96,101,160,177,183,204,222],"examined.":[97,156],"Quantitative":[98],"PCR":[99],"amplification":[100],"performed":[102],"determine":[104],"mRNA":[106,171,220],"expression":[107,221],"levels":[108],"IL17,":[110],"interferon":[111],"gamma":[112,122],"(IFNgamma),":[113],"receptor":[115,121],"(IL23R)":[116],"retinoic":[118],"acid-related":[119],"orphan":[120],"(RORC)":[123],"LP":[125,151,163,174,193,210],"cells,":[127],"IL12":[129],"family":[130],"members,":[131],"IL12p40,":[134],"IL12p35":[135],"IL23p19,":[137],"whole":[139],"mucosal":[140],"specimens.":[141],"The":[142],"effects":[143],"exogenous":[145],"on":[147],"RESULTS:":[157],"higher":[161],"than":[166],"PB.":[168],"Significant":[169],"upregulation":[172],"found":[178],"while":[181],"IFNgamma":[182,229],"increased":[184,206],"CD.":[186,201,217,231],"IL23R":[187],"RORC":[189],"upregulated":[191],"both":[198,245,255],"UC":[199,214,227,246],"significantly":[205],"but":[215],"not":[216],"Upregulated":[218],"IL23p19":[219],"correlated":[223],"with":[224],"CONCLUSIONS:":[232],"may":[234,252],"controlling":[239],"differential":[241],"Th1/Th17":[242],"balance":[243],"although":[249],"Th17":[250],"exist":[253]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":33},{"year":2018,"cited_by_count":37},{"year":2017,"cited_by_count":33},{"year":2016,"cited_by_count":35},{"year":2015,"cited_by_count":42},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":39},{"year":2012,"cited_by_count":35}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}