{"id":"https://openalex.org/W2166233845","doi":"https://doi.org/10.3109/02652049709015333","title":"The encapsulation of a model protein in poly (D, L lactide-co-glycolide) microparticles of various sizes: an evaluation of process reproducibility","display_name":"The encapsulation of a model protein in poly (D, L lactide-co-glycolide) microparticles of various sizes: an evaluation of process reproducibility","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2166233845","doi":"https://doi.org/10.3109/02652049709015333","mag":"2166233845","pmid":"https://pubmed.ncbi.nlm.nih.gov/9132471"},"language":"en","primary_location":{"id":"doi:10.3109/02652049709015333","doi":"https://doi.org/10.3109/02652049709015333","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02652049709015333","pdf_url":null,"source":{"id":"https://openalex.org/S160681128","display_name":"Journal of Microencapsulation","issn_l":"0265-2048","issn":["0265-2048","1464-5246"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microencapsulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. P. McGee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140213","display_name":"United Biomedical (United States)","ror":"https://ror.org/044bp3769","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140213"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. P. McGee","raw_affiliation_strings":["United Biomedical, Inc., Hauppauge, NY 11788, USA","United Biomedical, Inc., 25 Davids Drive, Hauppauge, NY, 11788, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United Biomedical, Inc., Hauppauge, NY 11788, USA","institution_ids":["https://openalex.org/I4210140213"]},{"raw_affiliation_string":"United Biomedical, Inc., 25 Davids Drive, Hauppauge, NY, 11788, USA","institution_ids":["https://openalex.org/I4210140213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024386461","display_name":"Manmohan Singh","orcid":"https://orcid.org/0000-0002-8396-5451","observed_orcids":["https://orcid.org/0000-0002-8396-5451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Singh","raw_affiliation_strings":["Chiron Corporation, 4560 Horton Street, Emeryville, CA, 94608, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiron Corporation, 4560 Horton Street, Emeryville, CA, 94608, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003599901","display_name":"Xuan-Mao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140213","display_name":"United Biomedical (United States)","ror":"https://ror.org/044bp3769","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140213"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. M. Li","raw_affiliation_strings":["United Biomedical, Inc., 25 Davids Drive, Hauppauge, NY, 11788, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United Biomedical, Inc., 25 Davids Drive, Hauppauge, NY, 11788, USA","institution_ids":["https://openalex.org/I4210140213"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140213","display_name":"United Biomedical (United States)","ror":"https://ror.org/044bp3769","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140213"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Qiu","raw_affiliation_strings":["United Biomedical, Inc., 25 Davids Drive, Hauppauge, NY, 11788, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United Biomedical, Inc., 25 Davids Drive, Hauppauge, NY, 11788, USA","institution_ids":["https://openalex.org/I4210140213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110000817","display_name":"Derek T. O\u2019Hagan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. T. O'hagan","raw_affiliation_strings":["Chiron Corporation, 4560 Horton Street, Emeryville, CA, 94608, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiron Corporation, 4560 Horton Street, Emeryville, CA, 94608, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.415,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.97086403,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"14","issue":"2","first_page":"197","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12048","display_name":"Microencapsulation and Drying Processes","score":0.1965000033378601,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poly-lactic-co-glycolic-acid","display_name":"poly(lactic-co-glycolic acid)","score":0.9620000123977661},{"id":"https://openalex.org/keywords/poly-d-l-lactide","display_name":"poly(D,L-lactide)","score":0.8820000290870667},{"id":"https://openalex.org/keywords/protein-microencapsulation","display_name":"protein microencapsulation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/microparticles","display_name":"microparticles","score":0.8190000057220459},{"id":"https://openalex.org/keywords/process-reproducibility","display_name":"process reproducibility","score":0.871999979019165},{"id":"https://openalex.org/keywords/protein-entrapment","display_name":"protein entrapment","score":0.7089999914169312},{"id":"https://openalex.org/keywords/microparticle-size","display_name":"microparticle size","score":0.8730000257492065},{"id":"https://openalex.org/keywords/solvent-evaporation","display_name":"solvent evaporation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/biodegradable-polymers","display_name":"biodegradable polymers","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6890641450881958},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.6721043586730957},{"id":"https://openalex.org/C81147070","wikidata":"https://www.wikidata.org/wiki/Q1172449","display_name":"Encapsulation (networking)","level":2,"score":0.6173520088195801},{"id":"https://openalex.org/C2776743539","wikidata":"https://www.wikidata.org/wiki/Q421313","display_name":"Lactide","level":4,"score":0.49274399876594543},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.48086267709732056},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.4801618456840515},{"id":"https://openalex.org/C2777521759","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microparticle","level":2,"score":0.4549923837184906},{"id":"https://openalex.org/C2984430287","wikidata":"https://www.wikidata.org/wiki/Q186249","display_name":"Pharmaceutical technology","level":2,"score":0.4377962648868561},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.4159370958805084},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3915606737136841},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3474830687046051},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.33646902441978455},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.29564839601516724},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22079598903656006},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.21345242857933044},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.19993868470191956},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.17674320936203003},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10612753033638},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09308686852455139},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/02652049709015333","doi":"https://doi.org/10.3109/02652049709015333","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02652049709015333","pdf_url":null,"source":{"id":"https://openalex.org/S160681128","display_name":"Journal of Microencapsulation","issn_l":"0265-2048","issn":["0265-2048","1464-5246"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microencapsulation","raw_type":"journal-article"},{"id":"pmid:9132471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9132471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microencapsulation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W23296051","https://openalex.org/W1261650543","https://openalex.org/W1536081943","https://openalex.org/W1936050068","https://openalex.org/W1988078869","https://openalex.org/W1999976043","https://openalex.org/W2012260545","https://openalex.org/W2014900050","https://openalex.org/W2019714972","https://openalex.org/W2020355224","https://openalex.org/W2020657255","https://openalex.org/W2022538444","https://openalex.org/W2067673936","https://openalex.org/W2067734332","https://openalex.org/W2125198898","https://openalex.org/W2777411000","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2154297591","https://openalex.org/W2009523551","https://openalex.org/W2030579793","https://openalex.org/W2147455405","https://openalex.org/W2165930198","https://openalex.org/W1536081943","https://openalex.org/W2117436946","https://openalex.org/W2142886817","https://openalex.org/W2085073341","https://openalex.org/W7095387713"],"abstract_inverted_index":{"Poly":[0],"(D,":[1,6],"L":[2,7],"lactide-co-glycolide)":[3],"and":[4,15,36,80,109,116,129,131,147],"poly":[5],"lactide)":[8],"microparticles":[9,55,77,104,136],"were":[10,78],"prepared":[11,105],"by":[12,94,110],"solvent":[13],"evaporation":[14],"the":[16,24,31,33,37,42,48,52,86,89,95,111,123,133],"process":[17],"reproducibility":[18,87,112],"was":[19,92,126],"evaluated":[20],"in":[21,66,140],"terms":[22,141],"of":[23,26,41,54,88,103,113,135,142],"loading":[25,143],"a":[27],"model":[28],"protein":[29,69,117],"into":[30],"microparticles,":[32],"microparticle":[34,114],"size":[35,115,146],"in-vitro":[38,96],"release":[39,97,148],"profiles":[40,98],"protein.":[43],"The":[44,76,119],"results":[45,120],"showed":[46],"that":[47,122],"microencapsulation":[49],"method":[50,91,125],"allowed":[51,132],"preparation":[53,90,124,134],"with":[56,68,137],"mean":[57],"sizes":[58],"from":[59,71,82],"<":[60],"0.5":[61,72],"micron":[62],"to":[63,73],"100":[64],"microns":[65],"size,":[67],"entrapment":[70],"5%":[74],"w/w.":[75],"smooth":[79],"free":[81],"surface":[83],"defects.":[84],"Moreover,":[85],"demonstrated":[93,121],"obtained":[99],"using":[100],"different":[101],"batches":[102],"under":[106],"similar":[107],"conditions":[108],"loading.":[118],"both":[127],"robust":[128],"reproducible":[130],"desired":[138],"characteristics":[139],"levels,":[144],"particle":[145],"rates.":[149]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}