{"id":"https://openalex.org/W2166148093","doi":"https://doi.org/10.1212/wnl.0000000000002175","title":"Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons","display_name":"Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons","publication_year":2015,"publication_date":"2015-11-04","ids":{"openalex":"https://openalex.org/W2166148093","doi":"https://doi.org/10.1212/wnl.0000000000002175","mag":"2166148093","pmid":"https://pubmed.ncbi.nlm.nih.gov/26537052","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4664125"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000002175","doi":"https://doi.org/10.1212/wnl.0000000000002175","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000002175","pdf_url":"https://n.neurology.org/content/neurology/85/22/1930.full.pdf","source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://n.neurology.org/content/neurology/85/22/1930.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043507147","display_name":"Patricia A. Boyle","orcid":"https://orcid.org/0000-0002-3245-3456","observed_orcids":["https://orcid.org/0000-0002-3245-3456"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia A. Boyle","raw_affiliation_strings":["From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101937767","display_name":"Lei Yu","orcid":"https://orcid.org/0000-0002-0237-8758","observed_orcids":["https://orcid.org/0000-0002-0237-8758","https://orcid.org/0000-0002-7176-1152","https://orcid.org/0000-0002-4044-0778"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Yu","raw_affiliation_strings":["From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015535104","display_name":"Sukriti Nag","orcid":"https://orcid.org/0000-0002-5193-1177","observed_orcids":["https://orcid.org/0000-0002-5193-1177"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sukriti Nag","raw_affiliation_strings":["From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070294274","display_name":"Sue E. Leurgans","orcid":"https://orcid.org/0000-0003-2536-1665","observed_orcids":["https://orcid.org/0000-0003-2536-1665"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue Leurgans","raw_affiliation_strings":["From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert S. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Wilson","raw_affiliation_strings":["From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014075642","display_name":"David Alan Bennett","orcid":"https://orcid.org/0000-0003-3689-554X","observed_orcids":["https://orcid.org/0000-0003-3689-554X"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Bennett","raw_affiliation_strings":["From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022605809","display_name":"Julie A. Schneider","orcid":"https://orcid.org/0000-0002-9482-1752","observed_orcids":["https://orcid.org/0000-0002-9482-1752"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Schneider","raw_affiliation_strings":["From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Rush Alzheimer's Disease Center (P.A.B., L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.) and Departments of Behavioral Sciences (P.A.B., R.S.W.), Neurological Sciences (L.Y., S.N., S.L., R.S.W., D.A.B., J.A.S.), and Pathology (S.N., J.A.S.), Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":null,"apc_paid":null,"fwci":17.8443,"has_fulltext":true,"cited_by_count":423,"citation_normalized_percentile":{"value":0.99669595,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"85","issue":"22","first_page":"1930","last_page":"1936"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.11249999701976776,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-amyloid-angiopathy","display_name":"cerebral amyloid angiopathy","score":1.0},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.9829999804496765},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8209999799728394},{"id":"https://openalex.org/keywords/alzheimer-disease-pathology","display_name":"Alzheimer disease pathology","score":0.718999981880188},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.5989999771118164},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.972000002861023},{"id":"https://openalex.org/keywords/microinfarcts","display_name":"microinfarcts","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.7900000214576721},{"id":"https://openalex.org/keywords/perceptual-speed","display_name":"perceptual speed","score":0.8429999947547913},{"id":"https://openalex.org/keywords/episodic-memory","display_name":"episodic memory","score":0.9990000128746033},{"id":"https://openalex.org/keywords/semantic-memory","display_name":"semantic memory","score":0.9729999899864197},{"id":"https://openalex.org/keywords/global-cognition","display_name":"global cognition","score":0.5720000267028809},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2777790613","wikidata":"https://www.wikidata.org/wiki/Q191562","display_name":"Cerebral amyloid angiopathy","level":4,"score":0.8684454560279846},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7932801246643066},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.6970003843307495},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6119754314422607},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5554917454719543},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.531227171421051},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4975455105304718},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.4955974817276001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4638550281524658},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.46316349506378174},{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.459328830242157},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3877650499343872},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3417940139770508},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2379232943058014}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1212/wnl.0000000000002175","doi":"https://doi.org/10.1212/wnl.0000000000002175","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000002175","pdf_url":"https://n.neurology.org/content/neurology/85/22/1930.full.pdf","source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4050537","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4664125","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4664125","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4664125","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Text"},{"id":"pmid:26537052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26537052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1212/wnl.0000000000002175","doi":"https://doi.org/10.1212/wnl.0000000000002175","is_oa":true,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000002175","pdf_url":"https://n.neurology.org/content/neurology/85/22/1930.full.pdf","source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1129744104","display_name":"Epidemiologic Study of Neural Reserve and Neurobiology of Aging","funder_award_id":"R01AG017917","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2576871581","display_name":"Epidemiologic Study of TDP-43 Pathology in Aging and Dementia","funder_award_id":"R01AG042210","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4875156105","display_name":"Risk Factors, Pathology, and Clinical Expressions of AD","funder_award_id":"R01AG015819","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5029820101","display_name":"Rush Alzheimer's Disease Core Center","funder_award_id":"P30AG010161","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8497221155","display_name":"Risk Factors, Pathology, and Clinical Expressions of AD","funder_award_id":"RF1AG015819","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000868891","display_name":"Characterizing the Behavior Profile of Healthy Cognitive Aging","funder_award_id":"R01AG034374","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2166148093.pdf","grobid_xml":"https://content.openalex.org/works/W2166148093.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1537321255","https://openalex.org/W1545961204","https://openalex.org/W1581476053","https://openalex.org/W1603244154","https://openalex.org/W1870043354","https://openalex.org/W1964251512","https://openalex.org/W1972186270","https://openalex.org/W1981711337","https://openalex.org/W1991965716","https://openalex.org/W1994609866","https://openalex.org/W2014670147","https://openalex.org/W2028502857","https://openalex.org/W2038703154","https://openalex.org/W2039937642","https://openalex.org/W2059313571","https://openalex.org/W2075091034","https://openalex.org/W2082496690","https://openalex.org/W2092592736","https://openalex.org/W2116108400","https://openalex.org/W2119519240","https://openalex.org/W2124681501","https://openalex.org/W2130067820","https://openalex.org/W2134836371","https://openalex.org/W2135374418","https://openalex.org/W2135705524","https://openalex.org/W2156220037","https://openalex.org/W2169452761","https://openalex.org/W2172053191"],"related_works":["https://openalex.org/W2071099913","https://openalex.org/W2907786298","https://openalex.org/W2103473142","https://openalex.org/W4312086849","https://openalex.org/W4390196046","https://openalex.org/W2897766055","https://openalex.org/W7169826067","https://openalex.org/W1964251512","https://openalex.org/W1981711337","https://openalex.org/W4283660775"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1],"tested":[2],"the":[3,51,58,211],"hypothesis":[4],"that":[5],"cerebral":[6],"amyloid":[7],"angiopathy":[8],"(CAA)":[9],"is":[10,218],"related":[11,145],"to":[12,91,146],"Alzheimer":[13],"disease":[14],"(AD)":[15],"dementia":[16,115,175,224],"and":[17,30,33,54,57,105,122,143,161,184,197,225],"decline":[18,127,189,226],"in":[19,23,139,190,227,231],"multiple":[20,228],"cognitive":[21,69,126,205,229],"systems":[22,230],"old":[24,232],"age,":[25],"independent":[26],"of":[27,49,74,81,98,111,141,173,188,202,213,222],"AD":[28,82,100,114,147,174,223],"plaque":[29],"tangle":[31],"pathology":[32,148],"other":[34,162],"common":[35,163],"age-related":[36,164],"neuropathologies.":[37],"METHODS:":[38],"Participants":[39],"(n":[40],"=":[41,150,178],"1,113)":[42],"came":[43],"from":[44],"2":[45],"longitudinal":[46],"clinical-pathologic":[47],"studies":[48],"aging,":[50],"Rush":[52],"Memory":[53],"Aging":[55],"Project":[56],"Religious":[59],"Orders":[60],"Study.":[61],"All":[62],"underwent":[63],"annual":[64],"clinical":[65,88],"evaluations":[66],"including":[67],"detailed":[68],"testing":[70],"for":[71,158],"a":[72],"mean":[73],"7.1":[75],"years":[76],"before":[77],"death.":[78],"Clinical":[79],"diagnoses":[80],"were":[83,207],"established":[84],"after":[85],"reviewing":[86],"all":[87],"data,":[89],"blinded":[90],"neuropathologic":[92],"information.":[93],"Neuropathologic":[94],"examinations":[95],"provided":[96],"measures":[97],"CAA,":[99],"pathology,":[101],"macroscopic":[102],"infarcts,":[103],"microinfarcts,":[104],"neocortical":[106],"Lewy":[107],"bodies.":[108],"The":[109,200],"association":[110,124],"CAA":[112,135,166,203,217],"with":[113,125,169,204],"was":[116,128,136,167],"examined":[117,129],"using":[118,130],"logistic":[119],"regression":[120],"models,":[121],"its":[123],"linear":[131],"mixed":[132],"models.":[133],"RESULTS:":[134],"common,":[137],"present":[138],"78.9%":[140],"participants,":[142],"moderately":[144],"(\u03c1":[149],"0.401,":[151],"p":[152],"<":[153],"0.0001).":[154],"In":[155],"analyses":[156],"adjusted":[157],"plaques,":[159],"tangles,":[160],"neuropathologies,":[165],"associated":[168],"an":[170,185,219],"increased":[171,186],"odds":[172],"(odds":[176],"ratio":[177],"1.237,":[179],"95%":[180],"confidence":[181],"interval":[182],"1.082-1.414)":[183],"rate":[187],"global":[191],"cognition,":[192],"perceptual":[193],"speed,":[194],"episodic":[195],"memory,":[196],"semantic":[198],"memory.":[199],"associations":[201],"outcomes":[206],"not":[208],"driven":[209],"by":[210],"presence":[212],"capillary":[214],"involvement.":[215],"CONCLUSIONS:":[216],"important":[220],"determinant":[221],"age.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":48},{"year":2025,"cited_by_count":54},{"year":2024,"cited_by_count":59},{"year":2023,"cited_by_count":38},{"year":2022,"cited_by_count":45},{"year":2021,"cited_by_count":43},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":31},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":20},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}