{"id":"https://openalex.org/W2166097710","doi":"https://doi.org/10.1002/ijc.2910510609","title":"A prospective study of transmission by transfusion of HTLV\u2010I and risk factors associated with seroconversion","display_name":"A prospective study of transmission by transfusion of HTLV\u2010I and risk factors associated with seroconversion","publication_year":1992,"publication_date":"1992-07-30","ids":{"openalex":"https://openalex.org/W2166097710","doi":"https://doi.org/10.1002/ijc.2910510609","mag":"2166097710","pmid":"https://pubmed.ncbi.nlm.nih.gov/1639536"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910510609","doi":"https://doi.org/10.1002/ijc.2910510609","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910510609","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110316095","display_name":"Angela Manns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Angela Manns","raw_affiliation_strings":["Viral Epidemiology Section, National Cancer Institute, Bethesda, MD 20892","Viral Epidemiology Section, National Cancer Institute, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Epidemiology Section, National Cancer Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Viral Epidemiology Section, National Cancer Institute, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029738136","display_name":"Rainford Wilks","orcid":"https://orcid.org/0000-0001-6494-6442","observed_orcids":["https://orcid.org/0000-0001-6494-6442"]},"institutions":[{"id":"https://openalex.org/I4210129319","display_name":"University of the West Indies","ror":"https://ror.org/03fkc8c64","country_code":"JM","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210129319"]}],"countries":["JM"],"is_corresponding":false,"raw_author_name":"Rainford J. Wilks","raw_affiliation_strings":["Tropical Medicine Research Unit and Department of Pathology, University of the West Indies, Kingston, Jamaica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tropical Medicine Research Unit and Department of Pathology, University of the West Indies, Kingston, Jamaica","institution_ids":["https://openalex.org/I4210129319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016750216","display_name":"Edward L. Murphy","orcid":"https://orcid.org/0000-0001-6515-3989","observed_orcids":["https://orcid.org/0000-0001-6515-3989"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward L. Murphy","raw_affiliation_strings":["Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Grace Haynes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163957","display_name":"Ministry of Health","ror":"https://ror.org/059v3b755","country_code":"JM","type":"government","lineage":["https://openalex.org/I4210163957"]}],"countries":["JM"],"is_corresponding":false,"raw_author_name":"Grace Haynes","raw_affiliation_strings":["National Transfusion Service and Ministry of Health, Kingston, Jamaica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Transfusion Service and Ministry of Health, Kingston, Jamaica","institution_ids":["https://openalex.org/I4210163957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103140120","display_name":"J. Peter Figueroa","orcid":"https://orcid.org/0000-0003-2794-7555","observed_orcids":["https://orcid.org/0000-0003-2794-7555"]},"institutions":[{"id":"https://openalex.org/I4210163957","display_name":"Ministry of Health","ror":"https://ror.org/059v3b755","country_code":"JM","type":"government","lineage":["https://openalex.org/I4210163957"]}],"countries":["JM"],"is_corresponding":false,"raw_author_name":"J. Peter Figueroa","raw_affiliation_strings":["National Transfusion Service and Ministry of Health, Kingston, Jamaica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Transfusion Service and Ministry of Health, Kingston, Jamaica","institution_ids":["https://openalex.org/I4210163957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113998162","display_name":"M Barnett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marge Barnett","raw_affiliation_strings":["Research Triangle Institute, Washington, DC 20036, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Triangle Institute, Washington, DC 20036, USA","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057353652","display_name":"Barrie Hanchard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129319","display_name":"University of the West Indies","ror":"https://ror.org/03fkc8c64","country_code":"JM","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210129319"]}],"countries":["JM"],"is_corresponding":false,"raw_author_name":"Barrie Hanchard","raw_affiliation_strings":["Tropical Medicine Research Unit and Department of Pathology, University of the West Indies, Kingston, Jamaica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tropical Medicine Research Unit and Department of Pathology, University of the West Indies, Kingston, Jamaica","institution_ids":["https://openalex.org/I4210129319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113488831","display_name":"William A. Blattner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Blattner","raw_affiliation_strings":["Viral Epidemiology Section, National Cancer Institute, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Epidemiology Section, National Cancer Institute, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5110316095"],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":2.7772,"has_fulltext":false,"cited_by_count":242,"citation_normalized_percentile":{"value":0.91721277,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"51","issue":"6","first_page":"886","last_page":"891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.03539999946951866,"subfield":{"id":"https://openalex.org/subfields/1405","display_name":"Management of Technology and Innovation"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htlv-1","display_name":"HTLV-1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/transfusion-transmitted-infections","display_name":"transfusion-transmitted infections","score":0.8379999995231628},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.9179999828338623},{"id":"https://openalex.org/keywords/blood-donor-screening","display_name":"blood donor screening","score":0.8840000033378601},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.8009999990463257},{"id":"https://openalex.org/keywords/jamaica","display_name":"Jamaica","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2777451964","wikidata":"https://www.wikidata.org/wiki/Q2141450","display_name":"Seroconversion","level":3,"score":0.9405564069747925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8696607947349548},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.6678357720375061},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6117967367172241},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5961300730705261},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5064405202865601},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.49864840507507324},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4874475300312042},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.47990286350250244},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45048922300338745},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4367210566997528},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.42143601179122925},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.26708510518074036},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001782","descriptor_name":"Blood Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007563","descriptor_name":"Jamaica","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015481","descriptor_name":"HTLV-I Antibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015490","descriptor_name":"HTLV-I Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015490","descriptor_name":"HTLV-I Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015490","descriptor_name":"HTLV-I Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065227","descriptor_name":"Transfusion Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.2910510609","doi":"https://doi.org/10.1002/ijc.2910510609","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910510609","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:1639536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1639536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W60183410","https://openalex.org/W1586575087","https://openalex.org/W1951279911","https://openalex.org/W1976402310","https://openalex.org/W1998809543","https://openalex.org/W2003852143","https://openalex.org/W2008672209","https://openalex.org/W2047357352","https://openalex.org/W2055157340","https://openalex.org/W2073993963","https://openalex.org/W2076019330","https://openalex.org/W2079504599","https://openalex.org/W2084714153","https://openalex.org/W2092453476","https://openalex.org/W2166265650","https://openalex.org/W2240041642","https://openalex.org/W2269049351","https://openalex.org/W2277231367","https://openalex.org/W2327931329","https://openalex.org/W2399778456","https://openalex.org/W2603880708","https://openalex.org/W2618481557","https://openalex.org/W2932339907","https://openalex.org/W4231579523","https://openalex.org/W4232791034","https://openalex.org/W4233631472"],"related_works":["https://openalex.org/W1971314068","https://openalex.org/W2043401451","https://openalex.org/W2079504599","https://openalex.org/W2139760291","https://openalex.org/W1994482657","https://openalex.org/W2412144761","https://openalex.org/W2081330737","https://openalex.org/W2055602298","https://openalex.org/W2000493448","https://openalex.org/W2000407049"],"abstract_inverted_index":{"To":[0],"evaluate":[1,61],"the":[2,62,235],"risk":[3,116,202,219],"of":[4,7,19,67,71,94,96,103,111,124,162,167,179,203,209,237],"transfusion-related":[5],"transmission":[6,205],"HTLV-I":[8,22,72,204,214,256],"in":[9,31,91,186,245],"Jamaica,":[10],"a":[11,20,125,200],"prospective":[12],"study":[13],"was":[14,74,188],"initiated,":[15],"prior":[16],"to":[17,60,147,158,176,190],"availability":[18],"licensed":[21],"serological":[23],"screening":[24,208,254],"assay.":[25],"This":[26],"information":[27],"would":[28],"prove":[29],"useful":[30],"formulating":[32],"strategies":[33],"for":[34,48,131,220,255],"blood-donor":[35,253],"screening.":[36],"We":[37],"followed":[38],"118":[39],"pre-transfusion":[40],"HTLV-I-negative":[41,112],"transfusion":[42,85,168,198],"recipients":[43,86,95,102,110],"at":[44,57,165,217,234],"monthly":[45],"intervals":[46],"post-transfusion":[47],"1":[49],"year.":[50],"Laboratory":[51],"and":[52,64,76,108,206],"questionnaire":[53],"data":[54,78],"were":[55,87,122,222,230],"obtained":[56],"each":[58],"visit":[59],"clinical":[63],"immunological":[65],"status":[66],"recipients.":[68],"Cumulative":[69],"incidence":[70],"seroconversion":[73,81,121,221],"estimated":[75,189],"risk-factor":[77],"associated":[79,118],"with":[80,119],"among":[82],"66":[83],"HTLV-I-exposed":[84],"analyzed.":[88],"Seroconversion":[89],"occurred":[90],"24/54":[92],"(44%)":[93],"HTLV-I-positive":[97],"cellular":[98,127],"blood":[99,128,197,211,249],"components,":[100,250],"0/12":[101],"positive":[104],"non-cellular":[105],"donor":[106,113,210],"units":[107],"0/52":[109],"units.":[114],"Significant":[115],"factors":[117],"recipient":[120],"receipt":[123],"seropositive":[126],"component":[129],"stored":[130],"less":[132],"than":[133],"one":[134],"week":[135],"[odds":[136],"ratio":[137],"(OR)":[138],"=":[139,145,152,156,170,174],"6.34,":[140],"95%":[141,154,172],"confidence":[142],"interval":[143],"(CI)":[144],"1.83":[146],"21.92],":[148],"male":[149],"sex":[150],"(OR":[151,169],"4.79,":[153],"CI":[155,173],"1.15":[157],"20.0)":[159],"or":[160,228],"use":[161],"immuno-suppressive":[163],"therapy":[164,233],"time":[166,236],"12.20,":[171],"0.95":[175],"156).":[177],"Risk":[178],"blood-borne":[180],"infection":[181],"per":[182,184],"person":[183],"year":[185],"Jamaica":[187],"be":[191,242],"0.009%.":[192],"Our":[193],"results":[194],"confirm":[195],"that":[196,207],"carries":[199],"significant":[201],"effectively":[212],"prevents":[213],"seroconversion.":[215],"Recipients":[216],"greatest":[218],"those":[223],"who":[224,229],"required":[225],"multiple":[226],"transfusions":[227],"receiving":[231,246],"immunosuppressive":[232],"transfusion.":[238],"These":[239],"patients":[240],"should":[241],"given":[243],"priority":[244],"selectively":[247],"screened":[248],"if":[251],"universal":[252],"is":[257],"not":[258],"possible.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}