{"id":"https://openalex.org/W2166090261","doi":"https://doi.org/10.1001/jama.2015.280","title":"Effect of Varenicline on Smoking Cessation Through Smoking Reduction","display_name":"Effect of Varenicline on Smoking Cessation Through Smoking Reduction","publication_year":2015,"publication_date":"2015-02-17","ids":{"openalex":"https://openalex.org/W2166090261","doi":"https://doi.org/10.1001/jama.2015.280","mag":"2166090261","pmid":"https://pubmed.ncbi.nlm.nih.gov/25688780","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4883651"},"language":"en","primary_location":{"id":"doi:10.1001/jama.2015.280","doi":"https://doi.org/10.1001/jama.2015.280","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2015.280","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4883651","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068595405","display_name":"Jon O. Ebbert","orcid":"https://orcid.org/0000-0002-7975-3704","observed_orcids":["https://orcid.org/0000-0002-7975-3704"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon O. Ebbert","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101433881","display_name":"John R. Hughes","orcid":"https://orcid.org/0000-0001-9893-7843","observed_orcids":["https://orcid.org/0000-0001-9893-7843","https://orcid.org/0000-0002-0092-9309"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Hughes","raw_affiliation_strings":["Department of Psychiatry, University of Vermont, Burlington, Vermont"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Vermont, Burlington, Vermont","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059645286","display_name":"Robert West","orcid":"https://orcid.org/0000-0001-6398-0921","observed_orcids":["https://orcid.org/0000-0001-6398-0921","https://orcid.org/0000-0002-0291-5760","https://orcid.org/0000-0003-1011-5795"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert J. West","raw_affiliation_strings":["Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083270547","display_name":"Stephen I. Rennard","orcid":"https://orcid.org/0000-0001-7909-0253","observed_orcids":["https://orcid.org/0000-0001-7909-0253"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen I. Rennard","raw_affiliation_strings":["Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Nebraska Medical Center, Omaha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Nebraska Medical Center, Omaha","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087610563","display_name":"Cristina Russ","orcid":"https://orcid.org/0000-0001-7248-9712","observed_orcids":["https://orcid.org/0000-0001-7248-9712"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Russ","raw_affiliation_strings":["Pfizer Inc, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, New York, New York","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077623642","display_name":"Thomas D. McRae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. McRae","raw_affiliation_strings":["Pfizer Inc, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, New York, New York","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054323712","display_name":"Joan Treadow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Treadow","raw_affiliation_strings":["Pfizer Inc, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, New York, New York","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041438669","display_name":"Ching\u2010Ray Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ching-Ray Yu","raw_affiliation_strings":["Pfizer Inc, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, New York, New York","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021268492","display_name":"Michael P. Dutro","orcid":"https://orcid.org/0009-0005-7634-2183","observed_orcids":["https://orcid.org/0009-0005-7634-2183"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Dutro","raw_affiliation_strings":["Pfizer Inc, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, New York, New York","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033306318","display_name":"Peter W. Park","orcid":"https://orcid.org/0000-0001-5536-1928","observed_orcids":["https://orcid.org/0000-0001-5536-1928"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W. Park","raw_affiliation_strings":["Pfizer Inc, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, New York, New York","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":18.4698,"has_fulltext":false,"cited_by_count":210,"citation_normalized_percentile":{"value":0.99678534,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"313","issue":"7","first_page":"687","last_page":"687"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/varenicline","display_name":"varenicline","score":0.9990000128746033},{"id":"https://openalex.org/keywords/smoking-cessation","display_name":"smoking cessation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/smoking-reduction","display_name":"smoking reduction","score":0.984000027179718},{"id":"https://openalex.org/keywords/nicotine-receptor-partial-agonist","display_name":"nicotine receptor partial agonist","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cigarette-consumption-reduction","display_name":"cigarette consumption reduction","score":0.4779999852180481},{"id":"https://openalex.org/keywords/nicotine-dependence","display_name":"nicotine dependence","score":0.503000020980835},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.335999995470047},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5979999899864197},{"id":"https://openalex.org/keywords/nicotine-withdrawal-symptoms","display_name":"nicotine withdrawal symptoms","score":0.382999986410141},{"id":"https://openalex.org/keywords/nicotine-replacement-therapy","display_name":"nicotine replacement therapy","score":0.32499998807907104},{"id":"https://openalex.org/keywords/nicotine-gum","display_name":"nicotine gum","score":0.44200000166893005},{"id":"https://openalex.org/keywords/bupropion","display_name":"bupropion","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2777053506","wikidata":"https://www.wikidata.org/wiki/Q411330","display_name":"Varenicline","level":3,"score":0.9560225009918213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9118592739105225},{"id":"https://openalex.org/C2780687700","wikidata":"https://www.wikidata.org/wiki/Q210978","display_name":"Abstinence","level":2,"score":0.829736590385437},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.7873585224151611},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7539510130882263},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.46882718801498413},{"id":"https://openalex.org/C3017583242","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Placebo group","level":4,"score":0.41517138481140137},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4027233123779297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35186830163002014},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.29752495884895325},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068580","descriptor_name":"Varenicline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014029","descriptor_name":"Tobacco Use Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016540","descriptor_name":"Smoking Cessation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1001/jama.2015.280","doi":"https://doi.org/10.1001/jama.2015.280","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2015.280","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"pmid:25688780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25688780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:3848426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4883651","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4883651","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4883651","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"JAMA","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.686.792","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.686.792","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jama.jamanetwork.com/data/Journals/JAMA/932761/joi150008.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3848426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4883651","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G312174694","display_name":"The UK Centre for Tobacco and Alcohol Studies (UKCTAS)","funder_award_id":"MR/K023195/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3315393415","display_name":"The UK Centre for Tobacco Control Studies","funder_award_id":"ES/G007489/1","funder_id":"https://openalex.org/F4320334630","funder_display_name":"Economic and Social Research Council"},{"id":"https://openalex.org/G7352162465","display_name":null,"funder_award_id":"A14135","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334630","display_name":"Economic and Social Research Council","ror":"https://ror.org/03n0ht308"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W118829757","https://openalex.org/W1620946795","https://openalex.org/W1647185577","https://openalex.org/W1984780607","https://openalex.org/W1993112595","https://openalex.org/W2002778671","https://openalex.org/W2008006280","https://openalex.org/W2010137196","https://openalex.org/W2021604300","https://openalex.org/W2046942554","https://openalex.org/W2059715562","https://openalex.org/W2067479516","https://openalex.org/W2081287796","https://openalex.org/W2099910799","https://openalex.org/W2107200746","https://openalex.org/W2110884234","https://openalex.org/W2116514043","https://openalex.org/W2118061336","https://openalex.org/W2121369880","https://openalex.org/W2130374023","https://openalex.org/W2131061920","https://openalex.org/W2132322340","https://openalex.org/W2141337174","https://openalex.org/W2164386461","https://openalex.org/W2171937180","https://openalex.org/W3022870108","https://openalex.org/W4241186196"],"related_works":["https://openalex.org/W2598601585","https://openalex.org/W2576764164","https://openalex.org/W2053457282","https://openalex.org/W2626688756","https://openalex.org/W2051592959","https://openalex.org/W2048021420","https://openalex.org/W2143238807","https://openalex.org/W2345064511","https://openalex.org/W2160546125","https://openalex.org/W2152585643"],"abstract_inverted_index":{"IMPORTANCE:":[0],"Some":[1],"cigarette":[2,17,76,326,342],"smokers":[3,77,327,382],"may":[4,12],"not":[5,80,328,386],"be":[6,13],"ready":[7],"to":[8,15,84,93,117,332,340],"quit":[9,85,99,148,333,347],"immediately":[10],"but":[11,91,338],"willing":[14,81,92,329,339],"reduce":[16,94,341],"consumption":[18,343],"with":[19,51,124,359],"the":[20,27,88,102,207,215,221,248,258,264,284,290,310,316,335,367],"goal":[21],"of":[22,31,114,128,134,309,315,353,369],"quitting.":[23],"OBJECTIVE:":[24],"To":[25],"determine":[26],"efficacy":[28,158],"and":[29,56,63,96,146,183,277,313,344,371],"safety":[30],"varenicline":[32,115,190,216,239,259,285,311,354],"for":[33,178,214,220,257,263,283,289,355,381],"increasing":[34],"smoking":[35,39,86,95,363,393],"abstinence":[36,165,177,199,245],"rates":[37,200,246,365],"through":[38,109,169,181,186,204,254,280],"reduction.":[40],"DESIGN,":[41],"SETTING,":[42],"AND":[43,155,323],"PARTICIPANTS:":[44],"Randomized,":[45],"double-blind,":[46],"placebo-controlled,":[47],"multinational":[48],"clinical":[49,389],"trial":[50],"a":[52,98,125,147,346,378],"24-week":[53],"treatment":[54,379],"period":[55],"28-week":[57],"follow-up":[58],"conducted":[59],"between":[60],"July":[61,64],"2011":[62],"2013":[65],"at":[66,349,366,373],"61":[67],"centers":[68],"in":[69,132,307],"10":[70],"countries.":[71],"The":[72,189,238],"1510":[73],"participants":[74],"were":[75,79,107,173],"who":[78],"or":[82,122,130,141,330],"able":[83,331],"within":[87,101,334],"next":[89,103,336],"month":[90,337],"make":[97,345],"attempt":[100,149,348],"3":[104,350],"months.":[105],"Participants":[106],"recruited":[108],"advertising.":[110],"INTERVENTIONS:":[111],"Twenty-four":[112],"weeks":[113,167,179,184,202,252,278,357],"titrated":[116],"1":[118,374],"mg":[119],"twice":[120],"daily":[121],"placebo":[123,208,222,249,265,291,317,360],"reduction":[126],"target":[127],"50%":[129],"more":[131,142],"number":[133],"cigarettes":[135],"smoked":[136],"by":[137,143,150,388],"4":[138],"weeks,":[139,145],"75%":[140],"8":[144],"12":[151],"weeks.":[152],"MAIN":[153],"OUTCOMES":[154],"MEASURES:":[156],"Primary":[157],"end":[159,368],"point":[160],"was":[161],"carbon":[162,174],"monoxide-confirmed":[163,175],"self-reported":[164,176],"during":[166,201,251],"15":[168,203],"24.":[170],"Secondary":[171],"outcomes":[172],"21":[180,185,253,279],"24":[182,205,255,356],"52.":[187],"RESULTS:":[188],"group":[191,209,217,240,250,260,286,312,318],"(n":[192,210],"=":[193,211,320],"760)":[194],"had":[195,241],"significantly":[196,242,361],"higher":[197,243],"continuous":[198,244],"vs":[206,218,247,261,287],"750)":[212],"(32.1%":[213],"6.9%":[219],"group;":[223,266,292],"risk":[224,232],"difference":[225],"(RD),":[226],"25.2%":[227,268],"[95%":[228,235,269,274,295,300],"CI,":[229,236,270,275,296,301],"21.4%-29.0%];":[230],"relative":[231],"(RR),":[233],"4.6":[234],"3.5-6.1]).":[237],"(37.8%":[256],"12.5%":[262],"RD,":[267,293],"21.1%-29.4%];":[271],"RR,":[272,298],"3.0":[273],"2.4-3.7])":[276],"52":[281],"(27.0%":[282],"9.9%":[288],"17.1%":[294],"13.3%-20.9%];":[297],"2.7":[299],"2.1-3.5]).":[302],"Serious":[303],"adverse":[304],"events":[305],"occurred":[306],"3.7%":[308],"2.2%":[314],"(P":[319],".07).":[321],"CONCLUSIONS":[322],"RELEVANCE:":[324],"Among":[325],"months,":[351],"use":[352],"compared":[358],"increased":[362],"cessation":[364],"treatment,":[370],"also":[372],"year.":[375],"Varenicline":[376],"offers":[377],"option":[380],"whose":[383],"needs":[384],"are":[385],"addressed":[387],"guidelines":[390],"recommending":[391],"abrupt":[392],"cessation.":[394],"TRIAL":[395],"REGISTRATION:":[396],"clinicaltrials.gov":[397],"Identifier:":[398],"NCT01370356.":[399]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":17}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}