{"id":"https://openalex.org/W2166059699","doi":null,"title":"Regional loss of imprinting of the insulin-like growth factor II gene occurs in human prostate tissues.","display_name":"Regional loss of imprinting of the insulin-like growth factor II gene occurs in human prostate tissues.","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W2166059699","mag":"2166059699","pmid":"https://pubmed.ncbi.nlm.nih.gov/9815946"},"language":"en","primary_location":{"id":"pmid:9815946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004593069","display_name":"David Frazier Jarrard","orcid":"https://orcid.org/0000-0001-8444-7165","observed_orcids":["https://orcid.org/0000-0001-8444-7165"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D F Jarrard","raw_affiliation_strings":["Brady Urological Institute, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, Maryland 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brady Urological Institute, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017052565","display_name":"Marion J.G. Bussemakers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M J Bussemakers","raw_affiliation_strings":["Radboud University Nijmegen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud University Nijmegen","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007957082","display_name":"G. Steven Bova","orcid":"https://orcid.org/0000-0003-1639-3104","observed_orcids":["https://orcid.org/0000-0003-1639-3104"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G S Bova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068348417","display_name":"William B. Isaacs","orcid":"https://orcid.org/0000-0001-6599-6775","observed_orcids":["https://orcid.org/0000-0001-6599-6775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W B Isaacs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8123,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.85050532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"1","issue":"12","first_page":"1471","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.9459999799728394},{"id":"https://openalex.org/keywords/genomic-imprinting","display_name":"genomic imprinting","score":0.9549999833106995},{"id":"https://openalex.org/keywords/loss-of-imprinting","display_name":"loss of imprinting","score":0.984000027179718},{"id":"https://openalex.org/keywords/biallelic-expression","display_name":"biallelic expression","score":0.8510000109672546},{"id":"https://openalex.org/keywords/prostate-adenocarcinoma","display_name":"prostate adenocarcinoma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/peripheral-zone","display_name":"peripheral zone","score":0.5149999856948853},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/allele-specific-expression","display_name":"allele-specific expression","score":0.7110000252723694},{"id":"https://openalex.org/keywords/apai-polymorphism","display_name":"ApaI polymorphism","score":0.9369999766349792},{"id":"https://openalex.org/keywords/prostate-cancer-susceptibility","display_name":"prostate cancer susceptibility","score":0.40799999237060547},{"id":"https://openalex.org/keywords/tissue-specific-gene-regulation","display_name":"tissue-specific gene regulation","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2779069268","wikidata":"https://www.wikidata.org/wiki/Q14874349","display_name":"Insulin-like growth factor 2","level":4,"score":0.7539071440696716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6630653738975525},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6576288342475891},{"id":"https://openalex.org/C201492766","wikidata":"https://www.wikidata.org/wiki/Q84087","display_name":"Genomic imprinting","level":5,"score":0.5862908363342285},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5653263926506042},{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.5459380149841309},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.48572832345962524},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47406667470932007},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4719330966472626},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46332308650016785},{"id":"https://openalex.org/C94715292","wikidata":"https://www.wikidata.org/wiki/Q624349","display_name":"Imprinting (psychology)","level":3,"score":0.4200572669506073},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3700975775718689},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3634260296821594},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2889077365398407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15079548954963684},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10740077495574951},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018392","descriptor_name":"Genomic Imprinting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9815946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2166059699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2488664870","display_name":"Urology Research Training Grant","funder_award_id":"T32DK007552","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6257854233","display_name":"SPORE in Prostate Cancer","funder_award_id":"P50CA058236","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7489798771","display_name":"SUPPRESSION OF PROSTATE CANCER","funder_award_id":"K11CA059457","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W601502985","https://openalex.org/W1968036473","https://openalex.org/W1970181305","https://openalex.org/W1986146441","https://openalex.org/W2019211320","https://openalex.org/W2020708296","https://openalex.org/W2035656617","https://openalex.org/W2038172435","https://openalex.org/W2040157600","https://openalex.org/W2076929503"],"related_works":["https://openalex.org/W2134418991","https://openalex.org/W1489739358","https://openalex.org/W2039744551","https://openalex.org/W7208354622","https://openalex.org/W2128171169","https://openalex.org/W2743747099","https://openalex.org/W2073679119","https://openalex.org/W2160602026","https://openalex.org/W2084117254","https://openalex.org/W2044814374"],"abstract_inverted_index":{"In":[0,213],"most":[1],"tissues,":[2],"the":[3,16,45,64,67,79,99,104,110,124,129,222,263,271],"insulin-like":[4],"growth":[5],"factor":[6],"II":[7],"gene":[8,86,245,258],"(IGF-II)":[9],"demonstrates":[10],"imprinting,":[11],"being":[12],"expressed":[13],"exclusively":[14],"from":[15,98],"paternal":[17],"allele.":[18],"Recently,":[19],"a":[20,74,229,240],"loss":[21],"of":[22,47,78,85,93,106,128,143,154,167,174,186,218,228,233,243,257,266,273],"IGF-II":[23,80,111,130,160,219,234,244],"imprinting":[24,108],"(i.e.,":[25],"biallelic":[26,76,231],"expression)":[27],"has":[28],"been":[29],"found":[30,148],"in":[31,54,90,113,123,164,182,201,235,248,262],"sporadic":[32],"Wilm's":[33],"tumors":[34],"and":[35,38,66,135,171,199,209,224],"lung":[36],"carcinomas,":[37],"this":[39,83,254],"molecular":[40],"event":[41],"may":[42,260],"contribute":[43],"to":[44,149],"pathogenesis":[46],"these":[48],"tumors.":[49],"Here,":[50],"we":[51],"report":[52],"that":[53,253],"prostates":[55],"removed":[56,116],"at":[57,109],"radical":[58,145],"surgery":[59],"for":[60,117,152,159,270],"localized":[61],"adenocarcinoma,":[62],"both":[63,221],"cancer":[65],"associated":[68],"normal":[69],"peripheral":[70,177,236,267],"zone":[71,178],"tissue":[72,269],"have":[73],"pronounced":[75],"expression":[77,87,158,202,232,259],"gene.":[81,131],"However,":[82],"pattern":[84,242,256],"is":[88],"uncommon":[89],"periurethral":[91],"samples":[92,170,180],"benign":[94],"prostatic":[95,268],"hyperplasia":[96],"(BPH)":[97],"same":[100],"specimens.":[101],"We":[102,251],"analyzed":[103],"status":[105],"genomic":[107],"locus":[112],"prostate":[114,179,211,237,249],"specimens":[115,147,238],"carcinoma":[118],"using":[119],"an":[120],"ApaI":[121],"polymorphism":[122],"3'":[125],"untranslated":[126],"exon":[127],"First-strand":[132],"cDNA":[133],"synthesis":[134],"subsequent":[136],"PCR":[137],"amplification":[138],"were":[139,192,203],"performed":[140],"on":[141],"13":[142],"35":[144],"prostatectomy":[146],"be":[150],"informative":[151],"analysis":[153],"allele-specific":[155],"expression.":[156],"Biallelic":[157],"RNA":[161,190],"was":[162],"demonstrated":[163,194],"10":[165],"(83%)":[166],"12":[168],"tumor":[169,210],"8":[172],"(73%)":[173],"11":[175,187],"matched":[176],"but":[181],"only":[183],"2":[184],"(18%)":[185],"BPH":[188],"samples.":[189],"transcripts":[191],"readily":[193],"by":[195,220],"Northern":[196],"blot":[197],"analysis,":[198],"differences":[200],"not":[204],"noted":[205],"among":[206],"normal,":[207],"BPH,":[208],"tissues.":[212],"situ":[214],"hybridization":[215],"revealed":[216],"production":[217],"epithelium":[223],"stroma.":[225],"The":[226],"finding":[227],"frequent":[230],"suggests":[239],"regional":[241],"regulation":[246],"exists":[247],"tissue.":[250],"hypothesize":[252],"tissue-specific":[255],"participate":[261],"marked":[264],"predilection":[265],"development":[272],"carcinogenesis.":[274]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}