{"id":"https://openalex.org/W2166007002","doi":"https://doi.org/10.1002/cmdc.201500188","title":"Therapeutic Developments Targeting Toll\u2010like Receptor\u20104\u2010Mediated Neuroinflammation","display_name":"Therapeutic Developments Targeting Toll\u2010like Receptor\u20104\u2010Mediated Neuroinflammation","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W2166007002","doi":"https://doi.org/10.1002/cmdc.201500188","mag":"2166007002","pmid":"https://pubmed.ncbi.nlm.nih.gov/26136385","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4983275"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.201500188","doi":"https://doi.org/10.1002/cmdc.201500188","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201500188","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4983275","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100337081","display_name":"Jing Li","orcid":"https://orcid.org/0000-0003-2504-1629","observed_orcids":["https://orcid.org/0000-0003-2504-1629","https://orcid.org/0009-0003-8164-6347","https://orcid.org/0009-0008-7505-4122"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, 100032 China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, 100032 China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004224366","display_name":"Adam Csakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Csakai","raw_affiliation_strings":["Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, CO, 80309-0596 USA","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, CO, 80309-0596 USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114020010","display_name":"Jialin Jin","orcid":"https://orcid.org/0009-0003-6043-4169","observed_orcids":["https://orcid.org/0009-0003-6043-4169","https://orcid.org/0009-0008-2704-9118"]},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Jialin Jin","raw_affiliation_strings":["Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing, 100082 China","Physikalisch-Astronomische Fakult\u00e4t Abbe School of Photonics  Jena 07743 Germany","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing, 100082 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Physikalisch-Astronomische Fakult\u00e4t Abbe School of Photonics  Jena 07743 Germany","institution_ids":["https://openalex.org/I76198965"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100783681","display_name":"Fengchun Zhang","orcid":"https://orcid.org/0000-0003-3484-4319","observed_orcids":["https://orcid.org/0000-0003-3484-4319","https://orcid.org/0000-0001-9295-4028"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fengchun Zhang","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, 100032 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, 100032 China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025581121","display_name":"Hang Hubert Yin","orcid":"https://orcid.org/0000-0002-9762-4818","observed_orcids":["https://orcid.org/0000-0002-9762-4818"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Hang Yin","raw_affiliation_strings":["Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing, 100082 China","Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, CO, 80309-0596 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing, 100082 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, CO, 80309-0596 USA","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5025581121","https://openalex.org/A5100783681"],"corresponding_institution_ids":["https://openalex.org/I188538660","https://openalex.org/I200296433","https://openalex.org/I2801228662","https://openalex.org/I99065089"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.7874,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.63692162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"2","first_page":"154","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.10830000042915344,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.984000027179718},{"id":"https://openalex.org/keywords/tlr4-agonist","display_name":"TLR4 agonist","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tlr4-antagonist","display_name":"TLR4 antagonist","score":1.0},{"id":"https://openalex.org/keywords/md-2","display_name":"MD-2","score":0.777999997138977},{"id":"https://openalex.org/keywords/lipopolysaccharide-binding-protein","display_name":"lipopolysaccharide-binding protein","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.7200000286102295},{"id":"https://openalex.org/keywords/opioid-tolerance","display_name":"opioid tolerance","score":0.9380000233650208},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.9110000133514404},{"id":"https://openalex.org/keywords/eritoran","display_name":"eritoran","score":0.8379999995231628},{"id":"https://openalex.org/keywords/small-molecule-modulators","display_name":"small molecule modulators","score":0.843999981880188},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9670000076293945},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.770794153213501},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.6431719064712524},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5969066023826599},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.58665931224823},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5807584524154663},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.4687530994415283},{"id":"https://openalex.org/C2776822972","wikidata":"https://www.wikidata.org/wiki/Q14907577","display_name":"Lipopolysaccharide binding protein","level":4,"score":0.4246666431427002},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4203781485557556},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4094018042087555},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3871530294418335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3839419484138489},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3725522756576538},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3612210750579834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34132882952690125},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3211696743965149},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.17807021737098694},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08894631266593933}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cmdc.201500188","doi":"https://doi.org/10.1002/cmdc.201500188","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201500188","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:26136385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26136385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4127956","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4983275","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4983275","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4983275","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ChemMedChem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4127956","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4983275","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7400000095367432}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5411682550","display_name":null,"funder_award_id":"81401333","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5700174641","display_name":"Exogenous Chemical Probes of TLR-Mediated Neuroinflammation","funder_award_id":"R01GM101279","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8935453674","display_name":null,"funder_award_id":"R01M101279","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335134","display_name":"National Institutes of Natural Sciences","ror":"https://ror.org/055n47h92"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":140,"referenced_works":["https://openalex.org/W171784049","https://openalex.org/W1464264675","https://openalex.org/W1488196937","https://openalex.org/W1499978168","https://openalex.org/W1503511302","https://openalex.org/W1514540900","https://openalex.org/W1519633296","https://openalex.org/W1527612695","https://openalex.org/W1534378060","https://openalex.org/W1535363884","https://openalex.org/W1558396077","https://openalex.org/W1567942330","https://openalex.org/W1580698661","https://openalex.org/W1591714343","https://openalex.org/W1605228689","https://openalex.org/W1612465238","https://openalex.org/W1622088669","https://openalex.org/W1673257055","https://openalex.org/W1877684281","https://openalex.org/W1925757606","https://openalex.org/W1953801166","https://openalex.org/W1955193942","https://openalex.org/W1965495262","https://openalex.org/W1965866432","https://openalex.org/W1966045089","https://openalex.org/W1966599176","https://openalex.org/W1966751608","https://openalex.org/W1967628584","https://openalex.org/W1967638463","https://openalex.org/W1969072247","https://openalex.org/W1970216382","https://openalex.org/W1971521446","https://openalex.org/W1972776583","https://openalex.org/W1973113582","https://openalex.org/W1973659410","https://openalex.org/W1974545869","https://openalex.org/W1977609213","https://openalex.org/W1979096813","https://openalex.org/W1980273234","https://openalex.org/W1983175066","https://openalex.org/W1988432393","https://openalex.org/W1988795126","https://openalex.org/W1990713194","https://openalex.org/W1991731944","https://openalex.org/W1992689290","https://openalex.org/W1994391392","https://openalex.org/W1995079250","https://openalex.org/W1995744610","https://openalex.org/W1995866508","https://openalex.org/W1997839876","https://openalex.org/W2000601337","https://openalex.org/W2002075586","https://openalex.org/W2004465286","https://openalex.org/W2004487653","https://openalex.org/W2005578275","https://openalex.org/W2008152503","https://openalex.org/W2008723209","https://openalex.org/W2009651861","https://openalex.org/W2011337627","https://openalex.org/W2016862474","https://openalex.org/W2019608563","https://openalex.org/W2022043453","https://openalex.org/W2024660851","https://openalex.org/W2033106089","https://openalex.org/W2035124901","https://openalex.org/W2036436547","https://openalex.org/W2037813178","https://openalex.org/W2039133694","https://openalex.org/W2042095978","https://openalex.org/W2043284163","https://openalex.org/W2045777328","https://openalex.org/W2046766958","https://openalex.org/W2047376205","https://openalex.org/W2052875305","https://openalex.org/W2053189438","https://openalex.org/W2057467676","https://openalex.org/W2057809738","https://openalex.org/W2061163173","https://openalex.org/W2062487226","https://openalex.org/W2064435741","https://openalex.org/W2064626913","https://openalex.org/W2065053912","https://openalex.org/W2066107239","https://openalex.org/W2068619092","https://openalex.org/W2072029769","https://openalex.org/W2072547768","https://openalex.org/W2074947781","https://openalex.org/W2076361525","https://openalex.org/W2077702475","https://openalex.org/W2083682196","https://openalex.org/W2085788584","https://openalex.org/W2086676026","https://openalex.org/W2088018826","https://openalex.org/W2088700961","https://openalex.org/W2090640877","https://openalex.org/W2094605832","https://openalex.org/W2095833996","https://openalex.org/W2096019298","https://openalex.org/W2096615733","https://openalex.org/W2096883861","https://openalex.org/W2100019645","https://openalex.org/W2102578857","https://openalex.org/W2103076324","https://openalex.org/W2103801183","https://openalex.org/W2108089395","https://openalex.org/W2108480438","https://openalex.org/W2109231206","https://openalex.org/W2119240151","https://openalex.org/W2120227455","https://openalex.org/W2120744259","https://openalex.org/W2121289311","https://openalex.org/W2124667416","https://openalex.org/W2126112217","https://openalex.org/W2126659405","https://openalex.org/W2127934565","https://openalex.org/W2129319296","https://openalex.org/W2130186203","https://openalex.org/W2130655121","https://openalex.org/W2131156766","https://openalex.org/W2132177571","https://openalex.org/W2134505828","https://openalex.org/W2135050229","https://openalex.org/W2135815512","https://openalex.org/W2136817329","https://openalex.org/W2140313585","https://openalex.org/W2140441724","https://openalex.org/W2141126238","https://openalex.org/W2145584783","https://openalex.org/W2146108501","https://openalex.org/W2148579227","https://openalex.org/W2155470233","https://openalex.org/W2156445477","https://openalex.org/W2159578148","https://openalex.org/W2162268745","https://openalex.org/W2165413779","https://openalex.org/W2166628824","https://openalex.org/W2270694175","https://openalex.org/W2404283831","https://openalex.org/W3146294080","https://openalex.org/W4312314020"],"related_works":["https://openalex.org/W1979096813","https://openalex.org/W4405555489","https://openalex.org/W2806045085","https://openalex.org/W2787008890","https://openalex.org/W2374926659","https://openalex.org/W2978931957","https://openalex.org/W1441835895","https://openalex.org/W1988795126","https://openalex.org/W3041295943","https://openalex.org/W4220961657"],"abstract_inverted_index":{"Toll-like":[0],"receptors":[1],"(TLRs)":[2],"have":[3,68,109],"been":[4],"shown":[5],"to":[6,113],"play":[7],"an":[8],"important":[9],"role":[10],"in":[11,63,81,88,142],"the":[12,58,82,100,152],"immune":[13],"system,":[14,84],"which":[15,85],"warrants":[16],"study":[17],"of":[18,26,57,77,99,103,115,125,157],"their":[19,106,140],"remarkable":[20],"potential":[21],"as":[22,40,91,93,121,128],"pharmacological":[23],"targets.":[24],"Activation":[25],"TLRs":[27,104,116],"requires":[28],"participation":[29],"from":[30],"specific":[31],"pathogen-associated":[32],"molecular":[33,101],"patterns":[34],"(PAMPs)":[35],"and":[36,50,96,105,118,130,145,154,160],"accessory":[37,107],"proteins":[38,108],"such":[39,120,127],"myeloid":[41],"differentiation":[42,52],"protein":[43,48],"2":[44],"(MD2),":[45],"lipopolysaccharide":[46],"binding":[47],"(LBP),":[49],"cluster":[51],"antigen":[53],"14":[54],"(CD14).":[55],"Assembly":[56],"TLR4-MD2-LPS":[59],"complex":[60],"is":[61,73],"essential":[62],"TLR4":[64,71,158],"activation.":[65],"Recent":[66],"studies":[67],"revealed":[69],"that":[70],"activation":[72],"a":[74,111],"significant":[75],"trigger":[76],"signal":[78],"transmission":[79],"pathways":[80],"nervous":[83],"could":[86],"result":[87],"chronic":[89],"pain":[90],"well":[92],"opioid":[94],"tolerance":[95],"dependence.":[97],"Researchers":[98],"structure":[102],"opened":[110],"door":[112],"syntheses":[114],"agonists":[117,159],"antagonists,":[119],"eritoran.":[122],"Small-molecule":[123],"modulators":[124],"TLR4,":[126],"MD2-I":[129],"tricyclic":[131],"antidepressants,":[132],"offer":[133],"more":[134],"promising":[135],"prospects":[136,156],"than":[137],"peptides,":[138],"given":[139],"convenience":[141],"oral":[143],"administration":[144],"lower":[146],"cost.":[147],"Herein":[148],"we":[149],"mainly":[150],"discuss":[151],"mechanisms":[153],"clinical":[155],"antagonists.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
