{"id":"https://openalex.org/W2165887323","doi":"https://doi.org/10.1158/1940-6207.capr-08-0025","title":"Targeting Transcription Factors for Cancer Prevention\u2014the Case of Nrf2","display_name":"Targeting Transcription Factors for Cancer Prevention\u2014the Case of Nrf2","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W2165887323","doi":"https://doi.org/10.1158/1940-6207.capr-08-0025","mag":"2165887323","pmid":"https://pubmed.ncbi.nlm.nih.gov/19138949"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.capr-08-0025","doi":"https://doi.org/10.1158/1940-6207.capr-08-0025","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-08-0025","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048962207","display_name":"Nancy H. Colburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy H. Colburn","raw_affiliation_strings":["Authors' Affiliations:\u20081Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland and 2Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland and 2Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072089972","display_name":"Thomas W. Kensler","orcid":"https://orcid.org/0000-0002-6676-261X","observed_orcids":["https://orcid.org/0000-0002-6676-261X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas W. Kensler","raw_affiliation_strings":["Authors' Affiliations:\u20081Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland and 2Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland and 2Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.233,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.78033951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":"3","first_page":"153","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.9480000138282776},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5910000205039978},{"id":"https://openalex.org/keywords/detoxification-genes","display_name":"detoxification genes","score":0.5870000123977661},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.8085762858390808},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.677258312702179},{"id":"https://openalex.org/C2778236027","wikidata":"https://www.wikidata.org/wiki/Q1090423","display_name":"Detoxication","level":3,"score":0.6030598878860474},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.546615719795227},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49039602279663086},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.490116685628891},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.4580584466457367},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4484809935092926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.447567343711853},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.322518914937973},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3172736167907715},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16058418154716492},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1191948652267456},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1940-6207.capr-08-0025","doi":"https://doi.org/10.1158/1940-6207.capr-08-0025","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-08-0025","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},{"id":"pmid:19138949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19138949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer prevention research (Philadelphia, Pa.)","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1978879532","https://openalex.org/W1980480652","https://openalex.org/W1993178967","https://openalex.org/W1994562522","https://openalex.org/W2023857791","https://openalex.org/W2076887683","https://openalex.org/W2080506742","https://openalex.org/W2087287360","https://openalex.org/W2124076790","https://openalex.org/W2124524961","https://openalex.org/W2124632579","https://openalex.org/W2128380182","https://openalex.org/W2132094103","https://openalex.org/W2141004419","https://openalex.org/W2145145182","https://openalex.org/W2146558971","https://openalex.org/W2155074399","https://openalex.org/W2161446823"],"related_works":["https://openalex.org/W2087108175","https://openalex.org/W2119511051","https://openalex.org/W2371277526","https://openalex.org/W77959829","https://openalex.org/W2413025138","https://openalex.org/W2085043661","https://openalex.org/W2051808967","https://openalex.org/W2165643859","https://openalex.org/W2094125478","https://openalex.org/W4283759062"],"abstract_inverted_index":{"NF-E2-related":[0],"factor":[1],"2":[2],"(Nrf2)":[3],"is":[4],"one":[5],"of":[6,29,32],"several":[7],"transcription":[8,28],"factors":[9],"that":[10,17],"are":[11],"altered":[12],"in":[13,22],"human":[14],"cancer":[15],"and":[16,34],"modulate":[18],"susceptibility":[19],"to":[20],"carcinogenesis":[21],"mouse":[23],"models":[24],"([1][1]\u2013[3][2]).":[25],"Nrf2":[26],"up-regulates":[27],"a":[30],"number":[31],"oxidant":[33],"electrophile":[35],"detoxication":[36],"genes":[37],"through":[38],"an":[39]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}