{"id":"https://openalex.org/W2165882851","doi":"https://doi.org/10.1007/bf02043650","title":"Effects of hypokalemia and disopyramide on electrical induction of ventricular tachyarrhythmia in nonischemic heart","display_name":"Effects of hypokalemia and disopyramide on electrical induction of ventricular tachyarrhythmia in nonischemic heart","publication_year":2005,"publication_date":"2005-08-13","ids":{"openalex":"https://openalex.org/W2165882851","doi":"https://doi.org/10.1007/bf02043650","mag":"2165882851"},"language":"en","primary_location":{"id":"doi:10.1007/bf02043650","doi":"https://doi.org/10.1007/bf02043650","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02043650","pdf_url":null,"source":{"id":"https://openalex.org/S107681283","display_name":"International Journal of Angiology","issn_l":"1061-1711","issn":["1061-1711","1615-5939"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Angiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112873550","display_name":"Katsusuke Yano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsusuke Yano","raw_affiliation_strings":["Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki-shi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki-shi, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065313670","display_name":"Gaston Kakota Kapuku","orcid":"https://orcid.org/0000-0002-0854-1413","observed_orcids":["https://orcid.org/0000-0002-0854-1413"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Gaston Kapuku","raw_affiliation_strings":["Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki-shi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki-shi, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026818876","display_name":"Tetsuya Hirata","orcid":"https://orcid.org/0000-0003-4560-0387","observed_orcids":["https://orcid.org/0000-0003-4560-0387"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Hirata","raw_affiliation_strings":["Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki-shi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki-shi, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090945555","display_name":"Motonobu Hayano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motonobu Hayano","raw_affiliation_strings":["Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki-shi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki-shi, Japan","institution_ids":["https://openalex.org/I43777268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I43777268"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.21303047,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"5","issue":"02","first_page":"105","last_page":"109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypokalemia","display_name":"hypokalemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/disopyramide","display_name":"disopyramide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ventricular-tachyarrhythmia","display_name":"ventricular tachyarrhythmia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"ventricular fibrillation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/drug-induced-arrhythmia","display_name":"drug-induced arrhythmia","score":0.753000020980835},{"id":"https://openalex.org/keywords/programmed-ventricular-stimulation","display_name":"programmed ventricular stimulation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/effective-refractory-period","display_name":"effective refractory period","score":0.9160000085830688},{"id":"https://openalex.org/keywords/qrs-duration","display_name":"QRS duration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/monophasic-action-potential","display_name":"monophasic action potential","score":0.847000002861023},{"id":"https://openalex.org/keywords/potassium-depletion","display_name":"potassium depletion","score":0.4410000145435333},{"id":"https://openalex.org/keywords/antiarrhythmic-drugs","display_name":"antiarrhythmic drugs","score":0.7509999871253967},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9360165596008301},{"id":"https://openalex.org/C2778242168","wikidata":"https://www.wikidata.org/wiki/Q794086","display_name":"Hypokalemia","level":2,"score":0.8746078610420227},{"id":"https://openalex.org/C2779831137","wikidata":"https://www.wikidata.org/wiki/Q425120","display_name":"Disopyramide","level":2,"score":0.8697309494018555},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7752892971038818},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7281725406646729},{"id":"https://openalex.org/C555175668","wikidata":"https://www.wikidata.org/wiki/Q539690","display_name":"Angiology","level":2,"score":0.5139083862304688}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/bf02043650","doi":"https://doi.org/10.1007/bf02043650","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02043650","pdf_url":null,"source":{"id":"https://openalex.org/S107681283","display_name":"International Journal of Angiology","issn_l":"1061-1711","issn":["1061-1711","1615-5939"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Angiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W72733011","https://openalex.org/W1506454783","https://openalex.org/W1986728006","https://openalex.org/W1988086452","https://openalex.org/W1988318129","https://openalex.org/W1988810491","https://openalex.org/W1993847838","https://openalex.org/W2014562798","https://openalex.org/W2016701526","https://openalex.org/W2031626805","https://openalex.org/W2035507272","https://openalex.org/W2044097193","https://openalex.org/W2074093573","https://openalex.org/W2074257744","https://openalex.org/W2083397218","https://openalex.org/W2084391819","https://openalex.org/W2087137849","https://openalex.org/W2090511011","https://openalex.org/W2094713088","https://openalex.org/W2400105742","https://openalex.org/W2401142424","https://openalex.org/W2486784081","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2084391819","https://openalex.org/W1633270438","https://openalex.org/W1967048535","https://openalex.org/W1978976461","https://openalex.org/W2035507272","https://openalex.org/W2002028917","https://openalex.org/W2126947595","https://openalex.org/W2362916501","https://openalex.org/W2062430880","https://openalex.org/W2094713088"],"abstract_inverted_index":{"This":[0],"study":[1],"examined":[2],"the":[3,20,47,65,131,137,140,272],"relationship":[4],"between":[5,143],"hypokalemia":[6,18,33,243],"and":[7,13,69,148],"ventricular":[8,24,59,162,181,185,204,208,216,236,247,257],"tachyarrhythmia":[9,163,217,248],"in":[10,64,164,238,250,267,271],"nonischemic":[11,251],"heart,":[12],"tried":[14],"to":[15,87,99,166,178,201,240],"determine":[16],"whether":[17],"enhances":[19],"proarrhythmic":[21,265],"effect":[22,266],"of":[23,38,41,72,139,146,152,156,171,189,194,223,231,246,256,274],"repolarization-prolonging":[25],"drugs.":[26],"In":[27,77,210],"12":[28,157,172,195],"mongrel":[29],"dogs":[30,52,158,174,197,212,234],"(group":[31,53,159,213],"1),":[32],"was":[34,62],"produced":[35],"by":[36,124],"infusion":[37],"5.0":[39],"g/kg":[40],"polystyrene":[42],"sulfonic":[43],"acid":[44],"calcium":[45],"into":[46],"colon":[48],"while":[49],"8":[50],"other":[51],"2)":[54],"were":[55],"maintained":[56],"normokalemic.":[57],"Programmed":[58],"stimulation":[60],"(PVS)":[61],"performed":[63],"two":[66,228],"groups":[67],"before":[68,221],"after":[70],"injection":[71],"disopyramide":[73,226],"(i.v.,":[74],"2.0":[75],"mg/kg).":[76],"group":[78],"1,":[79],"serum":[80],"potassium":[81],"decreased":[82],"from":[83,95],"4.1":[84],"\u00b1":[85,89,97,101],"0.3":[86],"2.7":[88],"0.4":[90],"mEq/L.":[91],"QRS":[92],"duration":[93],"increased":[94,112,130],"49":[96],"2":[98],"60":[100],"3":[102],"msec":[103],"(":[104,113],"p":[105,114],"<":[106,115],"0.01).":[107,116],"Effective":[108],"refractory":[109],"period":[110],"(ERP)":[111],"Monophasic":[117],"action":[118],"potential":[119],"at":[120],"90%":[121],"(MAP90)":[122],"lengthened":[123],"10%":[125],"(not":[126],"significant).":[127],"Disopyramide":[128],"significantly":[129],"above":[132],"parameters,":[133],"as":[134,136],"well":[135],"slope":[138],"linear":[141],"relation":[142],"percentage":[144],"changes":[145],"MAP90":[147],"potassium.":[149],"Before":[150],"production":[151],"hypokalemia,":[153],"none":[154],"out":[155,193,230],"1)":[160],"developed":[161,235],"response":[165,239],"PVS.":[167,241],"Five":[168],"(42%)":[169],"our":[170],"hypokalemic":[173,196],"showed":[175,198],"positive":[176,199],"responses":[177,200],"PVS":[179,202],"(four":[180],"fibrillation,":[182,205],"one":[183],"nonsustained":[184,207],"tachycardia).":[186,209],"After":[187,225],"administration":[188,222],"disopyramide,":[190],"7":[191],"(57%)":[192],"(three":[203],"four":[206],"normokalemic":[211,233],"2),":[214],"no":[215],"could":[218],"be":[219,261],"induced":[220],"disopyramide.":[224],"administration,":[227],"(25%)":[229],"eight":[232],"fibrillation":[237],"Thus,":[242],"is":[244],"predictive":[245],"even":[249],"heart.":[252],"Moreover,":[253],"disopyramide-related":[254],"prolongation":[255],"repolarization":[258],"time":[259],"can":[260],"a":[262,268],"condition":[263],"for":[264],"non-ischemic":[269],"heart":[270],"presence":[273],"hypokalemia.":[275]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}