{"id":"https://openalex.org/W2165882003","doi":null,"title":"Human retinal pigment epithelial lysis of extracellular matrix: functional urokinase plasminogen activator receptor, collagenase, and elastase.","display_name":"Human retinal pigment epithelial lysis of extracellular matrix: functional urokinase plasminogen activator receptor, collagenase, and elastase.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2165882003","mag":"2165882003","pmid":"https://pubmed.ncbi.nlm.nih.gov/12545698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1358967"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1358967","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1358967","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1358967/pdf/12545698.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Ophthalmol Soc","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1358967/pdf/12545698.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Susan G Elner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan G Elner","raw_affiliation_strings":["University of Michigan and University of Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan and University of Chicago, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":0.3772,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.55543653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"100","issue":null,"first_page":"273","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.4043000042438507,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.968999981880188},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator-receptor","display_name":"urokinase-type plasminogen activator receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/extracellular-matrix-proteolysis","display_name":"extracellular matrix proteolysis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/elastase","display_name":"elastase","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8240000009536743},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9760000109672546},{"id":"https://openalex.org/keywords/beta2-integrins","display_name":"beta2 integrins","score":0.6610000133514404},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.972000002861023},{"id":"https://openalex.org/keywords/retinal-disease","display_name":"retinal disease","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C56219504","wikidata":"https://www.wikidata.org/wiki/Q7900869","display_name":"Urokinase receptor","level":3,"score":0.9600018262863159},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.6298980116844177},{"id":"https://openalex.org/C2776232661","wikidata":"https://www.wikidata.org/wiki/Q5530373","display_name":"Gelatinase","level":3,"score":0.530120313167572},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5047155618667603},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.49923086166381836},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.492121160030365},{"id":"https://openalex.org/C177430391","wikidata":"https://www.wikidata.org/wiki/Q1173648","display_name":"Zymography","level":3,"score":0.4846975803375244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4637250304222107},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.4582076072692871},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4536927342414856},{"id":"https://openalex.org/C2777132095","wikidata":"https://www.wikidata.org/wiki/Q14906548","display_name":"Cathepsin G","level":4,"score":0.4216550886631012},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3971029222011566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3964012861251831},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.33366647362709045},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32693904638290405},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2912227511405945},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14512717723846436},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10133573412895203}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010960","descriptor_name":"Plasminogen Activators","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055293","descriptor_name":"Receptors, Urokinase Plasminogen Activator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1358967","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1358967","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1358967/pdf/12545698.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Ophthalmol Soc","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:1464694","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1358967","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:12545698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12545698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the American Ophthalmological Society","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.623.5655","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.623.5655","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.aosonline.org/xactions/2002/1545-6110_v100_p273.pdf","raw_type":"text"},{"id":"mag:2165882003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12545698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1358967","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1358967","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1358967/pdf/12545698.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Ophthalmol Soc","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4237093774","display_name":"RPE-Mphi Binding: Ca++_&O2-_Dependent AMD Responses","funder_award_id":"R01EY009441","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2165882003.pdf","grobid_xml":"https://content.openalex.org/works/W2165882003.grobid-xml"},"referenced_works_count":205,"referenced_works":["https://openalex.org/W1925067","https://openalex.org/W12248033","https://openalex.org/W30448767","https://openalex.org/W41075435","https://openalex.org/W58458749","https://openalex.org/W67777438","https://openalex.org/W75195725","https://openalex.org/W99379277","https://openalex.org/W119988801","https://openalex.org/W133719666","https://openalex.org/W150054392","https://openalex.org/W152397767","https://openalex.org/W155136349","https://openalex.org/W161597461","https://openalex.org/W169563596","https://openalex.org/W260014646","https://openalex.org/W271277419","https://openalex.org/W1479820498","https://openalex.org/W1482425689","https://openalex.org/W1486545677","https://openalex.org/W1494887343","https://openalex.org/W1495765353","https://openalex.org/W1502432090","https://openalex.org/W1504600626","https://openalex.org/W1504900014","https://openalex.org/W1507054304","https://openalex.org/W1508669465","https://openalex.org/W1526711176","https://openalex.org/W1527081333","https://openalex.org/W1533267622","https://openalex.org/W1540038532","https://openalex.org/W1544209267","https://openalex.org/W1546963451","https://openalex.org/W1550055752","https://openalex.org/W1553230368","https://openalex.org/W1556753324","https://openalex.org/W1557023478","https://openalex.org/W1574225807","https://openalex.org/W1581591459","https://openalex.org/W1582888773","https://openalex.org/W1605283518","https://openalex.org/W1611413521","https://openalex.org/W1624291957","https://openalex.org/W1670322156","https://openalex.org/W1759279244","https://openalex.org/W1759829349","https://openalex.org/W1815267743","https://openalex.org/W1889896208","https://openalex.org/W1937843063","https://openalex.org/W1964119221","https://openalex.org/W1965972514","https://openalex.org/W1966846271","https://openalex.org/W1967197264","https://openalex.org/W1968741611","https://openalex.org/W1971985496","https://openalex.org/W1973270637","https://openalex.org/W1977178235","https://openalex.org/W1977665979","https://openalex.org/W1977779461","https://openalex.org/W1978309686","https://openalex.org/W1979302845","https://openalex.org/W1980480613","https://openalex.org/W1980930513","https://openalex.org/W1980954887","https://openalex.org/W1982401187","https://openalex.org/W1983609115","https://openalex.org/W1984584032","https://openalex.org/W1984690640","https://openalex.org/W1986884128","https://openalex.org/W1987421318","https://openalex.org/W1987843579","https://openalex.org/W1988476950","https://openalex.org/W1990105301","https://openalex.org/W1990509128","https://openalex.org/W1992834760","https://openalex.org/W1993092256","https://openalex.org/W1994446864","https://openalex.org/W1996165246","https://openalex.org/W1996959663","https://openalex.org/W1998987726","https://openalex.org/W2002082738","https://openalex.org/W2002154344","https://openalex.org/W2002387352","https://openalex.org/W2005113904","https://openalex.org/W2010937508","https://openalex.org/W2011346825","https://openalex.org/W2011936885","https://openalex.org/W2012710893","https://openalex.org/W2012850990","https://openalex.org/W2014393992","https://openalex.org/W2016195577","https://openalex.org/W2019435681","https://openalex.org/W2021888919","https://openalex.org/W2023120719","https://openalex.org/W2024318861","https://openalex.org/W2026151657","https://openalex.org/W2027275036","https://openalex.org/W2029108634","https://openalex.org/W2030085593","https://openalex.org/W2031993236","https://openalex.org/W2032483872","https://openalex.org/W2032588194","https://openalex.org/W2033414925","https://openalex.org/W2035971911","https://openalex.org/W2038172095","https://openalex.org/W2039573204","https://openalex.org/W2041680454","https://openalex.org/W2042155824","https://openalex.org/W2042954975","https://openalex.org/W2043240855","https://openalex.org/W2044949296","https://openalex.org/W2046690431","https://openalex.org/W2047234875","https://openalex.org/W2047369161","https://openalex.org/W2047694858","https://openalex.org/W2049012407","https://openalex.org/W2049102738","https://openalex.org/W2050681289","https://openalex.org/W2053245285","https://openalex.org/W2056925926","https://openalex.org/W2056989349","https://openalex.org/W2057106552","https://openalex.org/W2057896496","https://openalex.org/W2058635875","https://openalex.org/W2061904908","https://openalex.org/W2064763603","https://openalex.org/W2065493263","https://openalex.org/W2070403771","https://openalex.org/W2071435247","https://openalex.org/W2071738584","https://openalex.org/W2072103796","https://openalex.org/W2072198264","https://openalex.org/W2073129561","https://openalex.org/W2074496269","https://openalex.org/W2075885982","https://openalex.org/W2076906139","https://openalex.org/W2077142428","https://openalex.org/W2077911419","https://openalex.org/W2079568721","https://openalex.org/W2082532338","https://openalex.org/W2083170138","https://openalex.org/W2085787101","https://openalex.org/W2086063025","https://openalex.org/W2087298204","https://openalex.org/W2087342203","https://openalex.org/W2088738897","https://openalex.org/W2088855481","https://openalex.org/W2089653763","https://openalex.org/W2091100304","https://openalex.org/W2094177787","https://openalex.org/W2099213932","https://openalex.org/W2102964731","https://openalex.org/W2103937103","https://openalex.org/W2106319388","https://openalex.org/W2113329139","https://openalex.org/W2114115245","https://openalex.org/W2115824889","https://openalex.org/W2115947409","https://openalex.org/W2120928437","https://openalex.org/W2125762952","https://openalex.org/W2126148027","https://openalex.org/W2128781206","https://openalex.org/W2129294561","https://openalex.org/W2129348665","https://openalex.org/W2131782272","https://openalex.org/W2135423586","https://openalex.org/W2138293547","https://openalex.org/W2141708853","https://openalex.org/W2141875260","https://openalex.org/W2142906420","https://openalex.org/W2143563076","https://openalex.org/W2143699288","https://openalex.org/W2144461828","https://openalex.org/W2149641391","https://openalex.org/W2150552267","https://openalex.org/W2152468904","https://openalex.org/W2152699331","https://openalex.org/W2154610968","https://openalex.org/W2155093913","https://openalex.org/W2155940571","https://openalex.org/W2156513567","https://openalex.org/W2161467354","https://openalex.org/W2163208874","https://openalex.org/W2164706325","https://openalex.org/W2169516356","https://openalex.org/W2170260797","https://openalex.org/W2286906990","https://openalex.org/W2311972351","https://openalex.org/W2322318138","https://openalex.org/W2325122796","https://openalex.org/W2395776626","https://openalex.org/W2398137194","https://openalex.org/W2402651214","https://openalex.org/W2404955004","https://openalex.org/W2406109196","https://openalex.org/W2416658475","https://openalex.org/W2416897117","https://openalex.org/W2417256524","https://openalex.org/W2419316371","https://openalex.org/W2479781631","https://openalex.org/W4211236610","https://openalex.org/W4243533108","https://openalex.org/W4299714896","https://openalex.org/W4300173368","https://openalex.org/W4313310030"],"related_works":["https://openalex.org/W2091434242","https://openalex.org/W1978168552","https://openalex.org/W1985336239","https://openalex.org/W1977178235","https://openalex.org/W2595220147","https://openalex.org/W2593089595","https://openalex.org/W4246032584","https://openalex.org/W12248033","https://openalex.org/W2045264078","https://openalex.org/W1009325601"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"show":[2],"(1)":[3],"human":[4,35,52,58],"retinal":[5,36,257,264],"pigment":[6],"epithelial":[7],"(HRPE)":[8],"expression":[9,32,119,209],"of":[10,21,51,56,72,112,147,161,198,207,233,262,291],"functional":[11,220,270],"urokinase":[12],"plasminogen":[13,105],"activator":[14,106],"receptor":[15],"(uPAR;":[16],"CD87),":[17],"(2)":[18],"HRPE":[19,27,46,93,130,166,177,186,216,242,253,267,278,293],"secretion":[20,125],"collagenase":[22,141,164,221],"and":[23,29,48,79,88,100,123,128,137,150,163,179,193,210,222,228,235,259,273,280],"elastase,":[24,274],"(3)":[25],"uPAR-dependent":[26],"migration,":[28],"(4)":[30],"uPAR":[31,41,78,94,118,162,172,188,208,248,282],"in":[33,49,165,244,256,260],"diseased":[34,263],"tissue.":[37,265],"METHODS:":[38],"Immunohistochemistry":[39],"for":[40,102],"was":[42,65,95,120,132,142,173,203,249],"performed":[43,66],"on":[44,85,117,175],"cultured":[45,176],"cells":[47,60,131,178,217,268],"sections":[50,258,261],"retina.":[53],"Double-immunofluorescent":[54],"staining":[55],"live":[57,185],"RPE":[59,86],"with":[61,77],"anti-CR3":[62],"antibody":[63],"(CD11b)":[64],"to":[67,195,236],"demonstrate":[68],"the":[69,159,252,288],"physical":[70],"proximity":[71],"this":[73],"beta":[74,114],"2":[75],"integrin":[76],"determine":[80],"whether":[81],"associations":[82],"were":[83,168],"dependent":[84],"confluence":[87],"polarity.":[89],"Extracellular":[90,201],"proteolysis":[91,202,279,286],"by":[92,104,126,134,145,152,181,213],"evaluated":[96],"using":[97],"fluorescent":[98,148],"bodipy-BSA":[99],"assessed":[101,144],"specificity":[103],"inhibitor-1":[107],"(PAI-1)":[108],"inhibition.":[109],"The":[110],"effect":[111],"interleukin-1":[113],"(IL-1":[115],"beta)":[116],"assessed.":[121,169],"Collagenase":[122],"elastase":[124,229],"unstimulated":[127],"IL-1-stimulated":[129],"measured":[133],"3H-labelled":[135],"collagen":[136],"elastin":[138],"cleavage.":[139],"HRPE-associated":[140],"also":[143],"cleavage":[146],"DQ-collagen":[149],"inhibited":[151,212],"phenanthroline.":[153],"Using":[154],"an":[155],"extracellular":[156],"matrix":[157],"assay,":[158],"roles":[160],"migration":[167,243],"RESULTS:":[170],"Immunoreactive":[171,247],"detected":[174],"increased":[180],"IL-1.":[182],"On":[183],"elongated,":[184],"cells,":[187],"dissociated":[189],"from":[190],"CD11b":[191],"(CR3)":[192],"translocated":[194],"anterior":[196],"poles":[197],"migrating":[199,292],"cells.":[200,294],"concentrated":[204],"at":[205,287],"sites":[206],"specifically":[211],"PAI-1.":[214],"Cultured":[215],"secreted":[218],"substantial,":[219],"elastase.":[223],"IL-1":[224],"upregulated":[225],"uPAR,":[226,234,271],"collagenase,":[227,240,272],"activities.":[230],"Specific":[231],"inhibition":[232],"a":[237],"lesser":[238],"degree":[239],"reduced":[241],"matrix/gel":[245],"assays.":[246],"present":[250],"along":[251],"basolateral":[254],"membrane":[255],"CONCLUSIONS:":[266],"express":[269],"which":[275],"may":[276,284],"permit":[277],"migration.":[281],"polarization":[283],"concentrate":[285],"leading":[289],"edge":[290]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
