{"id":"https://openalex.org/W2165861950","doi":"https://doi.org/10.1128/iai.68.2.796-800.2000","title":"Intranasal Immunization of Mice with a Mixture of the Pneumococcal Proteins PsaA and PspA Is Highly Protective against Nasopharyngeal Carriage ofStreptococcus pneumoniae","display_name":"Intranasal Immunization of Mice with a Mixture of the Pneumococcal Proteins PsaA and PspA Is Highly Protective against Nasopharyngeal Carriage ofStreptococcus pneumoniae","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W2165861950","doi":"https://doi.org/10.1128/iai.68.2.796-800.2000","mag":"2165861950","pmid":"https://pubmed.ncbi.nlm.nih.gov/10639448","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/97207"},"language":"en","primary_location":{"id":"doi:10.1128/iai.68.2.796-800.2000","doi":"https://doi.org/10.1128/iai.68.2.796-800.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.68.2.796-800.2000","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/97207","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110113203","display_name":"David E. Briles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Briles","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology1 and","<!--label omitted: 2-->Department of Pediatrics,2 University of Alabama at Birmingham, Birmingham, Alabama;","Department of Microbiology1 and","Department of Pediatrics,2 University of Alabama at Birmingham, Birmingham, Alabama;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology1 and","institution_ids":[]},{"raw_affiliation_string":"<!--label omitted: 2-->Department of Pediatrics,2 University of Alabama at Birmingham, Birmingham, Alabama;","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Microbiology1 and","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics,2 University of Alabama at Birmingham, Birmingham, Alabama;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073791283","display_name":"Eddie Ades","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eddie Ades","raw_affiliation_strings":["<!--label omitted: 3-->Centers for Disease Control and Prevention, Atlanta, Georgia3;","Centers for Disease Control and Prevention, Atlanta, Georgia3;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Centers for Disease Control and Prevention, Atlanta, Georgia3;","institution_ids":["https://openalex.org/I1289490764"]},{"raw_affiliation_string":"Centers for Disease Control and Prevention, Atlanta, Georgia3;","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055597053","display_name":"James C. Paton","orcid":"https://orcid.org/0000-0001-9807-5278","observed_orcids":["https://orcid.org/0000-0001-9807-5278"]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James C. Paton","raw_affiliation_strings":["<!--label omitted: 4-->Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, Australia4;","Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, Australia4;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 4-->Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, Australia4;","institution_ids":["https://openalex.org/I2801308011"]},{"raw_affiliation_string":"Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, Australia4;","institution_ids":["https://openalex.org/I2801308011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111932520","display_name":"Jacquelyn S. Sampson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacquelyn S. Sampson","raw_affiliation_strings":["<!--label omitted: 3-->Centers for Disease Control and Prevention, Atlanta, Georgia3;","Centers for Disease Control and Prevention, Atlanta, Georgia3;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Centers for Disease Control and Prevention, Atlanta, Georgia3;","institution_ids":["https://openalex.org/I1289490764"]},{"raw_affiliation_string":"Centers for Disease Control and Prevention, Atlanta, Georgia3;","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103813172","display_name":"George M. Carlone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George M. Carlone","raw_affiliation_strings":["<!--label omitted: 3-->Centers for Disease Control and Prevention, Atlanta, Georgia3;","Centers for Disease Control and Prevention, Atlanta, Georgia3;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Centers for Disease Control and Prevention, Atlanta, Georgia3;","institution_ids":["https://openalex.org/I1289490764"]},{"raw_affiliation_string":"Centers for Disease Control and Prevention, Atlanta, Georgia3;","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046988613","display_name":"Robert C. Huebner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert C. Huebner","raw_affiliation_strings":["<!--label omitted: 5-->Pasteur Me\u0301rieux Connaught, Swiftwater, Pennsylvania5;","Pasteur Me\u0301rieux Connaught, Swiftwater, Pennsylvania5;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 5-->Pasteur Me\u0301rieux Connaught, Swiftwater, Pennsylvania5;","institution_ids":[]},{"raw_affiliation_string":"Pasteur Me\u0301rieux Connaught, Swiftwater, Pennsylvania5;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047391051","display_name":"Anni Virolainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Anni Virolainen","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology1 and","<!--label omitted: 6-->Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, Finland6; and","Department of Microbiology1 and","Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, Finland6; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology1 and","institution_ids":[]},{"raw_affiliation_string":"<!--label omitted: 6-->Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, Finland6; and","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Department of Microbiology1 and","institution_ids":[]},{"raw_affiliation_string":"Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, Finland6; and","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009027494","display_name":"Edwin Swiatlo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin Swiatlo","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology1 and","<!--label omitted: 7-->Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Mississippi7","Department of Microbiology1 and","Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Mississippi7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology1 and","institution_ids":[]},{"raw_affiliation_string":"<!--label omitted: 7-->Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Mississippi7","institution_ids":["https://openalex.org/I29606459"]},{"raw_affiliation_string":"Department of Microbiology1 and","institution_ids":[]},{"raw_affiliation_string":"Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Mississippi7","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013040862","display_name":"Susan K. Hollingshead","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan K. Hollingshead","raw_affiliation_strings":["<!--label omitted: 1-->Department of Microbiology1 and","Department of Microbiology1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Microbiology1 and","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology1 and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.1999,"has_fulltext":false,"cited_by_count":307,"citation_normalized_percentile":{"value":0.99294335,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"68","issue":"2","first_page":"796","last_page":"800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nasopharyngeal-carriage","display_name":"nasopharyngeal carriage","score":0.8820000290870667},{"id":"https://openalex.org/keywords/psaa","display_name":"PsaA","score":0.7929999828338623},{"id":"https://openalex.org/keywords/pneumococcal-surface-protein-a","display_name":"PspA","score":0.996999979019165},{"id":"https://openalex.org/keywords/pneumolysin","display_name":"pneumolysin","score":0.968999981880188},{"id":"https://openalex.org/keywords/intranasal-immunization","display_name":"intranasal immunization","score":0.9520000219345093},{"id":"https://openalex.org/keywords/herd-immunity","display_name":"herd immunity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mucosal-vaccines","display_name":"mucosal vaccines","score":0.8679999709129333},{"id":"https://openalex.org/keywords/invasive-pneumococcal-disease","display_name":"invasive pneumococcal disease","score":0.7739999890327454},{"id":"https://openalex.org/keywords/bacteremia","display_name":"bacteremia","score":0.49799999594688416},{"id":"https://openalex.org/keywords/pneumonia-prevention","display_name":"pneumonia prevention","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C32762888","wikidata":"https://www.wikidata.org/wiki/Q235356","display_name":"Carriage","level":2,"score":0.851452112197876},{"id":"https://openalex.org/C2776088486","wikidata":"https://www.wikidata.org/wiki/Q7205996","display_name":"Pneumolysin","level":4,"score":0.8322010636329651},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.8088306188583374},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6984552145004272},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6059691309928894},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.5217262506484985},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4807046055793762},{"id":"https://openalex.org/C2776152631","wikidata":"https://www.wikidata.org/wiki/Q4366062","display_name":"Pneumococcal infections","level":4,"score":0.4646109640598297},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.45550230145454407},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4467332363128662},{"id":"https://openalex.org/C106192422","wikidata":"https://www.wikidata.org/wiki/Q736798","display_name":"Herd immunity","level":3,"score":0.4385862946510315},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42790886759757996},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.41651663184165955},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.29250097274780273},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25656431913375854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2339024841785431},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.1951022446155548},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001428","descriptor_name":"Bacterial Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009305","descriptor_name":"Nasopharynx","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045331","descriptor_name":"Photosystem I Protein Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/iai.68.2.796-800.2000","doi":"https://doi.org/10.1128/iai.68.2.796-800.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.68.2.796-800.2000","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:97207","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/97207","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:10639448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10639448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:97207","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/97207","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2761127245","display_name":null,"funder_award_id":"AI40645","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G428913397","display_name":null,"funder_award_id":"HL54818","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5408489098","display_name":null,"funder_award_id":"AI21548","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6537226469","display_name":"PspA:  A Potential Pneumococcal Vaccine Component","funder_award_id":"R01AI021548","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7791291794","display_name":"PspA mechanisms of humoral immunity, functional assays, and optimal vaccine const","funder_award_id":"R56AI021548","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320307856","display_name":"World Health Organization","ror":"https://ror.org/01f80g185"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W21246111","https://openalex.org/W1944120618","https://openalex.org/W1948307823","https://openalex.org/W1964578552","https://openalex.org/W1968766773","https://openalex.org/W1975425623","https://openalex.org/W1983401418","https://openalex.org/W1992601565","https://openalex.org/W2000164604","https://openalex.org/W2000615700","https://openalex.org/W2006256724","https://openalex.org/W2022867294","https://openalex.org/W2030520271","https://openalex.org/W2040483457","https://openalex.org/W2040513987","https://openalex.org/W2045808776","https://openalex.org/W2051206596","https://openalex.org/W2068056929","https://openalex.org/W2070088956","https://openalex.org/W2084541598","https://openalex.org/W2102134319","https://openalex.org/W2102439761","https://openalex.org/W2112990035","https://openalex.org/W2122153462","https://openalex.org/W2129847700","https://openalex.org/W2130169467","https://openalex.org/W2130788877","https://openalex.org/W2132993876","https://openalex.org/W2136782632","https://openalex.org/W2141234678","https://openalex.org/W2142009418","https://openalex.org/W2142890591","https://openalex.org/W2152933863","https://openalex.org/W2161806706","https://openalex.org/W2162339585","https://openalex.org/W2166256098","https://openalex.org/W2167696510","https://openalex.org/W2170651898","https://openalex.org/W2219768156"],"related_works":["https://openalex.org/W2142890591","https://openalex.org/W1964139041","https://openalex.org/W2149395493","https://openalex.org/W1975425623","https://openalex.org/W2811271369","https://openalex.org/W2795424954","https://openalex.org/W2150946928","https://openalex.org/W2171252321","https://openalex.org/W2057576654","https://openalex.org/W2047872630"],"abstract_inverted_index":{"Acquisition":[0],"of":[1,44,78,101],"pneumococci":[2,45],"is":[3],"generally":[4],"from":[5,9],"carriers":[6],"rather":[7],"than":[8,63],"infected":[10],"individuals.":[11],"Therefore,":[12],"to":[13,24,37,112,115,130],"induce":[14],"herd":[15,102],"immunity":[16,103,114],"against":[17,27,41,66,72,86],"Streptococcus":[18],"pneumoniae":[19],"it":[20],"will":[21],"be":[22,96],"necessary":[23],"elicit":[25,38,113],"protection":[26,40,62,71,85],"carriage.":[28,52,67,73,87,137],"Capsular":[29],"polysaccharide-protein":[30],"conjugates,":[31],"PspA,":[32],"and":[33,80,93,108,117],"PsaA":[34,59,79,94],"are":[35,110],"known":[36,111],"some":[39],"nasopharyngeal":[42],"carriage":[43],"but":[46],"do":[47],"not":[48],"always":[49],"completely":[50],"eliminate":[51],"In":[53],"this":[54],"study,":[55],"we":[56],"observed":[57],"that":[58,91],"elicited":[60,69,82],"better":[61],"did":[64],"PspA":[65,81,92,107],"Pneumolysin":[68],"no":[70],"Immunization":[74],"with":[75],"a":[76,122,128],"mixture":[77],"the":[83,99],"best":[84],"These":[88],"results":[89],"indicate":[90],"may":[95,125],"useful":[97],"for":[98],"elicitation":[100],"in":[104,121],"humans.":[105],"As":[106],"pneumolysin":[109],"bacteremia":[116],"pneumonia,":[118],"their":[119],"inclusion":[120],"mucosal":[123],"vaccine":[124,129],"enable":[126],"such":[127],"prevent":[131],"invasive":[132],"disease":[133],"as":[134,136],"well":[135]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}