{"id":"https://openalex.org/W2165840684","doi":null,"title":"Synaptic elimination and the complement system in Alzhaimer's disease","display_name":"Synaptic elimination and the complement system in Alzhaimer's disease","publication_year":2012,"publication_date":"2012-08-23","ids":{"openalex":"https://openalex.org/W2165840684","mag":"2165840684"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/29209","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/29209","pdf_url":"http://hdl.handle.net/2077/29209","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/29209","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025130545","display_name":"Jonny Daborg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Jonny Daborg","raw_affiliation_strings":["University of Gothenburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gothenburg","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025130545"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/synaptic-pruning","display_name":"synaptic pruning","score":0.902999997138977},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.9980000257492065},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9229999780654907},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.9490000009536743},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.5809999704360962},{"id":"https://openalex.org/keywords/complement-component-c2","display_name":"complement component C2","score":0.7080000042915344},{"id":"https://openalex.org/keywords/factor-b","display_name":"factor B","score":0.9760000109672546},{"id":"https://openalex.org/keywords/complement-receptor-1","display_name":"complement receptor 1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.718999981880188},{"id":"https://openalex.org/keywords/sensorimotor-cortex","display_name":"sensorimotor cortex","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.34200000762939453},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.8213656544685364},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7990149259567261},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.5887939929962158},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5777461528778076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5049965977668762},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.45774999260902405},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4503435790538788},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.43212610483169556},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28995999693870544},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19307371973991394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12480515241622925},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0995652973651886}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/29209","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/29209","pdf_url":"http://hdl.handle.net/2077/29209","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:2165840684","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/29209/4/gupea_2077_29209_4.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/29209","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/29209","pdf_url":"http://hdl.handle.net/2077/29209","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2165840684.pdf","grobid_xml":"https://content.openalex.org/works/W2165840684.grobid-xml"},"referenced_works_count":156,"referenced_works":["https://openalex.org/W158119579","https://openalex.org/W180788233","https://openalex.org/W644076287","https://openalex.org/W1482580692","https://openalex.org/W1490420159","https://openalex.org/W1498301041","https://openalex.org/W1500186234","https://openalex.org/W1504115109","https://openalex.org/W1513894681","https://openalex.org/W1517480469","https://openalex.org/W1523103679","https://openalex.org/W1553154837","https://openalex.org/W1847168837","https://openalex.org/W1886575365","https://openalex.org/W1950026089","https://openalex.org/W1964049915","https://openalex.org/W1965208860","https://openalex.org/W1965508391","https://openalex.org/W1966378425","https://openalex.org/W1966556202","https://openalex.org/W1966831629","https://openalex.org/W1967534538","https://openalex.org/W1970164987","https://openalex.org/W1970874743","https://openalex.org/W1971110401","https://openalex.org/W1971880089","https://openalex.org/W1972025839","https://openalex.org/W1972509050","https://openalex.org/W1972633594","https://openalex.org/W1972669895","https://openalex.org/W1976732198","https://openalex.org/W1977390447","https://openalex.org/W1978051744","https://openalex.org/W1978753457","https://openalex.org/W1980452424","https://openalex.org/W1980789245","https://openalex.org/W1983097317","https://openalex.org/W1983949152","https://openalex.org/W1984303089","https://openalex.org/W1984924722","https://openalex.org/W1985610082","https://openalex.org/W1986246328","https://openalex.org/W1986295281","https://openalex.org/W1986537744","https://openalex.org/W1988452935","https://openalex.org/W1990752558","https://openalex.org/W1991218496","https://openalex.org/W1993057071","https://openalex.org/W1994091239","https://openalex.org/W2000097259","https://openalex.org/W2001900724","https://openalex.org/W2003138766","https://openalex.org/W2003357296","https://openalex.org/W2005686453","https://openalex.org/W2005704128","https://openalex.org/W2005746752","https://openalex.org/W2007281508","https://openalex.org/W2008277940","https://openalex.org/W2009755157","https://openalex.org/W2014593683","https://openalex.org/W2014736805","https://openalex.org/W2021066844","https://openalex.org/W2022025213","https://openalex.org/W2026147918","https://openalex.org/W2030798246","https://openalex.org/W2031346817","https://openalex.org/W2032920422","https://openalex.org/W2035155363","https://openalex.org/W2035771895","https://openalex.org/W2035794436","https://openalex.org/W2036179978","https://openalex.org/W2036362108","https://openalex.org/W2036755018","https://openalex.org/W2038003980","https://openalex.org/W2040268226","https://openalex.org/W2046847750","https://openalex.org/W2046950900","https://openalex.org/W2046952010","https://openalex.org/W2047200672","https://openalex.org/W2047535883","https://openalex.org/W2050066016","https://openalex.org/W2053850015","https://openalex.org/W2055309257","https://openalex.org/W2055453151","https://openalex.org/W2055649795","https://openalex.org/W2056748460","https://openalex.org/W2058151549","https://openalex.org/W2058459224","https://openalex.org/W2058581619","https://openalex.org/W2059890547","https://openalex.org/W2063890956","https://openalex.org/W2065137341","https://openalex.org/W2066116456","https://openalex.org/W2066577814","https://openalex.org/W2070576387","https://openalex.org/W2072389508","https://openalex.org/W2078165545","https://openalex.org/W2078529082","https://openalex.org/W2080423414","https://openalex.org/W2080670841","https://openalex.org/W2082151254","https://openalex.org/W2084343514","https://openalex.org/W2086207996","https://openalex.org/W2086405243","https://openalex.org/W2090300105","https://openalex.org/W2092675319","https://openalex.org/W2092935640","https://openalex.org/W2093629582","https://openalex.org/W2096327192","https://openalex.org/W2096388312","https://openalex.org/W2096410114","https://openalex.org/W2098622411","https://openalex.org/W2099757754","https://openalex.org/W2106934216","https://openalex.org/W2107577990","https://openalex.org/W2108690001","https://openalex.org/W2109140840","https://openalex.org/W2109727228","https://openalex.org/W2112927743","https://openalex.org/W2113455273","https://openalex.org/W2118267556","https://openalex.org/W2119231364","https://openalex.org/W2119375868","https://openalex.org/W2121741898","https://openalex.org/W2121820194","https://openalex.org/W2122037893","https://openalex.org/W2122743846","https://openalex.org/W2124784918","https://openalex.org/W2126108937","https://openalex.org/W2128401893","https://openalex.org/W2132154794","https://openalex.org/W2134717514","https://openalex.org/W2135771073","https://openalex.org/W2136520115","https://openalex.org/W2146729934","https://openalex.org/W2148389554","https://openalex.org/W2150999725","https://openalex.org/W2152119060","https://openalex.org/W2152242321","https://openalex.org/W2152913498","https://openalex.org/W2153184101","https://openalex.org/W2153569004","https://openalex.org/W2156220037","https://openalex.org/W2156326104","https://openalex.org/W2161919187","https://openalex.org/W2163491445","https://openalex.org/W2164179897","https://openalex.org/W2165015386","https://openalex.org/W2166336042","https://openalex.org/W2169602339","https://openalex.org/W2170470411","https://openalex.org/W2397310495","https://openalex.org/W2405224322","https://openalex.org/W2604395407","https://openalex.org/W3147765177","https://openalex.org/W4214891130"],"related_works":["https://openalex.org/W4389990558","https://openalex.org/W4283826758","https://openalex.org/W2314634699","https://openalex.org/W4415273408","https://openalex.org/W2986920349","https://openalex.org/W4406201233","https://openalex.org/W3042658160","https://openalex.org/W2602750146","https://openalex.org/W7117265216","https://openalex.org/W4396509710"],"abstract_inverted_index":{"The":[0,9,100,271],"mechanisms":[1,411],"behind":[2],"Alzheimer\u2019s":[3],"disease":[4,10,48],"(AD)":[5],"are":[6,175],"largely":[7],"unknown.":[8],"is":[11,28,44,69,76,89,414,437],"to":[12,22,38,78,83,109,158,191,238,289,418],"a":[13,46,80,90,133,178,227,274,405],"large":[14],"extent":[15],"hereditary,":[16],"and":[17,85,87,169,217,255,333,360,424],"the":[18,23,26,40,94,113,122,140,150,166,170,187,194,229,240,243,297,327,334,372,394,410,430],"best":[19],"pathophysiological":[20],"correlate":[21,82],"severity":[24],"of":[25,30,34,56,59,67,104,132,146,173,199,207,231,242,269,291,299,320,351,356,374,385,396,415,432],"symptoms":[27],"loss":[29,233],"synapses.\\nThe":[31],"general":[32],"aim":[33],"this":[35,225],"thesis":[36,124],"was":[37,286],"examine":[39],"hypothesis":[41,373],"that":[42,63,92,97,128,223,306,382,388],"AD":[43,60,183,235,281,365,389,413,436],"primarily":[45,185],"synaptic":[47,377,402],"\u2013":[49],"with":[50,144,161,266,318,354,400],"an":[51,130,349],"emphasis":[52],"on":[53,112,429],"complement-mediated":[54],"elimination":[55,198,378,403,434],"synapses.\\nAnimal":[57],"models":[58],"have":[61],"shown":[62,108],"long-term":[64],"potentiation":[65],"(LTP)":[66],"synapses":[68,164,201],"inhibited":[70],"by":[71,205],"beta":[72],"amyloid":[73],"(A\u03b2).":[74],"LTP":[75,105],"considered":[77],"be":[79,110,290,316,393],"physiological":[81],"learning":[84],"memory,":[86],"A\u03b2":[88,101],"peptide":[91],"constitute":[93],"extracellular":[95],"plaques":[96],"characterise":[98],"AD.":[99,147,270,321],"induced":[102],"inhibition":[103],"has":[106],"been":[107],"dependent":[111],"receptor":[114,257],"for":[115,226,371],"advanced":[116],"glycation":[117],"end":[118],"products":[119],"(RAGE).":[120],"In":[121],"present":[123,126],"I":[125],"results":[127,222,272],"suggest":[129,224,387],"association":[131,350],"functional":[134],"single":[135],"nucleotide":[136],"polymorphism":[137],"(SNP)":[138],"in":[139,155,165,177,234,260,280,302,309,326,364,379,435],"gene":[141],"encoding":[142,311],"RAGE":[143],"diagnosis":[145,319],"Thus":[148],"linking":[149],"synapse":[151,232,433],"related":[152],"pathophysiology":[153],"observed":[154],"animal":[156],"models,":[157],"human":[159],"patients":[160,265],"AD.\\nDuring":[162],"development,":[163],"retinogeniculate":[167],"system":[168,196],"sensorimotor":[171],"cortex":[172],"mice":[174],"eliminated":[176],"complement":[179,195,208,244,247,251,256,278,300,312,328,336,375,398],"mediated":[180,376],"manner.":[181],"Since":[182],"pathology":[184],"affects":[186],"hippocampus,":[188],"we":[189,220,236,304,323,345],"sought":[190],"investigate":[192],"whether":[193],"mediates":[197],"hippocampal":[200],"as":[202,404],"well.":[203],"Indeed,":[204],"use":[206],"component":[209,248,337],"3":[210],"(C3)":[211],"deficient":[212],"mice,":[213],"electrophysiological,":[214],"histological,":[215],"molecular":[216],"behavioural":[218],"methods,":[219],"obtained":[221],"fact.\\nConsidering":[228],"importance":[230],"decided":[237],"measure":[239],"levels":[241,279],"proteins":[245,313],"C3,":[246,331],"4":[249],"(C4),":[250],"factor":[252],"B":[253],"(CFB)":[254],"1":[258],"(CR1)":[259],"cerebrospinal":[261],"fluid":[262],"(CSF)":[263],"from":[264],"various":[267],"degrees":[268],"showed":[273],"trend":[275],"towards":[276],"increased":[277],"patients.":[282],"This":[283],"association,":[284],"however,":[285,347],"too":[287],"weak":[288],"diagnostic":[292,422],"value.":[293],"Nevertheless":[294],"it":[295],"supports":[296],"notion":[298],"involvement":[301],"AD.\\nNext":[303],"hypothesised":[305],"genetic":[307],"variation":[308],"genes":[310,329],"could":[314],"potentially":[315],"associated":[317],"Therefore,":[322],"investigated":[324],"SNPs":[325,353],"CR1,":[330],"CFB,":[332],"second":[335],"(C2).":[338],"Although":[339],"no":[340],"such":[341],"associations":[342],"were":[343],"found,":[344],"did,":[346],"find":[348],"C2/CFB":[352],"measures":[355],"cognitive":[357],"function":[358],"(MMSE)":[359],"neuronal":[361],"damage":[362],"(tau)":[363],"patients,":[366],"thus":[367],"lending":[368],"further":[369,427],"support":[370],"AD.\\nI":[380],"conclude":[381],"several":[383],"lines":[384],"evidence":[386],"might":[390],"very":[391],"well":[392],"result":[395],"aberrant":[397],"regulation,":[399],"improper":[401],"consequence.":[406],"Precise":[407],"knowledge":[408],"about":[409],"underlying":[412],"great":[416],"value":[417],"research":[419,428],"into":[420],"accurate":[421],"methods":[423],"treatments,":[425],"thus,":[426],"subject":[431],"warranted.":[438]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
