{"id":"https://openalex.org/W2165737473","doi":"https://doi.org/10.1128/jb.01528-09","title":"Quorum-Sensing Regulation of a Copper Toxicity System in Pseudomonas aeruginosa","display_name":"Quorum-Sensing Regulation of a Copper Toxicity System in Pseudomonas aeruginosa","publication_year":2010,"publication_date":"2010-03-17","ids":{"openalex":"https://openalex.org/W2165737473","doi":"https://doi.org/10.1128/jb.01528-09","mag":"2165737473","pmid":"https://pubmed.ncbi.nlm.nih.gov/20233934","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2863569"},"language":"en","primary_location":{"id":"doi:10.1128/jb.01528-09","doi":"https://doi.org/10.1128/jb.01528-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.01528-09","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2863569/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085866405","display_name":"Joshua T. Thaden","orcid":"https://orcid.org/0000-0002-3250-0697","observed_orcids":["https://orcid.org/0000-0002-3250-0697"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua T. Thaden","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University College of Engineering, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University College of Engineering, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053422448","display_name":"Stephen Lory","orcid":"https://orcid.org/0000-0002-4079-5229","observed_orcids":["https://orcid.org/0000-0002-4079-5229"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111520","display_name":"Baim Institute for Clinical Research","ror":"https://ror.org/01va8fr66","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111520"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen Lory","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023845697","display_name":"Timothy S. Gardner","orcid":"https://orcid.org/0000-0001-5465-5828","observed_orcids":["https://orcid.org/0000-0001-5465-5828"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy S. Gardner","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University College of Engineering, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University College of Engineering, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053422448"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111520"],"apc_list":null,"apc_paid":null,"fwci":1.274,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.76379403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"192","issue":"10","first_page":"2557","last_page":"2568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11578","display_name":"Plant Pathogenic Bacteria Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9449999928474426},{"id":"https://openalex.org/keywords/copper-resistance","display_name":"copper resistance","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cuer","display_name":"CueR","score":0.8700000047683716},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.609000027179718},{"id":"https://openalex.org/keywords/promoter-binding-sites","display_name":"promoter binding sites","score":0.5519999861717224},{"id":"https://openalex.org/keywords/copper-toxicity","display_name":"copper toxicity","score":0.5709999799728394},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.5709999799728394},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.9512044787406921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8799134492874146},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7368607521057129},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.718120276927948},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6381262540817261},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6255308389663696},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5306602716445923},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.5124938488006592},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5107307434082031},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5005643367767334},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.48800650238990784},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.47805410623550415},{"id":"https://openalex.org/C2781196521","wikidata":"https://www.wikidata.org/wiki/Q24965710","display_name":"Response regulator","level":4,"score":0.425019234418869},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3910816013813019},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.357774555683136},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3245995342731476},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.184219092130661},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.09854111075401306},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jb.01528-09","doi":"https://doi.org/10.1128/jb.01528-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.01528-09","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmid:20233934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20233934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2863569","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2863569/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2863569","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2863569/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1275774671","display_name":null,"funder_award_id":"AI021451","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1291669562","display_name":"P. aeruginosa Virulence Determinants","funder_award_id":"R37AI021451","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6304148727","display_name":"Predicting Drug Mechanism via Chemogenomic Profiling","funder_award_id":"R01GM078987","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8180558660","display_name":"P. AERUGINOSA VIRULENCE DETERMINANTS","funder_award_id":"R01AI021451","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W102715436","https://openalex.org/W1529940414","https://openalex.org/W1546783991","https://openalex.org/W1554026413","https://openalex.org/W1566365029","https://openalex.org/W1571228333","https://openalex.org/W1595768312","https://openalex.org/W1665661757","https://openalex.org/W1903990541","https://openalex.org/W1936518287","https://openalex.org/W1942379186","https://openalex.org/W1968366930","https://openalex.org/W1968549820","https://openalex.org/W1968877792","https://openalex.org/W1977105094","https://openalex.org/W1978046264","https://openalex.org/W1978498893","https://openalex.org/W1980302797","https://openalex.org/W1987815733","https://openalex.org/W1988439545","https://openalex.org/W1995732138","https://openalex.org/W2003660859","https://openalex.org/W2005222994","https://openalex.org/W2020057555","https://openalex.org/W2020486543","https://openalex.org/W2022571490","https://openalex.org/W2033255695","https://openalex.org/W2033849847","https://openalex.org/W2038663142","https://openalex.org/W2044357500","https://openalex.org/W2055043387","https://openalex.org/W2061700743","https://openalex.org/W2063543009","https://openalex.org/W2074044150","https://openalex.org/W2074779228","https://openalex.org/W2077067853","https://openalex.org/W2088249775","https://openalex.org/W2088836561","https://openalex.org/W2092550686","https://openalex.org/W2096861885","https://openalex.org/W2097270286","https://openalex.org/W2097804984","https://openalex.org/W2103780237","https://openalex.org/W2109972881","https://openalex.org/W2117160134","https://openalex.org/W2120961145","https://openalex.org/W2127539199","https://openalex.org/W2134745492","https://openalex.org/W2137215017","https://openalex.org/W2137464895","https://openalex.org/W2138350975","https://openalex.org/W2138825607","https://openalex.org/W2142319547","https://openalex.org/W2148641266","https://openalex.org/W2149353640","https://openalex.org/W2150417163","https://openalex.org/W2150741646","https://openalex.org/W2152193238","https://openalex.org/W2155954664","https://openalex.org/W2157040738","https://openalex.org/W2166816492","https://openalex.org/W2167061432","https://openalex.org/W2167727224","https://openalex.org/W2171527366","https://openalex.org/W4285719527","https://openalex.org/W4294832400"],"related_works":["https://openalex.org/W7009753337","https://openalex.org/W2771211326","https://openalex.org/W2078377991","https://openalex.org/W7029178998","https://openalex.org/W2300166611","https://openalex.org/W1501160241","https://openalex.org/W1825982845","https://openalex.org/W2061057503","https://openalex.org/W2137215017","https://openalex.org/W2166345625"],"abstract_inverted_index":{"The":[0,37],"LasR/LasI":[1],"quorum-sensing":[2,21,38],"system":[3,22,32],"in":[4,118,174],"Pseudomonas":[5],"aeruginosa":[6,143],"influences":[7],"global":[8,39],"gene":[9,123,134],"expression":[10,104],"and":[11,54,63,75,90,98,113,156,165,167],"mediates":[12],"pathogenesis.":[13],"In":[14],"this":[15],"study,":[16],"we":[17,65,125],"show":[18,91,126],"that":[19,92,127],"the":[20,25,67,72,78,93,103,139,175],"activates,":[23],"via":[24],"transcriptional":[26,57],"regulator":[27,40],"PA4778,":[28,50,128,137],"a":[29,51,55,85,115,119,151,169],"copper":[30,146,173],"resistance":[31],"composed":[33],"of":[34,49,69,105,132,136,141],"11":[35,106,133],"genes.":[36],"LasR":[41,70,79],"was":[42],"recently":[43],"shown":[44],"to":[45,97,108,144,180],"directly":[46,95],"activate":[47],"transcription":[48],"cueR":[52],"homolog":[53],"MerR-type":[56],"regulator.":[58],"Using":[59,122],"molecular":[60],"genetic":[61],"methods":[62],"bioinformatics,":[64],"verify":[66],"interaction":[68],"with":[71,130],"PA4778":[73,87,155,182],"promoter":[74],"further":[76],"demonstrate":[77],"binding":[80,88],"site.":[81],"We":[82,178],"also":[83],"identify":[84],"putative":[86],"motif":[89],"protein":[94],"binds":[96],"activates":[99],"five":[100],"promoters":[101],"controlling":[102],"genes--PA3519":[107],"-15,":[109],"PA3520,":[110],"mexPQ-opmE,":[111],"PA3574.1,":[112],"cueA,":[114],"virulence":[116],"factor":[117],"murine":[120],"model.":[121],"disruptions,":[124],"along":[129],"7":[131],"targets":[135],"increases":[138],"sensitivity":[140],"P.":[142],"elevated":[145],"concentrations.":[147],"This":[148],"work":[149],"identifies":[150],"cellular":[152],"function":[153],"for":[154,172],"four":[157],"other":[158],"previously":[159],"unannotated":[160],"genes":[161],"(PA3515,":[162],"PA3516,":[163],"PA3517,":[164],"PA3518)":[166],"suggests":[168],"potential":[170],"role":[171],"quorum":[176],"response.":[177],"propose":[179],"name":[181],"cueR.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}