{"id":"https://openalex.org/W2165732124","doi":"https://doi.org/10.1158/1541-7786.mcr-08-0102","title":"Antisense MDM2 Enhances E2F1-Induced Apoptosis and the Combination Sensitizes Androgen-Dependent and Androgen-Independent Prostate Cancer Cells to Radiation","display_name":"Antisense MDM2 Enhances E2F1-Induced Apoptosis and the Combination Sensitizes Androgen-Dependent and Androgen-Independent Prostate Cancer Cells to Radiation","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W2165732124","doi":"https://doi.org/10.1158/1541-7786.mcr-08-0102","mag":"2165732124","pmid":"https://pubmed.ncbi.nlm.nih.gov/19010821","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2763100"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.mcr-08-0102","doi":"https://doi.org/10.1158/1541-7786.mcr-08-0102","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-08-0102","pdf_url":"https://aacrjournals.org/mcr/article-pdf/6/11/1742/3141711/1742.pdf","source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/mcr/article-pdf/6/11/1742/3141711/1742.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111144763","display_name":"Thirupandiyur S. Udayakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thirupandiyur S. Udayakumar","raw_affiliation_strings":["1Fox Chase Cancer Center, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fox Chase Cancer Center, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069528793","display_name":"Paul Hachem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Hachem","raw_affiliation_strings":["1Fox Chase Cancer Center, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fox Chase Cancer Center, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036656612","display_name":"Mansoor M. Ahmed","orcid":"https://orcid.org/0000-0002-4634-9430","observed_orcids":["https://orcid.org/0000-0002-4634-9430"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mansoor M. Ahmed","raw_affiliation_strings":["1Fox Chase Cancer Center, Philadelphia, Pennsylvania;","2Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fox Chase Cancer Center, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"2Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania; and","institution_ids":["https://openalex.org/I1293487830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069014764","display_name":"Sudhir Agrawal","orcid":"https://orcid.org/0000-0003-4275-2510","observed_orcids":["https://orcid.org/0000-0003-4275-2510"]},"institutions":[{"id":"https://openalex.org/I4210142714","display_name":"Idera Pharmaceuticals (United States)","ror":"https://ror.org/03zts9g74","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudhir Agrawal","raw_affiliation_strings":["3Idera Pharmaceuticals, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Idera Pharmaceuticals, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I4210142714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063389942","display_name":"Alan S Pollack","orcid":"https://orcid.org/0000-0002-1801-2865","observed_orcids":["https://orcid.org/0000-0002-1801-2865"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Pollack","raw_affiliation_strings":["1Fox Chase Cancer Center, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Fox Chase Cancer Center, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8798,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.76938019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"11","first_page":"1742","last_page":"1754"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.906000018119812},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8930000066757202},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8840000033378601},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.7210000157356262},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9269999861717224},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9739999771118164},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.7300000190734863},{"id":"https://openalex.org/keywords/caspase-7","display_name":"caspase-7","score":0.9929999709129333},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.652999997138977},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.8690000176429749},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8579999804496765},{"id":"https://openalex.org/keywords/puma","display_name":"PUMA","score":0.8740000128746033},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.5649999976158142},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.9488461017608643},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7125184535980225},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7032090425491333},{"id":"https://openalex.org/C183022183","wikidata":"https://www.wikidata.org/wiki/Q15333016","display_name":"E2F1","level":4,"score":0.5955979824066162},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.5629917979240417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5555654764175415},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5364853143692017},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5247457027435303},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4517136216163635},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.44317370653152466},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3458164930343628},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2419615387916565},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.14482739567756653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.052398681640625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014410","descriptor_name":"Tumor Stem Cell Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016373","descriptor_name":"DNA, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050687","descriptor_name":"E2F1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050687","descriptor_name":"E2F1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1541-7786.mcr-08-0102","doi":"https://doi.org/10.1158/1541-7786.mcr-08-0102","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-08-0102","pdf_url":"https://aacrjournals.org/mcr/article-pdf/6/11/1742/3141711/1742.pdf","source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:19010821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19010821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2763100","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2763100","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.mcr-08-0102","doi":"https://doi.org/10.1158/1541-7786.mcr-08-0102","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-08-0102","pdf_url":"https://aacrjournals.org/mcr/article-pdf/6/11/1742/3141711/1742.pdf","source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1066532999","display_name":null,"funder_award_id":"CA 101984-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2263150155","display_name":"Radiation, Hormones & Antisense Prostate Cancer Therapy","funder_award_id":"R01CA101984","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G501207485","display_name":null,"funder_award_id":"CA 006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000285491","display_name":"Comprehensive Cancer Center Program at Fox Chase","funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2165732124.pdf","grobid_xml":"https://content.openalex.org/works/W2165732124.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1517579686","https://openalex.org/W1804201762","https://openalex.org/W1834050293","https://openalex.org/W1865245803","https://openalex.org/W1883404648","https://openalex.org/W1928639891","https://openalex.org/W1965925173","https://openalex.org/W1970241197","https://openalex.org/W1970729738","https://openalex.org/W1978518304","https://openalex.org/W1983560442","https://openalex.org/W1983971803","https://openalex.org/W1986130846","https://openalex.org/W1986283059","https://openalex.org/W1994381948","https://openalex.org/W1997414785","https://openalex.org/W1999416824","https://openalex.org/W2003282728","https://openalex.org/W2007249806","https://openalex.org/W2012967468","https://openalex.org/W2015066175","https://openalex.org/W2015470552","https://openalex.org/W2015519364","https://openalex.org/W2027558915","https://openalex.org/W2029800672","https://openalex.org/W2036877110","https://openalex.org/W2038116705","https://openalex.org/W2038173255","https://openalex.org/W2038646359","https://openalex.org/W2046250359","https://openalex.org/W2048876993","https://openalex.org/W2049509123","https://openalex.org/W2050981751","https://openalex.org/W2056530510","https://openalex.org/W2061724992","https://openalex.org/W2063477993","https://openalex.org/W2064293531","https://openalex.org/W2074096371","https://openalex.org/W2082979850","https://openalex.org/W2087818316","https://openalex.org/W2091145752","https://openalex.org/W2093503192","https://openalex.org/W2095248073","https://openalex.org/W2096338082","https://openalex.org/W2103649663","https://openalex.org/W2107180444","https://openalex.org/W2108974866","https://openalex.org/W2115999967","https://openalex.org/W2120435603","https://openalex.org/W2123881706","https://openalex.org/W2128103722","https://openalex.org/W2132787016","https://openalex.org/W2134397011","https://openalex.org/W2137124052","https://openalex.org/W2144312885","https://openalex.org/W2144933973","https://openalex.org/W2146407643","https://openalex.org/W2146453903","https://openalex.org/W2148180201","https://openalex.org/W2152339538","https://openalex.org/W2154541005","https://openalex.org/W2158005145","https://openalex.org/W2166213130","https://openalex.org/W2167899505","https://openalex.org/W2171367003","https://openalex.org/W2322882509","https://openalex.org/W2396288039","https://openalex.org/W2401085532","https://openalex.org/W2409984201","https://openalex.org/W2417070019","https://openalex.org/W2591965476","https://openalex.org/W4253723837"],"related_works":["https://openalex.org/W2128103722","https://openalex.org/W1522370504","https://openalex.org/W2049509123","https://openalex.org/W2079909168","https://openalex.org/W2115999967","https://openalex.org/W2046250359","https://openalex.org/W2341768654","https://openalex.org/W96370630","https://openalex.org/W3023357497","https://openalex.org/W3021679587"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"shown":[3],"in":[4,48,64,70,103,116,123,186,198],"separate":[5],"studies":[6],"that":[7,41,175,194],"MDM2":[8,12,30],"knockdown":[9],"via":[10,17],"antisense":[11],"(AS-MDM2)":[13],"and":[14,29,36,62,85,89,95,108,130,148,151,155,160,169,180,193,205],"E2F1":[15,19,28],"overexpression":[16],"adenoviral-mediated":[18],"(Ad-E2F1)":[20],"sensitized":[21],"prostate":[22,52,72,187],"cancer":[23,53,73,188],"cells":[24,79,91,163,189],"to":[25,118,191],"radiation.":[26],"Because":[27],"affect":[31],"apoptosis":[32,111],"through":[33],"both":[34],"common":[35],"independent":[37],"pathways,":[38],"we":[39],"hypothesized":[40],"coupling":[42],"these":[43,132],"two":[44],"treatments":[45,122,134],"would":[46],"result":[47],"increased":[49],"killing":[50],"of":[51,60,105,110,138,144,153,167,178,203],"cells.":[54],"In":[55,128],"this":[56,195],"study,":[57],"the":[58,136,176,199],"effect":[59,100,196],"Ad-E2F1":[61,119,179],"AS-MDM2":[63,121,181],"combination":[65,133,177],"with":[66,82,141],"radiation":[67,192],"was":[68,101],"investigated":[69],"three":[71,125],"cell":[74,126,184],"lines:":[75],"LNCaP":[76,129],"cells,":[77],"LNCaP-Res":[78],"[androgen":[80],"insensitive":[81],"functional":[83],"p53":[84,140],"androgen":[86],"receptor":[87],"(AR)],":[88],"PC3":[90],"(androgen":[92],"insensitive,":[93],"p53(null),":[94],"AR(null)).":[96],"A":[97],"supra-additive":[98],"radiosensitizing":[99],"observed":[102],"terms":[104],"clonogenic":[106],"inhibition":[107],"induction":[109,143],"(caspase-3":[112],"+":[113],"caspase-7":[114],"activity)":[115],"response":[117],"plus":[120],"all":[124],"lines.":[127],"LNCaP-Res,":[131],"elevated":[135,165],"levels":[137,150,166],"phospho-Ser(15)":[139],"significant":[142],"p21(waf1/cip1),":[145],"phospho-gammaH2AX,":[146],"PUMA,":[147],"Bax":[149,168],"reduction":[152],"AR":[154,204],"bcl-2":[156],"expression.":[157,171],"Similarly,":[158],"AR(null)":[159],"p53(null)":[161],"PC-3":[162],"showed":[164],"phospho-gammaH2AX":[170],"These":[172],"findings":[173],"show":[174],"significantly":[182],"increases":[183],"death":[185],"exposed":[190],"occurs":[197],"presence":[200],"or":[201],"absence":[202],"p53.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}