{"id":"https://openalex.org/W216569477","doi":null,"title":"Sex Differences and the Effects of Stress on Subsequent Opioid Consumption in Adult Rats Following Adolescent Nicotine Exposure: A Psychopharmacologic Examination of the Gateway Hypothesis","display_name":"Sex Differences and the Effects of Stress on Subsequent Opioid Consumption in Adult Rats Following Adolescent Nicotine Exposure: A Psychopharmacologic Examination of the Gateway Hypothesis","publication_year":1997,"publication_date":"1997-07-18","ids":{"openalex":"https://openalex.org/W216569477","mag":"216569477"},"language":"en","primary_location":{"id":"pmh:ADA440503","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA440503","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062505005","display_name":"Laura Cousino Klein","orcid":"https://orcid.org/0000-0002-3964-3180","observed_orcids":["https://orcid.org/0000-0002-3964-3180"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Laura Cousino Klein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3964-3180","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062505005"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03523722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.05689999833703041,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adolescent-nicotine-exposure","display_name":"adolescent nicotine exposure","score":0.8820000290870667},{"id":"https://openalex.org/keywords/opioid-self-administration","display_name":"opioid self-administration","score":0.9539999961853027},{"id":"https://openalex.org/keywords/fentanyl","display_name":"fentanyl","score":0.8899999856948853},{"id":"https://openalex.org/keywords/gateway-hypothesis","display_name":"gateway hypothesis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8220000267028809},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.9729999899864197},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.8939999938011169},{"id":"https://openalex.org/keywords/naloxone-precipitated-withdrawal","display_name":"naloxone-precipitated withdrawal","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nicotine-cessation","display_name":"nicotine cessation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.6899999976158142},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.8980000019073486},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.8513175845146179},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6261726021766663},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6009055376052856},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5965141654014587},{"id":"https://openalex.org/C2778555786","wikidata":"https://www.wikidata.org/wiki/Q7448011","display_name":"Self-administration","level":2,"score":0.5844997763633728},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5604842901229858},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.542671799659729},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.5406327843666077},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4415079355239868},{"id":"https://openalex.org/C2778140631","wikidata":"https://www.wikidata.org/wiki/Q2026938","display_name":"Opiate","level":3,"score":0.44057315587997437},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4139842092990875},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32934898138046265},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.10008448362350464},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:ADA440503","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA440503","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},{"id":"pmh:oai:cdm16005.contentdm.oclc.org:p15459coll1/22057","doi":null,"is_oa":false,"landing_page_url":"http://cdm16005.contentdm.oclc.org/cdm/ref/collection/p15459coll1/id/22057","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Klein1997.pdf","raw_type":null},{"id":"mag:216569477","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/1011651.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052336354","https://openalex.org/W4245958748","https://openalex.org/W4389765836","https://openalex.org/W3133826256","https://openalex.org/W3089067637","https://openalex.org/W3008670673","https://openalex.org/W3174468170","https://openalex.org/W1966266993","https://openalex.org/W7110510550","https://openalex.org/W2053209019"],"abstract_inverted_index":{"The":[0],"present":[1],"experiment":[2],"examined":[3],"effects":[4,142,215,237],"of":[5,53,71,127,159,213,260,276],"nicotine":[6,160,277],"administration":[7],"during":[8,101],"adolescence":[9,102],"on":[10,134],"subsequent":[11,107],"opioid":[12,63,83,120],"consumption":[13,52,64,90,180,234,269],"in":[14,110,137,171,192,218,221,227,229,240,243,249,270],"male":[15,112,139,156,163,194,207,222,250,271],"and":[16,88,164,195,203,208,211,232,235,251,254,267,272],"female":[17,147,165,196,209,219,252,255,273],"rats.":[18,113,140,148,197,223],"Forty-one":[19],"day":[20],"old":[21],"rats":[22,66,150,166,210,253,256,274],"received":[23,67],"saline":[24],"(n":[25,30,36],"=40),":[26,31],"6":[27,131],"mg":[28,34,99,132],"nicotine/kg/day":[29,35,133],"or":[32,77,123],"12":[33],"=40)":[37],"by":[38],"osmotic":[39],"mini%pump":[40],"for":[41,44,58,146,181],"24":[42],"hours/day":[43],"19":[45],"days.":[46],"After":[47],"a":[48],"7-day":[49],"cessation":[50,225],"period,":[51],"fentanyl-HCl":[54],"solution":[55],"was":[56,103],"evaluated":[57,92],"4":[59],"weeks.":[60],"Throughout":[61],"the":[62,94,125],"phase,":[65],"either":[68],"20":[69],"minutes":[70],"immobilization":[72,116],"stress":[73,117],"(a":[74,79],"=":[75],"60)":[76],"no-stress":[78],"=60)":[80],"prior":[81,118],"to":[82,105,115,119,130,187],"availability.":[84],"Body":[85],"weight,":[86],"food,":[87],"water":[89],"were":[91,216,238],"throughout":[93],"experiment.":[95],"Nicotine":[96,184,198,224],"exposure":[97,129],"(6":[98],"nicotine/kg/day)":[100],"related":[104],"increased,":[106],"fentanyl":[108,135,153],"self-administration":[109,136,177],"non-stressed":[111],"Exposure":[114],"availability":[121],"attenuated":[122],"reversed":[124],"effect":[126],"adolescent":[128],"adult":[138],"These":[141],"did":[143,155,167],"not":[144,168],"occur":[145],"Female":[149],"consumed":[151],"more":[152],"than":[154,220,242],"rats,":[157],"regardless":[158,275],"pre-exposure,":[161],"but":[162],"display":[169],"differences":[170],"withdrawal":[172],"following":[173],"naloxone":[174],"challenge.":[175],"Opiate":[176],"decreased":[178,199,264],"food":[179,204,233,268],"all":[182],"animals.":[183],"history":[185],"appeared":[186],"increase":[188],"plasma":[189,247,261],"corticosterone":[190,248],"levels":[191,259],"non-stressed,":[193],"body":[200,230,265],"weight":[201,231,266],"gains":[202],"Consumption":[205],"among":[206],"both":[212],"these":[214,236],"greater":[217,239],"resulted":[226],"increases":[228],"females":[241],"males.":[244],"Stress":[245,263],"increased":[246],"had":[257],"higher":[258],"corticosterone.":[262],"history.":[278]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
