{"id":"https://openalex.org/W2165599173","doi":"https://doi.org/10.1210/endo-113-2-720","title":"Development of Hypothalamic Control of Growth Hormone Secretion in the Rat*","display_name":"Development of Hypothalamic Control of Growth Hormone Secretion in the Rat*","publication_year":1983,"publication_date":"1983-08-01","ids":{"openalex":"https://openalex.org/W2165599173","doi":"https://doi.org/10.1210/endo-113-2-720","mag":"2165599173","pmid":"https://pubmed.ncbi.nlm.nih.gov/6135598"},"language":"en","primary_location":{"id":"doi:10.1210/endo-113-2-720","doi":"https://doi.org/10.1210/endo-113-2-720","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-113-2-720","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065145602","display_name":"Omid Khorram","orcid":"https://orcid.org/0000-0003-4996-5762","observed_orcids":["https://orcid.org/0000-0003-4996-5762"]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O. KHORRAM","raw_affiliation_strings":["Department of Physiology, University of Texas Health Science Center at Dallas Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Texas Health Science Center at Dallas Dallas, Texas 75235","institution_ids":["https://openalex.org/I4210094379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049319532","display_name":"Louis DePalatis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. R. DEPALATIS","raw_affiliation_strings":["Department of Physiology, University of Texas Health Science Center at Dallas Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Texas Health Science Center at Dallas Dallas, Texas 75235","institution_ids":["https://openalex.org/I4210094379"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069185819","display_name":"Samuel M. McCann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. MCCANN","raw_affiliation_strings":["Department of Physiology, University of Texas Health Science Center at Dallas Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Texas Health Science Center at Dallas Dallas, Texas 75235","institution_ids":["https://openalex.org/I4210094379"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210094379"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.9801,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.93752461,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"113","issue":"2","first_page":"720","last_page":"728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.953000009059906},{"id":"https://openalex.org/keywords/hypothalamic-regulation","display_name":"hypothalamic regulation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.628000020980835},{"id":"https://openalex.org/keywords/prenatal-development","display_name":"prenatal development","score":0.6679999828338623},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neonatal-rats","display_name":"neonatal rats","score":0.4690000116825104},{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone","display_name":"thyrotropin-releasing hormone","score":0.9380000233650208},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hypothalamic-extract","display_name":"hypothalamic extract","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9005719423294067},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8877390623092651},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.6947020888328552},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.6883589625358582},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5679356455802917},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5538892149925232},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.5285193920135498},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5237612128257751},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5209916234016418},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4935415983200073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4876924753189087},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4108412265777588},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3552996516227722},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20713326334953308},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014020","descriptor_name":"Tissue Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-113-2-720","doi":"https://doi.org/10.1210/endo-113-2-720","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-113-2-720","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:6135598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6135598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1019760276","https://openalex.org/W1508518209","https://openalex.org/W1975248282","https://openalex.org/W1986075235","https://openalex.org/W1986780737","https://openalex.org/W1998409562","https://openalex.org/W2001710449","https://openalex.org/W2002997708","https://openalex.org/W2018161556","https://openalex.org/W2020801850","https://openalex.org/W2029244022","https://openalex.org/W2029951484","https://openalex.org/W2032511791","https://openalex.org/W2051645704","https://openalex.org/W2063587143","https://openalex.org/W2071200106","https://openalex.org/W2071310612","https://openalex.org/W2080185465","https://openalex.org/W2125138332","https://openalex.org/W2165406383","https://openalex.org/W2197735289","https://openalex.org/W2314243146"],"related_works":["https://openalex.org/W7097443606","https://openalex.org/W2168782055","https://openalex.org/W1998409562","https://openalex.org/W2071200106","https://openalex.org/W1964728412","https://openalex.org/W2468093702","https://openalex.org/W2060165461","https://openalex.org/W2304724679","https://openalex.org/W2006310963","https://openalex.org/W1965504455"],"abstract_inverted_index":{"The":[0,30,90,291],"development":[1],"of":[2,5,28,33,92,140,146,165,169,174,187,198,207,221,249,257,266,273,279,288,299,314,319,328,339,344],"hypothalamic":[3,160,176,267,321],"control":[4],"GH":[6,34,63,80,95,116,141,166,184,222,234,253,284,300,345],"in":[7,15,62,76,246,282,335],"the":[8,16,26,36,77,93,100,138,147,163,199,205,225,247,270,277,280,295,302,317,325,329,336],"late":[9,303],"prenatal":[10,83,120,304],"and":[11,69,107,135,150,305,333],"early":[12,260,306],"postnatal":[13,66,87,189],"periods":[14,308],"rat":[17,154,159],"was":[18,56,72,97,102],"studied":[19],"by":[20,58,236,311],"employing":[21],"a":[22,39,44,59,73,218,243,312,320],"static":[23],"system":[24],"for":[25],"incubation":[27,41],"pituitaries.":[29,111,155,227],"basal":[31],"secretion":[32,117,139,164,206,254],"into":[35,99],"medium":[37,101],"after":[38],"3-h":[40],"period":[42],"showed":[43],"gradual":[45,60],"increase":[46,245],"from":[47,82,104,109,133,167,196,213,224,255,286],"day":[48,52,84,88,121,128,239,262],"18":[49,85],"prenatally":[50],"to":[51,86,232,331],"1":[53],"postnatally.":[54,130],"This":[55,123],"followed":[57],"decline":[61],"release":[64,223,235,285,318],"on":[65,119,183],"days":[67],"5":[68,240],"8.":[70,89],"There":[71],"sustained":[74],"rise":[75],"total":[78,94],"pituitary":[79,330],"content":[81],"percentage":[91],"that":[96,294],"released":[98],"high":[103,271,296],"fetal":[105],"pituitaries":[106,145,168,190,237,256,287],"lower":[108],"neonatal":[110,175,226,307],"TRH":[112,124],"(100":[113,229],"ng/ml)":[114,230],"stimulated":[115,137,162],"starting":[118],"21.":[122],"effect":[125,182,278],"persisted":[126],"through":[127],"8":[129],"Hypothalamic":[131],"extracts":[132],"fetuses":[134],"neonates":[136,197],"when":[142],"coincubated":[143],"with":[144,151,191,269],"same":[148,200],"age":[149,201],"adult":[152,157,214],"male":[153,158],"Similarly,":[156],"extract":[161,177,194,212,268,281],"1-day-old":[170,289],"neonates.":[171],"Pronase":[172],"treatment":[173],"completely":[178],"abolished":[179],"its":[180],"stimulatory":[181],"release.":[185],"Incubation":[186],"1-day":[188],"cerebral":[192,210],"cortical":[193,211],"obtained":[195],"did":[202,216],"not":[203],"alter":[204],"GH;":[208],"however,":[209],"males":[215],"cause":[217],"significant":[219],"stimulation":[220],"Somatostatin":[228],"failed":[231],"inhibit":[233],"until":[238],"postnatally,":[241],"but":[242],"10-fold":[244],"concentration":[248,272],"somatostatin":[250,274],"significantly":[251,275],"inhibited":[252],"rats":[258],"as":[259,261],"21":[263],"prenatally.":[264],"Coincubation":[265],"attenuated":[276],"stimulating":[283],"rats.":[290],"results":[292],"suggest":[293],"circulating":[297],"levels":[298],"during":[301,346],"are":[309],"maintained":[310],"combination":[313],"factors":[315],"including":[316],"peptidergic":[322],"GH-releasing":[323],"factor,":[324],"relative":[326,337],"insensitivity":[327],"somatostatin,":[332],"changes":[334],"size":[338],"storage":[340],"vs.":[341],"releasable":[342],"pools":[343],"development.":[347]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}