{"id":"https://openalex.org/W2165548089","doi":"https://doi.org/10.2174/1874613601004010167","title":"Efficacy and Safety of Abacavir/Lamivudine/Zidovudine Plus Tenofovir in HBV/HIV-1 Coinfected Adults: 48-Week Data","display_name":"Efficacy and Safety of Abacavir/Lamivudine/Zidovudine Plus Tenofovir in HBV/HIV-1 Coinfected Adults: 48-Week Data","publication_year":2010,"publication_date":"2010-10-21","ids":{"openalex":"https://openalex.org/W2165548089","doi":"https://doi.org/10.2174/1874613601004010167","mag":"2165548089","pmid":"https://pubmed.ncbi.nlm.nih.gov/21253458","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3023942"},"language":"en","primary_location":{"id":"doi:10.2174/1874613601004010167","doi":"https://doi.org/10.2174/1874613601004010167","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874613601004010167","pdf_url":"https://openaidsjournal.com/VOLUME/4/PAGE/167/PDF/","source":{"id":"https://openalex.org/S173870981","display_name":"The Open AIDS Journal","issn_l":"1874-6136","issn":["1874-6136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open AIDS Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://openaidsjournal.com/VOLUME/4/PAGE/167/PDF/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015290437","display_name":"Allan E. Rodriguez","orcid":"https://orcid.org/0000-0001-9477-3327","observed_orcids":["https://orcid.org/0000-0001-9477-3327"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan E Rodriguez","raw_affiliation_strings":["University of Miami, Miami, Florida, USA","University of Miami, Miami, Florida,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami, Miami, Florida, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"University of Miami, Miami, Florida,","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Edwin DeJesus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120784","display_name":"Orlando Immunology Center","ror":"https://ror.org/02cj88v79","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210120784"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin DeJesus","raw_affiliation_strings":["Orlando Immunology Center , Orlando , Florida , and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orlando Immunology Center , Orlando , Florida , and","institution_ids":["https://openalex.org/I4210120784"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vanessa Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanessa Williams","raw_affiliation_strings":["GlaxoSmithKline , Research Triangle Park , North Carolina , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline , Research Triangle Park , North Carolina , USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Irlbeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Irlbeck","raw_affiliation_strings":["GlaxoSmithKline , Research Triangle Park , North Carolina , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline , Research Triangle Park , North Carolina , USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lisa Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Ross","raw_affiliation_strings":["GlaxoSmithKline , Research Triangle Park , North Carolina , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline , Research Triangle Park , North Carolina , USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Belinda Ha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Belinda Ha","raw_affiliation_strings":["GlaxoSmithKline , Research Triangle Park , North Carolina , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline , Research Triangle Park , North Carolina , USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"last","author":{"id":null,"display_name":"Charles T Lancaster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles T Lancaster","raw_affiliation_strings":["GlaxoSmithKline , Research Triangle Park , North Carolina , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline , Research Triangle Park , North Carolina , USA","institution_ids":["https://openalex.org/I4210114143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015290437"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":null,"apc_paid":null,"fwci":0.3833,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66243834,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"04","issue":"1","first_page":"167","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.1662999987602234,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenofovir","display_name":"tenofovir","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/antiviral-efficacy","display_name":"antiviral efficacy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hbv-dna-suppression","display_name":"HBV DNA suppression","score":0.6679999828338623},{"id":"https://openalex.org/keywords/hiv-1-rna-suppression","display_name":"HIV-1 RNA suppression","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.746999979019165},{"id":"https://openalex.org/keywords/antiretroviral-naive-patients","display_name":"antiretroviral-naive patients","score":0.8629999756813049},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.9112175703048706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8627775311470032},{"id":"https://openalex.org/C2779465607","wikidata":"https://www.wikidata.org/wiki/Q304330","display_name":"Abacavir","level":5,"score":0.8624328374862671},{"id":"https://openalex.org/C2780216070","wikidata":"https://www.wikidata.org/wiki/Q198504","display_name":"Zidovudine","level":4,"score":0.860685408115387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48615095019340515},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.46502992510795593},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4557674527168274},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.44468817114830017},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.4185616075992584},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4021527171134949},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.33431476354599},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.14821168780326843},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.11047482490539551}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2174/1874613601004010167","doi":"https://doi.org/10.2174/1874613601004010167","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874613601004010167","pdf_url":"https://openaidsjournal.com/VOLUME/4/PAGE/167/PDF/","source":{"id":"https://openalex.org/S173870981","display_name":"The Open AIDS Journal","issn_l":"1874-6136","issn":["1874-6136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open AIDS Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3023942","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3023942","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open AIDS J","raw_type":"Text"},{"id":"pmid:21253458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21253458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The open AIDS journal","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.292.8449","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.292.8449","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/4b/76/Open_AIDS_J_2010_Oct_21_4_167-170.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2174/1874613601004010167","doi":"https://doi.org/10.2174/1874613601004010167","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874613601004010167","pdf_url":"https://openaidsjournal.com/VOLUME/4/PAGE/167/PDF/","source":{"id":"https://openalex.org/S173870981","display_name":"The Open AIDS Journal","issn_l":"1874-6136","issn":["1874-6136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open AIDS Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2165548089.pdf","grobid_xml":"https://content.openalex.org/works/W2165548089.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W63324918","https://openalex.org/W2029914836","https://openalex.org/W2056290188","https://openalex.org/W2059268470","https://openalex.org/W2065177390","https://openalex.org/W2146780540","https://openalex.org/W2148750104","https://openalex.org/W2182777591","https://openalex.org/W2183940924","https://openalex.org/W2327827871","https://openalex.org/W4255663005"],"related_works":["https://openalex.org/W7096554879","https://openalex.org/W2077844977","https://openalex.org/W1982416677","https://openalex.org/W2886973671","https://openalex.org/W6892905256","https://openalex.org/W2403278064","https://openalex.org/W28488281","https://openalex.org/W2029914836","https://openalex.org/W1989065888","https://openalex.org/W2115776294"],"abstract_inverted_index":{"In":[0],"HBV/HIV-coinfected":[1,27],"patients,":[2],"the":[3],"risk":[4],"of":[5,82],"end-stage":[6],"liver":[7],"disease":[8],"and":[9,50,73,92,95,102,128,136],"death":[10],"is":[11],"increased.":[12],"This":[13],"open-label,":[14],"prospective,":[15],"pilot":[16],"study":[17],"evaluated":[18],"abacavir/lamivudine/zidovudine":[19,127],"twice":[20],"daily":[21,25],"plus":[22],"tenofovir":[23,129],"once":[24],"in":[26,89,110,143],"antiretroviral-na\u00efve":[28,145],"subjects.":[29,146],"Nine":[30],"adults":[31],"(8":[32],"males)":[33],"enrolled,":[34],"with":[35,133],"baseline":[36,59,109],"mean":[37],"HIV-1":[38,99,135],"RNA":[39,100],"=":[40,46],"4.5":[41],"log(10)":[42,48,87],"copies/mL,":[43,49,104],"HBV":[44,90,137],"DNA":[45],"9.0":[47],"median":[51],"CD4":[52,111],"count":[53,112],"=158":[54],"cells/mm(3).":[55,115],"No":[56],"subject":[57,117],"had":[58,85,98],"ALT":[60],">5x":[61],"ULN.SIX":[62],"SUBJECTS":[63],"COMPLETED":[64],"THE":[65],"STUDY:":[66],"1":[67],"withdrew":[68],"due":[69],"to":[70],"non-treatment-related":[71],"toxoplasmosis":[72],"2":[74],"were":[75,130],"lost-to-follow-up.":[76],"At":[77],"week":[78],"48,":[79],"100%":[80,93],"(6/6)":[81,94],"remaining":[83],"subjects":[84],"\u22652":[86],"decrease":[88],"DNA,":[91],"83%":[96],"(5/6)":[97],"<400":[101],"<50":[103],"respectively.":[105],"Median":[106],"change":[107],"from":[108],"was":[113],"157":[114],"One":[116],"experienced":[118],"treatment-related":[119],"grade":[120],"3":[121],"leukopenia.":[122],"These":[123],"results":[124],"demonstrate":[125],"that":[126],"well":[131],"tolerated":[132],"sustained":[134],"antiviral":[138],"activity":[139],"through":[140],"48":[141],"weeks":[142],"HBV/HIV-coinfected,":[144]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
