{"id":"https://openalex.org/W2165536622","doi":null,"title":"Abnormal regulation of DNA replication and increased lethality in ataxia telangiectasia cells exposed to carcinogenic agents.","display_name":"Abnormal regulation of DNA replication and increased lethality in ataxia telangiectasia cells exposed to carcinogenic agents.","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2165536622","mag":"2165536622","pmid":"https://pubmed.ncbi.nlm.nih.gov/6172195"},"language":"en","primary_location":{"id":"pmid:6172195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6172195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113590844","display_name":"N.G.J. Jaspers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N G Jaspers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110239155","display_name":"Jan de Wit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J de Wit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023704009","display_name":"Michael Regulski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Regulski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029869412","display_name":"D. Bootsma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Bootsma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1231,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.93015319,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"42","issue":"1","first_page":"335","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.8009999990463257},{"id":"https://openalex.org/keywords/x-ray-irradiation","display_name":"X-ray irradiation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dna-synthesis-inhibition","display_name":"DNA synthesis inhibition","score":0.699999988079071},{"id":"https://openalex.org/keywords/dna-strand-break-rejoining","display_name":"DNA strand break rejoining","score":0.796999990940094},{"id":"https://openalex.org/keywords/single-strand-breaks","display_name":"single-strand breaks","score":0.7620000243186951},{"id":"https://openalex.org/keywords/poly-adp-ribose-synthesis","display_name":"poly(ADP-ribose) synthesis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/nicotinamide","display_name":"nicotinamide","score":0.9829999804496765},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.7360000014305115},{"id":"https://openalex.org/keywords/4-nitroquinoline-1-oxide","display_name":"4-nitroquinoline 1-oxide","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dna-methylating-agents","display_name":"DNA methylating agents","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cell-lethality","display_name":"cell lethality","score":0.5809999704360962},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5874333381652832},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5844296216964722},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.5753452181816101},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5627620816230774},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5471524000167847},{"id":"https://openalex.org/C2779911484","wikidata":"https://www.wikidata.org/wiki/Q4637188","display_name":"4-Nitroquinoline 1-oxide","level":4,"score":0.5322263836860657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5169643759727478},{"id":"https://openalex.org/C2779486608","wikidata":"https://www.wikidata.org/wiki/Q387082","display_name":"Ataxia-telangiectasia","level":4,"score":0.5131660103797913},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.45913368463516235},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43415671586990356},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.41592666506767273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28104549646377563},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2760542929172516},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000477","descriptor_name":"Alkylating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008769","descriptor_name":"Methylnitronitrosoguanidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008937","descriptor_name":"Mitomycins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015112","descriptor_name":"4-Nitroquinoline-1-oxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016685","descriptor_name":"Mitomycin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6172195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6172195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2165536622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6172195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W35393141","https://openalex.org/W109594680","https://openalex.org/W851959888","https://openalex.org/W1476157207","https://openalex.org/W1499179356","https://openalex.org/W1533207440","https://openalex.org/W1555102186","https://openalex.org/W1575172090","https://openalex.org/W1582871837","https://openalex.org/W1591941252","https://openalex.org/W1598939796","https://openalex.org/W1972703796","https://openalex.org/W1972978214","https://openalex.org/W1990441503","https://openalex.org/W1995227047","https://openalex.org/W1999979286","https://openalex.org/W2004564881","https://openalex.org/W2014265884","https://openalex.org/W2023166804","https://openalex.org/W2025759199","https://openalex.org/W2034812020","https://openalex.org/W2035154953","https://openalex.org/W2044342782","https://openalex.org/W2051214017","https://openalex.org/W2068755788","https://openalex.org/W2075442531","https://openalex.org/W2075906592","https://openalex.org/W2077757406","https://openalex.org/W2078242581","https://openalex.org/W2085288390","https://openalex.org/W2087972730","https://openalex.org/W2092346499","https://openalex.org/W2092739327","https://openalex.org/W2115894941","https://openalex.org/W2118169258","https://openalex.org/W2144914134","https://openalex.org/W2396271923","https://openalex.org/W2418839081","https://openalex.org/W2419120917"],"related_works":["https://openalex.org/W2078242581","https://openalex.org/W157963143","https://openalex.org/W1999979286","https://openalex.org/W2036771063","https://openalex.org/W2050200628","https://openalex.org/W162096435","https://openalex.org/W2061514562","https://openalex.org/W1971069485","https://openalex.org/W2092346499","https://openalex.org/W2005891532"],"abstract_inverted_index":{"The":[0,22,155,209],"effect":[1],"of":[2,9,24,65,87,132,157,195,211,227,239,251,270,289],"different":[3,96],"carcinogenic":[4,277],"agents":[5,55,81,93],"on":[6,284],"the":[7,125,130,181,236,268,271,287],"rate":[8,23,210],"semiconservative":[10],"DNA":[11,25,66,133,158,166,184,212,240,272],"replication":[12,67,213,241],"in":[13,27,41,68,108,139,183,187,214,242,286],"normal":[14,42,69,98,112,150,190,207,218,298],"and":[15,71,111,149,175,189,217,279,297],"ataxia":[16],"telangiectasis":[17],"(AT)":[18],"cells":[19,43,59,73,89,151,198,219,245],"was":[20,33,74,94,135,220],"investigated.":[21],"synthesis":[26,134,185,293],"all":[28,252],"AT":[29,58,72,88,110,148,188,197,216,244,253,259,296],"cell":[30,113,141,254],"strains":[31],"tested":[32],"depressed":[34],"to":[35,46,53,56,121,124],"a":[36,105,248],"significantly":[37],"lesser":[38],"extent":[39],"than":[40,138,205],"after":[44,76,173],"exposure":[45],"X-rays":[47],"under":[48],"oxia":[49],"or":[50,52,82],"hypoxia":[51],"bleomycin,":[54],"which":[57],"are":[60],"hypersensitive.":[61],"In":[62,115],"contrast,":[63],"inhibition":[64,131,186,238],"human":[70],"similar":[75],"treatment":[77,174],"with":[78,91,101,180,258],"some":[79,116],"DNA-methylating":[80],"mitomycin":[83],"C.":[84],"Colony-forming":[85],"ability":[86],"treated":[90],"these":[92],"not":[95,177,221,264,282],"from":[97],"cells.":[99,191,208,299],"Treatment":[100],"4-nitroquinoline":[102],"1-oxide":[103],"elicited":[104],"variable":[106],"response":[107],"both":[109],"strains.":[114],"strains,":[117,142,255],"including":[118],"those":[119],"shown":[120],"be":[122,153,178],"hypersensitive":[123],"drug":[126],"by":[127,162,165,223,267,276],"other":[128,140],"workers,":[129],"more":[136,203],"pronounced":[137],"but":[143],"no":[144],"significant":[145],"difference":[146,182],"between":[147,294],"could":[152,176],"detected.":[154],"rejoining":[156],"strand":[159,273],"breaks":[160,201,274],"induced":[161],"X-rays,":[163,196],"measured":[164],"elution":[167],"techniques,":[168],"occurred":[169],"within":[170],"l2":[171],"hr":[172],"correlated":[179],"After":[192],"low":[193],"doses":[194],"rejoined":[199],"single-strand":[200],"slightly":[202],"slowly":[204],"did":[206],"X-irradiation":[215],"affected":[222],"nicotinamide,":[224],"an":[225],"inhibitor":[226],"poly(adenosine":[228,290],"diphosphate":[229,291],"ribose)":[230,292],"synthesis.":[231],"These":[232],"data":[233],"indicate":[234],"that":[235],"diminished":[237],"carcinogen-treated":[243],"(a)":[246],"is":[247,263,281],"general":[249],"characteristic":[250],"(b)":[256],"correlates":[257],"cellular":[260],"hypersensitivity,":[261],"(c)":[262],"directly":[265],"caused":[266],"bulk":[269],"produced":[275],"agents,":[278],"(d)":[280],"based":[283],"differences":[285],"induction":[288],"X-irradiated":[295]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}