{"id":"https://openalex.org/W2165490942","doi":null,"title":"The effect of systemically and locally administered clodronate on bone quality","display_name":"The effect of systemically and locally administered clodronate on bone quality","publication_year":2014,"publication_date":"2014-05-23","ids":{"openalex":"https://openalex.org/W2165490942","mag":"2165490942"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/45213","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/45213","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/45213","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028513125","display_name":"Kirsi Rosenqvist","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kirsi Rosenqvist","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028513125"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.6499000191688538,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.6499000191688538,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.18799999356269836,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.12780000269412994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-quality","display_name":"bone quality","score":0.7279999852180481},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.781000018119812},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7789999842643738},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/osteonecrosis-of-the-jaw","display_name":"osteonecrosis of the jaw","score":0.8119999766349792},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/bioactive-glass","display_name":"bioactive glass","score":0.8640000224113464},{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.8420000076293945},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.5149999856948853},{"id":"https://openalex.org/keywords/osteoclast-inhibition","display_name":"osteoclast inhibition","score":0.6499999761581421},{"id":"https://openalex.org/keywords/alveolar-bone-loss","display_name":"alveolar bone loss","score":0.7720000147819519},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.6930000185966492},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.949999988079071},{"id":"https://openalex.org/keywords/gastrointestinal-absorption","display_name":"gastrointestinal absorption","score":0.45100000500679016},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.35899999737739563},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.5742045044898987},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5602352619171143},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4762960970401764},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3362206220626831},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/45213","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/45213","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:2165490942","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/handle/10138/45213","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/45213","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/45213","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W60722128","https://openalex.org/W259985756","https://openalex.org/W302222318","https://openalex.org/W1429059433","https://openalex.org/W1524635504","https://openalex.org/W1575076017","https://openalex.org/W1575220329","https://openalex.org/W1621962689","https://openalex.org/W1787022796","https://openalex.org/W1798117942","https://openalex.org/W1800396987","https://openalex.org/W1817050866","https://openalex.org/W1906721103","https://openalex.org/W1963769607","https://openalex.org/W1964285784","https://openalex.org/W1966796789","https://openalex.org/W1972746971","https://openalex.org/W1974903174","https://openalex.org/W1978230324","https://openalex.org/W1978393630","https://openalex.org/W1978523374","https://openalex.org/W1980626147","https://openalex.org/W1981476886","https://openalex.org/W1981855172","https://openalex.org/W1982748889","https://openalex.org/W1986172208","https://openalex.org/W1986773319","https://openalex.org/W1987328883","https://openalex.org/W1987723996","https://openalex.org/W1987982020","https://openalex.org/W1988912401","https://openalex.org/W1990119475","https://openalex.org/W1990205440","https://openalex.org/W1990800850","https://openalex.org/W1993222490","https://openalex.org/W1995726009","https://openalex.org/W1996898338","https://openalex.org/W1999001495","https://openalex.org/W1999784276","https://openalex.org/W2006825597","https://openalex.org/W2006951696","https://openalex.org/W2007557778","https://openalex.org/W2010354575","https://openalex.org/W2013436047","https://openalex.org/W2013634568","https://openalex.org/W2015890015","https://openalex.org/W2018777439","https://openalex.org/W2019752637","https://openalex.org/W2020375060","https://openalex.org/W2020398976","https://openalex.org/W2021563247","https://openalex.org/W2022276080","https://openalex.org/W2023781848","https://openalex.org/W2024638985","https://openalex.org/W2025800523","https://openalex.org/W2026632377","https://openalex.org/W2027091257","https://openalex.org/W2027148835","https://openalex.org/W2031486735","https://openalex.org/W2031582882","https://openalex.org/W2032919208","https://openalex.org/W2034606501","https://openalex.org/W2036020663","https://openalex.org/W2036125852","https://openalex.org/W2037556871","https://openalex.org/W2038995854","https://openalex.org/W2039461013","https://openalex.org/W2040472663","https://openalex.org/W2040645421","https://openalex.org/W2040705925","https://openalex.org/W2042567846","https://openalex.org/W2042590273","https://openalex.org/W2045815025","https://openalex.org/W2049647212","https://openalex.org/W2049760032","https://openalex.org/W2050326989","https://openalex.org/W2058407607","https://openalex.org/W2058889454","https://openalex.org/W2058935296","https://openalex.org/W2064364394","https://openalex.org/W2066044604","https://openalex.org/W2066971622","https://openalex.org/W2072549873","https://openalex.org/W2072789990","https://openalex.org/W2074143050","https://openalex.org/W2074778320","https://openalex.org/W2076431103","https://openalex.org/W2077100337","https://openalex.org/W2079527690","https://openalex.org/W2080034365","https://openalex.org/W2080113982","https://openalex.org/W2080304382","https://openalex.org/W2081103702","https://openalex.org/W2081465994","https://openalex.org/W2085767802","https://openalex.org/W2086699454","https://openalex.org/W2087166333","https://openalex.org/W2087749556","https://openalex.org/W2088359126","https://openalex.org/W2088966553","https://openalex.org/W2089480064","https://openalex.org/W2092827097","https://openalex.org/W2094483196","https://openalex.org/W2097913481","https://openalex.org/W2102396389","https://openalex.org/W2105788132","https://openalex.org/W2106142458","https://openalex.org/W2107789045","https://openalex.org/W2108756374","https://openalex.org/W2111633168","https://openalex.org/W2114358979","https://openalex.org/W2116640790","https://openalex.org/W2124575477","https://openalex.org/W2124809732","https://openalex.org/W2125306238","https://openalex.org/W2127677509","https://openalex.org/W2131945108","https://openalex.org/W2133111205","https://openalex.org/W2133514604","https://openalex.org/W2140193218","https://openalex.org/W2146143139","https://openalex.org/W2153108218","https://openalex.org/W2155728216","https://openalex.org/W2155937162","https://openalex.org/W2158165331","https://openalex.org/W2160335632","https://openalex.org/W2161690532","https://openalex.org/W2163592625","https://openalex.org/W2163852287","https://openalex.org/W2167022931","https://openalex.org/W2167496620","https://openalex.org/W2168083201","https://openalex.org/W2169780026","https://openalex.org/W2268132833","https://openalex.org/W2321227665","https://openalex.org/W2341095176","https://openalex.org/W2341279955","https://openalex.org/W2395324139","https://openalex.org/W2398887094","https://openalex.org/W2415934797","https://openalex.org/W2460990622","https://openalex.org/W2497218093","https://openalex.org/W2584526132"],"related_works":["https://openalex.org/W2049647212","https://openalex.org/W2118138684","https://openalex.org/W2437340420","https://openalex.org/W2080684591","https://openalex.org/W2409960131","https://openalex.org/W130505114","https://openalex.org/W2067476193","https://openalex.org/W2037542472","https://openalex.org/W2460990622","https://openalex.org/W1875067624"],"abstract_inverted_index":{"The":[0,11,51,98,232,468,520,678],"effect":[1,20,134,622,680],"of":[2,13,21,30,49,54,101,135,141,167,186,195,234,238,274,279,305,318,339,365,393,408,415,446,485,494,500,510,532,538,557,577,623,657,665,681,697],"systemically":[3,24,150,191],"and":[4,32,40,65,84,124,149,165,182,230,262,323,425,430,449,474,476,489,535,575,588,610,637,667],"locally":[5],"administered":[6,151,192],"clodronate":[7,39,55,136,152,174,187,196,224,295,299,313,327,334,348,379,431,452,475,511,539],"on":[8,27,56,492,571,685],"bone":[9,31,57,64,67,85,96,122,126,144,280,306,319,366,394,606,673],"quality":[10,29,674],"aims":[12],"this":[14,102,239,275],"study":[15,565,568],"were":[16,437],"to":[17,33,79,105,198,201,210,226,242,301,358,384,389,442,512,550,652,694],"evaluate":[18],"the":[19,28,47,81,133,147,155,168,183,215,235,251,255,264,271,277,303,316,329,359,363,391,405,409,444,447,456,461,495,501,514,518,544,551,555,558,572,582,586,591,604,614,621,624,645,653,662,670,682,695],"clodronate,":[22],"given":[23,293,377,383],"or":[25,296,380,579],"locally,":[26],"develop":[34,243],"a":[35,203,244,399,411,450,529,563],"combination":[36,413,462,502,521,546,592,626,635,646,683],"product":[37,414,463,522,547,593,627,636,647,684],"including":[38],"bioactive":[41,416,472,600],"glass":[42,417,473,601],"for":[43,223,471,480,482,517,613,672],"local":[44,268,483],"administration":[45],"in":[46,63,72,92,113,128,207,217,254,286,307,324,402,460,465,554,562,633,644,692,700],"treatment":[48,484,556],"periodontitis.":[50],"beneficial":[52],"effects":[53,110,160,261],"are":[58,111],"known.":[59],"Clodronate":[60,382,439],"inhibits":[61],"osteoclasts":[62],"reduces":[66],"turnover.":[68],"It":[69,87],"is":[70,88,175,188,225,349,594,628],"used":[71],"breast":[73,118,291,375],"cancer":[74,292,376],"patients":[75,287,312,326,371,386],"with":[76,115,288,370,372,528,541,566],"non-osseous":[77],"metastases":[78,367],"reduce":[80,302,390],"osteolytic":[82],"complications":[83],"metastases.":[86,395],"widely":[89],"investigated":[90,488],"e.g.,":[91],"healthy":[93],"women":[94,114],"reducing":[95,263],"loss.":[97],"first":[99,272],"aim":[100,233],"thesis":[103,240],"was":[104,140,241,284,368,387,398,432,440,487,524,548],"investigate":[106],"whether":[107],"these":[108,308,385],"established":[109],"similar":[112],"primary":[116,289,373],"operable":[117,290,374],"cancer.":[119],"Since":[120],"skeletal":[121],"loss":[123,127,278,304,317],"alveolar":[125],"periodontitis":[129,486,559],"share":[130],"common":[131],"mechanisms,":[132],"upon":[137],"dental":[138],"application":[139],"interest.":[142],"Systemic":[143],"conditions":[145],"impact":[146],"periodontium":[148],"positively":[153],"affects":[154],"peridontium,":[156],"but":[157,642],"also":[158],"side":[159,260],"such":[161],"as":[162,504,506,597,599,659,661],"diarrhea,":[163],"rash":[164],"osteonecrosis":[166],"jaw":[169],"can":[170],"be":[171,199],"problematic.":[172],"However,":[173,650],"poorly":[176,350],"absorbed":[177,351],"from":[178,352],"gastrointestinal":[179],"(GI)":[180],"tract":[181,354],"oral":[184,193],"bioavailability":[185,229],"low.":[189],"Therefore,":[190,214],"dose":[194,266],"needs":[197],"high":[200],"achieve":[202,227,513],"therapeutic":[204],"effect,":[205],"which":[206],"turn":[208],"leads":[209],"increased":[211,328],"adverse":[212],"events.":[213],"challenge":[216],"developing":[218],"novel":[219,412,625],"drug":[220],"delivery":[221,246],"systems":[222],"improved":[228],"safety.":[231],"second":[236,406],"part":[237,273,407],"new":[245],"system":[247],"that":[248,347,620],"would":[249],"reach":[250],"target":[252],"site":[253,583],"periodontium,":[256],"while":[257],"limiting":[258],"unwanted":[259],"required":[265],"through":[267],"administration.":[269],"In":[270,310,361,404],"study,":[276,410,615],"mineral":[281],"density":[282],"(BMD)":[283],"studied":[285],"either":[294,378],"placebo.":[297,344,381],"Oral":[298],"appears":[300],"patients.":[309],"premenopausal":[311],"significantly":[314,336],"reduced":[315],"after":[320],"one":[321],"year":[322],"postmenopausal":[325],"spinal":[330],"BMD.":[331],"Patients":[332],"receiving":[333,343],"had":[335],"more":[337],"incidences":[338],"diarrhea":[340],"than":[341,464],"those":[342],"This":[345],"indicates":[346],"GI":[353],"thus":[355],"causing":[356],"irritation":[357],"intestine.":[360],"addition,":[362],"development":[364],"compared":[369,549],"shown":[388],"occurrence":[392],"Additionally,":[396,455],"there":[397],"significant":[400],"reduction":[401],"mortality.":[403],"(BAG,":[418],"SiO2":[419],"53%,":[420],"Na2O":[421],"23%,":[422],"CaO":[423],"20%":[424],"P2O5":[426],"4%":[427],"(w/w":[428],"%))":[429],"investigated.":[433],"Firstly,":[434],"preformulation":[435],"studies":[436],"performed.":[438],"found":[441],"promote":[443],"activity":[445],"BAG":[448,466,481,527,552,638,698],"calcium":[451],"precipitate":[453],"formed.":[454],"bioactivity":[457,493,516],"lasted":[458],"longer":[459],"alone.":[467,602],"optimal":[469,477],"ratio":[470],"particle":[478,530],"size":[479,531],"selected":[490,545,612],"based":[491],"BAG,":[496],"safest":[497],"pH":[498],"profile":[499],"product,":[503],"well":[505,660],"highest":[507],"possible":[508],"amount":[509],"enhanced":[515],"BAG.":[519],"chosen":[523],"1":[525],"g":[526],"0.5-0.8":[533],"mm":[534],"200":[536],"mg":[537],"premoisturized":[540],"saline.":[542],"Finally,":[543],"alone":[553,639,699],"maintenance":[560,702],"phase":[561],"pilot":[564],"ten":[567],"subjects.":[569],"Based":[570],"clinical":[573],"signs":[574],"symptoms":[576],"inflammation":[578],"infection":[580],"at":[581,595],"(evaluated":[584],"by":[585],"investigator)":[587],"overall":[589],"satisfaction":[590],"least":[596],"good":[598],"Of":[603],"two":[605],"remodeling":[607],"biomarkers":[608],"(osteoprotegerin":[609],"osteocalcin)":[611],"only":[616,676],"osteoprotegerin":[617],"data":[618],"indicate":[619],"beneficial.":[629],"Osteoprotegerin":[630],"levels":[631],"decreased":[632],"both":[634],"treated":[640,648,668],"teeth":[641],"less":[643],"teeth.":[649],"due":[651],"short":[654],"time":[655],"period":[656],"investigation":[658],"limited":[663],"number":[664],"subjects":[666],"teeth,":[669],"result":[671],"remains":[675],"indicative.":[677],"positive":[679],"tooth":[686],"sensitivity":[687],"may":[688],"bring":[689],"additional":[690],"benefits":[691],"comparison":[693],"use":[696],"periodontal":[701],"therapy.":[703]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
