{"id":"https://openalex.org/W2165490139","doi":"https://doi.org/10.2174/187152710793361559","title":"Gonadotropin-Releasing Hormone Receptor System: Modulatory Role in Aging and Neurodegeneration","display_name":"Gonadotropin-Releasing Hormone Receptor System: Modulatory Role in Aging and Neurodegeneration","publication_year":2010,"publication_date":"2010-11-01","ids":{"openalex":"https://openalex.org/W2165490139","doi":"https://doi.org/10.2174/187152710793361559","mag":"2165490139","pmid":"https://pubmed.ncbi.nlm.nih.gov/20632963","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2967575"},"language":"en","primary_location":{"id":"doi:10.2174/187152710793361559","doi":"https://doi.org/10.2174/187152710793361559","is_oa":false,"landing_page_url":"https://doi.org/10.2174/187152710793361559","pdf_url":null,"source":{"id":"https://openalex.org/S148418319","display_name":"CNS & Neurological Disorders - Drug Targets","issn_l":"1568-007X","issn":["1568-007X","1871-5273","1996-3181","2212-5299"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS &amp; Neurological Disorders - Drug Targets","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2967575","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107930462","display_name":"Liyun Wang","orcid":"https://orcid.org/0000-0002-6050-5911","observed_orcids":["https://orcid.org/0000-0002-6050-5911"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liyun Wang","raw_affiliation_strings":["Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore MD 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091278252","display_name":"Wayne Chadwick","orcid":"https://orcid.org/0000-0003-1465-8180","observed_orcids":["https://orcid.org/0000-0003-1465-8180"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne Chadwick","raw_affiliation_strings":["Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100765099","display_name":"Sung Soo Park","orcid":"https://orcid.org/0000-0002-1779-8683","observed_orcids":["https://orcid.org/0000-0002-1779-8683","https://orcid.org/0000-0002-8582-6391"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sung-Soo Park","raw_affiliation_strings":["Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026216205","display_name":"Yu Zhou","orcid":"https://orcid.org/0000-0003-1942-3073","observed_orcids":["https://orcid.org/0000-0003-1942-3073"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Zhou","raw_affiliation_strings":["Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055113466","display_name":"Nathan Silver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Silver","raw_affiliation_strings":["Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061101747","display_name":"Bronwen Martin","orcid":"https://orcid.org/0000-0002-9185-6925","observed_orcids":["https://orcid.org/0000-0002-9185-6925"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bronwen Martin","raw_affiliation_strings":["Metabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033862949","display_name":"Stuart R. Maudsley","orcid":"https://orcid.org/0000-0002-1868-184X","observed_orcids":["https://orcid.org/0000-0002-1868-184X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stuart Maudsley","raw_affiliation_strings":["Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore MD 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033862949"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"],"apc_list":null,"apc_paid":null,"fwci":4.5509,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.93682894,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"9","issue":"5","first_page":"651","last_page":"660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gnrh-receptor","display_name":"GnRH receptor","score":0.984000027179718},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5230000019073486},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-gonadal-axis","display_name":"hypothalamic-pituitary-gonadal axis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/gnrh-agonist-therapy","display_name":"GnRH agonist therapy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.6240000128746033},{"id":"https://openalex.org/keywords/reproductive-hormones","display_name":"reproductive hormones","score":0.6600000262260437},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.8479999899864197},{"id":"https://openalex.org/keywords/feeding-behavior","display_name":"feeding behavior","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.6564939618110657},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6314005255699158},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.626002311706543},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6021022796630859},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5657531023025513},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5650092959403992},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5292536616325378},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4906543791294098},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.44101086258888245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20184805989265442},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.19411331415176392},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.13506272435188293}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006066","descriptor_name":"Gonads","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006066","descriptor_name":"Gonads","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006066","descriptor_name":"Gonads","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011966","descriptor_name":"Receptors, LHRH","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011966","descriptor_name":"Receptors, LHRH","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011966","descriptor_name":"Receptors, LHRH","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2174/187152710793361559","doi":"https://doi.org/10.2174/187152710793361559","is_oa":false,"landing_page_url":"https://doi.org/10.2174/187152710793361559","pdf_url":null,"source":{"id":"https://openalex.org/S148418319","display_name":"CNS & Neurological Disorders - Drug Targets","issn_l":"1568-007X","issn":["1568-007X","1871-5273","1996-3181","2212-5299"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS &amp; Neurological Disorders - Drug Targets","raw_type":"journal-article"},{"id":"pmid:20632963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20632963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS & neurological disorders drug targets","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2967575","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2967575","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"CNS Neurol Disord Drug Targets","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2967575","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2967575","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"CNS Neurol Disord Drug Targets","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G966437622","display_name":"Age and pathology-induced alteration of G protein-coupled receptor signaling","funder_award_id":"Z01AG000318","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":151,"referenced_works":["https://openalex.org/W3114575","https://openalex.org/W57549556","https://openalex.org/W94830060","https://openalex.org/W159929055","https://openalex.org/W160686759","https://openalex.org/W267892546","https://openalex.org/W1502419589","https://openalex.org/W1503655230","https://openalex.org/W1542215809","https://openalex.org/W1556113948","https://openalex.org/W1593442063","https://openalex.org/W1603023934","https://openalex.org/W1964097082","https://openalex.org/W1964161286","https://openalex.org/W1964882593","https://openalex.org/W1968084526","https://openalex.org/W1968289018","https://openalex.org/W1968780740","https://openalex.org/W1970730143","https://openalex.org/W1972536915","https://openalex.org/W1973084192","https://openalex.org/W1973157134","https://openalex.org/W1975573998","https://openalex.org/W1979840897","https://openalex.org/W1980905876","https://openalex.org/W1982246065","https://openalex.org/W1984905844","https://openalex.org/W1987183665","https://openalex.org/W1990586473","https://openalex.org/W1991898842","https://openalex.org/W1994117869","https://openalex.org/W1994121039","https://openalex.org/W1995097220","https://openalex.org/W1996279569","https://openalex.org/W1997035764","https://openalex.org/W1997734601","https://openalex.org/W1998273730","https://openalex.org/W1998592142","https://openalex.org/W1999266526","https://openalex.org/W2001210466","https://openalex.org/W2001332800","https://openalex.org/W2002364151","https://openalex.org/W2004251605","https://openalex.org/W2004373819","https://openalex.org/W2004746698","https://openalex.org/W2004791695","https://openalex.org/W2005289288","https://openalex.org/W2005525008","https://openalex.org/W2005714988","https://openalex.org/W2007346285","https://openalex.org/W2007635326","https://openalex.org/W2009333542","https://openalex.org/W2010240177","https://openalex.org/W2010947290","https://openalex.org/W2015570501","https://openalex.org/W2018226990","https://openalex.org/W2018695499","https://openalex.org/W2018964300","https://openalex.org/W2019168768","https://openalex.org/W2020442036","https://openalex.org/W2022321394","https://openalex.org/W2022576341","https://openalex.org/W2023301418","https://openalex.org/W2024338758","https://openalex.org/W2024673490","https://openalex.org/W2026844245","https://openalex.org/W2027314789","https://openalex.org/W2027858580","https://openalex.org/W2029445497","https://openalex.org/W2030872161","https://openalex.org/W2031649802","https://openalex.org/W2034037477","https://openalex.org/W2034638348","https://openalex.org/W2035580278","https://openalex.org/W2036423270","https://openalex.org/W2037888939","https://openalex.org/W2039099840","https://openalex.org/W2039198739","https://openalex.org/W2045063195","https://openalex.org/W2045385139","https://openalex.org/W2045682412","https://openalex.org/W2047052340","https://openalex.org/W2050977591","https://openalex.org/W2052314601","https://openalex.org/W2053223614","https://openalex.org/W2054473560","https://openalex.org/W2054728846","https://openalex.org/W2056640259","https://openalex.org/W2056847739","https://openalex.org/W2057182436","https://openalex.org/W2057496129","https://openalex.org/W2057770183","https://openalex.org/W2058852821","https://openalex.org/W2059400053","https://openalex.org/W2061099010","https://openalex.org/W2062438517","https://openalex.org/W2063681422","https://openalex.org/W2071148852","https://openalex.org/W2072865274","https://openalex.org/W2073274309","https://openalex.org/W2073496706","https://openalex.org/W2074527323","https://openalex.org/W2074989385","https://openalex.org/W2078298588","https://openalex.org/W2078950638","https://openalex.org/W2079131274","https://openalex.org/W2079247790","https://openalex.org/W2079419441","https://openalex.org/W2083251488","https://openalex.org/W2086474341","https://openalex.org/W2088319284","https://openalex.org/W2093329660","https://openalex.org/W2093373029","https://openalex.org/W2093500419","https://openalex.org/W2093618389","https://openalex.org/W2094742992","https://openalex.org/W2095575977","https://openalex.org/W2098533587","https://openalex.org/W2099316702","https://openalex.org/W2103583482","https://openalex.org/W2105197323","https://openalex.org/W2109727228","https://openalex.org/W2114092053","https://openalex.org/W2117913544","https://openalex.org/W2124091258","https://openalex.org/W2124498637","https://openalex.org/W2128111072","https://openalex.org/W2130153694","https://openalex.org/W2130500839","https://openalex.org/W2130653478","https://openalex.org/W2131226468","https://openalex.org/W2134078345","https://openalex.org/W2135910109","https://openalex.org/W2139994320","https://openalex.org/W2141582604","https://openalex.org/W2144657436","https://openalex.org/W2151186972","https://openalex.org/W2152448788","https://openalex.org/W2155846608","https://openalex.org/W2156388228","https://openalex.org/W2156839821","https://openalex.org/W2157239926","https://openalex.org/W2161410503","https://openalex.org/W2163723358","https://openalex.org/W2165862740","https://openalex.org/W2166427101","https://openalex.org/W2166874814","https://openalex.org/W2292879214","https://openalex.org/W2397975063","https://openalex.org/W2410877012","https://openalex.org/W2589075404"],"related_works":["https://openalex.org/W2512764902","https://openalex.org/W4284684013","https://openalex.org/W4407921321","https://openalex.org/W4366134904","https://openalex.org/W2039099840","https://openalex.org/W2916783628","https://openalex.org/W2596638511","https://openalex.org/W91684446","https://openalex.org/W6884914715","https://openalex.org/W3023765996"],"abstract_inverted_index":{"Receptors":[0],"for":[1,151],"hormones":[2,17,25],"of":[3,20,105,114,131,140,154,198,215],"the":[4,10,61,83,112,186,202,208],"hypothalamic-pituitary-gonadal":[5],"axis":[6,22,28],"are":[7,80,109],"expressed":[8],"throughout":[9,82],"brain.":[11],"Age-related":[12],"decline":[13],"in":[14,26,43,60,69,107,146,156,164,185,220],"gonadal":[15],"reproductive":[16,48],"cause":[18],"imbalances":[19],"this":[21,27,132],"and":[23,46,78,97,100,218,225],"many":[24],"have":[29,205],"been":[30,53,67,174],"functionally":[31],"linked":[32],"to":[33,89,135,193],"neurodegenerative":[34,165],"pathophysiology.":[35,226],"Gonadotropin-releasing":[36],"hormone":[37],"(GnRH)":[38],"plays":[39],"a":[40,56,115,125,137,152,162,194,211],"vital":[41],"role":[42,153,214],"both":[44],"central":[45,157,196,212,222],"peripheral":[47,74],"regulation.":[49],"GnRH":[50,70,76,106,155,168,183,216],"has":[51,66,172,191],"historically":[52],"known":[54],"as":[55,95],"pituitary":[57],"hormone;":[58],"however,":[59],"past":[62],"few":[63],"years,":[64],"interest":[65],"raised":[68],"actions":[71,104],"at":[72],"non-pituitary":[73],"targets.":[75],"ligands":[77,200,217],"receptors":[79,219],"found":[81],"brain":[84],"where":[85],"they":[86],"may":[87],"act":[88],"control":[90],"multiple":[91],"higher":[92],"functions":[93,158],"such":[94],"learning":[96],"memory":[98],"function":[99],"feeding":[101],"behavior.":[102],"The":[103],"mammals":[108],"mediated":[110],"by":[111,161],"activation":[113],"unique":[116],"rhodopsin-like":[117],"G":[118],"protein-coupled":[119],"receptor":[120,133],"that":[121,143,176],"does":[122],"not":[123,180],"possess":[124],"cytoplasmic":[126],"carboxyl":[127],"terminal":[128],"sequence.":[129],"Activation":[130],"appears":[134],"mediate":[136],"wide":[138],"variety":[139],"signaling":[141],"mechanisms":[142],"show":[144],"diversity":[145],"different":[147],"tissues.":[148],"Epidemiological":[149],"support":[150],"is":[159],"evidenced":[160],"reduction":[163],"disease":[166],"after":[167],"agonist":[169],"therapy.":[170],"It":[171],"previously":[173],"considered":[175],"these":[177,199],"effects":[178],"were":[179],"via":[181],"direct":[182,195,213],"action":[184,197],"brain,":[187],"however":[188],"recent":[189],"data":[190],"pointed":[192],"outside":[201],"pituitary.":[203],"We":[204],"therefore":[206],"summarized":[207],"evidence":[209],"supporting":[210],"controlling":[221],"nervous":[223],"physiology":[224]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
