{"id":"https://openalex.org/W2165482002","doi":"https://doi.org/10.1002/j.1552-4604.1993.tb01931.x","title":"Finasteride, A Steroid 5\u03b1\u2010Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine","display_name":"Finasteride, A Steroid 5\u03b1\u2010Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine","publication_year":1993,"publication_date":"1993-10-01","ids":{"openalex":"https://openalex.org/W2165482002","doi":"https://doi.org/10.1002/j.1552-4604.1993.tb01931.x","mag":"2165482002","pmid":"https://pubmed.ncbi.nlm.nih.gov/7693768"},"language":"en","primary_location":{"id":"doi:10.1002/j.1552-4604.1993.tb01931.x","doi":"https://doi.org/10.1002/j.1552-4604.1993.tb01931.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1993.tb01931.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070756038","display_name":"Gregory A. Winchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G. A. Winchell","raw_affiliation_strings":["Merck Sharp & Dohme Research Laboratories, West Point, PA 19486","Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Sharp & Dohme Research Laboratories, West Point, PA 19486","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113294480","display_name":"Sabrina Gr\u00e9goire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Gregoire","raw_affiliation_strings":["Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111484007","display_name":"ALICE M. TAYLOR","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. M. Taylor","raw_affiliation_strings":["Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017862441","display_name":"Janet Hegland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Hegland","raw_affiliation_strings":["University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111588229","display_name":"Donald B. Hunninghake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. B. Hunninghake","raw_affiliation_strings":["University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070756038"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.7501,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.72263468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"33","issue":"10","first_page":"967","last_page":"970"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/finasteride","display_name":"finasteride","score":1.0},{"id":"https://openalex.org/keywords/antipyrine","display_name":"antipyrine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.6949999928474426},{"id":"https://openalex.org/keywords/5alpha-reductase-inhibitors","display_name":"5-alpha reductase inhibitors","score":0.796999990940094},{"id":"https://openalex.org/keywords/oxidative-metabolism","display_name":"oxidative metabolism","score":0.6460000276565552},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.949999988079071},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.6600000262260437},{"id":"https://openalex.org/keywords/urinary-metabolites","display_name":"urinary metabolites","score":0.8220000267028809},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9169999957084656},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2775874879","wikidata":"https://www.wikidata.org/wiki/Q424167","display_name":"Finasteride","level":4,"score":0.9665558338165283},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7131747603416443},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5759113430976868},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5578996539115906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5375231504440308},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.5169998407363892},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49257713556289673},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4882669448852539},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4403197765350342},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.4167994260787964},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3061225712299347},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21289336681365967},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.19090694189071655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11061593890190125},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018120","descriptor_name":"Finasteride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/j.1552-4604.1993.tb01931.x","doi":"https://doi.org/10.1002/j.1552-4604.1993.tb01931.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1993.tb01931.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:7693768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7693768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5199999809265137,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1812018792","https://openalex.org/W1981911995","https://openalex.org/W1991533040","https://openalex.org/W1999962914","https://openalex.org/W2000173210","https://openalex.org/W2001785554","https://openalex.org/W2018034899","https://openalex.org/W2035906469","https://openalex.org/W2046256234","https://openalex.org/W2056737903","https://openalex.org/W2105365213","https://openalex.org/W2150443486","https://openalex.org/W2402079146","https://openalex.org/W2886399197"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2031934750","https://openalex.org/W2059373368","https://openalex.org/W2093166709","https://openalex.org/W2104218156","https://openalex.org/W2074872267","https://openalex.org/W4311481317","https://openalex.org/W2016759257","https://openalex.org/W2124881865","https://openalex.org/W1855997514"],"abstract_inverted_index":{"A":[0,83],"single-blind":[1],"study":[2],"was":[3,91],"conducted":[4],"to":[5,116],"investigate":[6],"the":[7,19,26],"effect":[8,65],"of":[9,12,21,29,40,45,57,78,89,101,108],"multiple":[10],"doses":[11,44],"finasteride,":[13],"a":[14,38,105],"5":[15],"alpha-reductase":[16],"inhibitor":[17],"for":[18,59],"treatment":[20,53],"benign":[22,34],"prostatic":[23,35],"hyperplasia,":[24],"on":[25,66],"single-dose":[27],"pharmacokinetics":[28],"antipyrine.":[30],"Twelve":[31],"patients":[32],"with":[33,54],"hyperplasia":[36],"received":[37],"total":[39,109],"four":[41],"single":[42],"oral":[43],"18":[46],"mg/kg":[47],"antipyrine":[48,67,81,90,103],"before,":[49],"during,":[50],"and":[51,111,127],"after":[52],"10":[55],"mg/day":[56],"finasteride":[58,126],"28":[60],"days.":[61],"Finasteride":[62],"had":[63],"no":[64,73],"concentration":[68],"profiles.":[69],"There":[70],"were":[71],"also":[72],"changes":[74],"in":[75,86],"urinary":[76],"excretion":[77,100],"three":[79],"principal":[80],"metabolites.":[82],"slight":[84],"increase":[85],"renal":[87],"clearance":[88],"observed;":[92],"however,":[93],"this":[94],"is":[95,112],"not":[96,113],"considered":[97],"relevant":[98],"because":[99],"unchanged":[102],"represents":[104],"minor":[106],"fraction":[107],"elimination":[110],"directly":[114],"related":[115],"oxidative":[117],"metabolism.":[118],"These":[119],"results":[120],"imply":[121],"that":[122],"significant":[123],"interactions":[124],"between":[125],"drugs":[128],"metabolized":[129],"by":[130],"these":[131],"cytochrome":[132],"P-450":[133],"enzymes":[134],"are":[135],"unlikely.":[136]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
