{"id":"https://openalex.org/W2165457619","doi":"https://doi.org/10.1128/jvi.76.8.3709-3719.2002","title":"Parameters of Human Hepatitis Delta Virus Genome Replication: the Quantity, Quality, and Intracellular Distribution of Viral Proteins and RNA","display_name":"Parameters of Human Hepatitis Delta Virus Genome Replication: the Quantity, Quality, and Intracellular Distribution of Viral Proteins and RNA","publication_year":2002,"publication_date":"2002-04-15","ids":{"openalex":"https://openalex.org/W2165457619","doi":"https://doi.org/10.1128/jvi.76.8.3709-3719.2002","mag":"2165457619","pmid":"https://pubmed.ncbi.nlm.nih.gov/11907210","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/136113"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.76.8.3709-3719.2002","doi":"https://doi.org/10.1128/jvi.76.8.3709-3719.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.76.8.3709-3719.2002","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/136113","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065074773","display_name":"Severin O. Gudima","orcid":"https://orcid.org/0000-0003-3824-8952","observed_orcids":["https://orcid.org/0000-0003-3824-8952"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Severin Gudima","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497","Fox Chase Cancer Cen-ter, 7701 Burholme Ave., Philadelphia, PA 19111-2497"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Cen-ter, 7701 Burholme Ave., Philadelphia, PA 19111-2497","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023737081","display_name":"Jinhong Chang","orcid":"https://orcid.org/0000-0002-6723-494X","observed_orcids":["https://orcid.org/0000-0002-6723-494X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinhong Chang","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497","Fox Chase Cancer Cen-ter, 7701 Burholme Ave., Philadelphia, PA 19111-2497"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Cen-ter, 7701 Burholme Ave., Philadelphia, PA 19111-2497","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000116796","display_name":"Gloria Moraleda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gloria Moraleda","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497","Fox Chase Cancer Cen-ter, 7701 Burholme Ave., Philadelphia, PA 19111-2497"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Cen-ter, 7701 Burholme Ave., Philadelphia, PA 19111-2497","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041914470","display_name":"Anna Azvolinsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Azvolinsky","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497","Fox Chase Cancer Cen-ter, 7701 Burholme Ave., Philadelphia, PA 19111-2497"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Cen-ter, 7701 Burholme Ave., Philadelphia, PA 19111-2497","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088766033","display_name":"John M. Taylor","orcid":"https://orcid.org/0000-0002-4275-077X","observed_orcids":["https://orcid.org/0000-0002-4275-077X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John Taylor","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497","Fox Chase Cancer Cen-ter, 7701 Burholme Ave., Philadelphia, PA 19111-2497"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Cen-ter, 7701 Burholme Ave., Philadelphia, PA 19111-2497","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088766033"],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":null,"apc_paid":null,"fwci":3.5205,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.92497556,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"76","issue":"8","first_page":"3709","last_page":"3719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-delta-virus","display_name":"hepatitis delta virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatitis-delta-antigen","display_name":"hepatitis delta antigen","score":0.7139999866485596},{"id":"https://openalex.org/keywords/ribonucleoprotein-particles","display_name":"ribonucleoprotein particles","score":0.8659999966621399},{"id":"https://openalex.org/keywords/virus-assembly","display_name":"viral assembly","score":0.8019999861717224},{"id":"https://openalex.org/keywords/molar-ratio","display_name":"molar ratio","score":0.7080000042915344},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8009999990463257},{"id":"https://openalex.org/keywords/woodchuck","display_name":"woodchuck","score":0.5759999752044678},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.5460000038146973},{"id":"https://openalex.org/keywords/hepatoblastoma-cells","display_name":"hepatoblastoma cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8890345096588135},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6223423480987549},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6001400947570801},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5549514889717102},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5033504366874695},{"id":"https://openalex.org/C73616013","wikidata":"https://www.wikidata.org/wiki/Q5731703","display_name":"Hepatitis B virus PRE beta","level":5,"score":0.47137510776519775},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.46914973855018616},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4673393666744232},{"id":"https://openalex.org/C144001008","wikidata":"https://www.wikidata.org/wiki/Q458226","display_name":"Helper virus","level":4,"score":0.4140980541706085},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.3811763823032379},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22842413187026978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20990002155303955},{"id":"https://openalex.org/C194575299","wikidata":"https://www.wikidata.org/wiki/Q2843746","display_name":"Hepatitis B virus DNA polymerase","level":4,"score":0.1623581051826477}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003698","descriptor_name":"Hepatitis Delta Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003698","descriptor_name":"Hepatitis Delta Virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003699","descriptor_name":"Hepatitis D","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008392","descriptor_name":"Marmota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018963","descriptor_name":"Hepatitis Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018963","descriptor_name":"Hepatitis Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035923","descriptor_name":"Hepatitis delta Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.76.8.3709-3719.2002","doi":"https://doi.org/10.1128/jvi.76.8.3709-3719.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.76.8.3709-3719.2002","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:136113","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/136113","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:11907210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11907210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:136113","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/136113","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3253785729","display_name":null,"funder_award_id":"AI-26522","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4038086905","display_name":"Structure and Replication of Hepatitis Delta Virus","funder_award_id":"R01AI026522","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000027172","display_name":null,"funder_award_id":"CA-06927","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000285491","display_name":"Comprehensive Cancer Center Program at Fox Chase","funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G921727105","display_name":null,"funder_award_id":"CA06927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W120055528","https://openalex.org/W1490981311","https://openalex.org/W1491459594","https://openalex.org/W1495704598","https://openalex.org/W1532982349","https://openalex.org/W1539027848","https://openalex.org/W1551002949","https://openalex.org/W1569956738","https://openalex.org/W1576679006","https://openalex.org/W1578749259","https://openalex.org/W1587452408","https://openalex.org/W1593539572","https://openalex.org/W1608621108","https://openalex.org/W1656204388","https://openalex.org/W1673429509","https://openalex.org/W1747952605","https://openalex.org/W1768947898","https://openalex.org/W1922057900","https://openalex.org/W1938880095","https://openalex.org/W1946946449","https://openalex.org/W1952253497","https://openalex.org/W1982848096","https://openalex.org/W1998961564","https://openalex.org/W2012639973","https://openalex.org/W2013659134","https://openalex.org/W2017895919","https://openalex.org/W2035991334","https://openalex.org/W2049653756","https://openalex.org/W2052878129","https://openalex.org/W2059934461","https://openalex.org/W2066747004","https://openalex.org/W2076688148","https://openalex.org/W2096619494","https://openalex.org/W2098148473","https://openalex.org/W2131753705","https://openalex.org/W2138447062","https://openalex.org/W2140217111","https://openalex.org/W2143334476","https://openalex.org/W2145854423","https://openalex.org/W2149458214","https://openalex.org/W2156945424","https://openalex.org/W2157441620","https://openalex.org/W2158953615","https://openalex.org/W2159274063","https://openalex.org/W2403044285"],"related_works":["https://openalex.org/W1569956738","https://openalex.org/W2125645396","https://openalex.org/W998788273","https://openalex.org/W2146936833","https://openalex.org/W2145854423","https://openalex.org/W2131136045","https://openalex.org/W2110648462","https://openalex.org/W2004324989","https://openalex.org/W2239776994","https://openalex.org/W2059934461"],"abstract_inverted_index":{"Assembly":[0],"of":[1,12,23,29,46,57,61,65,96,181,186,207,225,233,245,274,290,297,311,322],"hepatitis":[2,51],"delta":[3,31],"virus":[4,190,264],"(HDV)":[5],"in":[6,40,82,102,121,131,136,146,156,216,301],"infected":[7],"human":[8,152],"hepatocytes":[9],"involves":[10],"association":[11],"the":[13,30,47,63,69,161,179,205,223,231,243,257,275,291,312,316],"1,679-":[14],"nucleotide":[15],"single-stranded":[16],"genomic":[17,100,228],"RNA":[18],"(deltaRNA)":[19],"with":[20,43,197,315],"multiple":[21],"copies":[22],"both":[24,74],"small":[25,66],"and":[26,76,134,139,148,183,209,227,235,254,266,294,299,319],"large":[27],"forms":[28],"protein":[32],"(deltaAg)":[33],"to":[34,84,99,166,202,282],"form":[35],"a":[36,58,308],"ribonucleoprotein":[37],"particle":[38,72],"which":[39,122],"turn":[41],"interacts":[42],"envelope":[44],"proteins":[45],"natural":[48],"helper":[49],"virus,":[50],"B":[52],"virus.":[53],"Subsequently,":[54],"for":[55,114,169,175],"initiation":[56,180,244],"new":[59],"round":[60],"replication,":[62,246],"amount":[64],"deltaAg":[67,90,97,208,226,234,259,277,298],"within":[68],"assembled":[70,103],"HDV":[71,104,123,170,214,284,323],"is":[73,91],"necessary":[75],"sufficient.":[77],"Quantitative":[78],"assays":[79,199],"were":[80,164,211,268],"used":[81,201],"order":[83],"better":[85,309],"understand":[86],"just":[87],"how":[88],"much":[89],"needed.":[92],"The":[93,219],"molar":[94,162],"ratio":[95,111],"species":[98],"deltaRNA":[101,210,300],"particles":[105],"was":[106,112,126,173,184,192,200,247],"approximately":[107],"200.":[108],"Next,":[109],"this":[110],"determined":[113],"cells":[115],"under":[116],"several":[117,302],"different":[118,176,303],"experimental":[119,304],"situations":[120,160],"genome":[124,324],"replication":[125,130,145,182,215],"occurring.":[127,193],"These":[128],"included":[129],"woodchuck":[132],"liver":[133,138],"also":[135],"mouse":[137],"skeletal":[140],"muscle,":[141],"as":[142,144],"well":[143],"stably":[147],"transiently":[149],"transfected":[150,217],"cultured":[151],"hepatoblastoma":[153],"cells.":[154,218],"Surprisingly,":[155],"almost":[157],"all":[158],"these":[159],"ratios":[163],"comparable":[165],"that":[167],"observed":[168],"particles.":[171],"This":[172],"true":[174],"times":[177,241],"after":[178,242],"independent":[185],"whether":[187,204],"or":[188,272],"not":[189,269],"assembly":[191,265],"Cell":[194],"fractionation":[195],"combined":[196],"quantitative":[198],"test":[203],"majority":[206,224],"colocalized":[212],"during":[213],"cytoplasmic":[220],"fraction":[221],"contained":[222],"deltaRNA.":[229],"Finally,":[230],"quality":[232,293],"deltaRNA,":[236],"especially":[237],"at":[238],"relatively":[239],"late":[240],"examined":[248],"by":[249],"using":[250],"reverse":[251],"transcription-PCR,":[252],"cloning,":[253],"sequencing":[255],"through":[256],"entire":[258],"open":[260],"reading":[261],"frame.":[262],"When":[263],"spread":[267],"possible,":[270],"20%":[271],"less":[273],"predicted":[276],"would":[278],"have":[279],"been":[280],"able":[281],"support":[283],"replication.":[285,325],"In":[286],"summary,":[287],"an":[288],"examination":[289],"quantity,":[292],"intracellular":[295],"distribution":[296],"systems":[305],"has":[306],"provided":[307],"understanding":[310],"parameters":[313],"associated":[314],"initiation,":[317],"maintenance,":[318],"ultimate":[320],"decline":[321]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}