{"id":"https://openalex.org/W2165325867","doi":"https://doi.org/10.4269/ajtmh.1998.58.645","title":"First-time-in-humans safety and pharmacokinetics of WR 238605, a new antimalarial.","display_name":"First-time-in-humans safety and pharmacokinetics of WR 238605, a new antimalarial.","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W2165325867","doi":"https://doi.org/10.4269/ajtmh.1998.58.645","mag":"2165325867","pmid":"https://pubmed.ncbi.nlm.nih.gov/9598455"},"language":"en","primary_location":{"id":"doi:10.4269/ajtmh.1998.58.645","doi":"https://doi.org/10.4269/ajtmh.1998.58.645","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.1998.58.645","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003377484","display_name":"Ralf P. Brueckner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R P Brueckner","raw_affiliation_strings":["Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061427649","display_name":"Kenneth C. Lasseter","orcid":"https://orcid.org/0000-0001-8175-2199","observed_orcids":["https://orcid.org/0000-0001-8175-2199"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K C Lasseter","raw_affiliation_strings":["Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109844065","display_name":"E T Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E T Lin","raw_affiliation_strings":["Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113466733","display_name":"Brian G. Schuster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B G Schuster","raw_affiliation_strings":["Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA","institution_ids":["https://openalex.org/I92664306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I92664306"],"apc_list":null,"apc_paid":null,"fwci":10.848,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.98324996,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"58","issue":"5","first_page":"645","last_page":"649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/8-aminoquinolines","display_name":"8-aminoquinolines","score":0.7689999938011169},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.9470000267028809},{"id":"https://openalex.org/keywords/first-in-human-safety","display_name":"first-in-human safety","score":0.6880000233650208},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.6850000023841858},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.4180000126361847},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.8690000176429749},{"id":"https://openalex.org/keywords/malaria-prophylaxis","display_name":"malaria prophylaxis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/radical-cure","display_name":"radical cure","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8990662097930908},{"id":"https://openalex.org/C2776793103","wikidata":"https://www.wikidata.org/wiki/Q419834","display_name":"Primaquine","level":4,"score":0.7081420421600342},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7038455605506897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6699336171150208},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5682281851768494},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4766350984573364},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4748302400112152},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.4712536633014679},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2531898021697998},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12313303351402283},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.0678040087223053},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4269/ajtmh.1998.58.645","doi":"https://doi.org/10.4269/ajtmh.1998.58.645","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.1998.58.645","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"journal-article"},{"id":"pmid:9598455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9598455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.543.9081","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.543.9081","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ajtmh.org/content/58/5/645.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W135494858","https://openalex.org/W157601593","https://openalex.org/W276279580","https://openalex.org/W754913612","https://openalex.org/W1589825032","https://openalex.org/W1590890055","https://openalex.org/W1915861691","https://openalex.org/W1977839354","https://openalex.org/W2018320053","https://openalex.org/W2071061494","https://openalex.org/W2085148882","https://openalex.org/W2085597837","https://openalex.org/W2089172952","https://openalex.org/W2139935582","https://openalex.org/W2145434855","https://openalex.org/W2159704093","https://openalex.org/W2279987464","https://openalex.org/W2411864248","https://openalex.org/W2415142055","https://openalex.org/W2491374885"],"related_works":["https://openalex.org/W1920717726","https://openalex.org/W2279987464","https://openalex.org/W2119444121","https://openalex.org/W2407631119","https://openalex.org/W2070855302","https://openalex.org/W2598900197","https://openalex.org/W2051078197","https://openalex.org/W104976927","https://openalex.org/W276279580","https://openalex.org/W2254051184"],"abstract_inverted_index":{"WR":[0,45,81],"238605":[1,46,82],"is":[2,89],"an":[3,99,114],"8-aminoquinoline":[4],"drug":[5,113],"currently":[6],"under":[7],"development":[8],"for":[9,117],"prophylaxis":[10],"and":[11,24,43,88,98,108,125],"treatment":[12],"of":[13,95,102],"malaria.":[14],"Preclinical":[15],"studies":[16],"have":[17],"demonstrated":[18,77],"that":[19],"it":[20],"has":[21,83],"greater":[22],"efficacy":[23,107],"less":[25],"toxicity":[26],"compared":[27],"with":[28,67,92],"primaquine.":[29],"In":[30],"this":[31,112],"first-time-in-human":[32],"randomized,":[33],"double-blind,":[34],"placebo-controlled":[35],"study":[36],"designed":[37],"to":[38,49,59],"evaluate":[39],"the":[40],"safety,":[41,106],"tolerance":[42],"pharmacokinetics,":[44],"was":[47,64],"administered":[48],"48":[50],"men":[51],"in":[52],"single":[53],"oral":[54],"doses":[55],"ranging":[56],"from":[57],"four":[58],"600":[60],"mg":[61],"(base).":[62],"It":[63],"well":[65],"tolerated,":[66],"gastrointestinal":[68],"disturbances":[69],"as":[70,120],"possible":[71],"side":[72],"effects.":[73],"Linear":[74],"kinetics":[75],"were":[76],"at":[78],"these":[79],"doses.":[80],"a":[84,93,121],"long":[85],"absorption":[86],"phase":[87],"slowly":[90],"metabolized,":[91],"tmax":[94],"12":[96],"hr":[97],"elimination":[100],"half-life":[101],"14":[103],"days.":[104],"These":[105],"pharmacokinetic":[109],"properties":[110],"make":[111],"excellent":[115],"candidate":[116],"further":[118],"testing":[119],"prophylactic,":[122],"radical":[123],"curative,":[124],"terminal":[126],"eradication":[127],"drug.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
