{"id":"https://openalex.org/W2165284441","doi":"https://doi.org/10.1128/jvi.72.6.4686-4693.1998","title":"Vpr Stimulates Viral Expression and Induces Cell Killing in Human Immunodeficiency Virus Type 1-Infected Dividing Jurkat T Cells","display_name":"Vpr Stimulates Viral Expression and Induces Cell Killing in Human Immunodeficiency Virus Type 1-Infected Dividing Jurkat T Cells","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2165284441","doi":"https://doi.org/10.1128/jvi.72.6.4686-4693.1998","mag":"2165284441","pmid":"https://pubmed.ncbi.nlm.nih.gov/9573232"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.72.6.4686-4693.1998","doi":"https://doi.org/10.1128/jvi.72.6.4686-4693.1998","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.72.6.4686-4693.1998","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/109992","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034471348","display_name":"Xiaojian Yao","orcid":"https://orcid.org/0000-0002-5022-1309","observed_orcids":["https://orcid.org/0000-0002-5022-1309"]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Xiao-Jian Yao","raw_affiliation_strings":["<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086850461","display_name":"Andrew J. Mouland","orcid":"https://orcid.org/0000-0002-1828-0296","observed_orcids":["https://orcid.org/0000-0002-1828-0296"]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew J. Mouland","raw_affiliation_strings":["<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026965229","display_name":"Ramu A. Subbramanian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ramu A. Subbramanian","raw_affiliation_strings":["<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109225919","display_name":"Janique Forget","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Janique Forget","raw_affiliation_strings":["<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021180401","display_name":"Nicole Rougeau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nicole Rougeau","raw_affiliation_strings":["<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109902818","display_name":"Dominique Bergeron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dominique Bergeron","raw_affiliation_strings":["<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025751053","display_name":"\u00c9ric A. Cohen","orcid":"https://orcid.org/0000-0003-1269-3791","observed_orcids":["https://orcid.org/0000-0003-1269-3791"]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eric A. Cohen","raw_affiliation_strings":["<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Laboratoire de re\u0301trovirologie humaine, De\u0301partement de microbiologie et immunologie, Faculte\u0301 de me\u0301decine, Universite\u0301 de Montre\u0301al, Montre\u0301al, Que\u0301bec, Canada H3C 3J7","institution_ids":["https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I70931966"],"apc_list":null,"apc_paid":null,"fwci":4.7178,"has_fulltext":false,"cited_by_count":169,"citation_normalized_percentile":{"value":0.95738943,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"72","issue":"6","first_page":"4686","last_page":"4693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-vpr","display_name":"HIV-1 Vpr","score":0.9449999928474426},{"id":"https://openalex.org/keywords/viral-gene-expression","display_name":"viral gene expression","score":0.6230000257492065},{"id":"https://openalex.org/keywords/cell-killing","display_name":"cell killing","score":0.5490000247955322},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.7260000109672546},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8389999866485596},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.6859999895095825},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cd4-t-cell-depletion","display_name":"CD4+ T cell depletion","score":0.8510000109672546},{"id":"https://openalex.org/keywords/superinfection","display_name":"superinfection","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9461276531219482},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.8004089593887329},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6655861139297485},{"id":"https://openalex.org/C2779057330","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis virus","level":3,"score":0.6357581615447998},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6039742231369019},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.495138555765152},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4586482346057892},{"id":"https://openalex.org/C25897203","wikidata":"https://www.wikidata.org/wiki/Q3241872","display_name":"Viral life cycle","level":4,"score":0.4197952151298523},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3049764037132263},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1314905285835266},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.07392963767051697}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016336","descriptor_name":"Gene Products, vpr","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016336","descriptor_name":"Gene Products, vpr","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016336","descriptor_name":"Gene Products, vpr","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D054325","descriptor_name":"vpr Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054325","descriptor_name":"vpr Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054325","descriptor_name":"vpr Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/jvi.72.6.4686-4693.1998","doi":"https://doi.org/10.1128/jvi.72.6.4686-4693.1998","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.72.6.4686-4693.1998","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmid:9573232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9573232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:166339","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC109992","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:109992","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/109992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.3866","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.3866","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/72/6/4686.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:109992","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/109992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W231371051","https://openalex.org/W1480448067","https://openalex.org/W1480555318","https://openalex.org/W1493428938","https://openalex.org/W1528266646","https://openalex.org/W1583870669","https://openalex.org/W1588896166","https://openalex.org/W1635094878","https://openalex.org/W1807747199","https://openalex.org/W1913681141","https://openalex.org/W1925504181","https://openalex.org/W1961049056","https://openalex.org/W1973398091","https://openalex.org/W1983747887","https://openalex.org/W1983827889","https://openalex.org/W1984621096","https://openalex.org/W2001243226","https://openalex.org/W2007150582","https://openalex.org/W2010840723","https://openalex.org/W2011630381","https://openalex.org/W2032884799","https://openalex.org/W2048656467","https://openalex.org/W2072901265","https://openalex.org/W2073140901","https://openalex.org/W2082788072","https://openalex.org/W2089135460","https://openalex.org/W2094023425","https://openalex.org/W2098625990","https://openalex.org/W2099644089","https://openalex.org/W2102679512","https://openalex.org/W2108779766","https://openalex.org/W2122266844","https://openalex.org/W2130200446","https://openalex.org/W2146187278","https://openalex.org/W2150134593","https://openalex.org/W2150514496","https://openalex.org/W2154610213","https://openalex.org/W2163942950","https://openalex.org/W2166291746","https://openalex.org/W2170434135","https://openalex.org/W2414075451","https://openalex.org/W6840821781"],"related_works":["https://openalex.org/W2151762510","https://openalex.org/W1964759127","https://openalex.org/W131865840","https://openalex.org/W2392362873","https://openalex.org/W2955520530","https://openalex.org/W1438272007","https://openalex.org/W2073321338","https://openalex.org/W3015678326","https://openalex.org/W2089114560","https://openalex.org/W2013929164"],"abstract_inverted_index":{"In":[0,59],"this":[1],"study":[2],"we":[3,82],"investigated":[4],"the":[5,36,46,94,107,122,137,140,149,156,168,176,212],"effects":[6,123,208],"of":[7,15,38,49,87,124,139,159,170,178],"Vpr":[8,39,125,160,171,185],"during":[9],"human":[10],"immunodeficiency":[11],"virus":[12,25],"(HIV)":[13],"infection":[14,103,177],"proliferating":[16],"Jurkat":[17],"T":[18,55,197],"cells":[19,56],"by":[20],"using":[21],"a":[22,42,62,144],"vesicular":[23],"stomatitis":[24],"envelope":[26],"G":[27],"glycoprotein":[28],"pseudotyped":[29],"HIV":[30,50],"superinfection":[31],"system.":[32],"We":[33],"observe":[34],"that":[35,84,102,155,184,205],"expression":[37,118,133],"results":[40,99,111,182],"in":[41,45,57,93,112,115,148,192,194,201],"severe":[43],"reduction":[44],"life":[47],"span":[48],"type":[51],"1":[52],"(HIV-1)-infected":[53],"dividing":[54,196],"culture.":[58],"agreement":[60],"with":[61,104,136,175,216],"recent":[63],"report":[64],"(S.":[65],"A.":[66],"Stewart,":[67],"B.":[68,71],"Poon,":[69],"J.":[70,78],"M.":[72],"Jowett,":[73],"and":[74,119,129],"I.":[75],"S.":[76],"Chen,":[77],"Virol.":[79],"71:5579-5592,":[80],"1997),":[81],"show":[83,101,154],"events":[85],"characteristic":[86],"apoptotic":[88],"cell":[89,127,145],"death":[90],"are":[91],"involved":[92],"Vpr-mediated":[95,206],"cytopathic":[96],"effects.":[97],"Our":[98],"also":[100,187],"viruses":[105],"expressing":[106],"wild-type":[108],"vpr":[109],"gene":[110,117,132],"an":[113],"increase":[114,189],"viral":[116,131,190],"production.":[120],"Interestingly,":[121],"on":[126,130],"viability":[128],"both":[134],"correlate":[135],"ability":[138],"protein":[141],"to":[142,211],"induce":[143],"cycle":[146],"arrest":[147],"G2/M":[150],"phase.":[151],"Mutagenesis":[152],"analyses":[153],"C":[157],"terminus":[158],"is":[161,172],"essential":[162],"for":[163],"these":[164,200],"biological":[165],"activities.":[166],"Although":[167],"role":[169],"currently":[173],"associated":[174,215],"nondividing":[179],"cells,":[180],"our":[181],"suggest":[183,204],"can":[186],"directly":[188],"replication":[191],"vivo":[193],"infected":[195],"cells.":[198],"Furthermore,":[199],"vitro":[202],"observations":[203],"cytotoxic":[207],"could":[209],"contribute":[210],"CD4+":[213],"depletion":[214],"AIDS":[217],"progression.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}