{"id":"https://openalex.org/W2165200875","doi":"https://doi.org/10.1194/jlr.m054882","title":"Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion","display_name":"Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion","publication_year":2015,"publication_date":"2015-05-08","ids":{"openalex":"https://openalex.org/W2165200875","doi":"https://doi.org/10.1194/jlr.m054882","mag":"2165200875","pmid":"https://pubmed.ncbi.nlm.nih.gov/25954050","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4479334"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.m054882","doi":"https://doi.org/10.1194/jlr.m054882","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m054882","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1194/jlr.m054882","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100322921","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0003-2046-7604","observed_orcids":["https://orcid.org/0000-0003-2046-7604"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":["Departments of Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX; Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX; Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080002702","display_name":"Viktoria Gusarova","orcid":"https://orcid.org/0000-0002-2266-783X","observed_orcids":["https://orcid.org/0000-0002-2266-783X"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viktoria Gusarova","raw_affiliation_strings":["Regeneron Pharmaceuticals, Tarrytown, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Tarrytown, NY","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025951810","display_name":"Serena Banfi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serena Banfi","raw_affiliation_strings":["Departments of Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008058230","display_name":"Jesper Gromada","orcid":"https://orcid.org/0000-0002-0278-3454","observed_orcids":["https://orcid.org/0000-0002-0278-3454"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesper Gromada","raw_affiliation_strings":["Regeneron Pharmaceuticals, Tarrytown, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Tarrytown, NY","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043796550","display_name":"Jonathan C. Cohen","orcid":"https://orcid.org/0000-0003-0984-2864","observed_orcids":["https://orcid.org/0000-0003-0984-2864","https://orcid.org/0000-0002-4673-7644"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan C. Cohen","raw_affiliation_strings":["Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX","To whom correspondence should be addressed. (H.H.H.); (J.C.C.); Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX; To whom correspondence should be addressed. (H.H.H.); (J.C.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"To whom correspondence should be addressed. (H.H.H.); (J.C.C.); Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX; To whom correspondence should be addressed. (H.H.H.); (J.C.C.)","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024723638","display_name":"Helen H. Hobbs","orcid":"https://orcid.org/0000-0002-8700-9897","observed_orcids":["https://orcid.org/0000-0002-8700-9897"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen H. Hobbs","raw_affiliation_strings":["Departments of Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX","To whom correspondence should be addressed. (H.H.H.); (J.C.C.); Departments of Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX; Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX; To whom correspondence should be addressed. (H.H.H.); (J.C.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]},{"raw_affiliation_string":"To whom correspondence should be addressed. (H.H.H.); (J.C.C.); Departments of Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX; Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX; To whom correspondence should be addressed. (H.H.H.); (J.C.C.)","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":11.1203,"has_fulltext":false,"cited_by_count":188,"citation_normalized_percentile":{"value":0.98955774,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"56","issue":"7","first_page":"1296","last_page":"1307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angptl3","display_name":"ANGPTL3","score":0.996999979019165},{"id":"https://openalex.org/keywords/vldl-triglyceride-secretion","display_name":"VLDL triglyceride secretion","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hepatic-lipoprotein-secretion","display_name":"hepatic lipoprotein secretion","score":0.8019999861717224},{"id":"https://openalex.org/keywords/apob-containing-lipoproteins","display_name":"apoB-containing lipoproteins","score":0.8889999985694885},{"id":"https://openalex.org/keywords/lipoprotein-clearance","display_name":"lipoprotein clearance","score":0.9110000133514404},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.5130000114440918},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.8090000152587891},{"id":"https://openalex.org/keywords/endothelial-lipase","display_name":"endothelial lipase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.4869999885559082},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lrp1","display_name":"LRP1","score":0.984000027179718},{"id":"https://openalex.org/keywords/syndecan-1","display_name":"syndecan-1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hypolipidemia","display_name":"hypolipidemia","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.6801292300224304},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.656004786491394},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6103157997131348},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5228307843208313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4623018801212311},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45050740242004395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3779769241809845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35181546211242676},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3499634861946106},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.27626609802246094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2082625925540924}],"mesh":[{"descriptor_ui":"D000075802","descriptor_name":"Angiopoietin-like Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091303","descriptor_name":"Angiopoietin-Like Protein 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008079","descriptor_name":"Lipoproteins, VLDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D026503","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042682","descriptor_name":"Angiopoietins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D042682","descriptor_name":"Angiopoietins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042682","descriptor_name":"Angiopoietins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053668","descriptor_name":"Syndecan-1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1194/jlr.m054882","doi":"https://doi.org/10.1194/jlr.m054882","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m054882","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4479334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4479334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Lipid Res","raw_type":"Text"},{"id":"pmid:25954050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25954050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cfc0a060063048f0935ef330539cd203","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cfc0a060063048f0935ef330539cd203","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 56, Iss 7, Pp 1296-1307 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1194/jlr.m054882","doi":"https://doi.org/10.1194/jlr.m054882","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m054882","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1566882731","display_name":"UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)","funder_award_id":"UL1TR001105","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7768474441","display_name":"Molecular Basis of Cholesterol Metabolism","funder_award_id":"P01HL020948","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000900892","display_name":"PNPLA3 in Susceptibility and Resistance to Fatty Liver Disease","funder_award_id":"R01DK090066","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1483242733","https://openalex.org/W1484612874","https://openalex.org/W1522459970","https://openalex.org/W1530283338","https://openalex.org/W1889257304","https://openalex.org/W1944135887","https://openalex.org/W1971694897","https://openalex.org/W1974471798","https://openalex.org/W1976791053","https://openalex.org/W1983724939","https://openalex.org/W1986046837","https://openalex.org/W1989730880","https://openalex.org/W1992864925","https://openalex.org/W1999469165","https://openalex.org/W2001564425","https://openalex.org/W2003247644","https://openalex.org/W2008688211","https://openalex.org/W2008805998","https://openalex.org/W2009126904","https://openalex.org/W2022676255","https://openalex.org/W2024522655","https://openalex.org/W2024629474","https://openalex.org/W2032456325","https://openalex.org/W2038706336","https://openalex.org/W2042381594","https://openalex.org/W2044894672","https://openalex.org/W2048899027","https://openalex.org/W2058804806","https://openalex.org/W2067089828","https://openalex.org/W2067539811","https://openalex.org/W2069259177","https://openalex.org/W2076846369","https://openalex.org/W2077576735","https://openalex.org/W2078052996","https://openalex.org/W2082508806","https://openalex.org/W2091015159","https://openalex.org/W2091080946","https://openalex.org/W2095786854","https://openalex.org/W2105711870","https://openalex.org/W2106937178","https://openalex.org/W2116015900","https://openalex.org/W2117617326","https://openalex.org/W2118676558","https://openalex.org/W2127791131","https://openalex.org/W2134306662","https://openalex.org/W2135503869","https://openalex.org/W2138408411","https://openalex.org/W2141137906","https://openalex.org/W2141428393","https://openalex.org/W2143741651","https://openalex.org/W2143975632","https://openalex.org/W2149487645","https://openalex.org/W2156718297","https://openalex.org/W2158686289","https://openalex.org/W2162023168","https://openalex.org/W2247997571","https://openalex.org/W2324770997","https://openalex.org/W2413545111","https://openalex.org/W2548661231","https://openalex.org/W4210953165","https://openalex.org/W6650244853"],"related_works":["https://openalex.org/W4312835056","https://openalex.org/W3041635484","https://openalex.org/W2408954029","https://openalex.org/W2095786854","https://openalex.org/W2757794608","https://openalex.org/W6902894639","https://openalex.org/W1944135887","https://openalex.org/W4390889569","https://openalex.org/W4387270331","https://openalex.org/W2761312904"],"abstract_inverted_index":{"Humans":[0],"and":[1,16,19,24,90,129,137],"mice":[2,63,84],"lacking":[3],"angiopoietin-like":[4],"protein":[5],"3":[6],"(ANGPTL3)":[7],"have":[8],"pan-hypolipidemia.":[9],"ANGPTL3":[10,28,46,61,149],"inhibits":[11],"two":[12],"intravascular":[13],"lipases,":[14],"LPL":[15],"endothelial":[17],"lipase,":[18],"the":[20,40,153,160,164,177],"low":[21,41],"plasma":[22,80],"TG":[23,124],"HDL-cholesterol":[25],"levels":[26,43,82],"in":[27,62,67,71,83,85,96,113,120,135,190,195],"deficiency":[29,47],"reflect":[30],"increased":[31,184],"activity":[32],"of":[33,73,103,148,155,186,193],"these":[34],"enzymes.":[35],"The":[36,183],"mechanism":[37],"responsible":[38],"for":[39],"LDL-cholesterol":[42],"associated":[44],"with":[45,64],"is":[48],"not":[49,100,151],"known.":[50],"Here":[51],"we":[52],"used":[53],"an":[54],"anti-ANGPTL3":[55],"monoclonal":[56],"antibody":[57],"(REGN1500)":[58],"to":[59],"inactivate":[60],"genetic":[65],"deficiencies":[66],"key":[68],"proteins":[69],"involved":[70],"clearance":[72,102,185],"ApoB-containing":[74,156],"lipoproteins.":[75],"REGN1500":[76,136],"treatment":[77],"consistently":[78],"reduced":[79],"cholesterol":[81],"which":[86],"Apoe,":[87],"Ldlr,":[88],"Lrp1,":[89],"Sdc1":[91],"were":[92,133],"inactivated":[93],"singly":[94],"or":[95,106],"combination,":[97],"but":[98,162],"did":[99],"alter":[101],"rabbit":[104],"(125)I-\u03b2VLDL":[105],"mouse":[107],"(125)I-LDL.":[108],"Despite":[109],"a":[110,180],"61%":[111],"reduction":[112],"VLDL-TG":[114],"production,":[115],"VLDL-ApoB-100":[116],"production":[117,192],"was":[118],"unchanged":[119],"REGN1500-treated":[121],"animals.":[122,140,197],"Hepatic":[123],"content,":[125],"fatty":[126,130],"acid":[127,131],"synthesis,":[128],"oxidation":[132],"similar":[134],"control":[138],"antibody-treated":[139],"Taken":[141],"together,":[142],"our":[143],"findings":[144],"indicate":[145],"that":[146,166,170],"inactivation":[147],"does":[150],"affect":[152],"number":[154],"lipoproteins":[157],"secreted":[158],"by":[159],"liver":[161],"alters":[163],"particles":[165],"are":[167,172],"made":[168],"such":[169],"they":[171],"cleared":[173],"more":[174],"rapidly":[175],"from":[176],"circulation":[178],"via":[179],"noncanonical":[181],"pathway(s).":[182],"lipolytic":[187],"remnants":[188],"results":[189],"decreased":[191],"LDL":[194],"ANGPTL3-deficient":[196]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}