{"id":"https://openalex.org/W2165153403","doi":null,"title":"Review: Mouse models of inflammatory bowel disease--insights into the mechanisms of inflammation-associated colorectal cancer.","display_name":"Review: Mouse models of inflammatory bowel disease--insights into the mechanisms of inflammation-associated colorectal cancer.","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2165153403","mag":"2165153403","pmid":"https://pubmed.ncbi.nlm.nih.gov/22773577"},"language":"en","primary_location":{"id":"pmid:22773577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22773577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008816371","display_name":"Dessislava N. Mladenova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136750679","display_name":"Garvan Institute of Medical Research","ror":"https://ror.org/01b3dvp57","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I136750679","https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Dessislava Mladenova","raw_affiliation_strings":["Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia","institution_ids":["https://openalex.org/I136750679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033797872","display_name":"Maija R.J. Kohonen\u2010Corish","orcid":"https://orcid.org/0000-0002-4073-1479","observed_orcids":["https://orcid.org/0000-0002-4073-1479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maija R J Kohonen-Corish","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8436,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.93115767,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"26","issue":"4","first_page":"627","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7129999995231628},{"id":"https://openalex.org/keywords/inflammation-associated-colorectal-cancer","display_name":"inflammation-associated colorectal cancer","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.6179999709129333},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9340000152587891},{"id":"https://openalex.org/keywords/colonic-epithelium","display_name":"colonic epithelium","score":0.8849999904632568},{"id":"https://openalex.org/keywords/intestinal-homeostasis","display_name":"intestinal homeostasis","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.819520115852356},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.7390736937522888},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6974098682403564},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6494329571723938},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6382244229316711},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5657231211662292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.540519118309021},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5356632471084595},{"id":"https://openalex.org/C111669997","wikidata":"https://www.wikidata.org/wiki/Q17163050","display_name":"Mouse model of colorectal and intestinal cancer","level":4,"score":0.5322149991989136},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.49958062171936035},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.4725634455680847},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.43064045906066895},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.351471483707428},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33290529251098633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3005390763282776},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.2506864666938782},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1729714572429657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1394176483154297}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22773577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22773577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"},{"id":"mag:2165153403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22773577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":209,"referenced_works":["https://openalex.org/W31519572","https://openalex.org/W113049030","https://openalex.org/W129664390","https://openalex.org/W178917835","https://openalex.org/W1496904177","https://openalex.org/W1511170374","https://openalex.org/W1515667338","https://openalex.org/W1531940878","https://openalex.org/W1533826708","https://openalex.org/W1570890934","https://openalex.org/W1579447084","https://openalex.org/W1607565295","https://openalex.org/W1640213901","https://openalex.org/W1811418524","https://openalex.org/W1845975704","https://openalex.org/W1855226200","https://openalex.org/W1902385211","https://openalex.org/W1906027219","https://openalex.org/W1954263225","https://openalex.org/W1962044813","https://openalex.org/W1964233303","https://openalex.org/W1964977785","https://openalex.org/W1965034702","https://openalex.org/W1965171188","https://openalex.org/W1967217097","https://openalex.org/W1967470099","https://openalex.org/W1969980017","https://openalex.org/W1970336778","https://openalex.org/W1970971661","https://openalex.org/W1972473113","https://openalex.org/W1973720695","https://openalex.org/W1974066136","https://openalex.org/W1978307333","https://openalex.org/W1978862810","https://openalex.org/W1982245720","https://openalex.org/W1982920345","https://openalex.org/W1984127959","https://openalex.org/W1985929046","https://openalex.org/W1986242902","https://openalex.org/W1988139137","https://openalex.org/W1988924112","https://openalex.org/W1989538067","https://openalex.org/W1990955264","https://openalex.org/W1992465269","https://openalex.org/W1993426597","https://openalex.org/W1995806548","https://openalex.org/W1996139830","https://openalex.org/W1996642861","https://openalex.org/W1996652335","https://openalex.org/W1998990856","https://openalex.org/W1999855196","https://openalex.org/W2000208875","https://openalex.org/W2002061924","https://openalex.org/W2002765518","https://openalex.org/W2004536682","https://openalex.org/W2004773897","https://openalex.org/W2005539293","https://openalex.org/W2007006826","https://openalex.org/W2008631743","https://openalex.org/W2009093325","https://openalex.org/W2011810742","https://openalex.org/W2011846070","https://openalex.org/W2012528572","https://openalex.org/W2013155982","https://openalex.org/W2014254878","https://openalex.org/W2015336843","https://openalex.org/W2016098250","https://openalex.org/W2018075167","https://openalex.org/W2018620221","https://openalex.org/W2018782206","https://openalex.org/W2018815492","https://openalex.org/W2019497869","https://openalex.org/W2020098501","https://openalex.org/W2020809562","https://openalex.org/W2021694662","https://openalex.org/W2021999210","https://openalex.org/W2023865737","https://openalex.org/W2025065287","https://openalex.org/W2025114863","https://openalex.org/W2026161448","https://openalex.org/W2026428548","https://openalex.org/W2027586189","https://openalex.org/W2032730667","https://openalex.org/W2034478850","https://openalex.org/W2034498760","https://openalex.org/W2036500213","https://openalex.org/W2040601022","https://openalex.org/W2041136224","https://openalex.org/W2041263849","https://openalex.org/W2041289222","https://openalex.org/W2041769554","https://openalex.org/W2041838266","https://openalex.org/W2042149293","https://openalex.org/W2044069347","https://openalex.org/W2044593828","https://openalex.org/W2045608427","https://openalex.org/W2045773854","https://openalex.org/W2047208232","https://openalex.org/W2047595952","https://openalex.org/W2049491375","https://openalex.org/W2050706371","https://openalex.org/W2052313621","https://openalex.org/W2052386537","https://openalex.org/W2052895824","https://openalex.org/W2054975808","https://openalex.org/W2055728853","https://openalex.org/W2057198053","https://openalex.org/W2058590329","https://openalex.org/W2061264646","https://openalex.org/W2061577358","https://openalex.org/W2063270450","https://openalex.org/W2063407488","https://openalex.org/W2063784028","https://openalex.org/W2066300320","https://openalex.org/W2068451393","https://openalex.org/W2068639447","https://openalex.org/W2071895328","https://openalex.org/W2074003071","https://openalex.org/W2074279306","https://openalex.org/W2075994961","https://openalex.org/W2076808345","https://openalex.org/W2078416432","https://openalex.org/W2079046187","https://openalex.org/W2079968415","https://openalex.org/W2081018709","https://openalex.org/W2082626794","https://openalex.org/W2083089709","https://openalex.org/W2083759302","https://openalex.org/W2084150021","https://openalex.org/W2085176939","https://openalex.org/W2085852125","https://openalex.org/W2089141914","https://openalex.org/W2089714303","https://openalex.org/W2093293871","https://openalex.org/W2093491412","https://openalex.org/W2094390470","https://openalex.org/W2095083228","https://openalex.org/W2095164057","https://openalex.org/W2100942351","https://openalex.org/W2101229561","https://openalex.org/W2102058303","https://openalex.org/W2103109433","https://openalex.org/W2103357560","https://openalex.org/W2104525140","https://openalex.org/W2104855101","https://openalex.org/W2105401596","https://openalex.org/W2108778111","https://openalex.org/W2108780695","https://openalex.org/W2110235509","https://openalex.org/W2110333077","https://openalex.org/W2110339407","https://openalex.org/W2110567472","https://openalex.org/W2111165032","https://openalex.org/W2111791268","https://openalex.org/W2113822705","https://openalex.org/W2115944543","https://openalex.org/W2116432220","https://openalex.org/W2118983602","https://openalex.org/W2119218139","https://openalex.org/W2120147264","https://openalex.org/W2121470572","https://openalex.org/W2122621644","https://openalex.org/W2122994808","https://openalex.org/W2124076790","https://openalex.org/W2127533496","https://openalex.org/W2127568565","https://openalex.org/W2127689078","https://openalex.org/W2128736190","https://openalex.org/W2130219349","https://openalex.org/W2130365699","https://openalex.org/W2131474316","https://openalex.org/W2131885678","https://openalex.org/W2133938746","https://openalex.org/W2134053452","https://openalex.org/W2134373120","https://openalex.org/W2135245523","https://openalex.org/W2136552678","https://openalex.org/W2136662222","https://openalex.org/W2137257146","https://openalex.org/W2137561439","https://openalex.org/W2139533724","https://openalex.org/W2140594539","https://openalex.org/W2143762235","https://openalex.org/W2145189896","https://openalex.org/W2148183280","https://openalex.org/W2148521032","https://openalex.org/W2149472502","https://openalex.org/W2149645123","https://openalex.org/W2149779130","https://openalex.org/W2149932234","https://openalex.org/W2150942684","https://openalex.org/W2151593963","https://openalex.org/W2152808619","https://openalex.org/W2153283433","https://openalex.org/W2155395286","https://openalex.org/W2155779547","https://openalex.org/W2157052021","https://openalex.org/W2157310133","https://openalex.org/W2157503717","https://openalex.org/W2159407688","https://openalex.org/W2162121911","https://openalex.org/W2166281548","https://openalex.org/W2166311080","https://openalex.org/W2167927725","https://openalex.org/W2171831396","https://openalex.org/W2171888610","https://openalex.org/W2171945667","https://openalex.org/W2171980652","https://openalex.org/W2396365631"],"related_works":["https://openalex.org/W3214026708","https://openalex.org/W2103186110","https://openalex.org/W2030589675","https://openalex.org/W2088183990","https://openalex.org/W2090259800","https://openalex.org/W1986406665","https://openalex.org/W2763151664","https://openalex.org/W2519989957","https://openalex.org/W3130378393","https://openalex.org/W1995494073"],"abstract_inverted_index":{"The":[0,32],"association":[1],"between":[2,43],"chronic":[3],"inflammation":[4,27],"and":[5,23,51,82,99],"cancer":[6,21,92],"has":[7],"been":[8],"noted":[9],"for":[10,61],"at":[11],"least":[12],"a":[13,36,41,52],"century":[14],"but":[15],"the":[16,44,48,56,63,69,74,97],"exact":[17],"molecular":[18],"mechanisms":[19],"of":[20,68,73,96],"initiation":[22],"promotion":[24],"by":[25],"such":[26],"are":[28],"still":[29],"poorly":[30],"understood.":[31],"gastrointestinal":[33],"tract":[34],"is":[35,59],"unique":[37],"organ":[38],"where":[39],"maintaining":[40],"balance":[42],"colonic":[45],"epithelial":[46],"cells,":[47],"immune":[49],"system":[50],"fine-tuned":[53],"response":[54],"to":[55,78],"resident":[57],"microflora":[58],"crucial":[60],"preserving":[62],"gut":[64],"homeostasis.":[65],"A":[66],"breakdown":[67],"tight":[70],"interdependent":[71],"regulation":[72],"epithelium-immunity-microbiota":[75],"triangle":[76],"leads":[77],"inflammatory":[79],"bowel":[80],"disorders":[81],"may":[83],"promote":[84],"cancer.":[85],"This":[86],"review":[87],"focuses":[88],"on":[89],"inflammation-associated":[90],"colorectal":[91],"in":[93],"mouse":[94],"models":[95],"disease":[98],"highlights":[100],"emerging":[101],"research":[102],"trends.":[103]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
