{"id":"https://openalex.org/W2165118740","doi":"https://doi.org/10.1016/s0021-9258(17)32985-x","title":"Time-dependent changes in Dictyostelium discoideum adenylate cyclase activity upon incubation with ATP.","display_name":"Time-dependent changes in Dictyostelium discoideum adenylate cyclase activity upon incubation with ATP.","publication_year":1976,"publication_date":"1976-11-01","ids":{"openalex":"https://openalex.org/W2165118740","doi":"https://doi.org/10.1016/s0021-9258(17)32985-x","mag":"2165118740","pmid":"https://pubmed.ncbi.nlm.nih.gov/988025"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)32985-x","doi":"https://doi.org/10.1016/s0021-9258(17)32985-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)32985-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)32985-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113967263","display_name":"EdwardF Rossomando","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E F Rossomando","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064999431","display_name":"Mary Ann Hesla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Hesla","raw_affiliation_strings":["From the Department of Oral Biology, The University of Connecticut Health Center, Farmington, Connecticut 06032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Oral Biology, The University of Connecticut Health Center, Farmington, Connecticut 06032","institution_ids":["https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5512,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81449233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"251","issue":"21","first_page":"6568","last_page":"6573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.3937999904155731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.3937999904155731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.25929999351501465,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.16349999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dictyostelium-discoideum","display_name":"Dictyostelium discoideum","score":0.9860000014305115},{"id":"https://openalex.org/keywords/amp-atp-ratio","display_name":"AMP/ATP ratio","score":0.8980000019073486},{"id":"https://openalex.org/keywords/5-nucleotidase","display_name":"5'-nucleotidase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/enzyme-inactivation","display_name":"enzyme inactivation","score":0.47200000286102295},{"id":"https://openalex.org/keywords/enzyme-recovery","display_name":"enzyme recovery","score":0.6389999985694885},{"id":"https://openalex.org/keywords/covalent-modification","display_name":"covalent modification","score":0.7120000123977661},{"id":"https://openalex.org/keywords/adenosine-analogues","display_name":"adenosine analogues","score":0.5519999861717224},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2775969001","wikidata":"https://www.wikidata.org/wiki/Q134351","display_name":"Dictyostelium discoideum","level":3,"score":0.9709701538085938},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.9309462308883667},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.7938764095306396},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.7700212001800537},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5153902769088745},{"id":"https://openalex.org/C2775889303","wikidata":"https://www.wikidata.org/wiki/Q17146891","display_name":"Dictyostelium","level":3,"score":0.47954225540161133},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4533871114253998},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3921108841896057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3199464678764343},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30044984817504883},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07090002298355103}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004023","descriptor_name":"Dictyostelium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009235","descriptor_name":"Myxomycetes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)32985-x","doi":"https://doi.org/10.1016/s0021-9258(17)32985-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)32985-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:988025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/988025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)32985-x","doi":"https://doi.org/10.1016/s0021-9258(17)32985-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)32985-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W28588250","https://openalex.org/W186392394","https://openalex.org/W1497393043","https://openalex.org/W1507593876","https://openalex.org/W1512655668","https://openalex.org/W1531386924","https://openalex.org/W1531829990","https://openalex.org/W1533618603","https://openalex.org/W1562597048","https://openalex.org/W1573331976","https://openalex.org/W1584357038","https://openalex.org/W1606477260","https://openalex.org/W1608221212","https://openalex.org/W1863678882","https://openalex.org/W1970503891","https://openalex.org/W1976079166","https://openalex.org/W2014672873","https://openalex.org/W2026162636","https://openalex.org/W2039413243","https://openalex.org/W2048078487","https://openalex.org/W2116200052","https://openalex.org/W2133932436"],"related_works":["https://openalex.org/W1976079166","https://openalex.org/W2091915897","https://openalex.org/W2071621304","https://openalex.org/W4232442067","https://openalex.org/W1987362275","https://openalex.org/W2034409252","https://openalex.org/W297106901","https://openalex.org/W7823589","https://openalex.org/W72540155","https://openalex.org/W2085041380"],"abstract_inverted_index":{"In":[0],"this":[1,32,47,69],"study":[2],"we":[3,114],"report":[4],"that":[5,31,72,116,171,201,212,238,257],"preincubation":[6,59],"of":[7,27,38,42,46,64,76,84,129,139,142,157,174,184,193,222,229,232,241,249],"Dictyostelium":[8],"discoideum":[9],"membrane-bound":[10,186],"adenylate":[11,159,202],"cyclase":[12,160,194,203,214,250,262],"with":[13],"ATP":[14,77,236,242,265],"over":[15],"the":[16,43,80,105,127,158,172,177,185,191,208,213,220,227,230,261],"concentration":[17],"range":[18],"0.5":[19],"to":[20,57,164,176,207],"100":[21],"mM":[22,53],"results":[23,60,133,197],"in":[24,61,101,137],"a":[25,55,119,153,246],"loss":[26,63,83,128,192,231],"catalytic":[28,85,130],"activity":[29,86,204,215,233,251],"and":[30,111,126,243],"effect":[33,48,70],"persists":[34],"even":[35],"after":[36],"removal":[37,183,240],"ATP.":[39],"An":[40],"analysis":[41],"time":[44],"course":[45],"shows":[49],"that,":[50],"at":[51],"25":[52],"ATP,":[54],"5-":[56],"10-min":[58],"50%":[62],"activity.":[65,131,195,224],"Additional":[66,168],"studies":[67,169],"on":[68,226],"showed":[71],"anhydride":[73],"bond":[74,124],"cleavage":[75,125],"occurs":[78],"during":[79],"preincubation.":[81],"However,":[82],"is":[87,118,205,252,266],"not":[88,199],"porduced":[89],"by":[90,219,235,264],"ADP,":[91],"AMP,":[92],"cAMP,":[93],"adenosine,":[94],"pyrophosphate,":[95],"or":[96,100,150],"phosphate":[97],"either":[98,145],"separately":[99],"pairs.":[102],"Further,":[103],"using":[104],"structural":[106],"analogs":[107],"adenosine":[108],"5'-(alpha,":[109],"beta-methylene)triphosphate":[110],"adenyl-5'-yl":[112],"imidodiphosphonate,":[113],"show":[115,170,237],"there":[117],"direct":[120],"correlation":[121],"between":[122],"alpha-beta-phosphoanhydride":[123],"These":[132,196],"can":[134,189,216],"be":[135,217],"interpreted":[136],"terms":[138],"two":[140],"classes":[141],"reaction":[143,178],"mechanisms:":[144],"those":[146,151],"involving":[147,152],"covalent":[148],"modifications":[149],"ligand-induced":[154],"slow":[155],"conversion":[156],"from":[161],"an":[162,165],"active":[163],"inactive":[166],"form.":[167],"addition":[173],"AMP":[175],"mixture,":[179],"as":[180,182],"well":[181],"5'-nucleotidase":[187,223],"activity,":[188],"prevent":[190],"suggest":[198],"only":[200],"related":[206],"AMP:ATP":[209],"ratio":[210],"but":[211],"modified":[218],"level":[221],"Studies":[225],"duration":[228],"produced":[234],"following":[239],"additional":[244],"incubation,":[245],"gradual":[247],"recovery":[248],"observed.":[253],"This":[254],"result":[255],"suggests":[256],"under":[258],"appropriate":[259],"conditions":[260],"inactivation":[263],"reversible.":[267]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
