{"id":"https://openalex.org/W2165098644","doi":"https://doi.org/10.1002/bit.260331111","title":"Media and environmental effects on phenolics production from tobacco cell cultures","display_name":"Media and environmental effects on phenolics production from tobacco cell cultures","publication_year":1989,"publication_date":"1989-05-01","ids":{"openalex":"https://openalex.org/W2165098644","doi":"https://doi.org/10.1002/bit.260331111","mag":"2165098644","pmid":"https://pubmed.ncbi.nlm.nih.gov/18587884"},"language":"en","primary_location":{"id":"doi:10.1002/bit.260331111","doi":"https://doi.org/10.1002/bit.260331111","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bit.260331111","pdf_url":null,"source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Andrew J. Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Schmidt","raw_affiliation_strings":["Department of Chemical Engineering, Washington State University, Pullman, Washington 99164, USA","Department of Chemical Engineering, Washington State University, Pullman, Washington 99164"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Washington State University, Pullman, Washington 99164, USA","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"Department of Chemical Engineering, Washington State University, Pullman, Washington 99164","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110270330","display_name":"James M. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James M. Lee","raw_affiliation_strings":["Department of Chemical Engineering, Washington State University, Pullman, Washington 99164"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Washington State University, Pullman, Washington 99164","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089189706","display_name":"Gynheung An","orcid":"https://orcid.org/0000-0002-8570-7587","observed_orcids":["https://orcid.org/0000-0002-8570-7587"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gynheung An","raw_affiliation_strings":["Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110270330"],"corresponding_institution_ids":["https://openalex.org/I72951846"],"apc_list":{"value":5060,"currency":"USD","value_usd":5060},"apc_paid":null,"fwci":3.0383,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.90034203,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"33","issue":"11","first_page":"1437","last_page":"1444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tobacco-cell-culture","display_name":"tobacco cell culture","score":0.8460000157356262},{"id":"https://openalex.org/keywords/immobilized-cells","display_name":"immobilized cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/culture-medium-composition","display_name":"culture medium composition","score":0.6499999761581421},{"id":"https://openalex.org/keywords/sucrose-content","display_name":"sucrose concentration","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dimethyl-sulfoxide","display_name":"dimethyl sulfoxide","score":0.8450000286102295},{"id":"https://openalex.org/keywords/oxygen-aeration","display_name":"oxygen aeration","score":0.7519999742507935},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.8370000123977661},{"id":"https://openalex.org/keywords/bioprocess-productivity","display_name":"bioprocess productivity","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C86922832","wikidata":"https://www.wikidata.org/wiki/Q381105","display_name":"Aeration","level":2,"score":0.7165358066558838},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.7077920436859131},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.679798424243927},{"id":"https://openalex.org/C172331833","wikidata":"https://www.wikidata.org/wiki/Q751029","display_name":"Packed bed","level":2,"score":0.6370471119880676},{"id":"https://openalex.org/C2778597767","wikidata":"https://www.wikidata.org/wiki/Q4027534","display_name":"Sucrose","level":2,"score":0.5858464241027832},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5601856708526611},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4507770240306854},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4397090673446655},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3619508445262909},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.322498083114624},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29853272438049316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22789430618286133},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09907951951026917},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/bit.260331111","doi":"https://doi.org/10.1002/bit.260331111","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bit.260331111","pdf_url":null,"source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},{"id":"pmid:18587884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18587884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and bioengineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W179424767","https://openalex.org/W1548864917","https://openalex.org/W1967118561","https://openalex.org/W1986991246","https://openalex.org/W1993768288","https://openalex.org/W2000625981","https://openalex.org/W2007147222","https://openalex.org/W2028883398","https://openalex.org/W2033266444","https://openalex.org/W2041648737","https://openalex.org/W2045953000","https://openalex.org/W2047955176","https://openalex.org/W2077899736","https://openalex.org/W2079292675","https://openalex.org/W2081590042","https://openalex.org/W2082607554","https://openalex.org/W2089126923","https://openalex.org/W2114004260","https://openalex.org/W2127056047","https://openalex.org/W2168863084"],"related_works":["https://openalex.org/W2051442620","https://openalex.org/W2045953000","https://openalex.org/W2067604869","https://openalex.org/W1986991246","https://openalex.org/W2495155495","https://openalex.org/W4400928578","https://openalex.org/W2040263574","https://openalex.org/W4416225417","https://openalex.org/W2051218858","https://openalex.org/W2042568599"],"abstract_inverted_index":{"The":[0],"effects":[1],"of":[2,35,58,72,96,100],"various":[3],"factors":[4],"in":[5,47,54,87,157,169],"culture":[6,77],"medium":[7,31,49,78],"on":[8],"the":[9,26,30,33,48,59,68,101,121,135],"phenolics":[10,36,60,81],"production":[11],"from":[12,29],"cultured":[13],"tobacco":[14],"cells":[15,103,155],"(free":[16],"and":[17,40,52,90,143],"immobilized)":[18],"were":[19],"studied.":[20],"It":[21,123],"was":[22,104,110,124,130],"found":[23,125],"that":[24,126,167],"removing":[25],"growth":[27,51],"hormone":[28],"increased":[32,80],"productivities":[34,57,82,163],"for":[37,61,67,106,140],"both":[38,88],"free":[39,89],"immobilized":[41,69,91,102],"cultures.":[42,93],"Low":[43],"initial":[44],"sucrose":[45],"concentration":[46],"restricted":[50],"resulted":[53],"high":[55,151],"cellular":[56],"freely":[62],"suspended":[63],"cells,":[64],"but":[65],"not":[66],"cells.":[70],"Addition":[71],"1.4%":[73],"DMSO":[74],"to":[75],"standard":[76],"greatly":[79],"without":[83],"affecting":[84],"cell":[85,92,128],"viability":[86,129],"Continuous":[94],"operation":[95],"a":[97,150,158],"packed-column":[98],"reactor":[99,136,161],"achieved":[105,162,168],"500":[107],"hours.":[108],"Aeration":[109],"accomplished":[111],"by":[112],"diffusing":[113],"pure":[114],"oxygen":[115],"through":[116],"silicone":[117],"tubing":[118],"placed":[119],"inside":[120],"reactor.":[122],"prolonged":[127],"contingent":[131],"upon":[132],"initially":[133],"operating":[134],"with":[137],"total":[138],"recycle":[139,152],"several":[141],"days,":[142],"then":[144],"introducing":[145],"fresh":[146],"feed":[147],"while":[148],"maintaining":[149],"rate.":[153],"Immobilized":[154],"packed":[156],"continuous":[159],"column":[160],"more":[164],"than":[165],"twice":[166],"any":[170],"batch":[171],"run.":[172]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}