{"id":"https://openalex.org/W2165083157","doi":"https://doi.org/10.4137/bic.s25248","title":"BRAF Mutation in Colorectal Cancer: An Update","display_name":"BRAF Mutation in Colorectal Cancer: An Update","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2165083157","doi":"https://doi.org/10.4137/bic.s25248","mag":"2165083157","pmid":"https://pubmed.ncbi.nlm.nih.gov/26396549","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4562608"},"language":"en","primary_location":{"id":"doi:10.4137/bic.s25248","doi":"https://doi.org/10.4137/bic.s25248","is_oa":true,"landing_page_url":"https://doi.org/10.4137/bic.s25248","pdf_url":null,"source":{"id":"https://openalex.org/S4210234771","display_name":"Biomarkers in Cancer","issn_l":"1179-299X","issn":["1179-299X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers in Cancer","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4137/bic.s25248","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087615913","display_name":"David Barras","orcid":"https://orcid.org/0000-0001-8985-4704","observed_orcids":["https://orcid.org/0000-0001-8985-4704"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"David Barras","raw_affiliation_strings":["SIB Swiss Institute of Bioinformatics, Bioinformatics Core Facility, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Bioinformatics Core Facility, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087615913"],"corresponding_institution_ids":["https://openalex.org/I12708293"],"apc_list":null,"apc_paid":null,"fwci":2.1898,"has_fulltext":false,"cited_by_count":147,"citation_normalized_percentile":{"value":0.90825472,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"7s1","issue":"Suppl 1","first_page":"BIC.S25248","last_page":"BIC.S25248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9169999957084656},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/braf-inhibitors","display_name":"BRAF inhibitors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7289999723434448},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7750895023345947},{"id":"https://openalex.org/C2776470698","wikidata":"https://www.wikidata.org/wiki/Q21851559","display_name":"V600E","level":4,"score":0.7190978527069092},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6601282954216003},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6471192836761475},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6276136040687561},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5850631594657898},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.570025622844696},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.4973466694355011},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4933389723300934},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48198503255844116},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3829194903373718},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34416744112968445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3013751208782196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2962988018989563},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19256961345672607},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.171662837266922},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.0994977355003357}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.4137/bic.s25248","doi":"https://doi.org/10.4137/bic.s25248","is_oa":true,"landing_page_url":"https://doi.org/10.4137/bic.s25248","pdf_url":null,"source":{"id":"https://openalex.org/S4210234771","display_name":"Biomarkers in Cancer","issn_l":"1179-299X","issn":["1179-299X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers in Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3551519","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4562608","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4562608","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4562608","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomark Cancer","raw_type":"Text"},{"id":"pmid:26396549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26396549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers in cancer","raw_type":"Journal Article"},{"id":"pmh:oai:libertasacademica.com/5051","doi":null,"is_oa":false,"landing_page_url":"http://insights.sagepub.com/redirect_file.php?fileId=6760&amp;filename=5051-BIC-BRAF-Mutation-in-Colorectal-Cancer:-An-Update\\n.pdf&amp;fileType=pdf","pdf_url":"http://insights.sagepub.com/redirect_file.php?fileId=6760&amp;filename=5051-BIC-BRAF-Mutation-in-Colorectal-Cancer:-An-Update\\n.pdf&amp;fileType=pdf","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://insights.sagepub.com/braf-mutation-in-colorectal-cancer-an-update-article-a5051","raw_type":null},{"id":"pmh:oai:doaj.org/article:57b4929a84ff49b4bcab27070a9296c8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/57b4929a84ff49b4bcab27070a9296c8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomarkers in Cancer, Vol 7s1 (2015)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:58116618a8c044a3b20fa22c12284f8c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/58116618a8c044a3b20fa22c12284f8c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomarkers in Cancer, Vol 2015, Iss Suppl. 1, Pp 9-12 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4137/bic.s25248","doi":"https://doi.org/10.4137/bic.s25248","is_oa":true,"landing_page_url":"https://doi.org/10.4137/bic.s25248","pdf_url":null,"source":{"id":"https://openalex.org/S4210234771","display_name":"Biomarkers in Cancer","issn_l":"1179-299X","issn":["1179-299X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers in Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W658517828","https://openalex.org/W1542666708","https://openalex.org/W1727309928","https://openalex.org/W1755477811","https://openalex.org/W1888056807","https://openalex.org/W1965370740","https://openalex.org/W1967410077","https://openalex.org/W1981284988","https://openalex.org/W1985199765","https://openalex.org/W1990376228","https://openalex.org/W2000581759","https://openalex.org/W2010873488","https://openalex.org/W2014881369","https://openalex.org/W2024067967","https://openalex.org/W2027902974","https://openalex.org/W2054946171","https://openalex.org/W2058390096","https://openalex.org/W2074768718","https://openalex.org/W2075253853","https://openalex.org/W2091723114","https://openalex.org/W2096387850","https://openalex.org/W2105660237","https://openalex.org/W2106543129","https://openalex.org/W2106787323","https://openalex.org/W2110682589","https://openalex.org/W2113029107","https://openalex.org/W2124003081","https://openalex.org/W2130921932","https://openalex.org/W2133523341","https://openalex.org/W2141172646","https://openalex.org/W2144026118","https://openalex.org/W2146737519","https://openalex.org/W2147001311","https://openalex.org/W2149528253","https://openalex.org/W2152435104","https://openalex.org/W2157049259","https://openalex.org/W2163188200","https://openalex.org/W4250745281"],"related_works":["https://openalex.org/W7098187334","https://openalex.org/W2606849884","https://openalex.org/W2194514412","https://openalex.org/W2144879635","https://openalex.org/W2951034455","https://openalex.org/W2087847384","https://openalex.org/W1988531223","https://openalex.org/W3107063879","https://openalex.org/W2933818151","https://openalex.org/W2313037686"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1,109],"(CRC)":[2],"is":[3,41],"still":[4],"one":[5],"of":[6,13,48,67,82,124],"the":[7,22,35,65,68,80,107,125],"deadliest":[8],"cancer-related":[9],"diseases.":[10],"About":[11],"10%":[12],"CRC":[14],"patients":[15,63,77,95],"are":[16],"characterized":[17],"by":[18],"a":[19,31],"mutation":[20,40,127],"in":[21,30,44,129],"B-Raf":[23],"proto-oncogene":[24],"serine/threonine":[25],"kinase":[26,88],"(BRAF)":[27],"gene":[28],"resulting":[29],"valine-to-glutamate":[32],"change":[33],"at":[34,64,114],"residue":[36],"600":[37],"(V600E).":[38],"This":[39,111],"also":[42],"present":[43],"more":[45],"than":[46],"60%":[47],"melanoma":[49],"patients.":[50],"BRAF":[51,83,126],"inhibitors":[52,84],"were":[53],"developed":[54],"and":[55],"found":[56],"to":[57,73],"improve":[58,121],"patient":[59],"survival;":[60],"however,":[61],"most":[62],"end":[66],"track":[69],"ultimately":[70],"develop":[71],"resistance":[72,104],"these":[74],"inhibitors.":[75],"Melanoma":[76],"benefit":[78],"from":[79],"combination":[81],"with":[85],"mitogen/extracellular":[86],"signal-regulated":[87],"(MEK)":[89],"inhibitors,":[90],"among":[91],"others.":[92],"Unfortunately,":[93],"colorectal":[94],"do":[96],"not":[97],"respond":[98],"much":[99],"efficiently,":[100],"which":[101],"suggests":[102],"different":[103],"mechanisms":[105],"between":[106],"two":[108],"types.":[110],"review":[112],"aims":[113],"shedding":[115],"light":[116],"on":[117],"recent":[118],"discoveries":[119],"that":[120],"our":[122],"understanding":[123],"biology":[128],"CRC.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
