{"id":"https://openalex.org/W2165077166","doi":"https://doi.org/10.1182/blood-2003-06-1789","title":"Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia","display_name":"Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia","publication_year":2003,"publication_date":"2003-07-22","ids":{"openalex":"https://openalex.org/W2165077166","doi":"https://doi.org/10.1182/blood-2003-06-1789","mag":"2165077166","pmid":"https://pubmed.ncbi.nlm.nih.gov/12869495"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2003-06-1789","doi":"https://doi.org/10.1182/blood-2003-06-1789","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2003-06-1789","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001640507","display_name":"Bryce A. Kerlin","orcid":"https://orcid.org/0000-0002-1756-8271","observed_orcids":["https://orcid.org/0000-0002-1756-8271"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Bryce A. Kerlin","raw_affiliation_strings":["From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France","institution_ids":["https://openalex.org/I168537998","https://openalex.org/I204308271","https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210141964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111669144","display_name":"Sau-Chi Betty Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"S. Betty Yan","raw_affiliation_strings":["From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France","institution_ids":["https://openalex.org/I168537998","https://openalex.org/I204308271","https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210141964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086990440","display_name":"Berend Isermann","orcid":"https://orcid.org/0000-0003-0714-6160","observed_orcids":["https://orcid.org/0000-0003-0714-6160"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Berend H. Isermann","raw_affiliation_strings":["From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France","institution_ids":["https://openalex.org/I168537998","https://openalex.org/I204308271","https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210141964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109951394","display_name":"John T. Brandt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"John T. Brandt","raw_affiliation_strings":["From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France","institution_ids":["https://openalex.org/I168537998","https://openalex.org/I204308271","https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210141964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031137294","display_name":"Rashmi Sood","orcid":"https://orcid.org/0000-0002-4523-9512","observed_orcids":["https://orcid.org/0000-0002-4523-9512"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Rashmi Sood","raw_affiliation_strings":["From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France","institution_ids":["https://openalex.org/I168537998","https://openalex.org/I204308271","https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210141964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050840013","display_name":"Bruce R. Basson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Bruce R. Basson","raw_affiliation_strings":["From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France","institution_ids":["https://openalex.org/I168537998","https://openalex.org/I204308271","https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210141964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082694590","display_name":"David E. Joyce","orcid":"https://orcid.org/0009-0002-5054-3794","observed_orcids":["https://orcid.org/0009-0002-5054-3794"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"David E. Joyce","raw_affiliation_strings":["From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France","institution_ids":["https://openalex.org/I168537998","https://openalex.org/I204308271","https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210141964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058688387","display_name":"Hartmut Weiler-Guettler","orcid":"https://orcid.org/0000-0003-4034-4249","observed_orcids":["https://orcid.org/0000-0003-4034-4249"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Hartmut Weiler","raw_affiliation_strings":["From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France","institution_ids":["https://openalex.org/I168537998","https://openalex.org/I204308271","https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210141964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108449226","display_name":"Jean-Fran\u00e7ois Dhainaut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Jean-Francois Dhainaut","raw_affiliation_strings":["From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee; Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN; and Department of Intensive Care, Cochin Hospital, AP-HP, Cochin Institute, Cochin Port-Royal Medical School, Paris V University, Paris, France","institution_ids":["https://openalex.org/I168537998","https://openalex.org/I204308271","https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210141964"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":10.24,"has_fulltext":false,"cited_by_count":169,"citation_normalized_percentile":{"value":0.98834898,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"102","issue":"9","first_page":"3085","last_page":"3092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.4124000072479248,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-v-leiden","display_name":"factor V Leiden","score":0.9900000095367432},{"id":"https://openalex.org/keywords/heterozygous-carriers","display_name":"heterozygous carriers","score":0.8019999861717224},{"id":"https://openalex.org/keywords/severe-sepsis","display_name":"severe sepsis","score":0.984000027179718},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/recombinant-activated-protein-c","display_name":"recombinant activated protein C","score":0.8420000076293945},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/protein-c-pathway","display_name":"protein C pathway","score":0.9459999799728394},{"id":"https://openalex.org/keywords/survival-benefit","display_name":"survival benefit","score":0.6669999957084656},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.5090000033378601},{"id":"https://openalex.org/keywords/vasopressor-use","display_name":"vasopressor use","score":0.7710000276565552},{"id":"https://openalex.org/keywords/prowess-trial","display_name":"PROWESS trial","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2777175894","wikidata":"https://www.wikidata.org/wiki/Q185986","display_name":"Factor V Leiden","level":4,"score":0.7843314409255981},{"id":"https://openalex.org/C2779936836","wikidata":"https://www.wikidata.org/wiki/Q890200","display_name":"Coagulopathy","level":2,"score":0.781853199005127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.714601993560791},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7129476070404053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.564548909664154},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5203132629394531},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.5013818740844727},{"id":"https://openalex.org/C2776046644","wikidata":"https://www.wikidata.org/wiki/Q422831","display_name":"Factor V","level":3,"score":0.46160784363746643},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4595772922039032},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.42084062099456787},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.15928915143013},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.10679510235786438}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2003-06-1789","doi":"https://doi.org/10.1182/blood-2003-06-1789","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2003-06-1789","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:12869495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12869495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1576303527","display_name":"Thrombomodulin Function in Cellular Physiology","funder_award_id":"R01HL060655","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W8668683","https://openalex.org/W172709144","https://openalex.org/W335124151","https://openalex.org/W1503286274","https://openalex.org/W1510008853","https://openalex.org/W1557208093","https://openalex.org/W1898928487","https://openalex.org/W1923666981","https://openalex.org/W1965306847","https://openalex.org/W1974759235","https://openalex.org/W1977905350","https://openalex.org/W1980233581","https://openalex.org/W1980575930","https://openalex.org/W1982149026","https://openalex.org/W2000985786","https://openalex.org/W2011042500","https://openalex.org/W2013155340","https://openalex.org/W2026106674","https://openalex.org/W2037143212","https://openalex.org/W2042931081","https://openalex.org/W2049979007","https://openalex.org/W2052494211","https://openalex.org/W2053367545","https://openalex.org/W2054186665","https://openalex.org/W2057344473","https://openalex.org/W2058144497","https://openalex.org/W2073806998","https://openalex.org/W2091508224","https://openalex.org/W2105703100","https://openalex.org/W2108435955","https://openalex.org/W2108675605","https://openalex.org/W2112348962","https://openalex.org/W2115301416","https://openalex.org/W2130292547","https://openalex.org/W2141868068","https://openalex.org/W2147581820","https://openalex.org/W2151446126","https://openalex.org/W2163798517","https://openalex.org/W2166862308","https://openalex.org/W2166970179","https://openalex.org/W2187990768","https://openalex.org/W2217475577","https://openalex.org/W2218246823","https://openalex.org/W2322121630","https://openalex.org/W2329073622","https://openalex.org/W2338765002","https://openalex.org/W2417642457","https://openalex.org/W2422736939"],"related_works":["https://openalex.org/W2024494263","https://openalex.org/W2085941287","https://openalex.org/W2060452011","https://openalex.org/W2184425568","https://openalex.org/W2072913659","https://openalex.org/W4206083109","https://openalex.org/W2980843629","https://openalex.org/W2436707969","https://openalex.org/W2130797348","https://openalex.org/W2156157701"],"abstract_inverted_index":{"Sepsis":[0],"is":[1],"associated":[2],"with":[3,115],"systemic":[4],"inflammation,":[5],"coagulopathy,":[6],"and":[7,36,89,110],"disrupted":[8],"protein":[9],"C":[10],"(PC)":[11],"pathway":[12],"function.":[13],"The":[14,55,72,174],"effect":[15],"of":[16,33,47,75,108,157,166,184,205],"prothrombotic":[17],"polymorphism,":[18],"factor":[19],"V":[20],"Leiden":[21,52,66,179,193],"(Arg506Gln;":[22],"FV":[23,51,178,192],"Leiden),":[24],"was":[25,58,82,121,161],"examined":[26],"in":[27,60,64,84,123,195,207],"a":[28,37,132,181,185,202],"large":[29],"clinical":[30],"trial":[31],"(PROWESS)":[32],"severe":[34,208],"sepsis":[35],"mouse":[38,139],"endotoxemia":[39],"model.":[40],"In":[41,131],"PROWESS,":[42],"4.1%":[43],"(n":[44],"=":[45],"65)":[46],"patients":[48,69,91,125],"were":[49],"heterozygous":[50],"(VL+/-)":[53],"carriers.":[54],"28-day":[56],"mortality":[57,73,145,156],"lower":[59,144],"VL+/-":[61,85,99,124,141,206],"(13.9%)":[62],"than":[63,146],"non-FV":[65],"(VL-/-;":[67],"27.9%)":[68],"(P":[70],"=.013).":[71],"benefit":[74],"recombinant":[76],"human":[77],"activated":[78],"PC":[79],"(rhAPC)":[80],"treatment":[81],"similar":[83],"(placebo,":[86,92],"15.6%;":[87],"rhAPC,12.1%)":[88],"VL-/-":[90],"31.0%;":[93],"rhAPC,":[94],"24.7%;":[95],"interaction":[96],"P":[97,129,152,172],"=.981).":[98],"status":[100],"did":[101],"not":[102],"appear":[103],"to":[104,164,201],"influence":[105],"baseline":[106],"biomarkers":[107],"coagulopathy":[109],"inflammation":[111],"or":[112],"disease":[113],"severity,":[114],"the":[116,155,191,196],"exception":[117],"that":[118,165,177,189],"vasopressor":[119],"usage":[120],"less":[122],"(46.2%":[126],"versus":[127,150,170],"63.0%;":[128],"=.009).":[130],"median":[133],"lethal":[134],"dose":[135],"(40":[136],"mg/kg)":[137],"endotoxin":[138],"model,":[140],"mice":[142,148,160,168],"had":[143],"wild-type":[147,167],"(19%":[149],"57%;":[151,171],"=.008),":[153],"whereas":[154],"homozygous":[158],"(VL+/+)":[159],"almost":[162],"identical":[163],"(65%":[169],"=.76).":[173],"findings":[175],"suggest":[176],"constitutes":[180],"rare":[182],"example":[183],"balanced":[186],"gene":[187,198],"polymorphism":[188],"maintains":[190],"mutation":[194],"general":[197],"pool":[199],"due":[200],"survival":[203],"advantage":[204],"sepsis.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}