{"id":"https://openalex.org/W2165057249","doi":"https://doi.org/10.1080/01926230290166779","title":"The Effect of Chronic Progressive Nephropathy on the Incidence of Renal Tubule Cell Neoplasms in Control Male F344 Rats","display_name":"The Effect of Chronic Progressive Nephropathy on the Incidence of Renal Tubule Cell Neoplasms in Control Male F344 Rats","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W2165057249","doi":"https://doi.org/10.1080/01926230290166779","mag":"2165057249","pmid":"https://pubmed.ncbi.nlm.nih.gov/12512869"},"language":"en","primary_location":{"id":"doi:10.1080/01926230290166779","doi":"https://doi.org/10.1080/01926230290166779","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01926230290166779","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015910036","display_name":"John Curtis Seely","orcid":"https://orcid.org/0000-0003-1050-4096","observed_orcids":["https://orcid.org/0000-0003-1050-4096"]},"institutions":[{"id":"https://openalex.org/I4210090135","display_name":"Experimental Pathology Laboratories","ror":"https://ror.org/00dv9aw81","country_code":"US","type":"company","lineage":["https://openalex.org/I4210090135"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John C. Seely","raw_affiliation_strings":["Experimental Pathology Laboratories, Inc, Research Triangle Park, North Carolina,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology Laboratories, Inc, Research Triangle Park, North Carolina,","institution_ids":["https://openalex.org/I4210090135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108432966","display_name":"Joseph K. Haseman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph K. Haseman","raw_affiliation_strings":["Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069612671","display_name":"Abraham Nyska","orcid":"https://orcid.org/0000-0002-7847-2513","observed_orcids":["https://orcid.org/0000-0002-7847-2513"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham Nyska","raw_affiliation_strings":["Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034576675","display_name":"Douglas C. Wolf","orcid":"https://orcid.org/0000-0003-1868-9574","observed_orcids":["https://orcid.org/0000-0003-1868-9574"]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas C. Wolf","raw_affiliation_strings":["Environmental Carcinogenesis Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Carcinogenesis Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049021093","display_name":"Jeffrey I. Everitt","orcid":"https://orcid.org/0000-0003-0273-6284","observed_orcids":["https://orcid.org/0000-0003-0273-6284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey I. Everitt","raw_affiliation_strings":["CT Centers for Health Research, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CT Centers for Health Research, Research Triangle Park, North Carolina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111851997","display_name":"James R. Hailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. Hailey","raw_affiliation_strings":["Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015910036"],"corresponding_institution_ids":["https://openalex.org/I4210090135"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.5028,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.6266881,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"6","first_page":"681","last_page":"686"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-progressive-nephropathy","display_name":"chronic progressive nephropathy","score":1.0},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.8709999918937683},{"id":"https://openalex.org/keywords/renal-tubular-epithelium","display_name":"renal tubular epithelium","score":0.8349999785423279},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.6200000047683716},{"id":"https://openalex.org/keywords/interstitial-inflammation","display_name":"interstitial inflammation","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6815404891967773},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5942893624305725},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.5930443406105042},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5489981770515442},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.523763120174408},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.483151376247406},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4715445339679718},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4691426157951355},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.44961801171302795},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.4455309510231018},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4212070107460022},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40119969844818115},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.35061246156692505},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008867","descriptor_name":"Microtomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009316","descriptor_name":"National Institutes of Health (U.S.)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/01926230290166779","doi":"https://doi.org/10.1080/01926230290166779","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01926230290166779","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:12512869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12512869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic pathology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.951.6329","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.951.6329","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://tpx.sagepub.com/content/30/6/681.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W69139415","https://openalex.org/W240701929","https://openalex.org/W1484985491","https://openalex.org/W1567712367","https://openalex.org/W1971818797","https://openalex.org/W1974039242","https://openalex.org/W1977947318","https://openalex.org/W2002664886","https://openalex.org/W2011528268","https://openalex.org/W2019431234","https://openalex.org/W2022564480","https://openalex.org/W2034602546","https://openalex.org/W2041378718","https://openalex.org/W2054188111","https://openalex.org/W2060314418","https://openalex.org/W2069801514","https://openalex.org/W2075029468","https://openalex.org/W2085188691","https://openalex.org/W2087092264","https://openalex.org/W2104592429","https://openalex.org/W2106858779","https://openalex.org/W2110864108","https://openalex.org/W2113879835","https://openalex.org/W2121271224","https://openalex.org/W2124343705","https://openalex.org/W2133302979","https://openalex.org/W2136453265","https://openalex.org/W2143397559","https://openalex.org/W2154430610","https://openalex.org/W2166202134","https://openalex.org/W2168234252","https://openalex.org/W2171506923","https://openalex.org/W2240867310","https://openalex.org/W2398078286","https://openalex.org/W4245239975"],"related_works":["https://openalex.org/W2152172471","https://openalex.org/W1968548800","https://openalex.org/W7098759541","https://openalex.org/W2158261690","https://openalex.org/W1976968090","https://openalex.org/W2096850473","https://openalex.org/W2161494051","https://openalex.org/W2962201287","https://openalex.org/W7095388136","https://openalex.org/W2048434506"],"abstract_inverted_index":{"Chronic":[0],"progressive":[1],"nephropathy":[2,176],"(CPN)":[3],"is":[4,40,146],"the":[5,11,103,110,165],"most":[6],"frequently":[7],"diagnosed":[8],"lesion":[9],"in":[10,74,114,125,130],"rat":[12],"kidney.":[13],"It":[14],"has":[15,94],"many":[16],"components":[17],"including":[18,55],"degeneration":[19],"and":[20,29,32,36,43,46,91,109,152,155],"regeneration":[21],"of":[22,38,53,70,81,107,112,167],"renal":[23,82],"tubule":[24,83],"(RT)":[25],"epithelium,":[26],"glomerular":[27],"lesions":[28],"interstitial":[30],"inflammation":[31],"fibrosis.":[33],"The":[34,87,99],"incidence":[35,80],"severity":[37,68,106,127],"CPN":[39,71,90,108,126,151],"strain,":[41],"age,":[42],"sex":[44],"dependent":[45],"may":[47,170],"be":[48,178],"altered":[49],"by":[50],"a":[51,77,147],"number":[52,166],"factors":[54],"exposure":[56],"to":[57,136,173],"xenobiotics.":[58],"In":[59],"National":[60],"Toxicology":[61],"Program":[62],"(NTP)":[63],"2-year":[64],"bioassays,":[65],"xenobiotic-associated":[66],"increased":[67,79],"(exacerbation)":[69],"often":[72],"occurs":[73],"association":[75,104,162],"with":[76,133],"marginal":[78,161],"cell":[84],"neoplasms":[85],"(RTCN).":[86],"relationship":[88],"between":[89,105,150],"RTCN":[92,113,134],"development":[93],"not":[95,158],"been":[96],"definitively":[97],"determined.":[98,159],"present":[100,129],"study":[101],"evaluated":[102],"occurrence":[111],"control":[115],"male":[116],"F344":[117],"rats.":[118],"A":[119],"slight":[120],"but":[121],"statistically":[122],"significant":[123],"increase":[124],"was":[128],"those":[131],"animals":[132],"compared":[135],"aged-matched":[137],"controls":[138],"without":[139],"RTCN.":[140],"Although":[141],"these":[142],"data":[143],"suggest":[144],"there":[145],"positive":[148],"correlation":[149],"RTCN,":[153],"cause":[154],"effect":[156],"were":[157],"This":[160],"suggests":[163],"that":[164,169],"RTCNs":[168],"develop":[171],"secondary":[172],"chemically":[174],"exacerbated":[175],"would":[177],"few.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}