{"id":"https://openalex.org/W2165035755","doi":null,"title":"Influence of highly active anti-retroviral therapy (HAART) on the natural history of extra-pulmonary tuberculosis in HIV patients.","display_name":"Influence of highly active anti-retroviral therapy (HAART) on the natural history of extra-pulmonary tuberculosis in HIV patients.","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W2165035755","mag":"2165035755","pmid":"https://pubmed.ncbi.nlm.nih.gov/12546112"},"language":"en","primary_location":{"id":"pmid:12546112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12546112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109463681","display_name":"Patricia Garc\u00eda de Olalla","orcid":"https://orcid.org/0000-0002-2293-3560","observed_orcids":["https://orcid.org/0000-0002-2293-3560"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Garc\u00eda de Olalla","raw_affiliation_strings":["Department of Epidemiology, Municipal Institute of Health, Barcelona, Spain. polalla@imsb.bcn.es","Department of Epidemiology, Municipal Institute of Health, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Municipal Institute of Health, Barcelona, Spain. polalla@imsb.bcn.es","institution_ids":[]},{"raw_affiliation_string":"Department of Epidemiology, Municipal Institute of Health, Barcelona, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056804384","display_name":"Miguel \u00c1ngel Mart\u00ednez\u2010Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-3917-9808","observed_orcids":["https://orcid.org/0000-0002-3917-9808"]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M A Mart\u00ednez-Gonz\u00e1lez","raw_affiliation_strings":["University of Navarra"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Navarra","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079468992","display_name":"Joan A. Cayl\u00e0","orcid":"https://orcid.org/0000-0003-3891-111X","observed_orcids":["https://orcid.org/0000-0003-3891-111X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Cayl\u00e0","raw_affiliation_strings":["Bloomberg School of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bloomberg School of Public Health","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110407427","display_name":"J.M. Jans\u00e0","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153292","display_name":"Institut Catal\u00e0 de la Salut","ror":"https://ror.org/04wkdwp52","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J M Jans\u00e0","raw_affiliation_strings":["Institut Catala de la Salut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Catala de la Salut","institution_ids":["https://openalex.org/I4210153292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005403093","display_name":"Bego\u00f1a Iglesias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153292","display_name":"Institut Catal\u00e0 de la Salut","ror":"https://ror.org/04wkdwp52","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"B Iglesias","raw_affiliation_strings":["Institut Catala de la Salut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Catala de la Salut","institution_ids":["https://openalex.org/I4210153292"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R Guerrero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314586196","display_name":"United States Department of Justice","ror":"https://ror.org/02916qm60","country_code":"US","type":"government","lineage":["https://openalex.org/I1314586196"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Guerrero","raw_affiliation_strings":["Department of Justice"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Justice","institution_ids":["https://openalex.org/I1314586196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113064051","display_name":"A Marco","orcid":"https://orcid.org/0000-0001-6623-9370","observed_orcids":["https://orcid.org/0000-0001-6623-9370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Marco","raw_affiliation_strings":["Men's Penitentiary Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Men's Penitentiary Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029992759","display_name":"Josep M. Gatell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Gatell","raw_affiliation_strings":["Ciutat Sanitaria de la Vail d'Hebron"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciutat Sanitaria de la Vail d'Hebron","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087175375","display_name":"Imma Ocan\u0303a","orcid":"https://orcid.org/0000-0003-3699-0790","observed_orcids":["https://orcid.org/0000-0003-3699-0790"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"I Oca\u00f1a","raw_affiliation_strings":["Autonomous University of Barcelona","University of Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autonomous University of Barcelona","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"University of Barcelona","institution_ids":["https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1026,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.78604094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"6","issue":"12","first_page":"1051","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.45170000195503235,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.45170000195503235,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.3521000146865845,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.14069999754428864,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extrapulmonary-tuberculosis","display_name":"extrapulmonary tuberculosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.8460000157356262},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8650000095367432},{"id":"https://openalex.org/keywords/aids-defining-illness","display_name":"AIDS-defining illness","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tuberculin-skin-test","display_name":"tuberculin skin test","score":0.9779999852180481},{"id":"https://openalex.org/keywords/directly-observed-therapy","display_name":"directly observed therapy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pulmonary-tuberculosis","display_name":"pulmonary tuberculosis","score":0.6620000004768372},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7129999995231628},{"id":"https://openalex.org/keywords/natural-history-disease","display_name":"natural history (disease)","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9628101587295532},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7506623268127441},{"id":"https://openalex.org/C2776247216","wikidata":"https://www.wikidata.org/wiki/Q29505","display_name":"Tuberculin","level":3,"score":0.633857250213623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5518749356269836},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5143395662307739},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5028583407402039},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5025687217712402},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4610859751701355},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46077507734298706},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.44563719630241394},{"id":"https://openalex.org/C163276114","wikidata":"https://www.wikidata.org/wiki/Q484591","display_name":"Natural history","level":2,"score":0.43097203969955444},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.43081021308898926},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10345512628555298},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.0625457763671875}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023801","descriptor_name":"Directly Observed Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12546112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12546112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Journal Article"},{"id":"mag:2165035755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12546112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W6116656","https://openalex.org/W66028914","https://openalex.org/W137384375","https://openalex.org/W1713420468","https://openalex.org/W1968993671","https://openalex.org/W2000062430","https://openalex.org/W2016264635","https://openalex.org/W2062594082","https://openalex.org/W2064597467","https://openalex.org/W2080629438","https://openalex.org/W2093644669","https://openalex.org/W2103660106","https://openalex.org/W2120305713","https://openalex.org/W2151923407","https://openalex.org/W2155509630","https://openalex.org/W2167575493","https://openalex.org/W2169348402","https://openalex.org/W2171515720","https://openalex.org/W2315806009","https://openalex.org/W2331043513","https://openalex.org/W2415930653","https://openalex.org/W2797916974","https://openalex.org/W4237383128"],"related_works":["https://openalex.org/W2401530687","https://openalex.org/W2038591022","https://openalex.org/W4239695816","https://openalex.org/W7017686524","https://openalex.org/W2019267779","https://openalex.org/W2020165121","https://openalex.org/W2018447651","https://openalex.org/W2116728343","https://openalex.org/W2032843404","https://openalex.org/W7096439807"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"factors":[3,86],"related":[4],"to":[5,42,84],"survival":[6,44,93,156,173,204],"in":[7],"acquired":[8],"immune-deficiency":[9],"syndrome":[10],"(AIDS)":[11],"patients":[12,32,103,158,176,207],"with":[13,33,88,104,152,177,202],"extra-pulmonary":[14],"tuberculosis":[15,67,141],"(EPTB),":[16],"when":[17],"this":[18],"condition":[19],"is":[20,212],"the":[21,36,52,162,188],"first":[22,37,105,181,209],"AIDS-defining":[23,38,182,210],"disease.":[24,39],"DESIGN:":[25],"A":[26,117,191],"retrospective":[27],"cohort-study":[28],"of":[29,54,157,164,174],"549":[30],"AIDS":[31,106],"EPTB":[34,57,178],"as":[35,179],"Potential":[40],"candidates":[41],"predict":[43],"were":[45,82,149],"sex,":[46],"human":[47],"immunodeficiency":[48],"virus":[49],"(HIV)":[50],"exposure,":[51],"coexistence":[53],"pulmonary":[55,140],"and":[56,69,78,110,138,196],"at":[58],"diagnosis,":[59],"tuberculin":[60,119,193],"skin":[61,194],"test,":[62],"directly":[63],"observed":[64],"therapy":[65,73],"for":[66,96,102,112],"(DOT),":[68],"highly":[70],"active":[71],"anti-retroviral":[72],"(HAART).":[74],"The":[75,155,172],"Kaplan-Meier":[76],"method":[77],"Cox":[79],"regression":[80],"models":[81],"used":[83],"assess":[85],"associated":[87,151,201],"survival.":[89,154],"RESULTS:":[90],"Estimated":[91],"3-year":[92],"was":[94],"47.0%":[95],"those":[97,113],"diagnosed":[98,114],"before":[99],"1993,":[100],"72.6%":[101],"diagnosis":[107],"during":[108,187],"1995-1996":[109],"84.6%":[111],"after":[115,161],"1996.":[116],"negative":[118,192],"test":[120,195],"(hazard":[121],"ratio":[122],"[HR]":[123],"=":[124],"1.6,":[125],"95%":[126,135,146,168],"CI":[127,136,147,169],"1.1-2.3),":[128],"not":[129,197],"being":[130],"on":[131],"DOT":[132,199],"(HR":[133,144,166],"2.2;":[134],"1.3-3.7)":[137],"having":[139],"involvement":[142],"also":[143],"1.3;":[145],"1.1-1.7)":[148],"independently":[150],"poorer":[153,203],"significantly":[159],"improved":[160,186],"introduction":[163],"HAART":[165],"0.4;":[167],"0.2-0.6).":[170],"CONCLUSION:":[171],"HIV":[175],"their":[180],"disease":[183,211],"has":[184],"substantially":[185],"last":[189],"decade.":[190],"receiving":[198],"are":[200],"among":[205],"HIV-infected":[206],"whose":[208],"EPTB.":[213]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}