{"id":"https://openalex.org/W2165026257","doi":"https://doi.org/10.1089/jomh.2014.0006","title":"Enclomiphene Citrate Stimulates Serum Testosterone in Men With Low Testosterone Within 14 Days","display_name":"Enclomiphene Citrate Stimulates Serum Testosterone in Men With Low Testosterone Within 14 Days","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2165026257","doi":"https://doi.org/10.1089/jomh.2014.0006","mag":"2165026257"},"language":"en","primary_location":{"id":"doi:10.1089/jomh.2014.0006","doi":"https://doi.org/10.1089/jomh.2014.0006","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jomh.2014.0006","pdf_url":null,"source":{"id":"https://openalex.org/S117063503","display_name":"Journal of Men s Health","issn_l":"1875-6859","issn":["1875-6859","1875-6867"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310318016","host_organization_name":"Codon Publications","host_organization_lineage":["https://openalex.org/P4310318016"],"host_organization_lineage_names":["Codon Publications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Men's Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112084884","display_name":"Ronald D. Wiehle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ronald D. Wiehle","raw_affiliation_strings":["Repros Therapeutics Inc., The Woodlands, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Repros Therapeutics Inc., The Woodlands, Texas","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076829462","display_name":"Gregory K. Fontenot","orcid":"https://orcid.org/0000-0002-1584-026X","observed_orcids":["https://orcid.org/0000-0002-1584-026X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory K. Fontenot","raw_affiliation_strings":["Repros Therapeutics Inc., The Woodlands, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Repros Therapeutics Inc., The Woodlands, Texas","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110082290","display_name":"Michael S. Willett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael S. Willett","raw_affiliation_strings":["Ready Clinical, LLC, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ready Clinical, LLC, Princeton, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005606599","display_name":"Wilfredo D. Garcia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wilfredo D. Garcia","raw_affiliation_strings":["Ready Clinical, LLC, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ready Clinical, LLC, Princeton, New Jersey","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040207560","display_name":"Joseph S. Podolski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph S. Podolski","raw_affiliation_strings":["Repros Therapeutics Inc., The Woodlands, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Repros Therapeutics Inc., The Woodlands, Texas","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112084884"],"corresponding_institution_ids":[],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":null,"fwci":0.8719,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.75391885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"11","issue":"4","first_page":"196","last_page":"205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/testosterone-deficiency","display_name":"androgen deficiency","score":0.7630000114440918},{"id":"https://openalex.org/keywords/male-hypogonadism","display_name":"male hypogonadism","score":0.9330000281333923},{"id":"https://openalex.org/keywords/secondary-hypogonadism","display_name":"secondary hypogonadism","score":0.8849999904632568},{"id":"https://openalex.org/keywords/testosterone-replacement-therapy","display_name":"testosterone replacement therapy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/topical-testosterone-gel","display_name":"topical testosterone gel","score":0.9549999833106995},{"id":"https://openalex.org/keywords/free-testosterone","display_name":"free testosterone","score":0.7200000286102295},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.9679999947547913},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9480000138282776},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.44699999690055847},{"id":"https://openalex.org/keywords/older-men","display_name":"older men","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.8662900924682617},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7405684590339661},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6795060634613037},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6335679292678833},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6275696754455566},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5891500115394592},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5872726440429688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5615423917770386},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.557547926902771},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.52604079246521},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2092510461807251},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1089/jomh.2014.0006","doi":"https://doi.org/10.1089/jomh.2014.0006","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jomh.2014.0006","pdf_url":null,"source":{"id":"https://openalex.org/S117063503","display_name":"Journal of Men s Health","issn_l":"1875-6859","issn":["1875-6859","1875-6867"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310318016","host_organization_name":"Codon Publications","host_organization_lineage":["https://openalex.org/P4310318016"],"host_organization_lineage_names":["Codon Publications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Men's Health","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W295423035","https://openalex.org/W1668969088","https://openalex.org/W1832065850","https://openalex.org/W1943633560","https://openalex.org/W1957142627","https://openalex.org/W1974581869","https://openalex.org/W1976239781","https://openalex.org/W1985623895","https://openalex.org/W1998972255","https://openalex.org/W2012256669","https://openalex.org/W2018431150","https://openalex.org/W2018767793","https://openalex.org/W2026287546","https://openalex.org/W2033887921","https://openalex.org/W2038858525","https://openalex.org/W2045206957","https://openalex.org/W2052157618","https://openalex.org/W2060470126","https://openalex.org/W2066887915","https://openalex.org/W2074522120","https://openalex.org/W2075118988","https://openalex.org/W2075595609","https://openalex.org/W2086191896","https://openalex.org/W2105899460","https://openalex.org/W2111674612","https://openalex.org/W2129402428","https://openalex.org/W2139372640","https://openalex.org/W2139893960","https://openalex.org/W2142563833","https://openalex.org/W2145546928","https://openalex.org/W2146971935","https://openalex.org/W2149547149","https://openalex.org/W2155877918","https://openalex.org/W2155965183","https://openalex.org/W2407205640","https://openalex.org/W2409783580","https://openalex.org/W2486998818","https://openalex.org/W3036378166"],"related_works":["https://openalex.org/W2400408391","https://openalex.org/W7161818266","https://openalex.org/W1957142627","https://openalex.org/W2052157618","https://openalex.org/W2149653703","https://openalex.org/W2341336633","https://openalex.org/W2062916016","https://openalex.org/W2467652876","https://openalex.org/W95503833","https://openalex.org/W2074522120"],"abstract_inverted_index":{"Background:":[0],"It":[1],"is":[2],"not":[3,139],"unusual":[4],"for":[5,74,112],"men":[6,294],"over":[7],"60":[8],"years":[9],"of":[10,21,27,36,79,132,143,160,230,247],"age":[11],"to":[12,43,54,162,210],"have":[13],"serum":[14],"testosterone":[15,66,81,178,184,198,262,285,291],"levels":[16,142,153,185,292],"below":[17],"the":[18,103,241,275],"lower":[19],"limits":[20],"younger":[22],"men,":[23],"prompting":[24],"a":[25,97,113,123,157,217],"diagnosis":[26],"hypogonadism.":[28],"This":[29],"study":[30],"evaluated":[31],"safety,":[32],"efficacy,":[33],"and":[34,88,110,135,172,176,225,260,274,288],"pharmacokinetics":[35],"oral":[37,55,71],"enclomiphene":[38,56,133,166,213,248,279],"citrate":[39,57,134,170,214,221,249,257,280],"as":[40],"an":[41,227],"alternative":[42],"currently":[44],"available":[45],"androgen":[46],"replacement":[47],"therapies.":[48],"Methods:":[49],"Fifty-two":[50],"subjects":[51,107],"were":[52,83,94,108,145,154,250],"randomized":[53],"(12.5":[58],"mg,":[59,61],"25":[60,171,242],"or":[62,70],"50":[63,173],"mg),":[64],"topical":[65,136,148,177],"gel":[67],"(5":[68,199],"g)":[69,180,200],"placebo":[72],"daily":[73,253],"14":[75,90,119,189,299],"days.":[76,300],"Pharmacodynamic":[77],"profiles":[78],"total":[80,259],"(TT)":[82],"obtained":[84],"on":[85],"day":[86,89,188,192],"1":[87,193],"after":[91,102],"dosing.":[92,254],"Subjects":[93],"assessed":[95],"in":[96,127,147,165,206,216,268,293],"follow-up":[98],"visit":[99],"7\u201310":[100],"days":[101],"final":[104],"dose.":[105,244],"Additional":[106],"rescreened":[109],"added":[111],"10-g":[114],"dose":[115],"cohort.":[116],"Results:":[117],"After":[118],"days,":[120],"there":[121],"was":[122,201,222,238],"significant,":[124],"dose-dependent":[125],"rise":[126],"TT":[128,144,152],"across":[129],"all":[130],"doses":[131,175],"testosterone,":[137],"but":[138],"placebo.":[140,196],"Supraphysiologic":[141],"observed":[146],"testosterone-treated":[149],"subjects,":[150],"whereas":[151],"maintained":[155],"within":[156,298],"desirable":[158],"range":[159],"400":[161],"700":[163],"ng/dL":[164],"citrate-treated":[167],"subjects.":[168],"Enclomiphene":[169,220,256],"mg":[174,243],"(10":[179],"treatment":[181],"elevated":[182],"free":[183,261],"more":[186],"at":[187,240],"compared":[190],"with":[191,203,252,278,295],"than":[194],"did":[195],"Topical":[197],"associated":[202],"disproportionate":[204],"increase":[205],"dihydrotestosterone":[207],"(DHT)":[208],"relative":[209],"TT,":[211],"while":[212],"resulted":[215],"modest":[218],"decrease.":[219],"rapidly":[223],"absorbed":[224],"had":[226],"elimination":[228],"half-life":[229],"about":[231],"10":[232],"hours.":[233],"A":[234],"non-dose-dependent":[235],"steady-state":[236],"level":[237],"maximal":[239],"The":[245],"effects":[246],"sustained":[251],"Conclusions:":[255],"increased":[258],"without":[263],"increasing":[264],"DHT":[265],"disproportionately.":[266],"Changes":[267],"luteinizing":[269],"hormone,":[270,273],"follicle":[271],"stimulating":[272],"DHT/TT":[276],"ratio":[277],"suggest":[281],"it":[282],"normalizes":[283],"endogenous":[284],"production":[286],"pathways":[287],"restores":[289],"normal":[290],"secondary":[296],"hypogonadism":[297]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-06-24T00:00:00"}
