{"id":"https://openalex.org/W2165020609","doi":null,"title":"Activin and basic fibroblast growth factor regulate neurogenesis of murine embryonal carcinoma cells.","display_name":"Activin and basic fibroblast growth factor regulate neurogenesis of murine embryonal carcinoma cells.","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W2165020609","mag":"2165020609","pmid":"https://pubmed.ncbi.nlm.nih.gov/8959336"},"language":"en","primary_location":{"id":"pmid:8959336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8959336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001920616","display_name":"R. F. Ameerun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R F Ameerun","raw_affiliation_strings":["Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210115206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103414538","display_name":"Johan P. de Winter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P de Winter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113681953","display_name":"A.J.M. van den Eijnden-van Raaij","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J van den Eijnden-van Raaij","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037786135","display_name":"Jeroen den Hertog","orcid":"https://orcid.org/0000-0002-8642-8088","observed_orcids":["https://orcid.org/0000-0002-8642-8088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J den Hertog","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111393836","display_name":"Siegfried W. de Laat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S W de Laat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023931636","display_name":"Leon G.J. Tertoolen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L G Tertoolen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3183,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.47215187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"12","first_page":"1679","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.14030000567436218,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.07859999686479568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/activin","display_name":"activin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":1.0},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/p19-embryonal-carcinoma-cells","display_name":"P19 embryonal carcinoma cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.8169999718666077},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.796999990940094},{"id":"https://openalex.org/keywords/activin-receptors","display_name":"activin receptors","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"fibroblast growth factor receptor","score":0.8999999761581421},{"id":"https://openalex.org/keywords/fgfr1","display_name":"FGFR1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/fgfr2","display_name":"FGFR2","score":0.996999979019165},{"id":"https://openalex.org/keywords/axon-growth","display_name":"axon growth","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/germ-layer-differentiation","display_name":"germ layer differentiation","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.7279323935508728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6726276874542236},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.6415302753448486},{"id":"https://openalex.org/C38643226","wikidata":"https://www.wikidata.org/wiki/Q4677604","display_name":"Activin type 2 receptors","level":4,"score":0.63882976770401},{"id":"https://openalex.org/C26805974","wikidata":"https://www.wikidata.org/wiki/Q7117837","display_name":"P19 cell","level":5,"score":0.610433042049408},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.576117217540741},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5474085211753845},{"id":"https://openalex.org/C2778649528","wikidata":"https://www.wikidata.org/wiki/Q4677603","display_name":"Activin receptor","level":3,"score":0.4855165481567383},{"id":"https://openalex.org/C2780327976","wikidata":"https://www.wikidata.org/wiki/Q1451877","display_name":"Embryonal carcinoma","level":4,"score":0.4593439996242523},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45466724038124084},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3634204864501953},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3518206775188446},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32408833503723145},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3141902685165405},{"id":"https://openalex.org/C111001777","wikidata":"https://www.wikidata.org/wiki/Q3562192","display_name":"TGF beta signaling pathway","level":3,"score":0.194688618183136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15291917324066162},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.11621153354644775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017978","descriptor_name":"Receptors, Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017978","descriptor_name":"Receptors, Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029404","descriptor_name":"Activin Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054278","descriptor_name":"Embryonal Carcinoma Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8959336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8959336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.514.4468","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.514.4468","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cgd.aacrjournals.org/cgi/reprint/7/12/1679.pdf","raw_type":"text"},{"id":"mag:2165020609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8959336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W963887890","https://openalex.org/W1489573122","https://openalex.org/W1513451331","https://openalex.org/W1527594560","https://openalex.org/W1527715380","https://openalex.org/W1568657070","https://openalex.org/W1750655836","https://openalex.org/W1965918354","https://openalex.org/W1975301960","https://openalex.org/W1977228353","https://openalex.org/W1979202854","https://openalex.org/W1989078983","https://openalex.org/W2000991526","https://openalex.org/W2003932465","https://openalex.org/W2011334059","https://openalex.org/W2016791091","https://openalex.org/W2017177010","https://openalex.org/W2018485286","https://openalex.org/W2021263701","https://openalex.org/W2021299623","https://openalex.org/W2027815400","https://openalex.org/W2033418096","https://openalex.org/W2042480227","https://openalex.org/W2045858906","https://openalex.org/W2055752373","https://openalex.org/W2055830220","https://openalex.org/W2056016311","https://openalex.org/W2060333964","https://openalex.org/W2060889469","https://openalex.org/W2065904520","https://openalex.org/W2069022895","https://openalex.org/W2069598734","https://openalex.org/W2083186952","https://openalex.org/W2085131417","https://openalex.org/W2085321659","https://openalex.org/W2089639494","https://openalex.org/W2091630371","https://openalex.org/W2094297257","https://openalex.org/W2096667049","https://openalex.org/W2103042473","https://openalex.org/W2116026731","https://openalex.org/W2142534050","https://openalex.org/W2171960232","https://openalex.org/W2184559181","https://openalex.org/W2247098456","https://openalex.org/W2383657268"],"related_works":["https://openalex.org/W7098278248","https://openalex.org/W2018827545","https://openalex.org/W2045858906","https://openalex.org/W2042550451","https://openalex.org/W1982678647","https://openalex.org/W2089639494","https://openalex.org/W2064321923","https://openalex.org/W2018012556","https://openalex.org/W1991197660","https://openalex.org/W2077179185"],"abstract_inverted_index":{"Murine":[0],"P19":[1],"embryonal":[2],"carcinoma":[3],"(EC)":[4],"cells":[5,46,65,81,101,161],"can":[6],"be":[7],"differentiated":[8,158],"into":[9,206],"various":[10],"germ":[11],"layer":[12],"derivatives.":[13],"The":[14],"addition":[15,112],"of":[16,29,38,86,116,122,225,248],"retinoic":[17],"acid":[18],"(RA)":[19],"to":[20,42,82,191],"P19-EC":[21,45],"cell":[22],"aggregates":[23,40],"results":[24,237],"in":[25,61,70,219,250],"a":[26,68,220],"transient":[27,146],"activation":[28],"receptor":[30,117],"protein":[31,184],"tyrosine":[32],"phosphatase-alpha":[33],"(RPTP":[34],"alpha).":[35],"Subsequent":[36],"replating":[37],"these":[39],"leads":[41],"neuronal":[43,56,75,197],"differentiation.":[44,76,198],"expressing":[47],"constitutively":[48],"active":[49],"RPTP":[50],"alpha":[51,64,80,100,160],"(P19-RPTP":[52],"alpha)":[53],"show":[54,97],"extensive":[55],"differentiation":[57,204],"upon":[58],"RA":[59,111,137],"treatment":[60],"monolayer.":[62],"P19-RPTP":[63,79,99,159],"thus":[66],"provide":[67],"suitable":[69],"vitro":[71],"model":[72],"for":[73,104],"studying":[74],"We":[77,96],"used":[78],"study":[83],"the":[84,164,203,239,251],"effects":[85],"activin":[87,109,150,200,242],"and":[88,107,125,135,169,174,188,243],"basic":[89],"fibroblast":[90],"growth":[91],"factor":[92],"(bFGF)":[93],"on":[94,195],"neurogenesis.":[95],"that":[98,241],"express":[102,162],"mRNA":[103],"types":[105],"I":[106,124],"II":[108,126],"receptors.":[110],"causes":[113],"an":[114],"up-regulation":[115],"type":[118,123],"IIA":[119],"expression.":[120],"Complexes":[121],"receptors":[127,166],"were":[128,141],"detectable":[129],"by":[130,145,180],"cross-linking":[131],"assays":[132,148],"both":[133],"before":[134],"after":[136],"treatment.":[138],"Receptor":[139],"complexes":[140],"functional":[142],"as":[143,155,157],"determined":[144],"transfection":[147],"with":[149],"responsive":[151],"reporter":[152],"constructs.":[153],"Undifferentiated":[154],"well":[156],"also":[163],"FGF":[165],"(FGFRs)":[167],"FGFR-1":[168],"FGFR-2":[170],"but":[171,215],"not":[172,211],"FGFR-3":[173],"FGFR-4.":[175],"Their":[176],"functionality":[177],"was":[178],"established":[179],"bFGF":[181,189,209,226,244],"induced":[182],"mitogen-activated":[183],"kinase":[185],"phosphorylation.":[186],"Activin":[187],"appeared":[190],"exert":[192],"differential":[193],"actions":[194],"RA-induced":[196],"Although":[199],"irreversibly":[201],"changes":[202],"fate":[205],"nonneuronal":[207],"directions,":[208],"does":[210],"affect":[212],"initial":[213],"neurogenesis":[214,249],"regulates":[216],"axonal":[217,228],"outgrowth":[218],"concentration-dependent":[221],"way;":[222],"low":[223],"concentrations":[224,232],"enhance":[227],"outgrowth,":[229],"whereas":[230],"high":[231],"inhibit":[233],"this":[234],"process.":[235],"These":[236],"strengthen":[238],"notion":[240],"are":[245],"important":[246],"regulators":[247],"mammalian":[252],"embryo.":[253]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}