{"id":"https://openalex.org/W216493098","doi":null,"title":"Assessing methylation status of PAX1 in cervical scrapings, as a novel diagnostic and predictive biomarker, was closely related to screen cervical cancer.","display_name":"Assessing methylation status of PAX1 in cervical scrapings, as a novel diagnostic and predictive biomarker, was closely related to screen cervical cancer.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W216493098","mag":"216493098","pmid":"https://pubmed.ncbi.nlm.nih.gov/25973053","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4396293"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3389389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4396293","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4396293","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101845456","display_name":"Jun Xu","orcid":"https://orcid.org/0000-0002-1419-8228","observed_orcids":["https://orcid.org/0000-0002-1419-8228"]},"institutions":[{"id":"https://openalex.org/I4210101358","display_name":"Minhang District Central Hospital","ror":"https://ror.org/00p0n9a62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Xu","raw_affiliation_strings":["Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital 170 Xinsong Road, Shanghai 201199, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital 170 Xinsong Road, Shanghai 201199, China","institution_ids":["https://openalex.org/I4210101358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101578426","display_name":"Ling Xu","orcid":"https://orcid.org/0000-0002-4038-3216","observed_orcids":["https://orcid.org/0000-0002-4038-3216"]},"institutions":[{"id":"https://openalex.org/I4210101358","display_name":"Minhang District Central Hospital","ror":"https://ror.org/00p0n9a62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Xu","raw_affiliation_strings":["Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital 170 Xinsong Road, Shanghai 201199, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital 170 Xinsong Road, Shanghai 201199, China","institution_ids":["https://openalex.org/I4210101358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102112465","display_name":"Baohua Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101358","display_name":"Minhang District Central Hospital","ror":"https://ror.org/00p0n9a62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baohua Yang","raw_affiliation_strings":["Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital 170 Xinsong Road, Shanghai 201199, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital 170 Xinsong Road, Shanghai 201199, China","institution_ids":["https://openalex.org/I4210101358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101930091","display_name":"Lifeng Wang","orcid":"https://orcid.org/0000-0002-7118-0163","observed_orcids":["https://orcid.org/0000-0002-7118-0163"]},"institutions":[{"id":"https://openalex.org/I4210101358","display_name":"Minhang District Central Hospital","ror":"https://ror.org/00p0n9a62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifeng Wang","raw_affiliation_strings":["Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital 170 Xinsong Road, Shanghai 201199, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital 170 Xinsong Road, Shanghai 201199, China","institution_ids":["https://openalex.org/I4210101358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054054959","display_name":"Xiao Lin","orcid":"https://orcid.org/0000-0003-3794-346X","observed_orcids":["https://orcid.org/0000-0003-3794-346X"]},"institutions":[{"id":"https://openalex.org/I4210101358","display_name":"Minhang District Central Hospital","ror":"https://ror.org/00p0n9a62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Lin","raw_affiliation_strings":["Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital 170 Xinsong Road, Shanghai 201199, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital 170 Xinsong Road, Shanghai 201199, China","institution_ids":["https://openalex.org/I4210101358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015807201","display_name":"Hong Tu","orcid":"https://orcid.org/0000-0002-8298-5207","observed_orcids":["https://orcid.org/0000-0002-8298-5207"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Tu","raw_affiliation_strings":["State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine 2200-25 Xietu Road, Shanghai 20032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine 2200-25 Xietu Road, Shanghai 20032, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7573,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.82241438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"8","issue":"2","first_page":"1674","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13544","display_name":"Women's cancer prevention and management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pax1","display_name":"PAX1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cervical-cancer-screening","display_name":"cervical cancer screening","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cervical-intraepithelial-neoplasia","display_name":"cervical intraepithelial neoplasia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cervical-scrapings","display_name":"cervical scrapes","score":0.8619999885559082},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6320000290870667},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pyrosequencing","display_name":"pyrosequencing","score":0.7789999842643738},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.790790319442749},{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.7879356741905212},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6986363530158997},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6973682641983032},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6875377893447876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6495848894119263},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5382354855537415},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5073134303092957},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43575167655944824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40348055958747864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23517045378684998},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15643811225891113},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09293636679649353},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.061524659395217896}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014626","descriptor_name":"Vaginal Smears","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D051761","descriptor_name":"Paired Box Transcription Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D051761","descriptor_name":"Paired Box Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3389389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4396293","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25973053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25973053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4396293","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4396293/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:216493098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25973053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3389389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4396293","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W316269977","https://openalex.org/W1659650024","https://openalex.org/W1908550723","https://openalex.org/W1942624055","https://openalex.org/W1967447825","https://openalex.org/W1977343466","https://openalex.org/W1981386770","https://openalex.org/W1982575342","https://openalex.org/W1993748140","https://openalex.org/W2019535129","https://openalex.org/W2025279347","https://openalex.org/W2026452076","https://openalex.org/W2036190704","https://openalex.org/W2040257851","https://openalex.org/W2041694981","https://openalex.org/W2044016423","https://openalex.org/W2077032415","https://openalex.org/W2084944692","https://openalex.org/W2114813165","https://openalex.org/W2119594769","https://openalex.org/W2133765716","https://openalex.org/W2133877856","https://openalex.org/W2134189685","https://openalex.org/W2135795223","https://openalex.org/W2142575677","https://openalex.org/W2159416556","https://openalex.org/W2324299759","https://openalex.org/W2410182588","https://openalex.org/W2419192305"],"related_works":["https://openalex.org/W1967447825","https://openalex.org/W4298393633","https://openalex.org/W3040311485","https://openalex.org/W2026369316","https://openalex.org/W1855515901","https://openalex.org/W2531118767","https://openalex.org/W4399708322","https://openalex.org/W2028712739","https://openalex.org/W2373581143","https://openalex.org/W2910382281"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Previous":[1],"studies":[2],"have":[3],"demonstrated":[4],"that":[5,31,279],"levels":[6,49,197],"of":[7,9,22,24,50,59,69,98,104,143,177,184,188,191,198,220,224,227,231,242,283],"hypermethylation":[8,241],"paired":[10],"boxed":[11],"gene":[12],"1":[13,118],"in":[14,27,40,53,81,96,147,175,218,248,287],"cervical":[15,25,54,57,82,99,106,115,199,202,250,288,295],"tissues":[16,58,83,203],"are":[17],"associated":[18],"with":[19,182],"the":[20,66,87,163,212,275,280],"grades":[21],"severities":[23],"neoplasia":[26,254],"women,":[28],"which":[29,133],"suggests":[30],"testing":[32,47,72],"for":[33,76,294],"DNA":[34,70],"methylation":[35,48,71,91,145,281],"has":[36],"a":[37,74,245,291],"potential":[38],"role":[39],"neoplasma":[41],"screening.":[42,297],"In":[43,210,273],"this":[44],"study,":[45],"by":[46,137,285],"PAX1":[51,90,144,171,243,284],"genes":[52],"scrapings":[55,107,200,289],"and":[56,84,93,127,162,201,229,265,269],"different":[60],"lesion":[61],"levels,":[62],"aims":[63],"to":[64,85],"evaluate":[65],"diagnostic":[67],"value":[68],"as":[73],"biomarker":[75],"early":[77],"detecting":[78,97],"cancerous":[79],"changes":[80],"compare":[86],"efficacy":[88],"between":[89,267],"test":[92,95,214],"HPV":[94,213],"cancer.":[100,233],"METHODS:":[101],"A":[102],"total":[103],"121":[105],"were":[108,134,271],"analyzed,":[109],"including":[110],"normal":[111,185,221],"(n":[112,124,130],"=":[113,121,125,131],"28),":[114],"intraepithelial":[116],"neoplasm":[117],"(CIN1;":[119],"n":[120],"32),":[122],"CIN2/3":[123,158,192],"34),":[126],"invasive":[128,148,178,232],"cancer":[129,149,179,251,296],"27),":[132],"all":[135],"diagnosed":[136],"pathologic":[138],"examination.":[139],"RESULTS:":[140],"The":[141,170],"values":[142],"reference":[146],"(mean":[150],"[SE],":[151],"26.3":[152],"[3.5])":[153],"was":[154,173,216,244],"significantly":[155],"higher":[156],"than":[157],"(13.":[159],"2":[160],"[2.2])":[161],"CIN1":[164],"(4.5":[165],"[0.45];":[166],"P":[167],"<":[168,194,257],"0.001).":[169,258],"promoter":[172],"hypermethylated":[174],"100%":[176],"tissue":[180],"compared":[181],"0%":[183],"tissue,":[186,222],"9%":[187],"CIN1,":[189,225],"44%":[190],"(P":[193,256],"0.01).":[195],"Methylation":[196],"represent":[204],"strong":[205],"consistency":[206],"within":[207],"each":[208],"group.":[209],"contrast,":[211],"result":[215],"positive":[217],"17%":[219],"81%":[223],"91%":[226],"CIN2/CIN3,":[228],"92%":[230],"Based":[234],"on":[235],"receiver":[236],"operating":[237],"characteristic":[238],"(ROC)":[239],"analysis,":[240],"significant":[246],"candidate":[247],"segregating":[249],"from":[252],"normal/cervical":[253],"cases":[255],"At":[259],"an":[260],"optimal":[261],"cutoff":[262],"value,":[263],"sensitivity":[264],"specificity":[266],"80%":[268],"93%":[270],"obtained.":[272],"conclusion,":[274],"current":[276],"results":[277],"indicated":[278],"density":[282],"pyrosequencing":[286],"held":[290],"great":[292],"promise":[293]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}