{"id":"https://openalex.org/W2164895920","doi":"https://doi.org/10.2174/157016211798998781","title":"Humanized Mouse Models of HIV-1 Latency","display_name":"Humanized Mouse Models of HIV-1 Latency","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2164895920","doi":"https://doi.org/10.2174/157016211798998781","mag":"2164895920","pmid":"https://pubmed.ncbi.nlm.nih.gov/22211664"},"language":"en","primary_location":{"id":"doi:10.2174/157016211798998781","doi":"https://doi.org/10.2174/157016211798998781","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157016211798998781","pdf_url":null,"source":{"id":"https://openalex.org/S203872900","display_name":"Current HIV Research","issn_l":"1570-162X","issn":["1570-162X","1873-4251"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current HIV Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030324216","display_name":"Rachel Van Duyne","orcid":"https://orcid.org/0000-0003-2914-6874","observed_orcids":["https://orcid.org/0000-0003-2914-6874"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel V. Duyne","raw_affiliation_strings":["George Mason University, National Center for Biodefense & Infectious Diseases, School of Systems Biology, Manassas, VA 20110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Mason University, National Center for Biodefense & Infectious Diseases, School of Systems Biology, Manassas, VA 20110, USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036392835","display_name":"Aarthi Narayanan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aarthi Narayanan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070743719","display_name":"Kylene K-Hall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kylene K.-Hall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109932699","display_name":"Mohammed Saifuddin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed Saifuddin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036394378","display_name":"Leonard D. Shultz","orcid":"https://orcid.org/0000-0002-4868-1031","observed_orcids":["https://orcid.org/0000-0002-4868-1031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonard Shultz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016700147","display_name":"Fatah Kashanchi","orcid":"https://orcid.org/0000-0001-9681-2780","observed_orcids":["https://orcid.org/0000-0001-9681-2780"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatah Kashanchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5052,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.63960692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"8","first_page":"595","last_page":"605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-latency","display_name":"HIV-1 latency","score":0.9929999709129333},{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hiv-1-reservoir","display_name":"HIV-1 reservoir","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hematopoietic-engraftment","display_name":"hematopoietic engraftment","score":0.8080000281333923},{"id":"https://openalex.org/keywords/immunodeficient-mice","display_name":"immunodeficient mice","score":0.6919999718666077},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.6240000128746033},{"id":"https://openalex.org/keywords/hiv-1-pathogenesis","display_name":"HIV-1 pathogenesis","score":0.6290000081062317},{"id":"https://openalex.org/keywords/hiv-1-transmission","display_name":"HIV-1 transmission","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2776156784","wikidata":"https://www.wikidata.org/wiki/Q3491954","display_name":"Humanized mouse","level":3,"score":0.7972568273544312},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7255494594573975},{"id":"https://openalex.org/C82876162","wikidata":"https://www.wikidata.org/wiki/Q17096504","display_name":"Latency (audio)","level":2,"score":0.6139845252037048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6028927564620972},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.564091682434082},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.559108555316925},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5087142586708069},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.47353217005729675},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46582624316215515},{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.460791677236557},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.46019840240478516},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.413523405790329},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.39443784952163696},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29165780544281006},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2817884087562561},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.1879395842552185},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1339971125125885},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10829240083694458},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2174/157016211798998781","doi":"https://doi.org/10.2174/157016211798998781","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157016211798998781","pdf_url":null,"source":{"id":"https://openalex.org/S203872900","display_name":"Current HIV Research","issn_l":"1570-162X","issn":["1570-162X","1873-4251"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current HIV Research","raw_type":"journal-article"},{"id":"pmid:22211664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22211664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current HIV research","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:stfb2011-1156","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb2011/161","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2011","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2922200860","https://openalex.org/W4382458708","https://openalex.org/W2883938228","https://openalex.org/W2775401818","https://openalex.org/W2749252116","https://openalex.org/W3014567824","https://openalex.org/W3106046115","https://openalex.org/W3134867019","https://openalex.org/W2270938714","https://openalex.org/W1983914881"],"abstract_inverted_index":{"The":[0,74],"existence":[1],"of":[2,6,10,46,62,83],"long-lasting":[3],"cellular":[4],"reservoirs":[5],"HIV-1":[7,41,112,138],"is":[8],"one":[9],"the":[11,59,134,147],"major":[12],"hurdles":[13],"in":[14,64,71,106,118,140,143],"developing":[15],"effective":[16],"anti-retroviral":[17],"therapies.":[18],"These":[19],"latently":[20],"infected":[21],"cells":[22,85],"and":[23,29,55,77,86,102,129,142,145],"tissues":[24,87],"efficiently":[25],"evade":[26],"immune":[27,104,127],"responses":[28,105],"remain":[30],"dormant":[31],"until":[32],"activated,":[33],"upon":[34,80],"which":[35],"they":[36],"can":[37],"generate":[38],"a":[39,69,107],"productive":[40],"infection.":[42,156],"This":[43],"classic":[44],"scenario":[45],"viral":[47],"latency":[48,139],"becomes":[49],"even":[50],"more":[51],"difficult":[52],"to":[53,58,97,122],"study":[54],"model":[56,98],"due":[57],"extreme":[60],"complexity":[61],"translating":[63],"vivo":[65,144],"virus-cell":[66],"interactions":[67],"into":[68],"controlled":[70],"vitro":[72,141],"system.":[73],"recent":[75,149],"developments":[76],"constant":[78],"improvements":[79],"hematopoietic":[81],"engraftment":[82],"human":[84,100],"onto":[88],"recipient":[89],"immunocompromised":[90],"murine":[91],"scaffolds":[92],"have":[93],"made":[94],"it":[95],"possible":[96],"complex":[99],"innate":[101],"adaptive":[103],"small":[108],"animal":[109],"model.":[110],"Specifically,":[111],"infection":[113],"has":[114],"been":[115],"successfully":[116],"modeled":[117],"these":[119],"humanized":[120,150],"mice":[121],"mimic":[123],"transmission,":[124],"pathogenesis,":[125],"host":[126],"responses,":[128],"treatment.":[130],"Here,":[131],"we":[132],"review":[133],"complexities":[135],"surrounding":[136],"modeling":[137],"highlight":[146],"most":[148],"mouse":[151],"models":[152],"that":[153],"support":[154],"retroviral":[155]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
