{"id":"https://openalex.org/W2164892292","doi":"https://doi.org/10.1111/j.1464-5491.1988.tb01047.x","title":"Aldose Reductase Inhibition in Diabetic Neuropathy: Clinical and Neurophysiological Studies of one Year's Treatment with Sorbinil","display_name":"Aldose Reductase Inhibition in Diabetic Neuropathy: Clinical and Neurophysiological Studies of one Year's Treatment with Sorbinil","publication_year":1988,"publication_date":"1988-09-01","ids":{"openalex":"https://openalex.org/W2164892292","doi":"https://doi.org/10.1111/j.1464-5491.1988.tb01047.x","mag":"2164892292","pmid":"https://pubmed.ncbi.nlm.nih.gov/2974776"},"language":"en","primary_location":{"id":"doi:10.1111/j.1464-5491.1988.tb01047.x","doi":"https://doi.org/10.1111/j.1464-5491.1988.tb01047.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-5491.1988.tb01047.x","pdf_url":null,"source":{"id":"https://openalex.org/S72944096","display_name":"Diabetic Medicine","issn_l":"0742-3071","issn":["0742-3071","1096-9136","1464-5491"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110330119","display_name":"JAMES P. O\u02bcHARE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802901496","display_name":"Bristol Royal Infirmary","ror":"https://ror.org/031p4kj21","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802901496","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J. P. O'Hare","raw_affiliation_strings":["Department of Medicine, Bristol Royal Infirmary, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bristol Royal Infirmary, UK","institution_ids":["https://openalex.org/I2802901496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113530743","display_name":"M. HILARY MORGAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802901496","display_name":"Bristol Royal Infirmary","ror":"https://ror.org/031p4kj21","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802901496","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. H. Morgan","raw_affiliation_strings":["Department of Medicine, Bristol Royal Infirmary, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bristol Royal Infirmary, UK","institution_ids":["https://openalex.org/I2802901496"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Alden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802901496","display_name":"Bristol Royal Infirmary","ror":"https://ror.org/031p4kj21","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802901496","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Alden","raw_affiliation_strings":["Department of Medicine, Bristol Royal Infirmary, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bristol Royal Infirmary, UK","institution_ids":["https://openalex.org/I2802901496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052792863","display_name":"S. Chissel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802901496","display_name":"Bristol Royal Infirmary","ror":"https://ror.org/031p4kj21","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802901496","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Chissel","raw_affiliation_strings":["Department of Medicine, Bristol Royal Infirmary, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bristol Royal Infirmary, UK","institution_ids":["https://openalex.org/I2802901496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113562590","display_name":"I.A.D. O'Brien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802901496","display_name":"Bristol Royal Infirmary","ror":"https://ror.org/031p4kj21","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802901496","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I. A. D. O'Brien","raw_affiliation_strings":["Department of Medicine, Bristol Royal Infirmary, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bristol Royal Infirmary, UK","institution_ids":["https://openalex.org/I2802901496"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112786383","display_name":"R. J. M. Corrall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802901496","display_name":"Bristol Royal Infirmary","ror":"https://ror.org/031p4kj21","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802901496","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. J. M. Corrall","raw_affiliation_strings":["Department of Medicine, Bristol Royal Infirmary, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bristol Royal Infirmary, UK","institution_ids":["https://openalex.org/I2802901496"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110330119"],"corresponding_institution_ids":["https://openalex.org/I2802901496"],"apc_list":{"value":4870,"currency":"USD","value_usd":4870},"apc_paid":null,"fwci":0.947,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.735987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"5","issue":"6","first_page":"537","last_page":"542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldose-reductase-inhibition","display_name":"aldose reductase inhibition","score":0.8539999723434448},{"id":"https://openalex.org/keywords/sorbinil","display_name":"sorbinil","score":0.8059999942779541},{"id":"https://openalex.org/keywords/diabetic-neuropathy","display_name":"diabetic neuropathy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nerve-conduction-velocity","display_name":"nerve conduction velocity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/autonomic-function","display_name":"autonomic function","score":0.8960000276565552},{"id":"https://openalex.org/keywords/vibration-threshold","display_name":"vibration threshold","score":0.8550000190734863},{"id":"https://openalex.org/keywords/neuropathic-ulcer","display_name":"neuropathic ulcer","score":0.6819999814033508},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.6660000085830688},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.414000004529953},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9652888774871826},{"id":"https://openalex.org/C2776614240","wikidata":"https://www.wikidata.org/wiki/Q1259458","display_name":"Sorbinil","level":5,"score":0.9435679912567139},{"id":"https://openalex.org/C2777374081","wikidata":"https://www.wikidata.org/wiki/Q4713968","display_name":"Aldose reductase inhibitor","level":4,"score":0.7314324378967285},{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.7310874462127686},{"id":"https://openalex.org/C2779178840","wikidata":"https://www.wikidata.org/wiki/Q2046550","display_name":"Diabetic neuropathy","level":3,"score":0.5679803490638733},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5349937677383423},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.44563013315200806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34680742025375366},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.314582884311676}],"mesh":[{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008475","descriptor_name":"Median Nerve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010543","descriptor_name":"Peroneal Nerve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013401","descriptor_name":"Sugar Alcohol Dehydrogenases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014636","descriptor_name":"Valsalva Maneuver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048289","descriptor_name":"Imidazolidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1464-5491.1988.tb01047.x","doi":"https://doi.org/10.1111/j.1464-5491.1988.tb01047.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-5491.1988.tb01047.x","pdf_url":null,"source":{"id":"https://openalex.org/S72944096","display_name":"Diabetic Medicine","issn_l":"0742-3071","issn":["0742-3071","1096-9136","1464-5491"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetic Medicine","raw_type":"journal-article"},{"id":"pmid:2974776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2974776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetic medicine : a journal of the British Diabetic Association","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W195500892","https://openalex.org/W1859167563","https://openalex.org/W1973310039","https://openalex.org/W1979171413","https://openalex.org/W2016038750","https://openalex.org/W2029102671","https://openalex.org/W2037674730","https://openalex.org/W2040644761","https://openalex.org/W2041715383","https://openalex.org/W2054980588","https://openalex.org/W2059474142","https://openalex.org/W2064616098","https://openalex.org/W2070717836","https://openalex.org/W2070875172","https://openalex.org/W2075504285","https://openalex.org/W2087454683","https://openalex.org/W2090243052","https://openalex.org/W2100973036","https://openalex.org/W2119495829","https://openalex.org/W2141581995","https://openalex.org/W2151772902","https://openalex.org/W2313488710","https://openalex.org/W2313945403"],"related_works":["https://openalex.org/W2070717836","https://openalex.org/W2087454683","https://openalex.org/W2151772902","https://openalex.org/W1990607360","https://openalex.org/W2088530335","https://openalex.org/W2006238137","https://openalex.org/W2033373388","https://openalex.org/W4236569773","https://openalex.org/W2151871266","https://openalex.org/W1969768439"],"abstract_inverted_index":{"In":[0],"a":[1,18,42,81],"double-blind":[2],"placebo-controlled":[3],"trial":[4,114],"the":[5,113,131,143,148],"effect":[6,136],"of":[7,52,73,91,130,137,160],"Sorbinil":[8,32,78,125,138],"(250":[9],"mg":[10],"daily)":[11],"on":[12,77,141,147],"diabetic":[13,155],"neuropathy":[14,92],"was":[15,93,139],"examined.":[16],"After":[17],"2-month":[19],"run-in":[20],"placebo":[21,132],"period":[22],"(with":[23],"three":[24],"major":[25],"assessments)":[26],"21":[27],"patients":[28,123,156],"were":[29,39,85,100],"randomized":[30],"to":[31,35],"and":[33,37,69,84,89,127],"10":[34],"placebo,":[36],"all":[38],"studied":[40],"for":[41],"further":[43],"12":[44,158],"months":[45,159],"with":[46,115],"neurophysiological":[47,149],"measurements":[48,150],"at":[49],"3-month":[50],"intervals":[51],"nerve":[53],"conduction":[54],"velocity":[55],"in":[56,103,121,128,152],"multiple":[57],"nerves,":[58],"autonomic":[59],"function":[60],"tests,":[61],"vibration":[62],"thresholds":[63],"as":[64,66,105],"well":[65],"clinical":[67,144],"examination":[68],"an":[70],"extensive":[71],"self-assessment":[72,108],"symptoms.":[74],"Two":[75],"subjects":[76],"treatment":[79,126],"developed":[80,120],"hypersensitivity":[82],"reaction":[83],"withdrawn.":[86],"Metabolic":[87],"control":[88],"severity":[90],"not":[94],"significantly":[95],"different":[96],"between":[97],"groups.":[98],"There":[99],"no":[101],"changes":[102],"symptoms":[104],"judged":[106],"by":[107],"scores.":[109],"No":[110,134],"patient":[111],"entered":[112],"neuropathic":[116,154],"ulcers":[117],"but":[118],"ulceration":[119],"4":[122],"during":[124],"1":[129],"group.":[133],"beneficial":[135],"demonstrated":[140],"either":[142],"manifestation":[145],"or":[146],"made":[151],"these":[153],"over":[157],"treatment.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
