{"id":"https://openalex.org/W2164889299","doi":null,"title":"REGULATION OF KALLIKREIN 6 GENE EXPRESSION AND PROTEIN SECRETION IN COLON CANCER MODEL SYSTEMS","display_name":"REGULATION OF KALLIKREIN 6 GENE EXPRESSION AND PROTEIN SECRETION IN COLON CANCER MODEL SYSTEMS","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2164889299","mag":"2164889299"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/196033","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/196033","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107521514","display_name":"Rebecca S. Henkhaus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rebecca S. Henkhaus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5107521514"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kallikrein-6","display_name":"kallikrein 6","score":0.9900000095367432},{"id":"https://openalex.org/keywords/kallikrein-related-peptidase-6","display_name":"KLK6","score":0.9330000281333923},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.7850000262260437},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.9549999833106995},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.765999972820282},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.824999988079071},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7739999890327454},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7540000081062317},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.9240000247955322},{"id":"https://openalex.org/keywords/matrigel","display_name":"Matrigel","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.8149999976158142},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7310000061988831},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.7666783928871155},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5439671277999878},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5161858201026917},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5088058114051819},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4787032902240753},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.468943327665329},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4176448583602905},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.413646936416626},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3670170307159424},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32459011673927307},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3229166269302368},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16702872514724731},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10383805632591248},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/196033","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/196033","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:2164889299","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/bitstream/10150/196033/1/azu_etd_2580_sip1_m.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":158,"referenced_works":["https://openalex.org/W15453418","https://openalex.org/W107971245","https://openalex.org/W137827881","https://openalex.org/W1439306656","https://openalex.org/W1498272454","https://openalex.org/W1546754115","https://openalex.org/W1549194476","https://openalex.org/W1593869902","https://openalex.org/W1595995023","https://openalex.org/W1598512610","https://openalex.org/W1602504912","https://openalex.org/W1633066991","https://openalex.org/W1907484284","https://openalex.org/W1938617858","https://openalex.org/W1963769095","https://openalex.org/W1964628210","https://openalex.org/W1964675052","https://openalex.org/W1966275499","https://openalex.org/W1967207031","https://openalex.org/W1968337848","https://openalex.org/W1969384522","https://openalex.org/W1972581901","https://openalex.org/W1973554661","https://openalex.org/W1974861755","https://openalex.org/W1975572503","https://openalex.org/W1981176258","https://openalex.org/W1984730682","https://openalex.org/W1988481255","https://openalex.org/W1990985882","https://openalex.org/W1991807950","https://openalex.org/W1992743702","https://openalex.org/W1992872682","https://openalex.org/W1995226883","https://openalex.org/W1997323541","https://openalex.org/W1998401471","https://openalex.org/W1999743098","https://openalex.org/W2000170100","https://openalex.org/W2000828944","https://openalex.org/W2001258296","https://openalex.org/W2002589261","https://openalex.org/W2007470455","https://openalex.org/W2010098875","https://openalex.org/W2011083424","https://openalex.org/W2011826559","https://openalex.org/W2012586068","https://openalex.org/W2012984784","https://openalex.org/W2013280663","https://openalex.org/W2014782775","https://openalex.org/W2014814276","https://openalex.org/W2015213611","https://openalex.org/W2015278187","https://openalex.org/W2017118245","https://openalex.org/W2017941401","https://openalex.org/W2018251273","https://openalex.org/W2019487348","https://openalex.org/W2020670793","https://openalex.org/W2022380333","https://openalex.org/W2022653182","https://openalex.org/W2024066414","https://openalex.org/W2027737365","https://openalex.org/W2028883860","https://openalex.org/W2029904263","https://openalex.org/W2036372337","https://openalex.org/W2036691369","https://openalex.org/W2037376917","https://openalex.org/W2038384842","https://openalex.org/W2039677504","https://openalex.org/W2044334025","https://openalex.org/W2046053482","https://openalex.org/W2048914280","https://openalex.org/W2049324939","https://openalex.org/W2050291058","https://openalex.org/W2053731989","https://openalex.org/W2054462619","https://openalex.org/W2054791134","https://openalex.org/W2055476265","https://openalex.org/W2055764506","https://openalex.org/W2056229778","https://openalex.org/W2060438880","https://openalex.org/W2061955385","https://openalex.org/W2065467435","https://openalex.org/W2065951922","https://openalex.org/W2066872433","https://openalex.org/W2072573412","https://openalex.org/W2077613860","https://openalex.org/W2080832370","https://openalex.org/W2082225843","https://openalex.org/W2084296762","https://openalex.org/W2084864591","https://openalex.org/W2086189449","https://openalex.org/W2087222747","https://openalex.org/W2089363480","https://openalex.org/W2091278620","https://openalex.org/W2095576233","https://openalex.org/W2097908823","https://openalex.org/W2098719212","https://openalex.org/W2099387726","https://openalex.org/W2100048800","https://openalex.org/W2101235425","https://openalex.org/W2102642039","https://openalex.org/W2103882085","https://openalex.org/W2103964329","https://openalex.org/W2106695011","https://openalex.org/W2106739397","https://openalex.org/W2107312415","https://openalex.org/W2109602297","https://openalex.org/W2109834412","https://openalex.org/W2112009693","https://openalex.org/W2112797229","https://openalex.org/W2114600333","https://openalex.org/W2117461801","https://openalex.org/W2119999174","https://openalex.org/W2122054605","https://openalex.org/W2123244768","https://openalex.org/W2123856998","https://openalex.org/W2126520642","https://openalex.org/W2129838502","https://openalex.org/W2131053533","https://openalex.org/W2136828548","https://openalex.org/W2138617644","https://openalex.org/W2140179680","https://openalex.org/W2140277678","https://openalex.org/W2140354759","https://openalex.org/W2142012657","https://openalex.org/W2142148410","https://openalex.org/W2144471460","https://openalex.org/W2146149227","https://openalex.org/W2146157811","https://openalex.org/W2146812359","https://openalex.org/W2147075172","https://openalex.org/W2148464651","https://openalex.org/W2150119709","https://openalex.org/W2151770149","https://openalex.org/W2154394909","https://openalex.org/W2154458783","https://openalex.org/W2154688757","https://openalex.org/W2155862964","https://openalex.org/W2155998628","https://openalex.org/W2159594827","https://openalex.org/W2160269020","https://openalex.org/W2160543963","https://openalex.org/W2161687477","https://openalex.org/W2161700413","https://openalex.org/W2164384409","https://openalex.org/W2165232049","https://openalex.org/W2167109216","https://openalex.org/W2169691126","https://openalex.org/W2172064884","https://openalex.org/W2334102774","https://openalex.org/W2335761521","https://openalex.org/W2409361713","https://openalex.org/W2416326858","https://openalex.org/W2418069209","https://openalex.org/W2435918407","https://openalex.org/W2437033065","https://openalex.org/W2468327850","https://openalex.org/W2520041693","https://openalex.org/W2746339049"],"related_works":["https://openalex.org/W1562387428","https://openalex.org/W2084296762","https://openalex.org/W1965960873","https://openalex.org/W2053731989","https://openalex.org/W2072416484","https://openalex.org/W4286224229","https://openalex.org/W3162570464","https://openalex.org/W2326587259","https://openalex.org/W2342284910","https://openalex.org/W2020005240"],"abstract_inverted_index":{"Colon":[0],"cancer":[1,84,124,132,210,235,262],"occurs":[2],"in":[3,9,39,59,123,207,234],"over":[4],"150,000":[5],"men":[6],"and":[7,15,48,61,91,126,182,191,203,227,265],"women":[8],"the":[10,22,40,99,163,179,183,220],"United":[11],"States":[12],"each":[13],"year":[14],"is":[16,81,95,215],"fatal":[17],"about":[18],"one":[19],"third":[20],"of":[21,98,105,113,136,169,223,258,268],"time.":[23],"There":[24,54],"are":[25,55,65],"many":[26,52,57],"well":[27],"characterized":[28],"genetic":[29],"transformations":[30],"which":[31,64,103],"commonly":[32],"occur":[33],"during":[34],"colon":[35,209,261,264],"carcinogenesis,":[36],"including":[37,178,260],"mutations":[38],"Adenometous":[41],"Polyposis":[42],"Coli":[43],"(APC),":[44],"Kirsten":[45],"RAS":[46],"(K-RAS)":[47],"p53":[49],"genes":[50],"among":[51],"others.":[53],"also":[56],"alterations":[58],"gene":[60,78,176,201],"protein":[62,101,194,205],"expression":[63,80,202],"not":[66],"yet":[67],"completely":[68],"elucidated.":[69],"We":[70],"have":[71,116],"identified":[72,140],"kallikrein":[73,100],"6":[74],"(KLK6)":[75],"as":[76,88,130,240,251],"a":[77,96,121,143,147,232,241,252],"whose":[79],"dependent":[82],"on":[83,146],"associated":[85,189],"proteins":[86],"such":[87],"K-RAS,":[89],"SRC":[90],"caveolin-1":[92],"(CAV-1).":[93],"KLK6":[94,137,161,175,200,204,218,230,246],"member":[97],"family":[102],"consists":[104],"15":[106],"secreted":[107],"serine":[108],"proteases.":[109],"Like":[110],"other":[111,266],"types":[112,257,267],"proteases,":[114],"kallikreins":[115],"been":[117],"demonstrated":[118],"to":[119,173],"play":[120],"role":[122,233],"progression":[125,236],"they":[127],"hold":[128],"promise":[129],"potential":[131,222,248],"biomarkers.":[133],"The":[134,153],"up-regulation":[135],"was":[138],"first":[139],"by":[141],"performing":[142],"microarray":[144],"analysis":[145],"mutant":[148],"K-RAS":[149,155,170],"transfected":[150,156,165],"Caco2":[151],"cells.":[152,212],"activated":[154],"cells":[157,224],"expressed":[158],"significantly":[159],"more":[160],"than":[162],"mock":[164],"controls.":[166],"Pathways":[167],"downstream":[168],"were":[171],"found":[172],"induce":[174],"expression,":[177],"p42/44":[180],"MAPK":[181],"PI3-K/AKT":[184],"pathways.":[185],"Caveolae,":[186],"plasma":[187],"membrane":[188],"structures,":[190],"their":[192],"principle":[193],"component,":[195],"CAV-1,":[196],"positively":[197],"influence":[198],"both":[199],"secretion":[206],"HCT116":[208],"derived":[211],"Finally,":[213],"it":[214,237],"shown":[216],"that":[217],"increases":[219],"invasive":[221],"through":[225],"laminin":[226],"Matrigel.":[228],"Because":[229],"plays":[231],"may":[238],"serves":[239],"novel":[242],"therapeutic":[243],"target.":[244],"Additionally,":[245],"holds":[247],"for":[249,255,263],"use":[250],"serum":[253],"biomarker":[254],"multiple":[256],"cancer,":[259],"cancer.":[269]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}