{"id":"https://openalex.org/W2164887085","doi":"https://doi.org/10.1086/504525","title":"Myeloid Differentiation Primary Response Gene (88)\u2013 and Toll\u2010Like Receptor 2\u2013Deficient Mice Are Susceptible to Infection with AerosolizedLegionella pneumophila","display_name":"Myeloid Differentiation Primary Response Gene (88)\u2013 and Toll\u2010Like Receptor 2\u2013Deficient Mice Are Susceptible to Infection with AerosolizedLegionella pneumophila","publication_year":2006,"publication_date":"2006-05-15","ids":{"openalex":"https://openalex.org/W2164887085","doi":"https://doi.org/10.1086/504525","mag":"2164887085","pmid":"https://pubmed.ncbi.nlm.nih.gov/16703513"},"language":"en","primary_location":{"id":"doi:10.1086/504525","doi":"https://doi.org/10.1086/504525","is_oa":false,"landing_page_url":"https://doi.org/10.1086/504525","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078366736","display_name":"Thomas R. Hawn","orcid":"https://orcid.org/0000-0003-2368-3185","observed_orcids":["https://orcid.org/0000-0003-2368-3185"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas\u00a0R. Hawn","raw_affiliation_strings":["Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA. thawn@u.washington.edu","Department of Medicine, University of Washington School of Medicine, Seattle","Institute for Systems Biology, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA. thawn@u.washington.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington School of Medicine, Seattle","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027246219","display_name":"Kelly D. Smith","orcid":"https://orcid.org/0000-0002-2368-4957","observed_orcids":["https://orcid.org/0000-0002-2368-4957"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly\u00a0D. Smith","raw_affiliation_strings":["Department of Pathology, University of Washington School of Medicine, Seattle","Institute for Systems Biology, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Washington School of Medicine, Seattle","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063227404","display_name":"Alan A. Aderem","orcid":"https://orcid.org/0000-0003-4031-5499","observed_orcids":["https://orcid.org/0000-0003-4031-5499"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Aderem","raw_affiliation_strings":["Institute for Systems Biology, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002204984","display_name":"Shawn J. Skerrett","orcid":"https://orcid.org/0000-0002-9622-4070","observed_orcids":["https://orcid.org/0000-0002-9622-4070"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn\u00a0J. Skerrett","raw_affiliation_strings":["Department of Medicine, University of Washington School of Medicine, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington School of Medicine, Seattle","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078366736"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I3148997608"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":4.1629,"has_fulltext":true,"cited_by_count":107,"citation_normalized_percentile":{"value":0.94928216,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"193","issue":"12","first_page":"1693","last_page":"1702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11916","display_name":"Legionella and Acanthamoeba research","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/legionella-pneumophila","display_name":"Legionella pneumophila","score":0.9919999837875366},{"id":"https://openalex.org/keywords/aerosolized-infection","display_name":"aerosolized infection","score":0.843999981880188},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/organizing-pneumonia","display_name":"organizing pneumonia","score":0.8539999723434448},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8429999947547913},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9229999780654907},{"id":"https://openalex.org/keywords/myd88-deficient-mice","display_name":"MyD88-deficient mice","score":0.8259999752044678},{"id":"https://openalex.org/keywords/tlr2-deficient-mice","display_name":"TLR2-deficient mice","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bacterial-clearance","display_name":"bacterial clearance","score":0.550000011920929},{"id":"https://openalex.org/keywords/disseminated-infection","display_name":"disseminated infection","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2776118409","wikidata":"https://www.wikidata.org/wiki/Q147885","display_name":"Legionella pneumophila","level":3,"score":0.8177695274353027},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7525887489318848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6947920918464661},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.6296036243438721},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6040828227996826},{"id":"https://openalex.org/C2779164008","wikidata":"https://www.wikidata.org/wiki/Q158013","display_name":"Legionella","level":3,"score":0.5497031807899475},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4918077290058136},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48749423027038574},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.47236400842666626},{"id":"https://openalex.org/C2994430510","wikidata":"https://www.wikidata.org/wiki/Q3270846","display_name":"Myeloid cells","level":3,"score":0.46934688091278076},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.4364683926105499},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.429935097694397},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41631802916526794},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15309923887252808},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.12247738242149353}],"mesh":[{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007877","descriptor_name":"Legionnaires' Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007877","descriptor_name":"Legionnaires' Disease","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007877","descriptor_name":"Legionnaires' Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016952","descriptor_name":"Legionella pneumophila","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D016952","descriptor_name":"Legionella pneumophila","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018410","descriptor_name":"Pneumonia, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018410","descriptor_name":"Pneumonia, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020556","descriptor_name":"Neutrophil Infiltration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1086/504525","doi":"https://doi.org/10.1086/504525","is_oa":false,"landing_page_url":"https://doi.org/10.1086/504525","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:16703513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16703513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1826341373","display_name":"Recognition of Bacterial Flagellin by Macrophages","funder_award_id":"R01AI052286","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2054826548","display_name":"Host Defense Against Intracellular Infection of the Lung","funder_award_id":"2r01hl054972-06a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3722109191","display_name":"TLR5 and Pulmonary Innate Immunity","funder_award_id":"R01AI061464","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6652059177","display_name":null,"funder_award_id":"R01 HL54972","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1517175505","https://openalex.org/W1527612695","https://openalex.org/W1535049394","https://openalex.org/W1550704138","https://openalex.org/W1592483123","https://openalex.org/W1700191035","https://openalex.org/W1907816840","https://openalex.org/W1930598094","https://openalex.org/W1946493814","https://openalex.org/W1958291016","https://openalex.org/W1971857640","https://openalex.org/W1972093499","https://openalex.org/W1986997900","https://openalex.org/W1996120614","https://openalex.org/W1999609081","https://openalex.org/W2004465286","https://openalex.org/W2013425197","https://openalex.org/W2046766351","https://openalex.org/W2046783872","https://openalex.org/W2057809738","https://openalex.org/W2075870534","https://openalex.org/W2083733667","https://openalex.org/W2090940365","https://openalex.org/W2092713594","https://openalex.org/W2099454764","https://openalex.org/W2106280019","https://openalex.org/W2107674270","https://openalex.org/W2109879905","https://openalex.org/W2119446930","https://openalex.org/W2126011873","https://openalex.org/W2129271960","https://openalex.org/W2133449490","https://openalex.org/W2138507798","https://openalex.org/W2148280592","https://openalex.org/W2153092306","https://openalex.org/W2159613168","https://openalex.org/W2162358868","https://openalex.org/W2163374608","https://openalex.org/W2168977023","https://openalex.org/W2182541906","https://openalex.org/W2261858505","https://openalex.org/W2483896833","https://openalex.org/W3143755808"],"related_works":["https://openalex.org/W2119256241","https://openalex.org/W2163468586","https://openalex.org/W2000022183","https://openalex.org/W2790038778","https://openalex.org/W2165767917","https://openalex.org/W2127364256","https://openalex.org/W2749602243","https://openalex.org/W2106280019","https://openalex.org/W2138802551","https://openalex.org/W1517175505"],"abstract_inverted_index":{"BACKGROUND:":[0],"Toll-like":[1],"receptors":[2],"(TLRs)":[3],"are":[4,18,38,207],"a":[5,178],"family":[6],"of":[7,27,47,114,124,185,190],"proteins":[8],"that":[9,177,202],"orchestrate":[10],"innate":[11],"immune":[12],"responses":[13],"to":[14,66,127,139,157,167,197],"microbes.":[15],"Although":[16],"pathogens":[17],"typically":[19],"recognized":[20],"by":[21],"multiple":[22,59],"TLRs,":[23,60],"the":[24,45,88,95,116,128,147,158,163],"specific":[25],"roles":[26,46],"individual":[28],"TLRs":[29],"in":[30,35,63,71,87,94,146],"mediating":[31,64],"host":[32],"protection":[33],"during":[34],"vivo":[36],"infection":[37,70,164],"not":[39],"well":[40,100],"understood.":[41],"METHODS:":[42],"We":[43],"compared":[44],"myeloid":[48],"differentiation":[49],"primary":[50],"response":[51],"gene":[52],"(88)":[53],"(MyD88),":[54],"which":[55,200],"regulates":[56],"signaling":[57],"through":[58],"and":[61,104,131,161,170,188],"TLR2":[62,193],"resistance":[65,196],"aerosolized":[67],"Legionella":[68],"pneumophila":[69,126,187],"vivo.":[72],"RESULTS:":[73],"In":[74],"comparison":[75],"with":[76,90,122,142],"wild-type":[77],"mice,":[78],"MyD88-deficient":[79],"(MyD88(-/-))":[80],"mice":[81,118,134,151],"had":[82],"dramatically":[83],"higher":[84,143],"bacterial":[85,144],"counts":[86,93,145],"lungs,":[89],"decreased":[91],"neutrophil":[92],"bronchoalveolar":[96],"lavage":[97],"fluid":[98],"as":[99,101],"absent":[102],"cytokine":[103],"chemokine":[105],"production":[106],"at":[107],"early":[108],"time":[109],"points.":[110],"By":[111],"day":[112],"6":[113],"infection,":[115],"MyD88(-/-)":[117],"developed":[119],"organizing":[120,168,191],"pneumonia":[121,169],"dissemination":[123],"L.":[125,140,186,198],"lymph":[129],"nodes":[130],"spleen.":[132],"TLR2(-/-)":[133,150],"were":[135],"also":[136],"more":[137],"susceptible":[138],"pneumophila,":[141,199],"lung.":[148],"However,":[149],"produced":[152],"proinflammatory":[153],"cytokines,":[154],"recruited":[155],"neutrophils":[156],"lung":[159],"alveoli,":[160],"cleared":[162],"without":[165],"progression":[166],"disseminated":[171],"disease.":[172],"CONCLUSIONS:":[173],"These":[174],"results":[175],"suggest":[176],"MyD88-dependent":[179],"pathway":[180],"is":[181],"required":[182],"for":[183,209],"eradication":[184],"prevention":[189],"pneumonia.":[192],"mediates":[194],"partial":[195],"indicates":[201],"additional":[203],"MyD88-dependent,":[204],"TLR2-independent":[205],"pathways":[206],"essential":[208],"full":[210],"protection.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}