{"id":"https://openalex.org/W2164881996","doi":"https://doi.org/10.1093/jat/22.5.362","title":"Simultaneous Extraction of Selected Benzodiazepines and Benzodiazepine-Glucuronides from Urine by Immunoadsorption","display_name":"Simultaneous Extraction of Selected Benzodiazepines and Benzodiazepine-Glucuronides from Urine by Immunoadsorption","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2164881996","doi":"https://doi.org/10.1093/jat/22.5.362","mag":"2164881996","pmid":"https://pubmed.ncbi.nlm.nih.gov/9737329"},"language":"en","primary_location":{"id":"doi:10.1093/jat/22.5.362","doi":"https://doi.org/10.1093/jat/22.5.362","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jat/22.5.362","pdf_url":null,"source":{"id":"https://openalex.org/S140972820","display_name":"Journal of Analytical Toxicology","issn_l":"0146-4760","issn":["0146-4760","1945-2403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083387503","display_name":"Cornelia Franzelius","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"C. Franzelius","raw_affiliation_strings":["Institute of Legal Medicine, Erlangen, Germany","Institute of Legal Medicine, Universit\u00e4tsstr. 22, D-91054 Erlangen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Legal Medicine, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Institute of Legal Medicine, Universit\u00e4tsstr. 22, D-91054 Erlangen","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109249662","display_name":"I. E. ACKERMANN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I. Ackermann","raw_affiliation_strings":["Institute of Legal Medicine, Universit\u00e4tsstr . 22, D-91054 Erlangen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Legal Medicine, Universit\u00e4tsstr . 22, D-91054 Erlangen","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035025615","display_name":"I. Deinl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I. Deinl","raw_affiliation_strings":["Institute of Legal Medicine, Universit\u00e4tsstr . 22, D-91054 Erlangen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Legal Medicine, Universit\u00e4tsstr . 22, D-91054 Erlangen","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075158483","display_name":"L. Angermaier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Angermaier","raw_affiliation_strings":["Boehringer Mannheim GmbH, Bahnhofstr. 9-15, D-82327 Tutzing, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Mannheim GmbH, Bahnhofstr. 9-15, D-82327 Tutzing, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040462814","display_name":"G. Machbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Machbert","raw_affiliation_strings":["Institute of Legal Medicine, Universit\u00e4tsstr . 22, D-91054 Erlangen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Legal Medicine, Universit\u00e4tsstr . 22, D-91054 Erlangen","institution_ids":["https://openalex.org/I181369854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083387503"],"corresponding_institution_ids":["https://openalex.org/I181369854"],"apc_list":{"value":4823,"currency":"USD","value_usd":4823},"apc_paid":null,"fwci":1.4582,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.81382002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"22","issue":"5","first_page":"359","last_page":"362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9819999933242798},{"id":"https://openalex.org/keywords/immunoadsorption","display_name":"immunoadsorption","score":0.9509999752044678},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.9459999799728394},{"id":"https://openalex.org/keywords/nordiazepam","display_name":"nordiazepam","score":0.8090000152587891},{"id":"https://openalex.org/keywords/temazepam","display_name":"temazepam","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxazepam","display_name":"oxazepam","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lorazepam","display_name":"lorazepam","score":0.996999979019165},{"id":"https://openalex.org/keywords/simultaneous-extraction","display_name":"simultaneous extraction","score":0.7149999737739563},{"id":"https://openalex.org/keywords/drug-metabolites","display_name":"drug metabolites","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C2776615572","wikidata":"https://www.wikidata.org/wiki/Q412299","display_name":"Oxazepam","level":4,"score":0.9483516812324524},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8608232736587524},{"id":"https://openalex.org/C2781006864","wikidata":"https://www.wikidata.org/wiki/Q414796","display_name":"Temazepam","level":4,"score":0.847693145275116},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.7803373336791992},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.7717058658599854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7486587166786194},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.6484463214874268},{"id":"https://openalex.org/C2779186261","wikidata":"https://www.wikidata.org/wiki/Q137786","display_name":"Glucuronide","level":3,"score":0.623585045337677},{"id":"https://openalex.org/C2777207853","wikidata":"https://www.wikidata.org/wiki/Q410078","display_name":"Nitrazepam","level":3,"score":0.4974541962146759},{"id":"https://openalex.org/C2780930544","wikidata":"https://www.wikidata.org/wiki/Q62962","display_name":"Hypnotic","level":2,"score":0.4881304204463959},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.3607480823993683},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3217710852622986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14625054597854614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06949403882026672},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005965","descriptor_name":"Glucuronates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007163","descriptor_name":"Immunosorbent Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007164","descriptor_name":"Immunosorbents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008140","descriptor_name":"Lorazepam","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008140","descriptor_name":"Lorazepam","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D010076","descriptor_name":"Oxazepam","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D013693","descriptor_name":"Temazepam","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/jat/22.5.362","doi":"https://doi.org/10.1093/jat/22.5.362","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jat/22.5.362","pdf_url":null,"source":{"id":"https://openalex.org/S140972820","display_name":"Journal of Analytical Toxicology","issn_l":"0146-4760","issn":["0146-4760","1945-2403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Toxicology","raw_type":"journal-article"},{"id":"pmid:9737329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9737329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of analytical toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W122891250","https://openalex.org/W1970462819","https://openalex.org/W2024569323","https://openalex.org/W2024900542","https://openalex.org/W2038126918","https://openalex.org/W2083972189","https://openalex.org/W2605274014"],"related_works":["https://openalex.org/W2071956050","https://openalex.org/W2041854250","https://openalex.org/W3046090423","https://openalex.org/W2106838407","https://openalex.org/W1985375154","https://openalex.org/W2065083077","https://openalex.org/W7027850088","https://openalex.org/W2312907147","https://openalex.org/W1975492044","https://openalex.org/W4302047395"],"abstract_inverted_index":{"A":[0],"rapid":[1],"and":[2,17,25,40,65],"selective":[3],"cleanup":[4],"procedure":[5],"based":[6],"on":[7],"immunoadsorption":[8],"is":[9,55],"described":[10],"for":[11,35],"the":[12,36,43,58,91,120,124],"simultaneous":[13],"extraction":[14,37],"of":[15,38,60,76,82,103,112,123],"diazepam":[16,113],"its":[18],"free":[19],"or":[20,78,114],"glucuronidated":[21],"metabolites":[22],"nordiazepam,":[23],"temazepam,":[24],"oxazepam":[26],"from":[27,106],"urine.":[28,83],"The":[29],"method":[30],"can":[31],"also":[32],"be":[33,49,94],"used":[34,95],"lorazepam":[39,115],"lorazepam-glucuronide.":[41],"Because":[42],"samples":[44,105],"do":[45],"not":[46],"have":[47],"to":[48,73,118],"hydrolyzed":[50],"before":[51],"extraction,":[52],"valuable":[53],"information":[54],"preserved.":[56],"With":[57],"exception":[59],"lorazepam-glucuronide,":[61],"recoveries":[62],"between":[63],"86":[64],"100%":[66],"were":[67],"obtained":[68],"at":[69,96],"spiking":[70],"levels":[71],"up":[72],"200":[74],"ng":[75],"benzodiazepine":[77],"glucuronide":[79],"per":[80],"milliliter":[81],"Using":[84],"methanol/water":[85],"(90:10,":[86],"v/v)":[87],"as":[88],"an":[89],"eluent,":[90],"immunoadsorber":[92],"could":[93],"least":[97],"20":[98],"times.":[99],"High-performance":[100],"liquid":[101],"chromatograms":[102],"urine":[104],"patients":[107],"receiving":[108],"low":[109],"therapeutic":[110],"dosages":[111],"are":[116],"shown":[117],"demonstrate":[119],"high":[121],"purity":[122],"extracts.":[125]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
