{"id":"https://openalex.org/W2164880427","doi":null,"title":"Desarrollo de vectores lentivirales para terapia g\u00e9nica del s\u00edndrome de Hiper-IgM ligado al cromosoma X (X-HIGM1)","display_name":"Desarrollo de vectores lentivirales para terapia g\u00e9nica del s\u00edndrome de Hiper-IgM ligado al cromosoma X (X-HIGM1)","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2164880427","mag":"2164880427"},"language":"es","primary_location":{"id":"pmh:oai:digibug.ugr.es:10481/2328","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10481/2328","pdf_url":null,"source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10481/2328","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033913363","display_name":"Zulema G. Romero","orcid":"https://orcid.org/0000-0001-8305-8184","observed_orcids":["https://orcid.org/0000-0001-8305-8184"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zulema Romero Garc\u00eda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033913363"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lentiviral-vectors","display_name":"lentiviral vectors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.906000018119812},{"id":"https://openalex.org/keywords/x-linked-hyper-igm-syndrome","display_name":"X-linked hyper-IgM syndrome","score":0.9309999942779541},{"id":"https://openalex.org/keywords/primary-immunodeficiency","display_name":"primary immunodeficiency","score":0.7590000033378601},{"id":"https://openalex.org/keywords/t-cell-receptor-delta-chain","display_name":"T cell receptor delta chain","score":0.35899999737739563},{"id":"https://openalex.org/keywords/class-switch-recombination","display_name":"class switch recombination","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.7373682260513306},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.32282426953315735},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.14494258165359497}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:digibug.ugr.es:10481/2328","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10481/2328","pdf_url":null,"source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:dnet:digibug_____::dcd5ab70f789d5601d2c0d9f16efb93e","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10481/2328","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/651960","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10481/2328","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2164880427","doi":null,"is_oa":false,"landing_page_url":"https://digibug.ugr.es/handle/10481/2328","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digibug.ugr.es:10481/2328","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10481/2328","pdf_url":null,"source":{"id":"https://openalex.org/S4306400567","display_name":"Institutional Repository of the University of Granada (University of Granada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173304897","host_organization_name":"Universidad de Granada","host_organization_lineage":["https://openalex.org/I173304897"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":171,"referenced_works":["https://openalex.org/W60880913","https://openalex.org/W124404536","https://openalex.org/W1208069797","https://openalex.org/W1464706687","https://openalex.org/W1481565655","https://openalex.org/W1482176142","https://openalex.org/W1499622448","https://openalex.org/W1501876040","https://openalex.org/W1502772682","https://openalex.org/W1504660023","https://openalex.org/W1528039184","https://openalex.org/W1528551608","https://openalex.org/W1542326554","https://openalex.org/W1553087660","https://openalex.org/W1561516029","https://openalex.org/W1568037402","https://openalex.org/W1579604458","https://openalex.org/W1586940012","https://openalex.org/W1604244424","https://openalex.org/W1621157891","https://openalex.org/W1835972708","https://openalex.org/W1924256095","https://openalex.org/W1965018476","https://openalex.org/W1968223547","https://openalex.org/W1968848464","https://openalex.org/W1971410311","https://openalex.org/W1972636814","https://openalex.org/W1973278012","https://openalex.org/W1974193054","https://openalex.org/W1975820470","https://openalex.org/W1976365653","https://openalex.org/W1978341830","https://openalex.org/W1980449150","https://openalex.org/W1981449360","https://openalex.org/W1981799120","https://openalex.org/W1982271550","https://openalex.org/W1983795855","https://openalex.org/W1984270581","https://openalex.org/W1985832579","https://openalex.org/W1987653378","https://openalex.org/W1990338101","https://openalex.org/W1990590909","https://openalex.org/W1993583999","https://openalex.org/W1995847556","https://openalex.org/W1998165633","https://openalex.org/W1998169663","https://openalex.org/W1998288885","https://openalex.org/W1998793015","https://openalex.org/W1999339723","https://openalex.org/W2001427569","https://openalex.org/W2001675896","https://openalex.org/W2001851867","https://openalex.org/W2002947836","https://openalex.org/W2003650919","https://openalex.org/W2003858277","https://openalex.org/W2004680931","https://openalex.org/W2005050639","https://openalex.org/W2005421795","https://openalex.org/W2005947192","https://openalex.org/W2006519535","https://openalex.org/W2006725662","https://openalex.org/W2006765654","https://openalex.org/W2009626008","https://openalex.org/W2009761723","https://openalex.org/W2011210369","https://openalex.org/W2012064354","https://openalex.org/W2014495927","https://openalex.org/W2015401858","https://openalex.org/W2016591994","https://openalex.org/W2019389990","https://openalex.org/W2020945276","https://openalex.org/W2021597023","https://openalex.org/W2021671588","https://openalex.org/W2024381893","https://openalex.org/W2024533323","https://openalex.org/W2024875691","https://openalex.org/W2025600002","https://openalex.org/W2025755006","https://openalex.org/W2025875442","https://openalex.org/W2026228148","https://openalex.org/W2027509829","https://openalex.org/W2028710436","https://openalex.org/W2028926218","https://openalex.org/W2029249439","https://openalex.org/W2030220702","https://openalex.org/W2031740608","https://openalex.org/W2033965938","https://openalex.org/W2035692642","https://openalex.org/W2037256495","https://openalex.org/W2038198568","https://openalex.org/W2039903760","https://openalex.org/W2040029402","https://openalex.org/W2040827928","https://openalex.org/W2041797639","https://openalex.org/W2042043269","https://openalex.org/W2042589075","https://openalex.org/W2043077443","https://openalex.org/W2044826629","https://openalex.org/W2045182270","https://openalex.org/W2050206872","https://openalex.org/W2051713886","https://openalex.org/W2052370283","https://openalex.org/W2054619185","https://openalex.org/W2054653938","https://openalex.org/W2054842943","https://openalex.org/W2057879405","https://openalex.org/W2059398856","https://openalex.org/W2061651784","https://openalex.org/W2067014075","https://openalex.org/W2067152527","https://openalex.org/W2071709617","https://openalex.org/W2071826279","https://openalex.org/W2075706751","https://openalex.org/W2076956056","https://openalex.org/W2078366306","https://openalex.org/W2078801104","https://openalex.org/W2080772353","https://openalex.org/W2084156847","https://openalex.org/W2084318119","https://openalex.org/W2084996586","https://openalex.org/W2086738987","https://openalex.org/W2088539556","https://openalex.org/W2089184630","https://openalex.org/W2090582369","https://openalex.org/W2090862795","https://openalex.org/W2093780401","https://openalex.org/W2094504947","https://openalex.org/W2094595339","https://openalex.org/W2095194823","https://openalex.org/W2096042508","https://openalex.org/W2101492664","https://openalex.org/W2102572112","https://openalex.org/W2103622571","https://openalex.org/W2105438365","https://openalex.org/W2106134589","https://openalex.org/W2107046588","https://openalex.org/W2107278930","https://openalex.org/W2109044040","https://openalex.org/W2110794606","https://openalex.org/W2110921202","https://openalex.org/W2111021707","https://openalex.org/W2115016218","https://openalex.org/W2116143158","https://openalex.org/W2116565356","https://openalex.org/W2119324304","https://openalex.org/W2128945877","https://openalex.org/W2131656392","https://openalex.org/W2132979902","https://openalex.org/W2134670044","https://openalex.org/W2136355116","https://openalex.org/W2137242970","https://openalex.org/W2137843368","https://openalex.org/W2140707292","https://openalex.org/W2142184151","https://openalex.org/W2143729842","https://openalex.org/W2148323678","https://openalex.org/W2152240340","https://openalex.org/W2158264132","https://openalex.org/W2162011666","https://openalex.org/W2165294470","https://openalex.org/W2232727836","https://openalex.org/W2262065180","https://openalex.org/W2269435508","https://openalex.org/W2287648822","https://openalex.org/W2323613689","https://openalex.org/W2330288813","https://openalex.org/W2341528981","https://openalex.org/W2397114778","https://openalex.org/W2406526239","https://openalex.org/W2409658803","https://openalex.org/W3120153401"],"related_works":["https://openalex.org/W7039696549","https://openalex.org/W2903095583","https://openalex.org/W6990575459","https://openalex.org/W7018622906","https://openalex.org/W2346605445","https://openalex.org/W7027823377","https://openalex.org/W2567714183","https://openalex.org/W2616003289","https://openalex.org/W2794174227","https://openalex.org/W7043699780"],"abstract_inverted_index":{"Tesis":[0],"Univ.":[1],"Granada.":[2],"Departamento":[3],"de":[4,15,17],"Bioqu\u00edmica":[5],"y":[6],"Biolog\u00eda":[7],"Molecular":[8],"III":[9],"e":[10],"Inmunolog\u00eda.":[11],"Le\u00edda":[12],"el":[13],"20":[14],"mayo":[16],"2009":[18]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}